Proteome Profiler Human Apoptosis Array Kit
Proteome Profiler Human Apoptosis Array Kit Summary
A membrane-based antibody array for the parallel determination of the relative levels of human apoptosis-related proteins. Validated for analyte detection in cell lysates.
Key Benefits
- Detects 35 human apoptosis-related proteins simultaneously
- Requires no specialized equipment
Principle of the Assay
The Proteome Profiler Human Apoptosis Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Captured proteins are detected with biotinylated detection antibodies (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount of the bound analyte.
Why Use an Antibody Array to Detect Apoptosis-Related Proteins?
Determining the expression of multiple proteins in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple proteins in a single sample can be cost-effective and also save time and sample.
- 4 Array Membranes
- 4-Well Multi-dish
- Array Buffers
- Lysis Buffer
- Wash Buffer
- Antibody Detection Cocktail
- Streptavidin-HRP
- Chemiluminescent Detection Reagents
- Transparency Overlay Template
- Detailed Protocol
For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.
Stability and Storage
Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.
Simultaneously detect the relative levels of these apoptosis-related proteins in a single sample. | ||
Bad | TRAIL R1/DR4 | PON2 |
Bax | TRAIL R2/DR5 | p21/CIP1/CDNK1A |
Bcl-2 | FADD | p27/Kip1 |
Bcl-x | Fas/TNFSF6 | Phospho-p53 (S15) |
Pro-Caspase-3 | HIF-1 alpha | Phospho-p53 (S46) |
Cleaved Caspase-3 | HO-1/HMOX1/HSP32 | Phospho-p53 (S392) |
Catalase | HO-2/HMOX2 | Phospho-Rad17 (S635) |
cIAP-1 | HSP27 | Pro-Caspase-3 |
cIAP-2 | HSP60 | SMAC/Diablo |
Claspin | HSP70 | Survivin |
Clusterin | HTRA2/Omi | TNF RI/TNFRSF1A |
Cytochrome c | Livin | XIAP |
Assays for analytes represented in the Human Apoptosis Array Kit
Analyte | Quantikine® ELISA Kits | DuoSet® ELISA Development Systems | DuoSet® IC ELISA Development Systems (Total) | DuoSet® IC ELISA Development Systems (Phospho or Active) |
Bad | DYC819 | |||
Bax | DYC820 | |||
Bcl-2 | DYC827B | |||
Bcl-x | ||||
Pro-Caspase-3 | ||||
Cleaved Caspase-3 | KM300 | DYC835 | ||
Catalase | ||||
cIAP-1 | ||||
cIAP-2 | ||||
Claspin | ||||
Clusterin | DCLU00 | DY5874 | DYC2937 | |
Cytochrome c | DCTC0 | DYC897 | ||
TRAIL R1/DR4 | ||||
TRAIL R2/DR5 | ||||
FADD | ||||
Fas/TNFSF6 | DFS00 | DY326 | ||
HIF-1alpha | DYC1935 | |||
HO-1/HMOX1/HSP32 | DYC3776 | |||
HO-2/HMOX2 | ||||
HSP27 | DYC1580 | DYC2314 | ||
HSP60 | DYC1800 | |||
HSP70 | DYC1663 | |||
HTRA2/Omi | ||||
Livin | ||||
PON2 | DYC4344 | |||
p21/CIP1/CDNK1A | DYC1047 | |||
p27/Kip1 | DYC2256 | |||
phospho-p53 (S15) | DYC1043 | DYC1839 | ||
phospho-p53 (S46) | DYC1043 | DYC1489 | ||
phospho-p53 (S392) | DYC1043 | DYC2996 | ||
phospho-Rad17 (S635) | ||||
SMAC/Diablo | DYC789 | |||
Survivin | DSV00 | DYC647 | ||
TNF RI/TNFRSF1A | DRT100 | DY225 | ||
XIAP | DYC822 |
Western blotting antibodies for analytes related to the Human Apoptosis Array Kit
Analyte | Phospho-Specific Antibodies | Affinity Purified Polyclonal Antibodies (Total) | Monoclonal Antibodies (Total) | Labeled Antibodies (Total) |
Bad | AF819 | MAB6405 | ||
Bax | AF820 | MAB846, MAB883, 2282-MC-100 | ||
Bcl-2 | AF810 | MAB8272 | ||
Bcl-x | AF800 | |||
Cleaved Caspase-3 | MAB835 | |||
Catalase | AF3398 | |||
cIAP-1 | AF8181 | MAB818 | ||
cIAP-2 | AF8171 | MAB817, MAB3400, MAB3310 | BAF8171 | |
Claspin | AF3310 | BAF3310 | ||
Clusterin | AF2937 | MAB2937 | BAF2937 | |
Cytochrome c | MAB897 | |||
Trail R1/DR4 | AF347 | BAF347 | ||
Trail R2/DR5 | AF631 | BAF631 | ||
FADD | MAB7047 (S194) | AF2938 | ||
Fas/TNFSF6 | AF326 | MAB142 | BAF326 | |
HIF-1alpha | AF1935 | MAB1536 | ||
HO-1/HMOX1/ HSP32 | AF3776 | MAB3776 | ||
HO-2/HMOX2 | AF3170 | MAB3170 | ||
HSP27 | AF2314 (S78/S82) | AF1580, AF15801 | ||
HSP60 | AF1800 | MAB1800 | ||
HSP70 | AF1663 | MAB1663 | ||
HTRA2/Omi | AF1458 | MAB1458 | ||
Livin | AF1161 | |||
PON2 | AF4344 | MAB4344 | ||
p21/CIP1/CDNK1A | AF1047 | MAB1047 | BAF1047 | |
p27/Kip1 | AF1555 (T157), AF3994 (T198) | AF2256 | MAB2256 | |
phospho-p53 (S15) | AF1043 (S15), MAB1839 (S15) | AF1355 | MAB1355 | BAF1355, HAF1355 |
phospho-p53 (S46) | AF1489 (S46), MAB1489 (S46) | AF1355 | MAB1355 | BAF1355, HAF1355 |
phospho-p53 (S392) | AF2996 (S392) | AF1355 | MAB1355 | BAF1355, HAF1355 |
phospho-Rad17 (S635) | AF1374 (S635) | AF1926 | ||
SMAC/Diablo | AF789, AF7891 | BAF789 | ||
TNF RI/TNFRSF1A | AF225 | MAB225, MAB625 | BAF225 | |
XIAP | AF8221 | MAB822 | BAF8221 |
Specifications
Product Datasheets
Scientific Data
Determination of Relative Levels of Human Apoptosis-related Proteins Using Proteome Profiler Human Apoptosis Array Kit.
Figure 1A: K562 human chronic myelogenous leukemia cells.
Figure 1B: THP-1 human acute monocytic leukemia cells.
Figure 1C: SK-Mel-28 human malignant melanoma cells.
Determination of Relative Levels of Human Apoptosis-related Proteins Using Proteome Profiler Human Apoptosis Array Kit. Jurkat human acute T cell leukemia cells were either untreated or treated with 25 µM etoposide for 6 hours. Etoposide is a topoisomerase II inhibitor that causes caspase-3 cleavage as apoptosis is induced.
Citations for Proteome Profiler Human Apoptosis Array Kit
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CTEN Induces Tumour Cell Invasion and Survival and Is Prognostic in Radiotherapy-Treated Head and Neck Cancer
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Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody
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Decreased Thymic Output Contributes to Immune Defects in Septic Patients
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Punicalagin Regulates Apoptosis-Autophagy Switch via Modulation of Annexin A1 in Colorectal Cancer
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Robustaflavone induces G0/G1 cell cycle arrest and apoptosis in human umbilical vein endothelial cells and exhibits anti-angiogenic effects in vivo
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Sequesterpene Lactones Isolated from a Brazilian Cerrado Plant (Eremanthus spp.) as Anti-Proliferative Compounds, Characterized by Functional and Proteomic Analysis, are Candidates for New Therapeutics in Glioblastoma
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Chemical, Physical and Biological Triggers of Evolutionary Conserved Bcl-xL-Mediated Apoptosis
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Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
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TAK1 regulates the tumor microenvironment through inflammatory, angiogenetic and apoptotic signaling cascades
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Two Sides to the Same Coin-Cytotoxicity vs. Potential Metastatic Activity of AgNPs Relative to Triple-Negative Human Breast Cancer MDA-MB-436 Cells
Authors: M Matysiak-K, M Czajka, B Jod?owska-, K Sawicki, P Wojty?a-Bu, M Kruszewski, L Kapka-Skrz
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Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
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The Effect of 4'-hydroxy-3,4,5-trimetoxystilbene, the Metabolite of Resveratrol Analogue DMU-212, on Growth, Cell Cycle and Apoptosis in DLD-1 and LOVO Colon Cancer Cell Lines
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Lapatinib, a preventive/therapeutic agent against mammary cancer, suppresses RTK-mediated signaling through multiple signaling pathways.
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Cancer Prev Res (Phila), 2011-07-26;4(8):1190-7. 2011-07-26
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LIM-class homeobox gene Lim1, a novel oncogene in human renal cell carcinoma.
Authors: Dormoy V, Beraud C, Lindner V, Thomas L, Coquard C, Barthelmebs M, Jacqmin D, Lang H, Massfelder T
Oncogene, 2010-12-06;30(15):1753-63. 2010-12-06
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CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1.
Authors: Datta D, Banerjee P, Gasser M
J. Biol. Chem., 2010-09-20;285(47):36842-8. 2010-09-20
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Inhibition of caspase-3 differentially affects vascular smooth muscle cell apoptosis in the concave versus convex aortic sites in ascending aneurysms with a bicuspid aortic valve.
Authors: Mohamed SA, Misfeld M, Hanke T, Charitos EI, Bullerdiek J, Belge G, Kuehnel W, Sievers HH
Ann. Anat., 2010-04-11;192(3):145-50. 2010-04-11
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Bitter melon (Momordica charantia) extract inhibits breast cancer cell proliferation by modulating cell cycle regulatory genes and promotes apoptosis.
Authors: Ray RB, Raychoudhuri A, Steele R
Cancer Res., 2010-02-23;70(5):1925-31. 2010-02-23
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A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
Authors: Cailleteau C, Liagre B, Beneytout JL
J. Cell. Biochem., 2009-07-01;107(4):785-96. 2009-07-01
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Average Rating: 4.9 (Based on 15 Reviews)
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HepG2 cell lysate, 320 ug loaded, NIR LICOR secondary antibody
The kit was used in human SW480 colorectal adenocarcinoma cells treated with gold nanoparticles synthesized with Ricinus communis extracts. Several pro-apoptotic proteins were modulated by the nanoparticles, inducing apoptosis in the cells.
Apoptosis array was used to evaluate the pro-apoptotic effect of a South American berry on human colon adenocarcinoma cancer cells (SW480). The kit was very easy to use, all steps are very clear, and results were very consistent. These results were used for a manuscript that is currently under review. We definitively would buy this array to be assayed not only for cell culture but also for tissues.
The figure shown depicts the impact of three samples (Aspirin, the South American berry or ABJ, and their combination) in the modulation of pro-apoptotic proteins from this kit.
COLO 205 cancer cells were drug treated and vehicle and apoptosis proteins analyzed. 3 minute exposure time.
Very nice kit with easy to follow protocol. Good tool for discovery biology. We used to test small molecule induction of apoptosis in breast cancer cells. I would recommend this kit to anyone looking to profile multiple apoptosis pathways at once. Spot placement was very consistent which made analysis easy.
This array is an excellent tool for screening potential apoptosis related targets. However, it would be nice that if more common targets can be included, e.g. tBid, cleaved PARP and cleaved Caspase9.
These are arrays are used to determine the changes in the expression of proteins of different apoptotic pathways. The signal is quantified to detect the changes. Protocol instructions are good and easy to follow.
Specificity: Reasonably specific
Sensitivity: Reasonably sensitive
Buffer: BSA
Dilution: 1:1000