Recombinant Human IL-1 beta/IL-1F2 Protein

IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination
Authors: Park, HJ;Shin, MS;Shin, JJ;Kim, H;Kang, B;Par-Young, J;Unlu, S;Afinogenova, Y;Catanzaro, J;Young, J;Kim, M;Lee, SJ;Jeon, S;You, S;Racke, MK;Bucala, R;Kang, I;
EBioMedicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling
Authors: Naoi, Y;Morinaga, T;Nagasaki, J;Ariyasu, R;Ueda, Y;Yamashita, K;Zhou, W;Kawashima, S;Kawase, K;Honobe-Tabuchi, A;Ohnuma, T;Kawamura, T;Umeda, Y;Kawahara, Y;Nakamura, Y;Kiniwa, Y;Yamasaki, O;Fukushima, S;Kawazu, M;Suzuki, Y;Nishikawa, H;Hanazawa, T;Ando, M;Inozume, T;Togashi, Y;
Cancer research
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
Authors: Oda, H;Manthiram, K;Chavan, PP;Rieser, E;Veli, Ö;Kaya, Ö;Rauch, C;Nakabo, S;Kuehn, HS;Swart, M;Wang, Y;Çelik, NI;Molitor, A;Ziaee, V;Movahedi, N;Shahrooei, M;Parvaneh, N;Alipour-Olyei, N;Carapito, R;Xu, Q;Preite, S;Beck, DB;Chae, JJ;Nehrebecky, M;Ombrello, AK;Hoffmann, P;Romeo, T;Deuitch, NT;Matthíasardóttir, B;Mullikin, J;Komarow, H;Stoddard, J;Niemela, J;Dobbs, K;Sweeney, CL;Anderton, H;Lawlor, KE;Yoshitomi, H;Yang, D;Boehm, M;Davis, J;Mudd, P;Randazzo, D;Tsai, WL;Gadina, M;Kaplan, MJ;Toguchida, J;Mayer, CT;Rosenzweig, SD;Notarangelo, LD;Iwai, K;Silke, J;Schwartzberg, PL;Boisson, B;Casanova, JL;Bahram, S;Rao, AP;Peltzer, N;Walczak, H;Lalaoui, N;Aksentijevich, I;Kastner, DL;
Nature immunology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Detection of Interleukin-1 ? (IL-1?) in Single Human Blastocyst-Conditioned Medium Using Ultrasensitive Bead-Based Digital Microfluidic Chip and Its Relationship with Embryonic Implantation Potential
Authors: Tsai, TC;Wang, YW;Lee, MS;Wu, WN;Hsu, W;Yao, DJ;Huang, HY;
International journal of molecular sciences
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Capture

Geniposidic acid alleviates osteoarthritis progression through inhibiting inflammation and chondrocytes ferroptosis
Authors: Sun, J;Song, X;Wang, C;Ruan, Q;
Journal of cellular and molecular medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TLR2 Supports ?? T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming
Authors: Zhu, W;Xu, X;Nagarajan, V;Guo, J;Peng, Z;Zhang, A;Liu, J;Mattapallil, MJ;Jittayasothorn, Y;Horai, R;Leger, AJS;Caspi, RR;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms
Authors: Joshi, IV;Chan, EC;Lack, JB;Liu, C;Druey, KM;
The Journal of biological chemistry
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Redox regulation of m6A methyltransferase METTL3 in ?-cells controls the innate immune response in type 1 diabetes
Authors: F De Jesus, D;Zhang, Z;Brown, NK;Li, X;Xiao, L;Hu, J;Gaffrey, MJ;Fogarty, G;Kahraman, S;Wei, J;Basile, G;Rana, TM;Mathews, C;Powers, AC;Parent, AV;Atkinson, MA;Dhe-Paganon, S;Eizirik, DL;Qian, WJ;He, C;Kulkarni, RN;
Nature cell biology
Species: Human
Sample Types: BALF, Recombinat Protein
Applications: Bioassay

Identification of new multi-substituted 1H-pyrazolo[3,4-c]pyridin-7(6H)-ones as soluble guanylyl cyclase (sGC) stimulators with vasoprotective and anti-inflammatory activities
Authors: Kintos, DP;Salagiannis, K;Sgouros, A;Nikolaropoulos, SS;Topouzis, S;Fousteris, MA;
Bioorganic chemistry
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteins
Authors: Alves, J;Schwinn, M;Machleidt, T;Goueli, SA;Cali, JJ;Zegzouti, H;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of TGF-? and p38 MAPK in TSG-6 Expression in Adipose Tissue-Derived Stem Cells In Vitro and In Vivo
Authors: Kwon, HY;Yoon, Y;Hong, JE;Rhee, KJ;Sohn, JH;Jung, PY;Kim, MY;Baik, SK;Ryu, H;Eom, YW;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia Dysregulates the Transcription of Myoendothelial Junction Proteins Involved with Nitric Oxide Production in Brain Endothelial Cells
Authors: Thomas, G;Banton, KL;Garrett, R;Palacio, CH;Acuna, D;Madayag, R;Bar-Or, D;
Biomedicines
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The long non-coding RNA HOTAIR contributes to joint-specific gene expression in rheumatoid arthritis
Authors: Elhai, M;Micheroli, R;Houtman, M;Mirrahimi, M;Moser, L;Pauli, C;Bürki, K;Laimbacher, A;Kania, G;Klein, K;Schätzle, P;Bertoncelj, MF;Edalat, SG;Keusch, L;Khmelevskaya, A;Toitou, M;Geiss, C;Rauer, T;Sakkou, M;Kollias, G;Armaka, M;Distler, O;Ospelt, C;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Akt, IL-4, and STAT Proteins Play Distinct Roles in Prostaglandin Production in Human Follicular Dendritic Cell-like Cells
Authors: Jeong, J;Choe, J;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function
Authors: Ma, X;Cao, L;Raneri, M;Wang, H;Cao, Q;Zhao, Y;Bediaga, NG;Naselli, G;Harrison, LC;Hawthorne, WJ;Hu, M;Yi, S;O'Connell, PJ;
JCI insight
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circulating senescent myeloid cells drive blood brain barrier breakdown and neurodegeneration
Authors: Wilk, CM;Cathomas, F;Török, O;Le Berichel, J;Park, MD;Heaton, GR;Hamon, P;Troncoso, L;Scull, BP;Dangoor, D;Silvin, A;Fleischmann, R;Belabed, M;Lin, H;Taouli, EM;Boettcher, S;Manz, MG;Kofler, JK;Yue, Z;Lira, SA;Ginhoux, F;Crary, JF;McClain, KL;Picarsic, JL;Russo, SJ;Allen, CE;Merad, M;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Progressively enhancing stemness of adoptively transferred T cells with PI3K? blockade improves metabolism and anti-tumor immunity
Authors: Rangel Rivera, GO;Dwyer, CJ;Knochelmann, HM;Smith, AS;Aksoy, BA;Cole, AC;Wyatt, MM;Kumaresan, S;Thaxton, JE;Lesinski, GB;Paulos, CM;
Cancer research
Species: Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-Induced iNOS in A549 Alveolar Epithelial Cells: A Potential Role in COVID-19 Lung Pathology
Authors: Barilli, A;Recchia Luciani, G;Visigalli, R;Sala, R;Soli, M;Dall'Asta, V;Rotoli, BM;
Biomedicines
Species: Human
Sample Types: Transfected Whole Cells, Whole Cells
Applications: Bioassay

Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway
Authors: Ruan, Q;Wang, C;Zhang, Y;Sun, J;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva
Authors: Yang, YS;Lin, C;Ma, H;Xie, J;Kaplan, FS;Gao, G;Shim, JH;
Biomolecules
Species: Human, Transgenic Mouse
Sample Types: Transduced Whole Cells, Whole Cells
Applications: Bioassay

TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Authors: Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Repurposing Fc gamma receptor I (Fc?RI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -?)
Authors: Çapk?n, E;Kutlu, A;Yüce, M;
Heliyon
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay

Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease
Authors: Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N;
EBioMedicine
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypoxia-inducible factor 1 signaling drives placental aging and can provoke preterm labor
Authors: Ciampa, EJ;Flahardy, P;Srinivasan, H;Jacobs, C;Tsai, L;Karumanchi, SA;Parikh, SM;
eLife
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Knockout studies using CD34+ hematopoietic cells suggest that CD44 is a physiological human neutrophil E-selectin ligand
Authors: Zhu, Y;Neelamegham, S;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TNF-?, IL-1B and IL-6 affect the differentiation ability of dental pulp stem cells
Authors: Sonmez Kaplan, S;Sazak Ovecoglu, H;Genc, D;Akkoc, T;
BMC oral health
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction
Authors: Shimizu, K;Kikuta, J;Ohta, Y;Uchida, Y;Miyamoto, Y;Morimoto, A;Yari, S;Sato, T;Kamakura, T;Oshima, K;Imai, R;Liu, YC;Okuzaki, D;Hara, T;Motooka, D;Emoto, N;Inohara, H;Ishii, M;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation
Authors: Converti, A;Bianchi, MS;Martinez, MD;Montaner, AD;Lux-Lantos, V;Bonaventura, MM;
Physiological reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Polynucleotides Suppress Inflammation and Stimulate Matrix Synthesis in an In Vitro Cell-Based Osteoarthritis Model
Authors: Kuppa, SS;Kim, HK;Kang, JY;Lee, SC;Yang, HY;Sankaranarayanan, J;Seon, JK;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Authors: Xu, D;Jiang, W;Wu, L;Gaudet, RG;Park, ES;Su, M;Cheppali, SK;Cheemarla, NR;Kumar, P;Uchil, PD;Grover, JR;Foxman, EF;Brown, CM;Stansfeld, PJ;Bewersdorf, J;Mothes, W;Karatekin, E;Wilen, CB;MacMicking, JD;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential regulation of BIRC2 and BIRC3 expression by inflammatory cytokines and glucocorticoids in pulmonary epithelial cells
Authors: Thorne, A;Bansal, A;Necker-Brown, A;Mostafa, MM;Gao, A;Georgescu, A;Kooi, C;Leigh, R;Newton, R;
PloS one
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Endogenous Dual Retinoid Receptor Agonist Alitretinoin Exhibits Immunoregulatory Functions on Antigen-Presenting Cells
Authors: Kislat, A;Olah, P;Kuchner, M;Gerber, PA;Schrader, J;Meller, S;Homey, B;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis
Authors: Qu, Y;Wang, Y;Wang, S;Yu, X;He, Y;Lu, R;Chen, S;Meng, C;Xu, H;Pei, W;Ni, B;Zhang, R;Huang, X;You, H;
Computers in biology and medicine
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dynamics of Ex Vivo Mesenchymal Stromal Cell Potency under Continuous Perfusion
Authors: Doshi, A;Erickson, P;Teryek, M;Parekkadan, B;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis
Authors: Suga, K;Suto, A;Tanaka, S;Sugawara, Y;Kageyama, T;Ishikawa, J;Sanayama, Y;Ikeda, K;Furuta, S;Kagami, SI;Iwata, A;Hirose, K;Suzuki, K;Ohara, O;Nakajima, H;
JCI insight
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Serelaxin Alleviates Fibrosis in Thyroid-Associated Ophthalmopathy via the Notch Pathway
Authors: Sun, A;Ye, H;Xu, Z;Chen, J;Xiao, W;Zhang, T;Sha, X;Bi, S;Zhou, T;Yang, H;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
Authors: Slieker, RC;Donnelly, LA;Akalestou, E;Lopez-Noriega, L;Melhem, R;G�ne?, A;Abou Azar, F;Efanov, A;Georgiadou, E;Muniangi-Muhitu, H;Sheikh, M;Giordano, GN;�kerlund, M;Ahlqvist, E;Ali, A;Banasik, K;Brunak, S;Barovic, M;Bouland, GA;Burdet, F;Canouil, M;Dragan, I;Elders, PJM;Fernandez, C;Festa, A;Fitipaldi, H;Froguel, P;Gudmundsdottir, V;Gudnason, V;Gerl, MJ;van der Heijden, AA;Jennings, LL;Hansen, MK;Kim, M;Leclerc, I;Klose, C;Kuznetsov, D;Mansour Aly, D;Mehl, F;Marek, D;Melander, O;Niknejad, A;Ottosson, F;Pavo, I;Duffin, K;Syed, SK;Shaw, JL;Cabrera, O;Pullen, TJ;Simons, K;Solimena, M;Suvitaival, T;Wretlind, A;Rossing, P;Lyssenko, V;Legido Quigley, C;Groop, L;Thorens, B;Franks, PW;Lim, GE;Estall, J;Ibberson, M;Beulens, JWJ;'t Hart, LM;Pearson, ER;Rutter, GA;
Nature communications
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Decellularized Scaffolds of Nopal (Opuntia Ficus-indica) for Bioengineering in Regenerative Dentistry
Authors: Zamudio-Ceja, RB;Garcia-Contreras, R;Chavez-Granados, PA;Aranda-Herrera, B;Alvarado-Garnica, H;Jurado, CA;Fischer, NG;
Journal of functional biomaterials
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tannic acid, an IL-1beta-direct binding compound, ameliorates IL-1beta-induced inflammation and cartilage degradation by hindering IL-1beta-IL-1R1 interaction
Authors: HR Lee, YJ Jeong, JW Lee, J Jhun, HS Na, KH Cho, SJ Kim, ML Cho, TH Heo
PLoS ONE, 2023-04-20;18(4):e0281834.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Capture

MicroRNA Signatures in Cartilage Ageing and Osteoarthritis
Authors: Balaskas, P;Goljanek-Whysall, K;Clegg, PD;Fang, Y;Cremers, A;Smagul, A;Welting, TJM;Peffers, MJ;
Biomedicines
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
Authors: MP Cabral-Pic, L Papagno, X Lahaye, F Perdomo-Ce, S Volant, E White, V Monceaux, S Llewellyn-, R Fromentin, DA Price, N Chomont, N Manel, A Saez-Cirio, V Appay
EBioMedicine, 2023-04-12;91(0):104557.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulatory mechanisms of kaempferol on iNOS expression in RINm5F beta-cells under exposure to interleukin-1beta
Authors: SY Chang, Y Ko, MJ Kim
Heliyon, 2023-03-23;9(4):e14818.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

BCL-XL Overexpression Protects Pancreatic beta-Cells against Cytokine- and Palmitate-Induced Apoptosis
Authors: AA Perez-Sern, RS Dos Santos, C Ripoll, A Nadal, DL Eizirik, L Marroqui
International Journal of Molecular Sciences, 2023-03-16;24(6):.
Species: Human, Rat
Sample Types: Whole Cells
Applications: Bioassay

Simultaneous quantitative analysis and in vitro anti-arthritic effects of five polyphenols from Terminalia chebula
Authors: F Liu, S Zhan, P Zhang, C Jia, Q Zhu, Q Dai, M Yu, L Cheng, L Xiong, F Sun, P Xia, X Zhang, J Hu
Frontiers in Physiology, 2023-03-08;14(0):1138947.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging
Authors: C Zhu, DM Potenza, Y Yang, G Ajalbert, KD Mertz, S von Gunten, XF Ming, Z Yang
Aging Cell, 2023-02-15;0(0):e13790.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
Authors: F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber
bioRxiv : the preprint server for biology, 2023-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective Transcription Factor Blockade Reduces Human Retinal Endothelial Cell Expression of Intercellular Adhesion Molecule-1 and Leukocyte Binding
Authors: Y Ma, LM Ashander, B Appukuttan, FJ Ryan, ACR Tan, JM Matthews, MZ Michael, DJ Lynn, JR Smith
International Journal of Molecular Sciences, 2023-02-07;24(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Salmonella Typhimurium Infection Reduces the Ascorbic Acid Uptake in the Intestine
Authors: T Teafatille, SB Subramanya, N Lambrecht, VS Subramania
Mediators of Inflammation, 2023-01-17;2023(0):2629262.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Micrococcus luteus-derived extracellular vesicles attenuate neutrophilic asthma by regulating miRNAs in airway epithelial cells
Authors: S Sim, DH Lee, KS Kim, HJ Park, YK Kim, Y Choi, HS Park
Experimental & Molecular Medicine, 2023-01-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Silencing miR-146a-5p Protects against Injury-Induced Osteoarthritis in Mice
Authors: H Qin, C Wang, Y He, A Lu, T Li, B Zhang, J Shen
Biomolecules, 2023-01-07;13(1):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes
Authors: DS Yoon, EJ Kim, S Cho, S Jung, KM Lee, KH Park, JW Lee, SH Kim
International journal of biological sciences, 2023-01-01;19(1):13-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune Response
Authors: L Cao, X Ma, J Zhang, M Yang, Z He, C Yang, S Li, P Rong, W Wang
Cell Transplantation, 2023-01-01;32(0):9636897221149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tannic acid, an IL-1beta-direct binding compound, ameliorates IL-1beta-induced inflammation and cartilage degradation by hindering IL-1beta-IL-1R1 interaction
Authors: HR Lee, YJ Jeong, JW Lee, J Jhun, HS Na, KH Cho, SJ Kim, ML Cho, TH Heo
PLoS ONE, 2023;18(4):e0281834.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Capture

Regulatory mechanisms of kaempferol on iNOS expression in RINm5F beta-cells under exposure to interleukin-1beta
Authors: SY Chang, Y Ko, MJ Kim
Heliyon, 2023;9(4):e14818.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

Gene Expression Linked to Reepithelialization of Human Skin Wounds
Authors: MS Ågren, T Litman, JO Eriksen, P Schjerling, M Bzorek, LMR Gjerdrum
International Journal of Molecular Sciences, 2022-12-12;23(24):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Authors: N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott, Y Zhang, K Johnson, J Shi, S Walter, Y Li, C Jacobi, N Laplanche, M Belaud, J Paul, G Glowacki, T Peters, KA Wharton, I Vostiar, F Polus, I Kramer, S Guth, A Seroutou, S Choudhury, D Laurent, J Gimbel, J Goldhahn, M Schieker, S Brachat, R Roubenoff, M Kneissel
Nature Medicine, 2022-12-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study
Authors: HJ Kim, SH Kim, YS Oh, SR Lee, HD Chae
Biomedicines, 2022-11-21;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

ST3GAL3 Promotes the Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Activating the TLR9/MyD88 Pathway
Authors: L Xu, X Niu, Y Liu, L Liu
Mediators of Inflammation, 2022-11-10;2022(0):4258742.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic beta Cells
Authors: S Kaur, C Frørup, AH Mirza, T Fløyel, R Yarani, ML Colli, J Johannesen, J Størling, DL Eizirik, F Pociot
Non-coding RNA, 2022-10-12;8(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism
Authors: R Chandrasek, C Mathieu, R Sheth, AP Cheng, D Fong, R McCormack, H El-Gabalaw, S Alishetty, M Paige, CD Hoemann
PLoS ONE, 2022-09-15;17(9):e0274420.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1beta-Induced Human Osteoarthritis Chondrocytes through NF-kappaB and NLRP3 Signal Pathway
Authors: Y Mu, L Wang, L Fu, Q Li
Mediators of Inflammation, 2022-09-12;2022(0):1870579.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-beta1-Dependent Mechanism
Authors: C Bouchet, G Cardouat, M Douard, F Coste, P Robillard, F Delcambre, T Ducret, JF Quignard, P Vacher, I Baudrimont, R Marthan, P Berger, C Guibert, V Freund-Mic
Cells, 2022-09-07;11(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-27 shapes the immune properties of human astrocytes and their impact on encountered human T lymphocytes
Authors: F Lemaître, N Farzam-Kia, A Carmena Mo, Y Carpentier, ML Clenet, O Tastet, A Cleret-Buh, JV Guimond, E Haddad, P Duquette, JM Girard, A Prat, C Larochelle, N Arbour
Journal of Neuroinflammation, 2022-09-01;19(1):212.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small Extracellular Vesicles from Inflamed Adipose Derived Stromal Cells Enhance the NF-kappaB-Dependent Inflammatory/Catabolic Environment of Osteoarthritis
Authors: C Cavallo, G Merli, N Zini, S D'Adamo, L Cattini, M Guescini, B Grigolo, A Di Martino, S Santi, RM Borzì, G Filardo
Stem Cells International, 2022-07-18;2022(0):9376338.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Articular surface integrity assessed by ultrasound is associated with biological characteristics of articular cartilage in early-stage degeneration
Authors: W Shi, T Kanamoto, M Aihara, S Oka, S Kuroda, T Nakai, T Mazuka, K Takenaka, Y Sato, M Tsukamoto, K Ebina, K Nakata
Scientific Reports, 2022-07-13;12(1):11970.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Meniscus surface texture is associated with degenerative changes in biological and biomechanical properties
Authors: S Otani, T Kanamoto, S Oyama, S Yamakawa, W Shi, R Miyazaki, M Aihara, S Oka, S Kuroda, T Nakai, K Takenaka, Y Sato, M Tsukamoto, A Tsujii, K Ebina, S Okada, K Nakata
Scientific Reports, 2022-07-13;12(1):11977.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-beta1 Expression in the Corneal Epithelium
Authors: J Xu, P Chen, X Luan, X Yuan, S Wei, Y Li, C Guo, X Wu, G Di
Investigative Ophthalmology & Visual Science, 2022-07-08;63(8):15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rosmarinic acid alleviates acetaminophen-induced hepatotoxicity by targeting Nrf2 and NEK7-NLRP3 signaling pathway
Authors: Y Yao, R Li, D Liu, L Long, N He
Ecotoxicology and environmental safety, 2022-06-24;241(0):113773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of a distal enhancer that determines the expression pattern of acute phase marker C-reactive protein
Authors: MY Wang, CM Zhang, HH Zhou, ZB Ge, CC Su, ZH Lou, XY Zhang, TT Xu, SY Li, L Zhu, YL Zhou, Y Wu, SR Ji
Oncogene, 2022-06-17;0(0):102160.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Clusterin exacerbates interleukin-1beta-induced inflammation via suppressing PI3K/Akt pathway in human fibroblast-like synoviocytes of knee osteoarthritis
Authors: T Ungsudecha, S Honsawek, J Jittikoon, W Udomsinpra
Oncogene, 2022-06-15;12(1):9963.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation
Authors: A Shetty, SK Tripathi, S Junttila, T Buchacher, R Biradar, SD Bhosale, T Envall, A Laiho, R Moulder, O Rasool, S Galande, LL Elo, R Lahesmaa
Nucleic Acids Research, 2022-05-20;50(9):4938-4958.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bead Number Effect in a Magnetic-Beads-Based Digital Microfluidic Immunoassay
Authors: W Hsu, YT Shih, MS Lee, HY Huang, WN Wu
Biosensors, 2022-05-16;12(5):.
Species: Human
Sample Types: Recombinant Proteins
Applications: ELISA Capture

Modified lipid metabolism and cytosolic phospholipase A2 activation in mesangial cells under pro-inflammatory conditions
Authors: R Boi, K Ebefors, M Henricsson, J Borén, J Nyström
Scientific Reports, 2022-05-05;12(1):7322.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation
Authors: R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun
Cell Reports, 2022-04-12;39(2):110646.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
Authors: Y Huang, E Motta, C Nanvuma, LD Kuhrt, Y Yuan, P Xia, M Lubas, S Zhu, M Schnauss, N Qazi, F Hu, H Zhang, T Lei, M Synowitz, C Flüh, H Kettenmann
Cell Reports, 2022-04-12;39(2):110670.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Citrullination of glucokinase is linked to autoimmune diabetes
Authors: ML Yang, S Horstman, R Gee, P Guyer, TT Lam, J Kanyo, AL Perdigoto, C Speake, CJ Greenbaum, A Callebaut, L Overbergh, RG Kibbey, KC Herold, EA James, MJ Mamula
Nature Communications, 2022-04-06;13(1):1870.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1
Authors: T Lehtola, E Nummenmaa, L Tuure, M Hämäläinen, RM Nieminen, T Moilanen, A Pemmari, E Moilanen
International Journal of Molecular Sciences, 2022-03-31;23(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-kappaB pathways
Authors: M Yu, X Wu, J Wang, M He, H Han, S Hu, J Xu, M Yang, Q Tan, Y Wang, H Wang, W Xie, H Kong
International Journal of Medical Sciences, 2022-03-28;19(4):681-694.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RORgammat phosphorylation protects against T�cell-mediated inflammation
Authors: S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang
Cell Reports, 2022-03-15;38(11):110520.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
Cancers, 2022-03-11;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Human C1q Regulates Influenza A Virus Infection and Inflammatory Response via Its Globular Domain
Authors: PM Varghese, U Kishore, R Rajkumari
International Journal of Molecular Sciences, 2022-03-11;23(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pro-Inflammatory Cytokines Trigger the Overexpression of Tumour-Related Splice Variant RAC1B in Polarized Colorectal Cells
Authors: JFS Pereira, C Bessa, P Matos, P Jordan
Cancers, 2022-03-09;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling
Authors: C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu
Redox Biology, 2022-02-24;51(0):102274.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL?1beta?induced pentraxin 3 inhibits the proliferation, invasion and cell cycle of trophoblasts in preeclampsia and is suppressed by IL?1beta antagonists
Authors: X Wang, J Zhang, J Ji
Molecular Medicine Reports, 2022-02-09;25(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The IGFBP3/TMEM219 pathway regulates beta cell homeostasis
Authors: F D'Addio, A Maestroni, E Assi, M Ben Nasr, G Amabile, V Usuelli, C Loretelli, F Bertuzzi, B Antonioli, F Cardarelli, B El Essawy, A Solini, IC Gerling, C Bianchi, G Becchi, S Mazzucchel, D Corradi, GP Fadini, D Foschi, JF Markmann, E Orsi, J Škrha, MG Camboni, R Abdi, AM James Shap, F Folli, J Ludvigsson, S Del Prato, G Zuccotti, P Fiorina
Nature Communications, 2022-02-03;13(1):684.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Extracellular Vesicles Derived from Primed Mesenchymal Stromal Cells Loaded on Biphasic Calcium Phosphate Biomaterial Exhibit Enhanced Macrophage Polarization
Authors: N Rana, S Suliman, N Al-Sharabi, K Mustafa
Cells, 2022-01-29;11(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

miR-29b inhibits TGF-beta1-induced cell proliferation in articular chondrocytes
Authors: M Horita, SN Hsu, A Raper, C Farquharso, LA Stephen
Biochemistry and Biophysics Reports, 2022-01-24;29(0):101216.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial
Authors: N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott, Y Zhang, K Johnson, J Shi, S Walter, Y Li, C Jacobi, N Laplanche, M Belaud, J Paul, G Glowacki, T Peters, KA Wharton, I Vostiar, F Polus, I Kramer, S Guth, A Seroutou, S Choudhury, D Laurent, J Gimbel, J Goldhahn, M Schieker, S Brachat, R Roubenoff, M Kneissel
Nature Medicine, 2022;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication
Authors: JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger
Oncogene, 2021-12-31;0(0):101430.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Reduced Interleukin-17-Expressing Cells in Cutaneous Melanoma
Authors: A Tosi, L Nardinocch, ML Carbone, L Capriotti, E Pagani, S Mastroeni, C Fortes, F Scopelliti, C Cattani, F Passarelli, A Rosato, S D'Atri, CM Failla, A Cavani
Biomedicines, 2021-12-16;9(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
Authors: A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial
Cell Reports, 2021-11-23;37(8):110037.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Takinib Inhibits Inflammation in Human Rheumatoid Arthritis Synovial Fibroblasts by Targeting the Janus Kinase-Signal Transducer and Activator of Transcription 3 (JAK/STAT3) Pathway
Authors: PM Panipinto, AK Singh, FS Shaikh, RJ Siegel, M Chourasia, S Ahmed
International Journal of Molecular Sciences, 2021-11-22;22(22):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo
Authors: SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis
PLoS ONE, 2021-11-09;16(11):e0248034.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling
Authors: C Xu, J Tang, Q Yang, H Zhao, Y Liu, J Cao, Y Zhou, X Chen, J Chen
The Journal of Biological Chemistry, 2021-11-03;0(0):101380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HSPA13 facilitates NF-kappaB-mediated transcription and attenuates cell death responses in TNFalpha signaling
Authors: C Gao, J Deng, H Zhang, X Li, S Gu, M Zheng, M Tang, Y Zhu, X Lin, J Jin, L Zhang, J Huang, J Zou, ZP Xia, PL Xu, L Shen, B Zhao, XH Feng
Science Advances, 2021-10-06;7(41):eabh1756.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Systematic investigation of cytokine signaling activity at the tissue and single-cell levels
Authors: P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen
Nature methods, 2021-09-30;18(10):1181-1191.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway
Authors: H Yu, M Xie, Z Meng, CY Lo, FL Chan, L Jiang, X Meng, X Yao
British Journal of Cancer, 2021-09-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis
Authors: HK Min, S Kim, JY Lee, KW Kim, SH Lee, HR Kim
Journal of Translational Medicine, 2021-09-16;19(1):392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation
Authors: JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng
Frontiers in Cellular Neuroscience, 2021-09-07;15(0):683687.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes
Authors: N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko
Cell Reports, 2021-08-24;36(8):109613.
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation

Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model
Authors: T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker
Scientific Reports, 2021-08-23;11(1):17028.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function
Authors: H Gassmann, K Schneider, V Evdokimova, P Ruzanov, SJ Schober, B Xue, K von Heykin, M Thiede, GHS Richter, MW Pfaffl, E Noessner, LD Stein, PH Sorensen, SEG Burdach, U Thiel
Cells, 2021-08-13;10(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD147 mediates the CD44s-dependent differentiation of myofibroblasts driven by transforming growth factor-beta1
Authors: EL Woods, IV Grigorieva, AC Midgley, CVM Brown, YA Lu, AO Phillips, T Bowen, S Meran, R Steadman
The Journal of Biological Chemistry, 2021-08-06;0(0):100987.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of PHLPP1/2 phosphatases rescues pancreatic beta-cells in diabetes
Authors: B Lupse, K Annamalai, H Ibrahim, S Kaur, S Geravandi, B Sarma, A Pal, S Awal, A Joshi, S Rafizadeh, MK Madduri, M Khazaei, H Liu, T Yuan, W He, KDD Gorrepati, Z Azizi, Q Qi, K Ye, J Oberholzer, K Maedler, A Ardestani
Cell Reports, 2021-08-03;36(5):109490.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
Authors: R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini
Nature Communications, 2021-07-27;12(1):4559.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells
Authors: S Luostarine, M Hämäläinen, N Hatano, K Muraki, E Moilanen
Pulmonary pharmacology & therapeutics, 2021-07-21;70(0):102059.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis
Authors: JK Park, S Shon, HJ Yoo, DH Suh, D Bae, J Shin, JH Jun, N Ha, H Song, YI Choi, T Pap, YW Song
Arthritis Research & Therapy, 2021-07-05;23(1):177.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells
Authors: L Liu, B Zheng, Z Wang
Molecular Medicine Reports, 2021-07-02;24(3):.
Species: Rat
Sample Types: Cell Culture Supernates

Post-myocardial infarction heart failure dysregulates the bone vascular niche
Authors: J Hoffmann, G Luxán, WT Abplanalp, SF Glaser, T Rasper, A Fischer, M Muhly-Rein, M Potente, B Assmus, D John, AM Zeiher, S Dimmeler
Nature Communications, 2021-06-25;12(1):3964.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Susceptibility of cyclin-dependent kinase inhibitor 1-deficient mice to rheumatoid arthritis arising from interleukin-1beta-induced inflammation
Authors: Y Takashima, S Hayashi, K Fukuda, T Maeda, M Tsubosaka, T Kamenaga, K Kikuchi, M Fujita, Y Kuroda, S Hashimoto, N Nakano, T Matsumoto, R Kuroda
Scientific Reports, 2021-06-15;11(1):12516.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Food Contaminants Effects on an In Vitro Model of Human Intestinal Epithelium
Authors: M Guibourden, J Haug, N Chevalier, M Spatz, N Barbezier, J Gay-Quéhei, PM Anton
Toxics, 2021-06-09;9(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

In vitro responses to platelet-rich-plasma are associated with variable clinical outcomes in patients with knee osteoarthritis
Authors: H Zahir, B Dehghani, X Yuan, Y Chinenov, C Kim, A Burge, R Bandhari, D Nemirov, P Fava, P Moley, H Potter, J Nguyen, B Halpern, L Donlin, L Ivashkiv, S Rodeo, M Otero
Scientific Reports, 2021-06-01;11(1):11493.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The discriminatory power of the T cell receptor
Authors: J Pettmann, A Huhn, E Abu Shah, MA Kutuzov, DB Wilson, ML Dustin, SJ Davis, PA van der Me, O Dushek
Elife, 2021-05-25;10(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Repression of CTSG, ELANE and PRTN3-mediated histone H3 proteolytic cleavage promotes monocyte-to-macrophage differentiation
Authors: P Cheung, S Schaffert, SE Chang, M Dvorak, M Donato, C Macaubas, MH Foecke, TM Li, L Zhang, JP Coan, GS Schulert, AA Grom, LA Henderson, PA Nigrovic, JE Elias, O Gozani, ED Mellins, P Khatri, PJ Utz, AJ Kuo
Nature Immunology, 2021-05-20;22(6):711-722.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Multi-Omics Analysis of Anti-Inflammatory Action of Alkaline Extract of the Leaves of Sasa sp
Authors: H Sakagami, S Nakatani, A Enomoto, S Ota, M Kaneko, M Sugimoto, M Horiuchi, K Toeda, T Oizumi
Journal of Clinical Medicine, 2021-05-13;10(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Empagliflozin Inhibits IL-1&beta-Mediated Inflammatory Response in Human Proximal Tubular Cells
Authors: M Pirklbauer, S Sallaberge, P Staudinger, U Corazza, J Leierer, G Mayer, H Schramek
International Journal of Molecular Sciences, 2021-05-11;22(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Oral Administration of Lactobacillus rhamnosus Ameliorates the Progression of Osteoarthritis by Inhibiting Joint Pain and Inflammation
Authors: J Jhun, KH Cho, DH Lee, JY Kwon, JS Woo, J Kim, HS Na, SH Park, SJ Kim, ML Cho
Cells, 2021-04-29;10(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-inflammatory Effects of Alcohol Are Associated with JNK-STAT3 Downregulation in an In Vitro Inflammation Model in HepG2 Cells
Authors: K Mörs, R Sturm, JA Hörauf, S Kany, P Cavalli, J Omari, M Powerski, A Surov, I Marzi, AJ Nowak, B Relja
Disease Markers, 2021-03-18;2021(0):6622701.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effect of NIR Laser Therapy by MLS-MiS Source on Fibroblast Activation by Inflammatory Cytokines in Relation to Wound Healing
Authors: S Genah, F Cialdai, V Ciccone, E Sereni, L Morbidelli, M Monici
Biomedicines, 2021-03-16;9(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Authors: P Rueda, J Merlin, S Chimenti, M Feletou, J Paysant, PJ White, A Christopou, PM Sexton, RJ Summers, WN Charman, LT May, CJ Langmead
Frontiers in Pharmacology, 2021-03-11;12(0):628060.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

N4BP1 negatively regulates NF-&kappaB by binding and inhibiting NEMO oligomerization
Authors: H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler
Nature Communications, 2021-03-02;12(1):1379.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1&alpha Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation
Authors: K Bernau, JP Leet, H Floerke, EM Bruhn, AL Noll, IS McDermott, S Esnault, NN Jarjour, N Sandbo
Cells, 2021-03-02;10(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
Authors: P Gao, P Gao, J Zhao, S Shan, W Luo, OJ Slivano, W Zhang, A Tabuchi, SA LeMaire, L Maegdefess, YH Shen, JM Miano, HA Singer, X Long
Redox Biology, 2021-02-20;41(0):101903.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?
Authors: P Kvacskay, N Yao, JH Schnotz, R Scarpone, RA Carvalho, KD Klika, W Merkt, T Tretter, HM Lorenz, LO Tykocinski
Arthritis Research & Therapy, 2021-02-15;23(1):56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA?186?5p downregulation inhibits osteoarthritis development by targeting MAPK1
Authors: Q Li, M Wu, G Fang, K Li, W Cui, L Li, X Li, J Wang, Y Cang
Molecular Medicine Reports, 2021-02-04;23(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-&kappaB dependent inflammatory/catabolic environment of osteoarthritis
Authors: C Cavallo, G Merli, RM Borzì, N Zini, S D'Adamo, M Guescini, B Grigolo, A Di Martino, S Santi, G Filardo
Scientific Reports, 2021-01-13;11(1):1053.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes
Authors: TM Garcia-Bat, ML Palma, RR Anderko, DC Hsu, J Ananworani, BT Korber, GD Gaiha, N Phanuphak, R Thomas, S Tovanabutr, BD Walker, JW Mellors, PA Piazza, E Kroon, SA Riddler, NL Michael, CR Rinaldo, RB Mailliard, I4C and RV
EBioMedicine, 2021-01-12;63(0):103175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
Authors: Y Yang, P Shen, T Yao, J Ma, Z Chen, J Zhu, Z Gong, S Shen, X Fang
Theranostics, 2021-01-01;11(4):1877-1900.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Benefit of Belatacept in Cord Blood-Derived Regulatory T Cell-Mediated Suppression of Alloimmune Response
Authors: X He, S Li, J Zhang, L Cao, C Yang, P Rong, S Yi, K Ghimire, X Ma, W Wang
Cell Transplantation, 2021-01-01;30(0):9636897211046.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models
Authors: E Nummenmaa, M Hämäläinen, A Pemmari, LJ Moilanen, L Tuure, RM Nieminen, T Moilanen, K Vuolteenah, E Moilanen
International Journal of Molecular Sciences, 2020-12-23;22(1):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

CDK8 Fine-Tunes IL-6 Transcriptional Activities by Limiting STAT3 Resident Time at the Gene Loci
Authors: J Martinez-F, L Wang, E Pohler, A Cozzani, S Wilmes, M Kazemian, S Mitra, I Moraga
Cell Reports, 2020-12-22;33(12):108545.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
Authors: N Gatto, C Dos Santos, AC Shaw, SM Bell, MA Myszczynsk, S Powers, K Meyer, LM Castelli, E Karyka, H Mortiboys, M Azzouz, GM Hautbergue, NM Márkus, PJ Shaw, L Ferraiuolo
Aging Cell, 2020-12-13;0(0):e13281.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roles of Interleukin-1 Receptor Antagonist in Prostate Cancer Progression
Authors: YC Fan, KD Lee, YC Tsai
Biomedicines, 2020-12-13;8(12):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Shared Immunogenic Poly-Epitope Frameshift Mutations in Microsatellite Unstable Tumors.
Authors: Roudko V, Bozkus C, Orfanelli T, McClain C, Carr C, O'Donnell T, Chakraborty L, Samstein R, Huang K, Blank S, Greenbaum B, Bhardwaj N
Cell, 2020-11-30;183(6):1634-1649.e17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In vitro model of distinct catabolic and inflammatory response patterns of endothelial cells to intervertebral disc cell degeneration
Authors: MH Hwang, HG Son, J Kim, H Choi
Sci Rep, 2020-11-26;10(1):20596.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells
Authors: MM Mostafa, A Bansal, AN Michi, SK Sasse, D Proud, AN Gerber, R Newton
J Biol Chem, 2020-11-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

In vitro mechanical vibration down-regulates pro-inflammatory and pro-fibrotic signaling in human vocal fold fibroblasts
Authors: D Hortobagyi, T Grossmann, M Tschernitz, M Grill, A Kirsch, C Gerstenber, M Gugatschka
PLoS ONE, 2020-11-19;15(11):e0241901.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Endogenous antisense RNA curbs CD39 expression in Crohn's disease
Authors: RP Harshe, A Xie, M Vuerich, LA Frank, B Gromova, H Zhang, RJ Robles, S Mukherjee, E Csizmadia, E Kokkotou, AS Cheifetz, AC Moss, SK Kota, SC Robson, MS Longhi
Nat Commun, 2020-11-18;11(1):5894.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In Vitro Anti-Inflammatory Activity in Arthritic Synoviocytes of A. brachypoda Root Extracts and Its Unusual Dimeric Flavonoids
Authors: C Salgado, H Morin, N Coriolano, L Neff, C Quintino d, W Vilegas, L Marcourt, JL Wolfender, O Jordan, E Ferreira Q, E Allémann
Molecules, 2020-11-09;25(21):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

&beta-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes
Authors: VV Edara, S Nooka, J Proulx, S Stacy, A Ghorpade, K Borgmann
Biomedicines, 2020-11-06;8(11):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Inflammation-associated senescence promotes Helicobacter pylori-induced atrophic gastritis
Authors: Q Cai, P Shi, Y Yuan, J Peng, X Ou, W Zhou, J Li, T Su, L Lin, S Cai, Y He, J Xu
Cell Mol Gastroenterol Hepatol, 2020-11-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations
Authors: D He, D Wang, P Lu, N Yang, Z Xue, X Zhu, P Zhang, G Fan
Oncogene, 2020-11-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Boosting NAD Level Suppresses Inflammatory Activation of PBMC in Heart Failure
Authors: B Zhou, DD Wang, Y Qiu, S Airhart, Y Liu, A Stempien-O, KD O'Brien, R Tian
J. Clin. Invest., 2020-11-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Luteolin Attenuates IL-1&beta-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-&kappaB and MAPK Pathways
Authors: WC Huang, CJ Liou, SC Shen, S Hu, CY Hsiao, SJ Wu
Mediators Inflamm, 2020-10-16;2020(0):9421340.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Binding Mode Exploration of B1 Receptor Antagonists' by the Use of Molecular Dynamics and Docking Simulation-How Different Target Engagement Can Determine Different Biological Effects
Authors: M Gemei, C Talarico, L Brandolini, C Manelfi, L Za, S Bovolenta, C Liberati, LD Vecchio, R Russo, C Cerchia, M Allegretti, AR Beccari
Int J Mol Sci, 2020-10-16;21(20):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation
Authors: EM Wilfong, R Croze, X Fang, M Schwede, E Niemi, GY López, JW Lee, MC Nakamura, MA Matthay
PLoS ONE, 2020-10-06;15(10):e0240319.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression
Authors: CM Schafer, JM Gurley, K Kurylowicz, PK Lin, W Chen, MH Elliott, GE Davis, F Bhatti, CT Griffin
Proc Natl Acad Sci U S A, 2020-10-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Oleanolic Acid Decreases IL-1&beta-Induced Activation of Fibroblast-Like Synoviocytes via the SIRT3-NF-&kappaB Axis in Osteoarthritis
Authors: J Bao, W Yan, K Xu, M Chen, Z Chen, J Ran, Y Xiong, L Wu
Oxid Med Cell Longev, 2020-09-28;2020(0):7517219.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
EBioMedicine, 2020-09-23;60(0):102984.
Species: Mouse
Sample Types: Reference Standard, Whole Cells
Applications: Inhibition

Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/I&kappaB&alpha pathway
Authors: HK Min, JY Won, BM Kim, KA Lee, SJ Lee, SH Lee, HR Kim, KW Kim
Arthritis Research & Therapy, 2020-09-23;22(1):222.
Species: Human
Sample Types: Reference Standard

Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes
Authors: C Wang, Y Xiao, M Lao, J Wang, S Xu, R Li, X Xu, Y Kuang, M Shi, Y Zou, Q Wang, L Liang, SG Zheng, H Xu
JCI Insight, 2020-09-17;5(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The innate immunity protein IFITM3 modulates &gamma-secretase in Alzheimer's disease
Authors: JY Hur, GR Frost, X Wu, C Crump, SJ Pan, E Wong, M Barros, T Li, P Nie, Y Zhai, JC Wang, J Tcw, L Guo, A McKenzie, C Ming, X Zhou, M Wang, Y Sagi, AE Renton, BT Esposito, Y Kim, KR Sadleir, I Trinh, RA Rissman, R Vassar, B Zhang, DS Johnson, E Masliah, P Greengard, A Goate, YM Li
Nature, 2020-09-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells
Authors: M Fellermann, C Huchler, L Fechter, T Kolb, F Wondany, D Mayer, J Michaelis, S Stenger, K Mellert, P Möller, TFE Barth, S Fischer, H Barth
Toxins (Basel), 2020-09-01;12(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia
Authors: S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim
Cells, 2020-08-31;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Peucedanum ostruthium Inhibits E-Selectin and VCAM-1 Expression in Endothelial Cells through Interference with NF-&kappaB Signaling
Authors: C Lammel, J Zwirchmayr, J Seigner, JM Rollinger, R de Martin
Biomolecules, 2020-08-21;10(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation
Authors: C Salgado, L Guénée, R ?erný, E Allémann, O Jordan
Int J Pharm, 2020-08-19;589(0):119783.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human CD8+ T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses
Authors: E Abu-Shah, N Trendel, P Kruger, J Nguyen, J Pettmann, M Kutuzov, O Dushek
J. Immunol., 2020-08-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Protein tyrosine phosphatase 1B as a therapeutic target for Graves' orbitopathy in an in vitro model
Authors: HJ Byeon, JY Kim, J Ko, EJ Lee, K Don, JS Yoon
PLoS ONE, 2020-08-06;15(8):e0237015.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

Oxidized Low-Density Lipoprotein Induces Macrophage Production of Prothrombotic Microparticles
Authors: JF Marchini, A Manica, P Crestani, J Dutzmann, EJ Folco, H Weber, P Libby, K Croce
J Am Heart Assoc, 2020-07-31;9(15):e015878.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hypochlorite-induced porcine model of peritoneal fibrosis through the activation of IL1&beta-CX3CL1-TGF&beta1 signal axis
Authors: YT Hsu, CH Wu, CY Chao, YS Wei, YC Chang, YT Chen, SL Lin, SY Tsai, YJ Lee, PS Tsai
Sci Rep, 2020-07-13;10(1):11496.
Species: Porcine
Sample Types: Serum

Inflammation Differentially Modulates the Biological Features of Adult Derived Human Liver Stem/Progenitor Cells
Authors: H El-Kehdy, M Najar, J De Kock, DM Agha, V Rogiers, M Merimi, L Lagneaux, EM Sokal, M Najimi
Cells, 2020-07-08;9(7):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

The Leucine-Rich Repeat Region of CARMIL1 Regulates IL-1-Mediated ERK Activation, MMP Expression, and Collagen Degradation
Authors: Q Wang, K Notay, GP Downey, CA McCulloch
Cell Rep, 2020-06-30;31(13):107781.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LC-ESI-FT-MSn Metabolite Profiling of Symphytum officinale L. Roots Leads to Isolation of Comfreyn A, an Unusual Arylnaphthalene Lignan
Authors: G D'Urso, M Masullo, J Seigner, YM Holper-Sch, R de Martin, A Plaza, S Piacente
Int J Mol Sci, 2020-06-30;21(13):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Agonism of GPR120 prevented IL-1&beta-induced reduction of extracellular matrix through SOX-9
Authors: Z Xu, T Ke, Y Zhang, C Fu, W He
Aging (Albany NY), 2020-06-24;12(12):12074-12085.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
Authors: MP Wandel, BH Kim, ES Park, KB Boyle, K Nayak, B Lagrange, A Herod, T Henry, M Zilbauer, J Rohde, JD MacMicking, F Randow
Nat. Immunol., 2020-06-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone
Authors: F Nishimura, H Mogami, K Moriuchi, Y Chigusa, M Mandai, E Kondoh
PLoS ONE, 2020-05-04;15(5):e0231944.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
Authors: A Rao, O Strauss, E Kokkinou, M Bruchard, KP Tripathi, H Schlums, A Carrasco, L Mazzurana, V Konya, EJ Villablanc, NK Björkström, U Lindforss, H Spits, J Mjösberg
Nat Commun, 2020-04-27;11(1):2049.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prostaglandin E2 stimulates COX-2 expression via mitogen-activated protein kinase p38 but not ERK in human follicular dendritic cell-like cells
Authors: W Cho, J Choe
BMC Immunol., 2020-04-17;21(1):20.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Effect of Chemically Induced Hypoxia on Osteogenic and Angiogenic Differentiation of Bone Marrow Mesenchymal Stem Cells and Human Umbilical Vein Endothelial Cells in Direct Coculture
Authors: VT Nguyen, B Canciani, F Cirillo, L Anastasia, GM Peretti, L Mangiavini
Cells, 2020-03-19;9(3):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Therapeutic Effect of Guggulsterone in Primary Cultured Orbital Fibroblasts Obtained From Patients with Graves' Orbitopathy
Authors: BR Kim, J Kim, JE Lee, EJ Lee, JS Yoon
Invest. Ophthalmol. Vis. Sci., 2020-03-09;61(3):39.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Anti?inflammatory and anti?catabolic effect of non?animal stabilized hyaluronic acid and mesenchymal stem cell?conditioned medium in an osteoarthritis coculture model
Authors: M Simental-M, SA Lozano-Sep, V Pérez-Silo, L Fuentes-Me, HG Martínez-R, CA Acosta-Oli, VM Peña-Martí, F Vilchez-Ca
Mol Med Rep, 2020-02-26;21(5):2243-2250.
Species: Human
Sample Types: Tissue Explant
Applications: Bioassay

Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis
Authors: N Hafsia, M Forien, F Renaudin, D Delacour, P Reboul, P Van Lent, M Cohen-Sola, F Lioté, F Poirier, HK Ea
Int J Mol Sci, 2020-02-22;21(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Anti-fibrotic effect of decorin in peritoneal dialysis and PD-associated peritonitis
Authors: N Jiang, Q Zhang, MK Chau, MS Yip, SL Lui, S Liu, KM Chu, HY Ngan, TM Chan, S Yung
EBioMedicine, 2020-02-12;52(0):102661.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration
Authors: D Parate, ND Kadir, C Celik, EH Lee, JHP Hui, A Franco-Obr, Z Yang
Stem Cell Res Ther, 2020-02-03;11(1):46.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Interleukin 1&beta/1RA axis in colorectal cancer regulates tumor invasion, proliferation and apoptosis via autophagy
Authors: Y Chen, Z Yang, B Deng, D Wu, Y Quan, Z Min
Oncol. Rep., 2020-01-22;43(3):908-918.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1&beta Production
Authors: JH Jang, DH Kim, JM Lim, JW Lee, SJ Jeong, KP Kim, YJ Surh
Cancer Res, 2020-01-22;80(6):1342-1356.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-oxidative and anti-adipogenic effects of caffeine in an in vitro model of Graves' orbitopathy
Authors: J Ko, JY Kim, JW Kim, JS Yoon
Endocr. J., 2020-01-16;0(0):.
Species: Human
Sample Types:
Applications: Cell Culture

Pro-inflammatory cytokines induce cell death, inflammatory responses, and endoplasmic reticulum stress in human iPSC-derived beta cells
Authors: S Demine, AA Schiavo, S Marín-Caña, P Marchetti, M Cnop, DL Eizirik
Stem Cell Res Ther, 2020-01-03;11(1):7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue
Authors: R Xu, RK Shears, R Sharma, M Krishna, C Webb, R Ali, X Wei, A Kadioglu, Q Zhang
Mucosal Immunol, 2020-01-02;13(3):460-470.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells
Authors: MM Mostafa, A Bansal, AN Michi, SK Sasse, D Proud, AN Gerber, R Newton
The Journal of Biological Chemistry, 2020-01-01;296(0):100065.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KLF2 Protects against Osteoarthritis by Repressing Oxidative Response through Activation of Nrf2/ARE Signaling In Vitro and In Vivo
Authors: X Gao, S Jiang, Z Du, A Ke, Q Liang, X Li
Oxid Med Cell Longev, 2019-11-19;2019(0):8564681.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-29a Mitigates Subacromial Bursa Fibrosis in Rotator Cuff Lesion with Shoulder Stiffness
Authors: JY Ko, WS Lian, TC Tsai, YS Chen, CK Hsieh, CW Kuo, FS Wang
Int J Mol Sci, 2019-11-15;20(22):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Neratinib protects pancreatic beta cells in diabetes
Authors: A Ardestani, S Li, K Annamalai, B Lupse, S Geravandi, A Dobrowolsk, S Yu, S Zhu, TD Baguley, M Surakattul, J Oetjen, L Hauberg-Lo, R Herranz, S Awal, D Altenhofen, V Nguyen-Tra, S Joseph, PG Schultz, AK Chatterjee, N Rogers, MS Tremblay, W Shen, K Maedler
Nat Commun, 2019-11-01;10(1):5015.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Microenvironmental IL1beta promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
Authors: R Eyre, DG Alférez, A Santiago-G, K Spence, JC McConnell, C Hart, BM Simões, D Lefley, C Tulotta, J Storer, A Gurney, N Clarke, M Brown, SJ Howell, AH Sims, G Farnie, PD Ottewell, RB Clarke
Nat Commun, 2019-11-01;10(1):5016.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism
Authors: K Terabe, Y Ohashi, S Tsuchiya, S Ishizuka, CB Knudson, W Knudson
J. Biol. Chem., 2019-10-16;0(0):.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay

Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
Authors: C Merriman, D Fu
J. Biol. Chem., 2019-10-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae, in Fibroblasts From Patients With Graves' Orbitopathy
Authors: JS Lee, J Kim, EJ Lee, JS Yoon
Invest. Ophthalmol. Vis. Sci., 2019-10-01;60(13):4129-4140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
Authors: P Dolzani, E Assirelli, L Pulsatelli, R Meliconi, E Mariani, S Neri
PLoS ONE, 2019-09-24;14(9):e0222947.
Species: Human
Sample Types: Tissue Explant
Applications: Bioassay

Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
Authors: J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke
Breast Cancer Res., 2019-09-18;21(1):109.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32
Authors: JC Dos Santos, AM Barroso de, MV Teodoro Si, B Cirovic, LCJ de Bree, MSMA Damen, SJCFM Moorlag, RS Gomes, MM Helsen, M Oosting, ST Keating, A Schlitzer, MG Netea, F Ribeiro-Di, LAB Joosten
Cell Rep, 2019-09-03;28(10):2659-2672.e6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)-dependent manner
Authors: X Zhang, YS Hwang
Oncol Lett, 2019-08-27;18(5):4645-4650.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Glucocorticoid receptor inhibits M�ller glial galectin-1 expression via DUSP1-dependent and -independent deactivation of AP-1 signalling
Authors: I Hirose, A Kanda, K Noda, S Ishida
J. Cell. Mol. Med., 2019-07-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies
Authors: JH Bernink, Y Ohne, MBM Teunissen, J Wang, J Wu, L Krabbendam, C Guntermann, R Volckmann, J Koster, S van Tol, I Ramirez, Y Shrestha, MA de Rie, H Spits, X Romero Ros, AA Humbles
Nat. Immunol., 2019-07-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
Mol. Vis., 2019-06-30;25(0):329-344.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Juvenile idiopathic arthritis associated with a mutation in GATA3
Authors: AE Patrick, W Wang, E Brokamp, TB Graham, TM Aune, JB Duis
Arthritis Res. Ther., 2019-06-25;21(1):156.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis
Authors: MJ Park, SJ Moon, JA Baek, EJ Lee, KA Jung, EK Kim, DS Kim, JH Lee, SK Kwok, JK Min, SJ Kim, SH Park, ML Cho
J. Immunol., 2019-05-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52
Authors: K Hacker, S Benke, B Agerer, S Scinicarie, V Budroni, GA Versteeg
Sci Rep, 2019-05-27;9(1):7901.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration
Authors: C De Witte, K Demeyere, S De Bruycke, B Taminiau, G Daube, R Ducatelle, E Meyer, F Haesebrouc
Vet. Res., 2019-05-24;50(1):39.
Species: Human
Sample Types: Recombinant Protein
Applications: Western Blot Control

Expression of the RANK/RANKL/OPG system in the human intervertebral disc: implication for the pathogenesis of intervertebral disc degeneration
Authors: T Sano, K Akeda, J Yamada, N Takegami, T Sudo, A Sudo
BMC Musculoskelet Disord, 2019-05-17;20(1):225.
Species: Human
Sample Types: Primary Cells
Applications: Cell Culture

Effect of diclofenac etalhyaluronate (SI-613) on the production of high molecular weight sodium hyaluronate in human synoviocytes
Authors: T Kisukeda, J Onaya, K Yoshioka
BMC Musculoskelet Disord, 2019-05-10;20(1):201.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

A Symphytum officinale Root Extract Exerts Anti-inflammatory Properties by Affecting Two Distinct Steps of NF-?B Signaling
Authors: J Seigner, M Junker-Sam, A Plaza, G D'Urso, M Masullo, S Piacente, YM Holper-Sch, R de Martin
Front Pharmacol, 2019-04-26;10(0):289.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
Authors: S Vig, M Buitinga, D Rondas, I Crèvecoeur, M van Zandvo, E Waelkens, DL Eizirik, C Gysemans, P Baatsen, C Mathieu, L Overbergh
Cell Death Dis, 2019-04-05;10(4):309.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
Authors: T Hochdörfer, C Winkler, K Pardali, J Mjösberg
Eur. J. Immunol., 2019-03-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation
Authors: A Castellano, I Santin, A Olazagoiti, I Romero-Gar, A Jauregi-Mi, M Legarda, JR Bilbao
Sci Rep, 2019-03-12;9(1):4220.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Determination of two fluoroquinolones and their combinations with hyaluronan effect in in vitro canine cartilage explants
Authors: P Siengdee, W Pradit, S Chomdej, K Nganvongpa
PeerJ, 2019-03-12;7(0):e6553.
Species: Canine
Sample Types: Tissue Explants
Applications: Bioassay

Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression
Authors: KC Doh, BM Kim, KW Kim, BH Chung, CW Yang
BMC Complement Altern Med, 2019-03-04;19(1):54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis
Authors: X Qin, M Liu, S Zhang, C Wang, T Zhang
Cytokine, 2019-03-01;117(0):84-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of Tropomyosin Receptor Kinase A Signaling Negatively Regulates Megakaryopoiesis and induces Thrombopoiesis
Authors: A Kizilyer, MV Singh, VB Singh, S Suwunnakor, J Palis, SB Maggirwar
Sci Rep, 2019-02-26;9(1):2781.
Species: Human
Sample Types:
Applications: Bioassay

hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye
Authors: K Spekker-Bo, CM Ufermann, M Maywald, A Zimmermann, A Domröse, C Woite, W Däubener, SK Eller
Int J Mol Sci, 2019-02-16;20(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1? Protein during Virion-Mediated Activation of the AIM2 Inflammasome
Authors: S Botto, J Abraham, N Mizuno, K Pryke, B Gall, I Landais, DN Streblow, KJ Fruh, VR DeFilippis
MBio, 2019-02-12;10(1):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
Nat Commun, 2019-02-12;10(1):709.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis
Authors: BA Kane, H An, P Rajasekari, HP McNeil, K Bryant, N Tedla
Sci Rep, 2019-02-04;9(1):1149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS
Authors: T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker
Cancer Res., 2019-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Hydroxylase Inhibition Selectively Induces Cell Death in Monocytes
Authors: B Crifo, B Schaible, E Brown, DN Halligan, CC Scholz, SF Fitzpatric, A Kirwan, HM Roche, M Criscuoli, A Naldini, H Giffney, D Crean, A Blanco, MA Cavadas, EP Cummins, Z Fabian, CT Taylor
J. Immunol., 2019-01-30;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rifamycin SV exhibits strong anti-inflammatory in�vitro activity through pregnane X receptor stimulation and NF?B inhibition
Authors: C Rosette, FJ Agan, N Rosette, L Moro, A Mazzetti, C Hassan, M Gerloni
Drug Metab. Pharmacokinet., 2019-01-17;34(3):172-180.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis
Authors: MR Tanner, MW Pennington, SS Chauhan, T Laragione, PS Gulko, C Beeton
Arthritis Res. Ther., 2019-01-07;21(1):6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In�Vitro Expansion of Anti-viral T Cells from Cord Blood by Accelerated Co-cultured Dendritic Cells
Authors: K Kuranda, S Caillat-Zu, S You, R Mallone
Mol Ther Methods Clin Dev, 2018-12-31;13(0):112-120.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Intravascular heavy chain-modification of hyaluronan during endotoxic shock
Authors: K Ni, A Gill, D Cao, K Koike, KS Schweitzer, S Garantziot, I Petrache
Biochem Biophys Rep, 2018-12-26;17(0):114-121.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts
Authors: SJ Lee, J Kim, J Ko, EJ Lee, HJ Koh, JS Yoon
PLoS ONE, 2018-12-21;13(12):e0209583.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Authors: R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang
Oncogene, 2018-12-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes
Authors: AN Bubak, CN Como, AM Blackmon, D Jones, MA Nagel
J Neuroinflammation, 2018-11-15;15(1):318.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phosphorylation and inhibition of ceramide kinase by protein kinase C-?: Their changes by serine residue mutations
Authors: H Takahashi, H Ashikawa, H Nakamura, T Murayama
Cell. Signal., 2018-11-15;0(0):.
Species: Human
Sample Types:
Applications: Cell Culture

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells
Authors: W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor
Sci Rep, 2018-11-09;8(1):16636.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
Authors: L Kasper, A König, PA Koenig, MS Gresnigt, J Westman, RA Drummond, MS Lionakis, O Gro beta, J Ruland, JR Naglik, B Hube
Nat Commun, 2018-10-15;9(1):4260.

Effect of Polydeoxyribonucleotide on Angiogenesis and Wound Healing in an In Vitro Model of Osteoarthritis
Authors: A Baek, Y Kim, JW Lee, SC Lee, SR Cho
Cell Transplant, 2018-10-12;0(0):9636897188041.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma
Authors: U Painuly, V Ramakrishn, T Kimlinger, L Wellik, J Haug, W Gonsalves, L Bi, Z Huang, SV Rajkumar, S Kumar
Oncotarget, 2018-10-02;9(77):34582-34594.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Plasminogen-Dependent Collagenolytic Properties of Staphylococcus aureus in Collagen Gel Cultures of Human Corneal Fibroblasts
Authors: K Sugioka, A Kodama-Tak, T Sato, K Okada, J Murakami, AM Park, H Mishima, Y Shimomura, S Kusaka, T Nishida
Invest. Ophthalmol. Vis. Sci., 2018-10-01;59(12):5098-5107.
Species: Human
Sample Types: Whole Cells

Anacardic acid suppresses fibroblast-like synoviocyte proliferation and invasion and ameliorates collagen-induced arthritis in a mouse model
Authors: GH Yang, C Zhang, N Wang, Y Meng, YS Wang
Cytokine, 2018-09-28;111(0):350-356.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression
Authors: B Zhang, Z Li, W Wang, J Guo, S Kang, S Liu, H Li, D Wang, X Qi
Cell. Physiol. Biochem., 2018-09-27;49(6):2396-2413.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Circulating monocytes from prostate cancer patients promote invasion and motility of epithelial cells
Authors: KA Cavassani, RJ Meza, DM Habiel, JF Chen, A Montes, M Tripathi, GA Martins, TR Crother, S You, CM Hogaboam, N Bhowmick, EM Posadas
Cancer Med, 2018-08-09;0(0):.
Species: Human
Sample Types: Cell Culture Supernates

ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes
Authors: SL Figenschau, E Knutsen, I Urbarova, C Fenton, B Elston, M Perander, ES Mortensen, KA Fenton
Sci Rep, 2018-08-06;8(1):11720.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-?, IL-1?, and IFN-?
Authors: M Schwede, EM Wilfong, RL Zemans, PJ Lee, C Dos Santos, X Fang, MA Matthay
Physiol Rep, 2018-08-01;6(16):e13831.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation
Authors: C Angiolilli, PA Kabala, AM Grabiec, M Rossato, WS Lai, G Fossati, P Mascagni, C Steinkühle, PJ Blackshear, KA Reedquist, DL Baeten, TRDJ Radstake
Arthritis Res. Ther., 2018-07-20;20(1):148.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity
Authors: JK Brenke, GM Popowicz, K Schorpp, I Rothenaign, M Roesner, I Meininger, C Kalinski, L Ringelstet, O R'kyek, G Jürjens, M Vincendeau, O Plettenbur, M Sattler, D Krappmann, K Hadian
J. Biol. Chem., 2018-06-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation
Authors: JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani
Cell Death Dis, 2018-06-04;9(6):665.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth
Authors: A Kock, K Larsson, F Bergqvist, N Eissler, LHM Elfman, J Raouf, M Korotkova, JI Johnsen, PJ Jakobsson, P Kogner
EBioMedicine, 2018-05-24;32(0):84-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anisakis pegreffii impacts differentiation and function of human dendritic cells
Authors: C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti
Parasite Immunol., 2018-05-01;0(0):e12527.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Class 3 semaphorins modulate the invasive capacity of rheumatoid arthritis fibroblast-like synoviocytes
Authors: MW Tang, B Malvar Fer, SP Newsom, JD van Buul, TRDJ Radstake, DL Baeten, PP Tak, KA Reedquist, S García
Rheumatology (Oxford), 2018-05-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation

Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms
Authors: E Vorkapic, A Kunath, D Wågsäter
Mol Med Rep, 2018-04-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RIPK1 downregulation in keratinocyte enhances TRAIL signaling in psoriasis
Authors: N Saito, M Honma, T Shibuya, S Iinuma, S Igawa, M Kishibe, A Ishida-Yam
J. Dermatol. Sci., 2018-04-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prolactin protects against cytokine-induced beta cell death by NFkB and JNK inhibition
Authors: TR Nardelli, EC Vanzela, KC Benedicto, F Brozzi, A Fujita, AK Cardozo, D Eizirik, AC Boschero, F Ortis
J. Mol. Endocrinol., 2018-04-09;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Canagliflozin inhibits interleukin-1?-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms
Authors: SJ Mancini, D Boyd, OJ Katwan, A Strembitsk, TA Almabrouk, S Kennedy, TM Palmer, IP Salt
Sci Rep, 2018-03-27;8(1):5276.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus
Authors: D Sireesh, U Dhamodhara, K Ezhilarasi, V Vijay, KM Ramkumar
Sci Rep, 2018-03-23;8(1):5126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1? on rheumatoid arthritis fibroblast-like synoviocytes
Authors: B Bergström, H Carlsten, AH Ekwall
Arthritis Res. Ther., 2018-03-20;20(1):49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression and regulation of alarmin cytokine IL-1? in human retinal pigment epithelial cells
Authors: ZM Bian, MG Field, SG Elner, VM Elner
Exp. Eye Res., 2018-03-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
Authors: KA Jhang, JS Park, HS Kim, YH Chong
J Neuroinflammation, 2018-03-12;15(1):75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Vasoreparative Function of Myeloid Angiogenic Cells Is Impaired in Diabetes Through the Induction of IL1?
Authors: SEJ Chambers, CL O'Neill, J Guduric-Fu, KJ McLoughlin, A Liew, AM Egan, T O'Brien, AW Stitt, RJ Medina
Stem Cells, 2018-03-09;36(6):834-843.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interactome analysis of transforming growth factor-?-activated kinase 1 inHelicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37
Authors: O Sokolova, T Kähne, K Bryan, M Naumann
Oncotarget, 2018-02-21;9(18):14366-14381.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells
Authors: ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner
Exp. Eye Res., 2018-02-16;170(0):29-39.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Galectin-3 is an amplifier of the interleukin-1?-mediated inflammatory response in corneal keratinocytes
Authors: Y Uchino, AM Woodward, J Mauris, K Peterson, P Verma, UJ Nilsson, J Rajaiya, P Argüeso
Immunology, 2018-02-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models
Authors: A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, M Ding, J Synnergren, H Zetterberg, G Brolén, R Hicks, A Herland, A Falk
Stem Cell Reports, 2018-02-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
Authors: AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims
Diabetologia, 2018-02-14;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature
Authors: W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi
Neurobiol. Dis., 2018-02-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Virus-like infection induces human ? cell dedifferentiation
Authors: M Oshima, KP Knoch, M Diedisheim, A Petzold, P Cattan, M Bugliani, P Marchetti, P Choudhary, GC Huang, SR Bornstein, M Solimena, O Albagli-Cu, R Scharfmann
JCI Insight, 2018-02-08;3(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Depletion of aquaporin 1 decreased ADAMTS?4 expression in human chondrocytes
Authors: M Haneda, S Hayashi, T Matsumoto, S Hashimoto, K Takayama, N Chinzei, S Kihara, K Takeuchi, K Nishida, R Kuroda
Mol Med Rep, 2018-02-02;17(4):4874-4882.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
Authors: H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi
Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature
Authors: WR Swindell, MA Beamer, MK Sarkar, S Loftus, J Fullmer, X Xing, NL Ward, LC Tsoi, MJ Kahlenberg, Y Liang, JE Gudjonsson
Front Immunol, 2018-01-29;9(0):80.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
Authors: F Zhang, G Liu, D Li, C Wei, J Hao
J. Immunol., 2018-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of IL-1 signaling through control of focal adhesion assembly
Authors: Q Wang, J Delcorde, T Tang, GP Downey, CA McCulloch
FASEB J., 2018-01-22;0(0):fj201700966R.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock
Authors: TA Nakada, P Wacharasin, JA Russell, JH Boyd, E Nakada, SA Thair, T Shimada, KR Walley
J Innate Immun, 2018-01-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro
Authors: M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini
Mol Brain, 2018-01-15;11(1):3.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Authors: RJW Arts, SJCFM Moorlag, B Novakovic, Y Li, SY Wang, M Oosting, V Kumar, RJ Xavier, C Wijmenga, LAB Joosten, CBEM Reusken, CS Benn, P Aaby, MP Koopmans, HG Stunnenber, R van Crevel, MG Netea
Cell Host Microbe, 2018-01-10;23(1):89-100.e5.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells
Authors: YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo
PLoS ONE, 2018-01-03;13(1):e0190638.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells
Authors: X Zhang, Y Zhang, J Xu, H Wang, X Zheng, Y Lou, B Han
J Cancer, 2018-01-01;9(2):367-374.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nitric Oxide Mediates Crosstalk between Interleukin 1? and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression
Authors: L Zhong, S Schivo, X Huang, J Leijten, M Karperien, JN Post
Int J Mol Sci, 2017-11-22;18(11):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proinflammatory cytokine interferon-? increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cells
Authors: RK Kutty, W Samuel, T Duncan, O Postnikova, C Jaworski, CN Nagineni, TM Redmond
Cytokine, 2017-10-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Healing of Preterm Ruptured Fetal Membranes
Authors: H Mogami, A Hari Kisho, Y Akgul, RA Word
Sci Rep, 2017-10-13;7(1):13139.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
JCI Insight, 2017-09-07;2(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Stimulation of Macrophages with TLR Ligands Supports Increased IL-19 Expression in Inflammatory Bowel Disease Patients and in Colitis Models
Authors: A Steinert, I Linas, B Kaya, M Ibrahim, A Schlitzer, P Hruz, K Radulovic, L Terraccian, AJ Macpherson, JH Niess
J. Immunol., 2017-09-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Role of Inflammation in ?-cell Dedifferentiation
Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
Sci Rep, 2017-07-24;7(1):6285.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone
Authors: L Ding, JA Buckwalter, JA Martin
Mediators Inflamm., 2017-07-18;2017(0):2642549.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels
Authors: AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema
Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection
Authors: R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar
J. Leukoc. Biol., 2017-06-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy
Authors: J Ye, Y Wang, X Liu, L Li, A Opejin, EC Hsueh, H Luo, T Wang, D Hawiger, G Peng
J. Immunol., 2017-06-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis
Authors: L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský
Cytokine, 2017-06-26;97(0):187-192.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
Authors: J Shen, C Wang, D Li, T Xu, J Myers, JM Ashton, T Wang, MJ Zuscik, A McAlinden, RJ O'Keefe
JCI Insight, 2017-06-15;2(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition
Authors: E Forcade, K Paz, R Flynn, B Griesenaue, T Amet, W Li, L Liu, G Bakoyannis, D Jiang, HW Chu, M Lobera, J Yang, DS Wilkes, J Du, K Gartlan, GR Hill, KP MacDonald, EL Espada, P Blanco, JS Serody, J Koreth, CS Cutler, JH Antin, RJ Soiffer, J Ritz, S Paczesny, BR Blazar
JCI Insight, 2017-06-15;2(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
Authors: R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage
Stem Cell Reports, 2017-06-06;8(6):1757-1769.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells
Authors: NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski
Elife, 2017-06-06;6(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

RANK/RANKL/OPG system in the intervertebral disc
Authors: N Takegami, K Akeda, J Yamada, T Sano, K Murata, J Huang, K Masuda, A Sudo
Arthritis Res. Ther., 2017-06-02;19(1):121.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis
Authors: F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai
Scand. J. Immunol., 2017-06-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MicroRNA-29b Contributes to Collagens Imbalance in Human Osteoarthritic and Dedifferentiated Articular Chondrocytes
Authors: D Moulin, V Salone, M Koufany, T Clément, I Behm-Ansma, C Branlant, B Charpentie, JY Jouzeau
Biomed Res Int, 2017-05-22;2017(0):9792512.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells
Authors: J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen
Nat. Immunol., 2017-05-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
Authors: A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid
Arthritis Res. Ther., 2017-05-08;19(1):89.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy
Authors: J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon
Invest. Ophthalmol. Vis. Sci., 2017-05-01;58(5):2544-2553.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Microglia-derived IL-1? promotes chemokine expression by M�ller cells and RPE in focal retinal degeneration
Authors: R Natoli, N Fernando, M Madigan, JA Chu-Tan, K Valter, J Provis, M Rutar
Mol Neurodegener, 2017-04-24;12(1):31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
Stem Cell Res Ther, 2017-04-17;8(1):79.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A functional DC cross talk promotes human ILC homeostasis in humanized mice
Authors: S Lopez-Last, G Masse-Rans, O Fiquet, S Darche, N Serafini, Y Li, M Dusséaux, H Strick-Mar, JP Di Santo
Blood Adv, 2017-04-06;1(10):601-614.
Species: Human
Sample Types: Whole Cells

Siglec-7 restores ?-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes
Authors: G Dharmadhik, K Stolz, M Hauke, NG Morgan, A Varki, E de Koning, S Kelm, K Maedler
Sci Rep, 2017-04-05;7(0):45319.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific
Authors: N Nishijima, T Hirai, K Misato, M Aoyama, E Kuroda, KJ Ishii, K Higashisak, Y Yoshioka, Y Tsutsumi
Front Immunol, 2017-04-03;8(0):379.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer
Authors: A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr
J. Pathol, 2017-04-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells
Authors: A Camelo, G Rosignoli, Y Ohne, RA Stewart, C Overed-Say, MA Sleeman, RD May
Blood Adv, 2017-03-30;1(10):577-589.
Species: Human
Sample Types: Whole Cells

Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
Authors: D Li, N Liu, HH Zhao, X Zhang, H Kawano, L Liu, L Zhao, HP Li
J Neuroinflammation, 2017-03-29;14(1):67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas
Authors: BX Ross, N Gao, X Cui, TJ Standiford, J Xu, FX Yu
J. Immunol, 2017-03-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients
Authors: V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr
Sci Rep, 2017-03-22;7(0):44941.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells
Authors: Y Kokubu, T Yamaguchi, K Kawabata
Biochem. Biophys. Res. Commun, 2017-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparison of the effects of cefazolin and ceftriaxone on canine chondrocyte culture
Authors: P Siengdee, W Pradit, T Euppayo, S Chomdej, K Nganvongpa
J. Vet. Pharmacol. Ther, 2017-03-19;0(0):.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

ICOSL expression in human bone marrow-derived mesenchymal stem cells promotes induction of regulatory T cells
Authors: HJ Lee, SN Kim, MS Jeon, T Yi, SU Song
Sci Rep, 2017-03-14;7(0):44486.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation
Authors: WC Chu, S Zhang, TJ Sng, YJ Ong, WL Tan, VY Ang, CB Foldager, WS Toh
Int J Oral Sci, 2017-03-10;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Chondroprotective�Effects�of�Ginsenoside�Rg1�in� Human�Osteoarthritis�Chondrocytes�and�a�Rat�Model� of�Anterior�Cruciate�Ligament�Transection
Authors: W Cheng, J Jing, Z Wang, D Wu, Y Huang
Nutrients, 2017-03-10;9(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations
Authors: C Guntermann, A Piaia, ML Hamel, D Theil, T Rubic-Schn, A Del Rio-Es, L Dong, A Billich, K Kaupmann, J Dawson, K Hoegenauer, D Orain, S Hintermann, R Stringer, DD Patel, A Doelemeyer, M Deurinck, J Schümann
JCI Insight, 2017-03-09;2(5):e91127.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4
Authors: F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker
PLoS ONE, 2017-03-09;12(3):e0172738.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK?
Authors: MH Hancock, LM Hook, J Mitchell, JA Nelson
MBio, 2017-03-07;8(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption
Authors: CY Chiu, SC Su, WL Fan, SH Lai, MH Tsai, SH Chen, KS Wong, WH Chung
Sci Rep, 2017-02-24;7(0):43469.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity
Authors: L Israel, Y Wang, K Bulek, E Della Mina, Z Zhang, V Pedergnana, M Chrabieh, NA Lemmens, V Sancho-Shi, M Descatoire, T Lasseau, E Israelsson, L Lorenzo, L Yun, A Belkadi, A Moran, LE Weisman, F Vandenesch, F Batteux, S Weller, M Levin, J Herberg, A Abhyankar, C Prando, Y Itan, WJB van Wamel, C Picard, L Abel, D Chaussabel, X Li, B Beutler, PD Arkwright, JL Casanova, A Puel
Cell, 2017-02-23;168(5):789-800.e10.
Species: Human
Sample Types: Whole Blood, Whole Cells
Applications: Bioassay, Cell Culture

Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models
Authors: SC Liu, CP Chiu, CH Tsai, CY Hung, TM Li, YC Wu, CH Tang
Sci Rep, 2017-02-22;7(0):43205.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Explicit Modeling of siRNA-Dependent On- and Off-Target Repression Improves the Interpretation of Screening Results
Authors: A Riba, M Emmenlauer, A Chen, F Sigoillot, F Cong, C Dehio, J Jenkins, M Zavolan
Cell Syst, 2017-02-15;4(2):182-193.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
Am J Transl Res, 2017-02-15;9(2):454-465.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates
Authors: MM Shikhagaie, ÅK Björklund, J Mjösberg, JS Erjefält, AS Cornelisse, XR Ros, SM Bal, JJ Koning, RE Mebius, M Mori, M Bruchard, B Blom, H Spits
Cell Rep, 2017-02-14;18(7):1761-1773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
Clin. Cancer Res, 2017-02-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation
Authors: A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala
Mol. Ther, 2017-01-04;25(1):102-119.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
Autophagy, 2017-01-01;0(0):0.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TGF-beta Affects the Differentiation of Human GM-CSF+ CD4+ T Cells in an Activation- and Sodium-Dependent Manner.
Authors: Elias S, Schmidt A, Kannan V, Andersson J, Tegner J
Front Immunol, 2016-12-23;7(0):603.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Analysis of CXCR5(+)Th17 cells in relation to disease activity and TNF inhibitor therapy in Rheumatoid Arthritis
Sci Rep, 2016-12-22;6(0):39474.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity
Authors: Shailesh Dudhgaonka
J. Immunol, 2016-12-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression
Stem Cell Res Ther, 2016-12-01;7(1):175.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016-12-01;6(0):37977.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation
Authors: Andrea Todisco
Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
Authors: Derek N J Hart
J. Immunol., 2016-11-11;0(0):.
Species: Human
Sample Types: Whole Cells

Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
Authors: Nathalie Castex-Riz
Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
Authors: Robert Sabat
Mediators Inflamm., 2016-10-23;2016(0):4097574.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
Aging Cell, 2016-09-22;0(0):.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
J Biol Chem, 2016-09-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue
J Immunol, 2016-09-19;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

Negative regulation of NF-?B p65 activity by serine 536 phosphorylation.
Authors: Jean-Philippe Pradère, Céline Hernandez, Christiane Koppe, Richard A Friedman, Tom Luedde, Robert F Schwabe
Science Signaling, 2016-08-23;0(0):1937-9145.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

DUSP1 maintains IRF1 and leads to increased expression of IRF1-dependent genes: A mechanism promoting glucocorticoid-insensitivity
J Biol Chem, 2016-08-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of microRNA-181a-5p and microRNA-4454 as mediators of facet cartilage degeneration
JCI Insight, 2016-08-04;1(12):e86820.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia
Authors: I de Weerdt, V van Hoeven, JM Munneke, S Endstra, T Hofland, MD Hazenberg, AP Kater
Haematologica, 2016-08-04;101(11):e461-e464.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism
Stem Cells Transl Med, 2016-07-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop
Authors: Jenny Z Kechagia
Sci Rep, 2016-06-20;6(0):28261.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts
Authors: Chan-Mi Lee
Cell Biosci, 2016-06-16;6(0):43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Structural and functional attributes of the Interleukin-36 receptor
Authors: Guanghui Yi
J Biol Chem, 2016-06-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
Authors: Marcin Ratajewski
J Leukoc Biol, 2016-06-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
J Immunol, 2016-05-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Silk-based blood stabilization for diagnostics
Proc Natl Acad Sci USA, 2016-05-09;113(21):5892-7.
Species: Human
Sample Types: Urine
Applications: Bioassay

Tissue factor is induced by interleukin-33 in human endothelial cells: a new link between coagulation and inflammation
Sci Rep, 2016-05-04;6(0):25171.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7
Authors: MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker
Stem Cells Dev., 2016-05-02;25(10):774-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rebamipide Attenuates Mandibular Condylar Degeneration in a Murine Model of TMJ-OA by Mediating a Chondroprotective Effect and by Downregulating RANKL-Mediated Osteoclastogenesis
PLoS ONE, 2016-04-28;11(4):e0154107.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

4-methylumbelliferone diminishes catabolically-activated articular chondrocytes and cartilage explants via a mechanism independent of hyaluronan inhibition
J Biol Chem, 2016-04-25;0(0):.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs
Authors: SM Bal, JH Bernink, M Nagasawa, J Groot, MM Shikhagaie, K Golebski, CM van Drunen, R Lutter, RE Jonkers, P Hombrink, M Bruchard, J Villaudy, JM Munneke, W Fokkens, JS Erjefält, H Spits, XR Ros
Nat Immunol, 2016-04-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis
Authors: M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu, D Ren, B Yu, L Zheng, X Hu, W Shi, J Xu
Stem Cell Res Ther, 2016-04-23;7(1):63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ubiquitin D regulates IRE1?/JNK-dependent apoptosis in pancreatic beta cells
Authors: F Brozzi, S Gerlo, FA Grieco, M Juusola, A Balhuizen, S Lievens, C Gysemans, M Bugliani, C Mathieu, P Marchetti, J Tavernier, DL Eizirik
J Biol Chem, 2016-04-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism
Authors: R Flynn, K Paz, J Du, DK Reichenbac, PA Taylor, A Panoskalts, A Vulic, L Luznik, KK MacDonald, GR Hill, MS Nyuydzefe, JM Weiss, W Chen, A Trzeciak, JS Serody, EG Aguilar, WJ Murphy, I Maillard, D Munn, J Koreth, CS Cutler, JH Antin, J Ritz, SD Waksal, A Zanin-Zhor, BR Blazar
Blood, 2016-03-16;127(17):2144-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

NF-?B Signaling Pathway in Controlling Intervertebral Disk Cell Response to Inflammatory and Mechanical Stressors
Authors: Gwendolyn Sowa
Phys Ther, 2016-02-18;96(5):704-11.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
Authors: Guo Z, Zheng L, Liao X, Geller D
PLoS ONE, 2016-01-11;11(1):e0146640.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Preferential Induction of the T Cell Auxiliary Signaling Molecule B7-H3 on Synovial Monocytes in Rheumatoid Arthritis
Authors: BR Yoon, YH Chung, SJ Yoo, K Kawara, J Kim, IS Yoo, CG Park, SW Kang, WW Lee
J. Biol. Chem, 2015-12-23;291(8):4048-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ultraviolet light converts propranolol, a nonselective beta-blocker and potential lupus-inducing drug, into a proinflammatory AhR ligand.
Authors: Dorgham K, Amoura Z, Parizot C, Arnaud L, Frances C, Pionneau C, Devilliers H, Pinto S, Zoorob R, Miyara M, Larsen M, Yssel H, Gorochov G, Mathian A
Eur J Immunol, 2015-10-16;45(11):3174-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1beta, IFN-beta, and IL-15 Pathways.
Authors: Mattiola I, Pesant M, Tentorio P, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
J Immunol, 2015-08-14;195(6):2818-28.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor.
Authors: Saha S, Singh D, Raymond E, Ganesan R, Caviness G, Grimaldi C, Woska J, Mennerich D, Brown S, Mbow M, Kao C
J Biol Chem, 2015-08-12;290(39):23997-4006.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pro-Inflammatory Cytokine IL-1beta Up-Regulates CXC Chemokine Receptor 4 via Notch and ERK Signaling Pathways in Tongue Squamous Cell Carcinoma.
Authors: Sun Y, Zhu D, Wang G, Wang D, Zhou H, Liu X, Jiang M, Liao L, Zhou Z, Hu J
PLoS ONE, 2015-07-15;10(7):e0132677.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-4 Downregulates IL-1beta and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine.
Authors: Onderdijk A, Baerveldt E, Kurek D, Kant M, Florencia E, Debets R, Prens E
J Immunol, 2015-07-13;195(4):1744-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human group3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation.
Authors: Ahn Y, Weeres M, Neulen M, Choi J, Kang S, Heo D, Bergerson R, Blazar B, Miller J, Verneris M
Eur J Immunol, 2015-06-22;45(8):2335-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
J Transl Med, 2015-06-20;13(0):197.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Eupatilin Exerts Antinociceptive and Chondroprotective Properties in a Rat Model of Osteoarthritis by Downregulating Oxidative Damage and Catabolic Activity in Chondrocytes.
Authors: Jeong J, Moon S, Jhun J, Yang E, Cho M, Min J
PLoS ONE, 2015-06-17;10(6):e0130882.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
Authors: Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L
J Exp Med, 2015-05-25;212(6):939-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of articular chondrocytes from human pluripotent stem cells.
Authors: Craft A, Rockel J, Nartiss Y, Kandel R, Alman B, Keller G
Nat Biotechnol, 2015-05-11;33(6):638-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Transforming Growth Factor-beta and Interleukin-1beta Signaling Pathways Converge on the Chemokine CCL20 Promoter.
Authors: Brand O, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson A, Hill A, Jablons D, Wolters P, Lou J, Marks J, Baron J, Nishimura S
J Biol Chem, 2015-04-27;290(23):14717-28.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis.
Authors: Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, Ikinciogullari A, Dogu F, Belkadi A, Levy R, Migaud M, Boisson B, Bolze A, Itan Y, Goudin N, Cottineau J, Picard C, Abel L, Bustamante J, Casanova J, Puel A
J Exp Med, 2015-04-27;212(5):619-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Curcuminoids extract, hydrolyzed collagen and green tea extract synergically inhibit inflammatory and catabolic mediator's synthesis by normal bovine and osteoarthritic human chondrocytes in monolayer.
Authors: Comblain F, Sanchez C, Lesponne I, Balligand M, Serisier S, Henrotin Y
PLoS ONE, 2015-03-23;10(3):e0121654.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
Nat Med, 2015-03-16;21(4):363-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.
Authors: Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M
Infect Immun, 2015-03-02;83(5):1973-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The expression and regulation of chemerin in the epidermis.
Authors: Banas M, Zegar A, Kwitniewski M, Zabieglo K, Marczynska J, Kapinska-Mrowiecka M, LaJevic M, Zabel B, Cichy J
PLoS ONE, 2015-02-06;10(2):e0117830.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.
Authors: Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R
PLoS ONE, 2015-01-27;10(1):e0116773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells.
Authors: Scarlata C, Celse C, Pignon P, Ayyoub M, Valmori D
Eur J Immunol, 2015-01-16;45(2):474-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Short term exposure of beta cells to low concentrations of interleukin-1beta improves insulin secretion through focal adhesion and actin remodeling and regulation of gene expression.
Authors: Arous C, Ferreira P, Dermitzakis E, Halban P
J Biol Chem, 2015-01-13;290(10):6653-69.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta.
Authors: Yan X, Jiang E, Weng H
J Neuroinflammation, 2015-01-09;12(0):222.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection.
Authors: Li H, Richert-Spuhler L, Evans T, Gillis J, Connole M, Estes J, Keele B, Klatt N, Reeves R
PLoS Pathog, 2014-12-11;10(12):e1004551.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1 beta enhances human multipotent mesenchymal stromal cell proliferative potential and their ability to maintain hematopoietic precursor cells.
Authors: Bigildeev A, Zezina E, Shipounova I, Drize N
Cytokine, 2014-11-24;71(2):246-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Anti-apoptotic NF-kappaB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production.
Authors: Muller I, Beissert S, Kulms D
J Invest Dermatol, 2014-11-07;135(3):851-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
Mol Ther, 2014-11-04;23(2):387-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

1,25-Dihydroxyvitamin D3 and its analog TX527 promote a stable regulatory T cell phenotype in T cells from type 1 diabetes patients.
Authors: Van Belle T, Vanherwegen A, Feyaerts D, De Clercq P, Verstuyf A, Korf H, Gysemans C, Mathieu C
PLoS ONE, 2014-10-03;9(10):e109194.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets.
Authors: Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L
J Clin Invest, 2014-09-17;124(10):4657-67.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014-09-03;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cyclic phosphatidic acid relieves osteoarthritis symptoms.
Authors: Gotoh M, Nagano A, Tsukahara R, Murofushi H, Morohoshi T, Otsuka K, Murakami-Murofushi K
Mol Pain, 2014-08-14;10(0):52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nitric oxide enhances Th9 cell differentiation and airway inflammation.
Authors: Niedbala W, Besnard A, Nascimento D, Donate P, Sonego F, Yip E, Guabiraba R, Chang H, Fukada S, Salmond R, Schmitt E, Bopp T, Ryffel B, Liew F
Nat Commun, 2014-08-07;5(0):4575.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
J Immunol, 2014-07-30;193(5):2297-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells.
Authors: Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B
J Biol Chem, 2014-07-28;289(37):25546-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
Authors: Brozzi F, Gerlo S, Grieco F, Nardelli T, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, Eizirik D
J Biol Chem, 2014-07-25;289(30):20677-93.
Species: Human, Rat
Sample Types: Whole Cells
Applications: Bioassay

Improving membrane based multiplex immunoassays for semi-quantitative detection of multiple cytokines in a single sample.
Authors: Altara, Raffaele, Manca, Marco, Hessel, Marleen, Janssen, Ben J, Struijker-Boudier, Harry H, Hermans, Rob J J, Blankesteijn, W Matthi
BMC Biotechnol, 2014-07-15;14(0):63.
Applications: ELISA (Standard)

A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Authors: Lewis, Nuruddee, Patnaude, Lori A, Pelletier, Josephin, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan, Stefanopoulos, Dimitria, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christia, Hickey, Eugene R, Modis, Louise K
PLoS ONE, 2014-06-26;9(6):e100883.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Authors: Kastrati I, Canestrari E, Frasor J
Oncogene, 2014-06-23;34(18):2309-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors.
Authors: Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D
J Immunol, 2014-06-23;193(3):1047-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inhibitory effects of prostaglandin E2 on collagen synthesis and cell proliferation in human stellate cells from pancreatic head adenocarcinoma.
Authors: Pomianowska E, Sandnes D, Grzyb K, Schjolberg A, Aasrum M, Tveteraas I, Tjomsland V, Christoffersen T, Gladhaug I
BMC Cancer, 2014-06-09;14(0):413.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
J Allergy Clin Immunol, 2014-06-06;134(2):373-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.
Authors: Duhen T, Campbell D
J Immunol, 2014-06-02;193(1):120-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-33 induces urokinase in human endothelial cells--possible impact on angiogenesis.
Authors: Stojkovic S, Kaun C, Heinz M, Krychtiuk K, Rauscher S, Lemberger C, de Martin R, Groger M, Petzelbauer P, Huk I, Huber K, Wojta J, Demyanets S
J Thromb Haemost, 2014-06-01;12(6):948-57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells.
Authors: Backman S, Kollara A, Haw R, Stein L, Brown T
PLoS ONE, 2014-05-21;9(5):e97997.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1beta-stimulated production of chemokines and matrix-degrading enzymes in vitro.
Authors: Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzi R, Meliconi R
PLoS ONE, 2014-05-12;9(5):e96925.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells.
Authors: Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D
J Clin Invest, 2014-05-08;124(6):2513-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells.
Authors: Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C
PLoS ONE, 2014-05-02;9(5):e96695.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Additive effects of EGF and IL-1beta regulate tumor cell migration and invasion in gastric adenocarcinoma via activation of ERK1/2.
Authors: Han J, Xie Y, Lan F, Yu Y, Liu W, Chen J, Zheng F, Ouyang X, Lin X, Lin Y, Huang Q, Wang L, Tan J
Int J Oncol, 2014-04-28;45(1):291-301.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments.
Authors: Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D
PLoS ONE, 2014-04-21;9(4):e95586.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice.
Authors: Liu J, Ren Y, Kang L, Zhang L
PLoS ONE, 2014-04-10;9(4):e94912.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone.
Authors: Shah S, King E, Chandrasekhar A, Newton R
J Biol Chem, 2014-04-01;289(19):13667-79.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pathogen sensing pathways in human embryonic stem cell derived-endothelial cells: role of NOD1 receptors.
Authors: Reed, Daniel M, Foldes, Gabor, Gatheral, Timothy, Paschalaki, Koralia, Lendvai, Zsuzsann, Bagyura, Zsolt, Nemeth, Tamas, Skopal, Judit, Merkely, Bela, Telcian, Aurica G, Gogsadze, Leila, Edwards, Michael, Gough, Peter J, Bertin, John, Johnston, Sebastia, Harding, Sian E, Mitchell, Jane A
PLoS ONE, 2014-04-01;9(4):e91119.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients.
Authors: Teunissen M, Munneke J, Bernink J, Spuls P, Res P, Te Velde A, Cheuk S, Brouwer M, Menting S, Eidsmo L, Spits H, Hazenberg M, Mjosberg J
J Invest Dermatol, 2014-03-21;134(9):2351-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis.
Authors: Coward W, Feghali-Bostwick C, Jenkins G, Knox A, Pang L
FASEB J, 2014-03-20;28(7):3183-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.
Authors: Ardestani, Amin, Paroni, Federico, Azizi, Zahra, Kaur, Supreet, Khobragade, Vrushali, Yuan, Ting, Frogne, Thomas, Tao, Wufan, Oberholzer, Jose, Pattou, Francois, Kerr Conte, Julie, Maedler, Kathrin
Nat Med, 2014-03-16;20(4):385-97.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic beta-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.
Authors: Marroqui L, Santin I, Dos Santos R, Marselli L, Marchetti P, Eizirik D
Diabetes, 2014-03-07;63(7):2516-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.
Authors: Gresnigt M, Bozza S, Becker K, Joosten L, Abdollahi-Roodsaz S, van der Berg W, Dinarello C, Netea M, Fontaine T, De Luca A, Moretti S, Romani L, Latge J, van de Veerdonk F
PLoS Pathog, 2014-03-06;10(3):e1003936.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.
Authors: Cushing L, Stochaj W, Siegel M, Czerwinski R, Dower K, Wright Q, Hirschfield M, Casanova J, Picard C, Puel A, Lin L, Rao V
J Biol Chem, 2014-02-24;289(15):10865-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014-02-18;44(5):1330-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
Authors: Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M
PLoS ONE, 2014-02-14;9(2):e88714.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.
Authors: Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J
J Immunol, 2014-02-05;192(5):2449-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
Mol Ther, 2014-02-05;22(5):999-1007.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9.
Authors: Huang Q, Lan F, Wang X, Yu Y, Ouyang X, Zheng F, Han J, Lin Y, Xie Y, Xie F, Liu W, Yang X, Wang H, Dong L, Wang L, Tan J
Mol Cancer, 2014-01-31;13(0):18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA.
Authors: Chiliveru S, Rahbek S, Jensen S, Jorgensen S, Nissen S, Christiansen S, Mogensen T, Jakobsen M, Iversen L, Johansen C, Paludan S
J Immunol, 2014-01-31;192(5):2395-404.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
Authors: Haseeb A, Makki M, Haqqi T
J Biol Chem, 2014-01-27;289(10):6877-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma.
Authors: Sidney L, Kirkham G, Buttery L
Stem Cells Dev, 2014-01-23;23(6):605-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pigment epithelium-derived factor (PEDF) suppresses IL-1beta-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling.
Authors: Gattu A, Birkenfeld A, Iwakiri Y, Jay S, Saltzman M, Doll J, Protiva P, Samuel V, Crawford S, Chung C
Endocrinology, 2014-01-23;155(4):1373-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.
Authors: Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H
Proc Natl Acad Sci U S A, 2014-01-13;111(4):1509-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-6 signaling drives fibrosis in unresolved inflammation.
Authors: Fielding C, Jones G, McLoughlin R, McLeod L, Hammond V, Uceda J, Williams A, Lambie M, Foster T, Liao C, Rice C, Greenhill C, Colmont C, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig K, Williams J, Williams G, Davies S, Humphreys I, O'Donnell V, Taylor P, Jenkins B, Topley N, Jones S
Immunity, 2014-01-09;40(1):40-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

TNF-alpha blockade induces IL-10 expression in human CD4+ T cells.
Authors: Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L
Nat Commun, 2014-01-01;5(0):3199.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

High activities of BACE1 in brains with mild cognitive impairment.
Authors: Cheng X, He P, Lee T, Yao H, Li R, Shen Y
Am J Pathol, 2014-01-01;184(1):141-7.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

IL-32 promotes angiogenesis.
Authors: Nold-Petry C, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho S, Zepp J, Azam T, Dinkel H, Palmer B, Boisvert W, Cool C, Taraseviciene-Stewart L, Heinhuis B, Joosten L, Dinarello C, Voelkel N, Nold M
J Immunol, 2013-12-11;192(2):589-602.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis.
Authors: Ho L, Hung L, Liu F, Hou T, Lin L, Huang C, Lai J
PLoS ONE, 2013-12-11;8(12):e82033.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZEB1/2.
Authors: Konradi S, Yasmin N, Haslwanter D, Weber M, Gesslbauer B, Sixt M, Strobl H
Eur J Immunol, 2013-12-02;44(2):553-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
Authors: Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H
FEBS Lett, 2013-11-21;588(1):131-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of Ca2+/calmodulin-dependent kinase II-IRAK1 interaction in LMP1-induced NF-kappaB activation.
Authors: Kim J, Kim S, Lim S, Kieff E, Song Y
Mol Cell Biol, 2013-11-18;34(3):325-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis.
Authors: Cucchiarini M, Madry H, Terwilliger E
J Cell Mol Med, 2013-11-17;18(1):115-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Detailed mechanistic analysis of gevokizumab, an allosteric anti-IL-1beta antibody with differential receptor-modulating properties.
Authors: Issafras H, Corbin J, Goldfine I, Roell M
J Pharmacol Exp Ther, 2013-11-05;348(1):202-15.
Applications: Binding Assay, Surface Plasmon Resonance

The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
Authors: Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A
PLoS Pathog, 2013-10-17;9(10):e1003700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
Clin Cancer Res, 2013-09-13;19(23):6484-94.
Species: Human
Sample Types: Whole Tissue
Applications: Cell Culture

A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.
Authors: Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H
Elife, 2013-07-23;2(0):e00762.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
Authors: Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Muller I
Eur J Immunol, 2013-07-23;43(10):2741-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CD161 expression characterizes a subpopulation of human regulatory T cells that produces IL-17 in a STAT3-dependent manner.
Authors: Afzali B, Mitchell P, Edozie F, Povoleri G, Dowson S, Demandt L, Walter G, Canavan J, Scotta C, Menon B, Chana P, Khamri W, Kordasti S, Heck S, Grimbacher B, Tree T, Cope A, Taams L, Lechler R, John S, Lombardi G
Eur J Immunol, 2013-07-03;43(8):2043-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands.
Authors: Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M
Eur J Immunol, 2013-05-08;43(7):1727-34.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

p53 controls autoimmune arthritis via STAT-mediated regulation of the Th17 cell/Treg cell balance in mice.
Authors: Park J, Lim M, Cho M, Ryu J, Moon Y, Jhun J, Byun J, Kim E, Hwang S, Ju J, Kwok S, Kim H
Arthritis Rheum, 2013-04-01;65(4):949-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
J Immunol, 2013-03-13;190(8):4196-204.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets.
Authors: El-Zaatari M, Kao J, Tessier A, Bai L, Hayes M, Fontaine C, Eaton K, Merchant J
PLoS ONE, 2013-03-08;8(3):e58935.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Independent and interdependent immunoregulatory effects of IL-27, IFN-beta, and IL-10 in the suppression of human Th17 cells and murine experimental autoimmune encephalomyelitis.
Authors: Fitzgerald D, Fonseca-Kelly Z, Cullimore M, Safabakhsh P, Saris C, Zhang G, Rostami A
J Immunol, 2013-03-01;190(7):3225-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells.
Authors: Tang, Xin-Zi, Jo, Juandy, Tan, Anthony, Sandalova, Elena, Chia, Adeline, Tan, Kai Chah, Lee, Kang Hoe, Gehring, Adam J, De Libero, Gennaro, Bertoletti, Antonio
J Immunol, 2013-02-27;190(7):3142-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cetuximab-activated natural killer and dendritic cells collaborate to trigger tumor antigen-specific T-cell immunity in head and neck cancer patients.
Authors: Srivastava R, Lee S, Andrade Filho P, Lord C, Jie H, Davidson H, Lopez-Albaitero A, Gibson S, Gooding W, Ferrone S, Ferris R
Clin Cancer Res, 2013-02-26;19(7):1858-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Unraveling the signaling pathways promoting fibrosis in Dupuytren's disease reveals TNF as a therapeutic target.
Authors: Verjee L, Verhoekx J, Chan J, Krausgruber T, Nicolaidou V, Izadi D, Davidson D, Feldmann M, Midwood K, Nanchahal J
Proc Natl Acad Sci U S A, 2013-02-19;110(10):E928-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

EpCAM modulates NF-kappaB signaling and interleukin-8 expression in breast cancer.
Authors: Sankpal N, Fleming T, Gillanders W
Mol Cancer Res, 2013-02-01;11(4):418-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Self double-stranded (ds)DNA induces IL-1beta production from human monocytes by activating NLRP3 inflammasome in the presence of anti-dsDNA antibodies.
Authors: Shin M, Kang Y, Lee N, Wahl E, Kim S, Kang K, Lazova R, Kang I
J Immunol, 2013-01-11;190(4):1407-15.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture

Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
Authors: Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C
Nat Immunol, 2012-10-28;13(12):1178-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis.
J. Exp. Med., 2012-10-15;209(11):2033-47.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
PLoS ONE, 2012-09-24;7(9):e45700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients.
Authors: Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y
J Biol Chem, 2012-08-14;287(42):35484-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
Authors: Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K
Infect Immun, 2012-08-13;80(11):3795-803.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
Nature, 2012-07-26;487(7408):505-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
J. Exp. Med., 2012-07-16;209(8):1505-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Authors: Flanagan K, Fitzgerald K, Baker J
PLoS ONE, 2012-07-06;7(7):e40443.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
PLoS ONE, 2012-06-22;7(6):e38721.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased levels of inflammatory cytokines and endothelin-1 in alveolar macrophages from patients with chronic heart failure.
Authors: Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, ØIe E
PLoS ONE, 2012-05-15;7(5):e36815.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012-04-18;7(4):e34965.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
Eur. J. Immunol., 2012-04-01;42(4):936-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
Authors: Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D
Oncoimmunology, 2012-03-01;1(2):129-140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Authors: Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
J. Clin. Invest., 2011-11-21;121(12):4889-902.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Gene Ther, 2011-11-10;19(10):1035-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Authors: Ramirez-Carrozzi V, Sambandam A, Luis E
Nat. Immunol., 2011-10-12;12(12):1159-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.
Authors: Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M
J Transl Med, 2011-09-13;9(0):151.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Measurement of interleukin-33 (IL-33) and IL-33 receptors (sST2 and ST2L) in patients with rheumatoid arthritis.
Authors: Hong YS, Moon SJ, Moon S, Joo YB, Joo Y, Jeon CH, Jeon C, Cho ML, Ju JH, Oh HJ, Heo YJ, Heo Y, Park SH, Kim HY, Min JK
J Korean Med Sci, 2011-09-01;26(9):1132-9.
Applications: ELISA (Standard)

Identification of IDO-positive and IDO-negative human dendritic cells after activation by various proinflammatory stimuli.
Authors: Von Bubnoff D, Scheler M, Wilms H, Fimmers R, Bieber T
J. Immunol., 2011-05-04;186(12):6701-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cadherin-11 regulates fibroblast inflammation.
Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB
Proc. Natl. Acad. Sci. U.S.A., 2011-05-02;108(20):8402-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

B cells as a therapeutic target for IFN-beta in relapsing-remitting multiple sclerosis.
Authors: Ramgolam VS, Sha Y, Marcus KL, Choudhary N, Troiani L, Chopra M, Markovic-Plese S
J. Immunol., 2011-03-02;186(0):4518.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression.
Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
J. Immunol., 2011-01-17;186(4):2613-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cortisol Synthesis in Epidermis Is Induced by IL-1 and Tissue Injury.
Authors: Vukelic S, Stojadinovic O, Pastar I, Rabach M, Krzyzanowska A, Lebrun E, Davis SC, Resnik S, Brem H, Tomic-Canic M
J. Biol. Chem., 2011-01-14;286(12):10265-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
MAbs, 2011-01-01;3(1):49-60.
Species: Human
Sample Types: Buffer
Applications: Binding Assay

Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
Authors: Shin HS, Xu F, Bagchi A, Herrup E, Wilhelmsen K
J. Immunol., 2010-12-17;186(2):1119-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1.
Authors: Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S
Am. J. Reprod. Immunol., 2010-11-19;65(5):470-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
Authors: Xu H, Wang X, Pahar B
J. Immunol., 2010-11-08;185(12):7340-8.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Suppression of TNF-alpha and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
Authors: Kalliolias GD, Gordon RA, Ivashkiv LB
J. Immunol., 2010-10-22;185(11):7047-56.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.
Authors: Lee B, Kim TH, Jun JB, Yoo DH, Woo JH, Choi SJ, Lee YH, Song GG, Sohn J, Park-Min KH, Ivashkiv LB, Ji JD
J. Immunol., 2010-10-08;185(10):5926-34.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
Authors: Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA
FASEB J., 2010-09-08;25(1):409-19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distinct roles of hepatocyte- and myeloid cell-derived IL-1 receptor antagonist during endotoxemia and sterile inflammation in mice.
Authors: Lamacchia C, Palmer G, Bischoff L, Rodriguez E, Talabot-Ayer D, Gabay C
J. Immunol., 2010-07-16;185(0):2516-24.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
Authors: Mengshol JA, Golden-Mason L, Arikawa T
PLoS ONE, 2010-03-04;5(3):e9504.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
Nat. Med., 2010-01-10;16(2):191-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of interleukin 1-like cytokine interleukin 33 and its receptor complex (ST2L and IL1RAcP) in human pancreatic myofibroblasts.
Authors: Nishida A, Andoh A, Imaeda H, Inatomi O, Shiomi H, Fujiyama Y
Gut, 2009-12-08;59(4):531-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
J Biol Chem, 2009-07-15;284(36):24035-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009-07-05;10(8):857-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Central opioid inhibition of neuroendocrine stress responses in pregnancy in the rat is induced by the neurosteroid allopregnanolone.
Authors: Brunton PJ, McKay AJ, Ochedalski T, Piastowska A, Rebas E, Lachowicz A, Russell JA
J. Neurosci., 2009-05-20;29(20):6449-60.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Interleukin-32 expression in the pancreas.
Authors: Nishida A, Andoh A, Inatomi O, Fujiyama Y
J. Biol. Chem., 2009-04-21;284(26):17868-76.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy.
Authors: Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, Overall CM, Power C
FASEB J., 2009-04-20;23(9):2928-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009-03-09;206(3):535-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009-03-02;44(6):1143-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells.
Authors: Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G
Circulation, 2009-03-02;119(10):1424-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes.
Authors: Yammani RR, Long D, Loeser RF
Arthritis Rheum., 2009-03-01;60(3):792-800.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation.
Authors: Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K
Clin. Exp. Immunol., 2008-12-01;154(3):384-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway.
Authors: Chang SY, Su PF, Lee TC
Cytokine, 2008-11-20;45(1):32-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epigallocatechin-3-gallate inhibits IL-6 synthesis and suppresses transsignaling by enhancing soluble gp130 production.
Authors: Ahmed S, Marotte H, Kwan K, Ruth JH, Campbell PL, Rabquer BJ, Pakozdi A, Koch AE
Proc. Natl. Acad. Sci. U.S.A., 2008-09-16;105(38):14692-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
Authors: Crocker SJ, Frausto RF, Whitton JL, Milner R
Glia, 2008-08-15;56(0):1187-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Endogenous IL-32 controls cytokine and HIV-1 production.
Authors: Nold MF, Nold-Petry CA, Pott GB, Zepp JA, Saavedra MT, Kim SH, Dinarello CA
J. Immunol., 2008-07-01;181(1):557-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cytokine mRNA induction by interleukin-1beta or tumor necrosis factor alpha in vitro and in vivo.
Authors: Taishi P, Churchill L, De A, Obal F, Krueger JM
Brain Res., 2008-06-05;1226(0):89-98.
Species: Rat
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
Authors: Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
J. Allergy Clin. Immunol., 2008-06-01;121(6):1484-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
J. Immunol., 2008-05-15;180(10):6629-39.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes.
Authors: Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB, Park BH
Life Sci., 2008-04-20;82(23):1203-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
Authors: Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D
Arthritis Rheum., 2008-04-01;58(4):1001-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death.
Authors: Das S, Mishra MK, Ghosh J, Basu A
J. Neuroimmunol., 2008-03-28;195(1):60-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
Applications: ELISA (Standard)

Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
J. Leukoc. Biol., 2008-02-15;83(5):1181-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pre-eclampsia is associated with dendritic cell recruitment into the uterine decidua.
Authors: Huang SJ, Chen CP, Schatz F, Rahman M, Abrahams VM, Lockwood CJ
J. Pathol., 2008-02-01;214(3):328-36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury.
Authors: Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007-12-07;294(2):L334-43.
Species: Human
Sample Types: BALF
Applications: Bioassay

Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
Authors: Pfleger C, Schloot N, ter Veld F
J. Immunol. Methods, 2007-10-22;329(1):214-8.
Applications: ELISA (Standard)

Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells.
Authors: Lee SK, Pi SH, Kim SH, Min KS, Lee HJ, Chang HS, Kang KH, Kim HR, Shin HI, Lee SK, Kim EC
Clin. Exp. Immunol., 2007-10-09;150(3):567-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Central role of the MEK/ERK MAP kinase pathway in a mouse model of rheumatoid arthritis: potential proinflammatory mechanisms.
Authors: Thiel MJ, Schaefer CJ, Lesch ME, Mobley JL, Dudley DT, Tecle H, Barrett SD, Schrier DJ, Flory CM
Arthritis Rheum., 2007-10-01;56(10):3347-57.
Species: Rabbit
Sample Types: In Vivo
Applications: In Vivo

Ultrasensitive flow-based immunoassays using single-molecule counting.
Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
Clin. Chem., 2007-09-21;53(11):1990-5.
Applications: ELISA (Standard)

Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
Transplantation, 2007-07-27;84(2):196-206.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay

Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates.
Authors: Luty WH, Rodeberg D, Parness J, Vyas YM
J. Immunol., 2007-07-15;179(2):819-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.
Authors: Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S
J. Clin. Invest., 2007-07-01;117(7):1951-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Epithelial overexpression of interleukin-32alpha in inflammatory bowel disease.
Authors: Shioya M, Nishida A, Yagi Y, Ogawa A, Tsujikawa T, Kim-Mitsuyama S, Takayanagi A, Shimizu N, Fujiyama Y, Andoh A
Clin. Exp. Immunol., 2007-06-22;149(3):480-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.
Authors: Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS
Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-18;293(2):L375-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1/2): possible role for its anti-psoriatic effect.
Authors: Gesser B, Johansen C, Rasmussen MK, Funding AT, Otkjaer K, Kjellerup RB, Kragballe K, Iversen L
J. Invest. Dermatol., 2007-05-10;127(9):2129-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007-05-01;178(9):5973-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
Authors: Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S
Gut, 2007-04-20;56(9):1257-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Mitogen- and stress-activated protein kinase 2 and cyclic AMP response element binding protein are activated in lesional psoriatic epidermis.
Authors: Funding AT, Johansen C, Kragballe K, Iversen L
J. Invest. Dermatol., 2007-04-12;127(8):2012-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
Dig. Dis. Sci., 2007-04-06;52(12):3404-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
Authors: Muselet-Charlier C, Roque T, Boncoeur E, Chadelat K, Clement A, Jacquot J, Tabary O
Biochem. Biophys. Res. Commun., 2007-04-02;357(2):402-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Authors: Kang YM, Kim SY, Kang JH
Arthritis Rheum., 2007-04-01;56(4):1106-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression.
Authors: Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H
Int. J. Oncol., 2007-04-01;30(4):977-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
Authors: Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B
Blood, 2007-04-01;109(7):2806-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
Dig. Dis. Sci., 2007-03-30;52(10):2775-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia.
Authors: Girard BM, Young BA, Buttolph TR, White SL, Parsons RL
Neuroscience, 2007-03-23;146(2):584-93.
Species: Guinea Pig
Sample Types: Whole Cells
Applications: Bioassay

P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
Authors: Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC
Br. J. Pharmacol., 2007-03-12;151(1):115-27.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, Western Blot

Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Authors: Brechter AB, Lerner UH
Arthritis Rheum., 2007-03-01;56(3):910-23.
Species: Human, Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Bioassay

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production.
Authors: Emsley HC, Smith CJ, Gavin CM
BMC Neurol, 2007-02-28;7(0):5.
Applications: ELISA (Standard)

The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
Authors: Sa SM, Valdez PA, Wu J
J. Immunol., 2007-02-15;178(4):2229-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007-02-08;109(10):4272-9.
Applications: ELISA (Standard)

The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro.
Authors: Yeh CC, Kao SJ, Lin CC, Wang SD, Liu CJ, Kao ST
Life Sci., 2007-02-03;80(20):1821-31.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
J. Immunol., 2007-01-15;178(2):1172-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway.
Authors: Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2007-01-01;210(1):192-200.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.
Authors: Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I
J. Immunol., 2007-01-01;178(1):253-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
AIDS, 2007;21(10):1263-72.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard)

Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model.
Authors: Sadowsky DW, Adams KM, Gravett MG, Witkin SS, Novy MJ
Am. J. Obstet. Gynecol., 2006-12-01;195(6):1578-89.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: In Vivo
Applications: In Vivo

Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
J. Immunol., 2006-12-01;177(11):7665-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
Glia, 2006-11-01;54(6):619-29.
Species: Human
Sample Types: N/A, Whole Cells
Applications: Bioassay, ELISA (Standard)

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.
Authors: Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY
Diabetes, 2006-10-01;55(10):2713-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Changes in periodontal and rheumatological conditions after 2 years in patients with juvenile idiopathic arthritis.
Authors: Miranda LA, Braga F, Fischer RG, Sztajnbok FR, Figueredo CM, Gustafsson A
J. Periodontol., 2006-10-01;77(10):1695-700.
Applications: ELISA (Standard)

Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures.
Authors: Fearon U, Mullan R, Markham T, Connolly M, Sullivan S, Poole AR, FitzGerald O, Bresnihan B, Veale DJ
Arthritis Rheum., 2006-10-01;54(10):3152-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
J. Endocrinol., 2006-10-01;191(1):65-81.
Species: Hamster
Sample Types: Whole Cells
Applications: Bioassay

Kinin receptor expression during Staphylococcus aureus infection.
Authors: Bengtson SH, Phagoo SB, Norrby-Teglund A, Pahlman L, Morgelin M, Zuraw BL, Leeb-Lundberg LM, Herwald H
Blood, 2006-05-30;108(6):2055-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
Authors: Macagno A, Molteni M, Rinaldi A
J. Exp. Med., 2006-05-22;203(6):1481-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
Authors: Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2006-05-01;36(5):1309-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes.
Authors: Magne D, Palmer G, Barton JL, Mezin F, Talabot-Ayer D, Bas S, Duffy T, Noger M, Guerne PA, Nicklin MJ, Gabay C
Arthritis Res. Ther., 2006-04-28;8(3):R80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Authors: Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS
Exp. Cell Res., 2006-04-04;312(10):1909-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
J. Immunol., 2006-03-15;176(6):3742-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Th2 cytokine response in Major Depressive Disorder patients before treatment.
Authors: Kiryushko D, Pavon L, Novitskaya V, Sandoval-Lopez G, Soroka V, Eugenia Hernandez M, Klingelhofer J, Loria F, Lukanidin E, Estrada I, Berezin V, Perez M, Bock E, Moreno J, Avila U, Leff P, Anton B, Heinze G
J. Neuroimmunol., 2006-02-02;172(1):156-65.
Applications: ELISA (Standard)

Combination therapy: Synergistic suppression of virus-induced chemokines in airway epithelial cells.
Authors: Edwards MR, Johnson MW, Johnston SL
Am. J. Respir. Cell Mol. Biol., 2006-01-19;34(5):616-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2005-12-05;38(4):497-508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
J. Immunol. Methods, 2005-11-21;308(1):138-55.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells

Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005-09-07;31(5):335-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1).
Authors: Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C
Cytokine, 2005-07-21;31(2):153-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle.
Authors: Ameredes BT, Calhoun WJ
J. Allergy Clin. Immunol., 2005-07-01;116(1):65-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Ultraviolet radiation-induced injury, chemokines, and leukocyte recruitment: An amplification cycle triggering cutaneous lupus erythematosus.
Authors: Meller S, Winterberg F, Gilliet M, Muller A, Lauceviciute I, Rieker J, Neumann NJ, Kubitza R, Gombert M, Bunemann E, Wiesner U, Franken-Kunkel P, Kanzler H, Dieu-Nosjean MC, Amara A, Ruzicka T, Lehmann P, Zlotnik A, Homey B
Arthritis Rheum., 2005-05-01;52(5):1504-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1beta induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP.
Authors: Tang C, Sula MJ, Bohnet S, Rehman A, Taishi P, Krueger JM
Brain Res. Mol. Brain Res., 2005-04-25;137(1):213-22.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta.
Authors: Nagineni CN, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2005-04-01;203(1):35-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.
Authors: Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT
J. Rheumatol., 2005-04-01;32(4):713-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
Arthritis Rheum., 2005-03-01;52(3):770-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1.
Authors: Yamamoto H, Nagata M, Sakamoto Y
Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay

TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation.
Authors: Miller AM, McPhaden AR, Preston A, Wadsworth RM, Wainwright CL
Atherosclerosis, 2004-12-23;179(1):51-9.
Species: Rabbit
Sample Types: Whole Tissue
Applications: Bioassay

trans fatty acids and systemic inflammation in heart failure.
Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5.
Applications: ELISA (Standard)

A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
J. Exp. Med., 2004-11-22;200(11):1419-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Authors: Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C
Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
J. Immunol., 2004-11-01;173(9):5810-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Expression of Fas but not Fas ligand on fetal pig beta cells.
Authors: Bai L, Maedler K, Donath M, Tuch BE
Xenotransplantation, 2004-09-01;11(5):426-35.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay

IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
J. Immunol., 2004-09-01;173(5):3482-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells.
Authors: Morita K, Miyasako T, Kitayama S, Dohi T
Biochim. Biophys. Acta, 2004-08-04;1673(3):160-9.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
Authors: Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM
Biochem. J., 2004-06-01;380(0):425-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
Authors: Phillips TM
Electrophoresis, 2004-06-01;25(10):1652-9.

Lack of phenotypic and functional impairment in dendritic cells from chimpanzees chronically infected with hepatitis C virus.
Authors: Larsson M, Babcock E, Grakoui A, Shoukry N, Lauer G, Rice C, Walker C, Bhardwaj N
J. Virol., 2004-06-01;78(12):6151-61.
Species: Primate - Pan troglodytes (Chimpanzee)
Sample Types: Whole Cells
Applications: Bioassay

CD14 is an acute-phase protein.
Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
J. Immunol., 2004-04-01;172(7):4470-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
Blood, 2004-03-25;104(2):314-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interferon-gamma inhibits transforming growth factor-beta production in human airway epithelial cells by targeting Smads.
Authors: Wen FQ, Liu X, Kobayashi T, Abe S, Fang Q, Kohyama T, Ertl R, Terasaki Y, Manouilova L, Rennard SI
Am. J. Respir. Cell Mol. Biol., 2004-01-12;30(6):816-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Proline-rich tyrosine kinase 2 and Src kinase signaling transduce monosodium urate crystal-induced nitric oxide production and matrix metalloproteinase 3 expression in chondrocytes.
Authors: Liu R, Liote F, Rose DM, Merz D, Terkeltaub R
Arthritis Rheum., 2004-01-01;50(1):247-58.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay

Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
Authors: Copeland S, Siddiqui J, Remick D
J. Immunol. Methods, 2004-01-01;284(1):99-106.
Applications: ELISA (Standard)

Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition.
Authors: Studer RK, Bergman R, Stubbs T, Decker K
Arthritis Res. Ther., 2003-11-07;6(1):R56-R64.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay

ING-1(heMAb), a monoclonal antibody to epithelial cell adhesion molecule, inhibits tumor metastases in a murine cancer model.
Authors: Ruan HH, Scott KR, Bautista E, Ammons WS
Neoplasia, 2003-11-01;5(6):489-94.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
J. Clin. Invest., 2003-08-01;112(4):598-607.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta.
Authors: Park JS, 107290, Kim YS, Jee YK, Myong NH, Lee KY
Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models, 2003-05-01;57(5):463-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
Authors: Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE
Immunity, 2003-01-01;18(1):87-96.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

Alteration of locus coeruleus neuronal activity by interleukin-1 and the involvement of endogenous corticotropin-releasing hormone.
Authors: Borsody MK, Weiss JM
Neuroimmunomodulation, 2003-01-01;10(2):101-21.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo

Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
Authors: Yang CM, Luo SF, Wang CC, Chiu CT, Chien CS, Lin CC, Hsiao LD
Br. J. Pharmacol., 2000-06-01;130(4):891-9.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay

Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.
Authors: Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L
Eur. J. Oral Sci., 1998-06-01;106(3):778-87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Estrogen’s bone-protective effects may involve differential IL-1 receptor regulation in human osteoclast-like cells
Species: Human
Sample Types: Whole Cells
Applications: Bioassay