世界卫生组织(WHO)标准换算系数表

世界卫生组织(WHO)的单位标准取决于既定的检测方法。更多关于WHO标准的信息可查看NIBSC网站

R&D Systems Cytokine R&D Systems Catalog Number Reference Cytokine NIBSC Product Number Reference Standard Units/µg Cell Line used for Bioassay R&D Systems Cytokine 1 µg = units
rhActivin A 338-AC rhActivin A 91/626 1 K562 1
rhBDNF 248-BD rhBDNF 96/534 800 BaF/3 hTrkB 1.3 x 103
rhBMP-2 355-BM rhBMP-2 93/574 500 ATDC-5 781
rhEGF 236-EG rhEGF 91/530 1.0 x 103 Balb-3T3 1.4 x 103
rhEpo 286-EP rhEpo 11/170 150 TF-1 150
rhFGF-7 251-KG rhFGF-7 03/148 900 4MBr-5 520
rhFGF basic 233-FB rhFGF basic 90/712 800 NR6R-3T3 800
rhFSH 5925-FS rhFSH 92/642 13.8 HEK293/h FSH R 17.5
rhFlt-3 Ligand 308-FK rhFlt-3 Ligand 96/532 1.0 x 103 Baflt 1.2 x 103
rhG-CSF 214-CS rhG-CSF 88/502 1.0 x 105 NFS-60 2.6 x 105
rhGH 1067-GH hGH 80/505 2.6 x 10-3 Nb2-11 5.4 x 10-3
rhGM-CSF 215-GM rhGM-CSF 88/646 1.0 x 104 TF-1 1.5 x 104
rmGM-CSF 415-ML rmGM-CSF 91/658 1.0 x 105 DA3 3.5 x 105
rhGRO alpha 275-GR rhGRO alpha 92/722 1.0 x 105 PMN 2.11 x 105
rhHGF 294-HG rhHGF 96/564 1.0 x 103 Saos-2 1.5 x 103
rhIFN-beta 8499-IF rhIFN-beta 00/572 2.0 x 105 HeLa 2.8 x 105
rhIFN-gamma 285-IF rhIFN-gamma 87/586 2.0 x 104 HeLa 2.0 x 104
rmIFN-beta 8234-MB mIFN-beta NR-3079** NA L929 1.2 x 106
rmIFN-gamma 485-MI rmIFN-gamma NIHGg02-901-533 1.0 x 103 L929 8.43 x 103
rhIGF-I 291-G1 rhIGF-I 91/554 1 MCF-7 1.9
rhIGF-II 292-G2 rhIGF-II 96/538 1000 MCF-7 850
rhIL-1 alpha 200-LA rhIL-1 alpha 86/632 1.0 x 105 D10.G4.1 1.6 x 105
rmIL-1 alpha 400-ML rmIL-1 alpha 93/672 1.0 x 106 D10.G4.1 7.1 x 105
rhIL-1 beta 201-LB rhIL-1 beta 86/680 1.0 x 105 D10.G4.1 1.4 x 105
rmIL-1 beta 401-ML rmIL-1 beta 93/668 1.0 x 106 D10.G4.1 1.1 x 106
rhIL-1ra 280-RA rhIL-1ra 92/644 1.0 x 10-3 D10.G4.1 1.0 x 10-3
rhIL-2 202-IL rhIL-2 86/500 1.4 x 104 CTLL-2 2.1 x 104
rmIL-2 402-ML rmIL-2 93/566 1.0 x 105 CTLL-2 2.5 x 105
rhIL-3 203-IL rhIL-3 91/510 1.7 x 103 TF-1 1.8 x 103
rmIL-3 403-ML rmIL-3 91/662 1.0 x 105 NFS-6 1.7 x 105
rhIL-4 204-IL rhIL-4 88/656 1.0 x 104 TF-1 2.9 x 104
rmIL-4 404-ML rmIL-4 91/656 1.0 x 104 HT-2 1.8 x 105
rhIL-5 205-IL rhIL-5 90/586 1.0 x 104 TF-1 4.4 x 104
rhIL-6 206-IL rhIL-6 89/548 1.0 x 105 T1165.85.2.1 1.1 x 105
rmIL-6 406-ML rmIL-6 93/730 1.0 x 105 T1165.85.2.1 9.0 x 105
rhIL-7 207-IL rhIL-7 90/530 1.0 x 105 activated PBL 4.4 x 105
rmIL-7 407-ML rmIL-7 93/740 5.0 x 104 activated PBL 1.5 x 105
rhIL-8 208-IL rhIL-8 89/520 1.0 x 103 PMN see below**
rhIL-9 209-IL rhIL-9 91/678 1.0 x 104 MO7e 8.4 x 103
rmIL-9 409-ML rmIL-9 93/504 NA TS1 0.9 µg
rhIL-10 217-IL rhIL-10 93/722 5.0 x 103 MC/9 1.45 x 104
rhIL-11 218-IL rhIL-11 92/788 1.0 x 104 T11 1.05 x 104
rhIL-12 219-IL rhIL-12 95/544 1.0 x 104 PBL 1.1x 104
rhIL-13 213-ILB rhIL-13 94/622 1.0 x 103 TF-1 780
rhIL-15 247-IL rhIL-15 95/554 1.0 x 104 MO7e 4.5 x 105
rhLeptin 398-LP rhLeptin 97/594 800 BaF3/h OB R 1.2 x 103
rmLeptin 498-OB rmLeptin 97/626 1.0 x 103 BaF3/h OB R 1.7 x 103
rhLIF 7734-LF rhLIF 93/562 1 x 104 TF-1 1.27 x 104
rhM-CSF 216-MC rhM-CSF 89/512 6.0 x 104 M-NFS-60 1.68 x 105
rhMCP-1 279-MC rhMCP-1 92/794 1.0 x 103 MNC 1.36 x 103
rhMCP-2 281-CP rhMCP-2 96/594 2.5 x 103 MNC see below**
rhMIP-1 alpha 270-LD rhMIP-1 alpha 92/518 100 MNC 200
rhMIP-1 beta 271-BME rhMIP-1 beta 96/588 1.0 x 103 MNC 1.6 x 103
rhbeta-NGF 256-GF rhbeta-NGF 93/556 1.0 x 103 TF-1 1.0 x 103
rhNT-3 267-N3 rhNT-3 98/718 1.0 x 103 BaF/3 hTrkB 2.1 x 103
rhOSM 295-OM rhOSM 93/564 5.0 x 104 TF-1 6.2 x 104
rhPDGF-BB 220-BB rhPDGF-BB 94/728 750 NR6R-3T3 5.8 x 103
rhProlactin 682-PL rhProlactin 84/500 0.0212 Nb2-11 0.054
rhRANTES 278-RN rhRANTES 92/520 1.0 x 104 MNC 2.5 x 104
rhSCF 255-SC rhSCF 91/682 1.0 x 103 TF-1 564
porcine TGF-beta 1 101-B1 bTGF-beta 1 89/516 18750 HT-2 2.1 x 104
porcine TGF-beta 2 102-B2 hTGF-beta 2 90/696 2.0 x 104 HT-2 5.6 x 104
rhTGF-beta 240-B rhTGF-beta 1 89/514 1.9 x 104 HT-2 2.5 x 104
rhTGF-beta 3 243-B3 rhTGF-beta 3 09/234 1.9 x 104 HT-2 2.2 x 104
rhTNF-alpha 210-TA rhTNF-alpha 88/786 4.65 x 104 L-929 7.6 x 104
rmTNF-alpha 410-MT rmTNF-alpha 88/532 2.0 x 105 L-929 2.7 x 105
rhTNF-beta 211-TB rhTNF-beta 87/640 1.5 x 105 L-929 4.6 x 104
rhTRAIL 375-TEC(E. coli) rhTRAIL 04/166 1.0 x 104 L-929 5.6 x 103
rhTRAIL 375-TL(NS0) rhTRAIL 04/166 1.0 x 104 L-929 3.2 x 103
rhTSH 4610-TH rhTSH 94/674 6.7 x 10-3 HEK293/h TSH R 7.9 x 10-3
rhVEGF165 293-VE rhVEGF165 02/286 1.0 x 103 HUVEC 1.1 x 103

*人IL-2蛋白与该蛋白在WHO的第一个国际标准品进行比较

**与R&D Systems的产品平行比较,WHO标准品的最大信号远低于R&D Systems产品,故不能使用ED50方法进行活性比较