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Recombinant Mouse IL-2 Protein

Catalog #: 402-ML
261 Citations 9 Reviews Datasheet / COA / SDS

Carrier Free

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402-ML-020/CF
402-ML-100/CF
402-ML-500/CF

With Carrier

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402-ML-020
402-ML-100
402-ML-500
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Recombinant Mouse IL-2 Protein Bioactivity
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Product Details
Citations (261)
FAQs
Reviews (9)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IL-2 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. Gearing, A.J.H. and C.B. Bird (1987) in Lymphokines and Interferons, A Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 295. The ED50 for this effect is 0.1-0.4 ng/mL.
Source
E. coli-derived mouse IL-2 protein
Ala21-Gln169, with and without an N-terminal Met
Accession #
P04351
N-terminal Sequence
Analysis
Ala21 & Met
Predicted Molecular Mass
17.2 kDa

Product Datasheets

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402-ML (with carrier)

Product Datasheet
COA
SDS

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402-ML/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

402-ML

Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80 with BSA as a carrier protein.
Reconstitution Reconstitute at 100-200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

402-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and Tween®-80.
Reconstitution Reconstitute at 100-200 μg/mL in sterile deionized water.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse IL-2 Protein Bioactivity View Larger

Recombinant Mouse IL-2 (Catalog # 402-ML) stimulates cell proliferation of the CTLL-2 mouse cytotoxic T cell line. The ED50 for this effect is 0.1-0.4 ng/mL.

SDS-PAGE Recombinant Mouse IL-2 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse IL-2 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band(s) at 19 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-2

Interleukin‑2 (IL‑2) is a O‑glycosylated four alpha ‑helix bundle cytokine that has potent stimulatory activity for antigen‑activated T cells. It is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils (1‑3). Mature mouse IL‑2 shares 56% and 73% aa sequence identity with human and rat IL‑2, respectively. It shows strain‑specific heterogeneity in an N‑terminal region that contains a poly‑glutamine stretch (4). Mouse and human IL‑2 exhibit cross‑species activity (5). The receptor for IL‑2 consists of three subunits that are present on the cell surface in varying preformed complexes (6‑8). The 55 kDa IL‑2 R alpha is specific for IL‑2 and binds with low affinity. The 75 kDa IL‑2 R beta, which is also a component of the IL‑15 receptor, binds IL‑2 with intermediate affinity. The 64 kDa common gamma chain gamma c/IL-2 R gamma, which is shared with the receptors for IL‑4, ‑7, ‑9, ‑15, and ‑21, does not independently interact with IL‑2. Upon ligand binding, signal transduction is performed by both IL‑2 R beta and gamma c. IL‑2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL‑2 and IL‑2 R alpha synthesis (1, 2). It contributes to T cell homeostasis by promoting the Fas‑induced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes (9). IL‑2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells (10‑12). Thus, IL‑2 may be a key cytokine in the natural suppression of autoimmunity (13, 14).

References
  1. Ma, A. et al. (2006) Annu. Rev. Immunol. 24:657.
  2. Gaffen, S.L. and K.D. Liu (2004) Cytokine 28:109.
  3. Kashima, N. et al. (1985) Nature 313:402.
  4. Matesanz, F. et al. (1993) Immunogenetics 38:300.
  5. Mosmann, T.R. et al. (1987) J. Immunol. 138:1813.
  6. Liparoto, S.F. et al. (2002) Biochemistry 41:2543.
  7. Wang, X. et al. (2005) Science 310:1159.
  8. Bodnar, A. et al. (2008) Immunol. Lett. 116:117.
  9. Jaleco, S. et al. (2003) J. Immunol. 171:61.
  10. Malek, T.R. (2003) J. Leukoc. Biol. 74:961.
  11. Laurence, A. et al. (2007) Immunity 26:371.
  12. Kryczek, I. et al. (2007) J. Immunol. 178:6730.
  13. Afzali, B. et al. (2007) Clin. Exp. Immunol. 148:32.
  14. Fehervari, Z. et al. (2006) Trends Immunol. 27:109.
Long Name
Interleukin 2
Entrez Gene IDs
3558 (Human); 16183 (Mouse); 116562 (Rat); 396868 (Porcine); 280822 (Bovine); 403989 (Canine); 100034204 (Equine); 751114 (Feline); 100302458 (Rabbit)
Alternate Names
Aldesleukin; IL2; IL-2; IL-2lymphokine; interleukin 2; interleukin-2; involved in regulation of T-cell clonal expansion; Proleukin; T cell growth factor; T-cell growth factor; TCGF

Citations for Recombinant Mouse IL-2 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

261 Citations: Showing 1 - 10
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  1. SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation
    Authors: Chang, YH;Yamamoto, K;Fujino, T;Wang, TW;Sugimoto, E;Zhang, W;Yabushita, T;Suzaki, K;Pietsch, EC;Weir, BA;Crescenzo, R;Cowley, GS;Attar, R;Philippar, U;Wunderlich, M;Mizukawa, B;Zheng, Y;Enomoto, Y;Imai, Y;Kitamura, T;Goyama, S;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Infection with mpox virus via the genital mucosae increases shedding and transmission in the multimammate rat (Mastomys natalensis)
    Authors: Port, JR;Riopelle, JC;Smith, SG;Myers, L;Kaiser, FK;Lewis, MC;Gallogly, S;Okumura, A;Bushmaker, T;Schulz, JE;Rosenke, R;Prado-Smith, J;Carmody, A;Bane, S;Smith, BJ;Saturday, G;Feldmann, H;Rosenke, K;Munster, VJ;
    Nature microbiology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Lupus susceptibility gene Pbx1 controls the development, stability, and function of regulatory T cells via Rtkn2 expression
    Authors: Choi, SC;Park, YP;Roach, T;Jimenez, D;Fisher, A;Zadeh, M;Ma, L;Sobel, ES;Ge, Y;Mohamadzadeh, M;Morel, L;
    Science advances
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Down-regulation of zinc finger protein 335 undermines natural killer cell function in mouse colitis-associated colorectal carcinoma
    Authors: Jiang, B;Zhou, H;Xie, X;Xia, T;Ke, C;
    Heliyon
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Type 1 interferons and Foxo1 down-regulation play a key role in age-related T-cell exhaustion in mice
    Authors: Durand, A;Bonilla, N;Level, T;Ginestet, Z;Lombès, A;Guichard, V;Germain, M;Jacques, S;Letourneur, F;Do Cruzeiro, M;Marchiol, C;Renault, G;Le Gall, M;Charvet, C;Le Bon, A;Martin, B;Auffray, C;Lucas, B;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Sema6D forward signaling impairs T cell activation and proliferation in head and neck cancer
    Authors: Hirai, T;Naito, Y;Koyama, S;Nakanishi, Y;Masuhiro, K;Izumi, M;Kuge, T;Naito, M;Mizuno, Y;Yamaguchi, Y;Kang, S;Yaga, M;Futami, Y;Nojima, S;Nishide, M;Morita, T;Kato, Y;Tsuda, T;Takemoto, N;Kinugasa-Katayama, Y;Aoshi, T;Villa, JK;Yamashita, K;Enokida, T;Hoshi, Y;Matsuura, K;Tahara, M;Takamatsu, H;Takeda, Y;Inohara, H;Kumanogoh, A;
    JCI insight
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Stimulation
  7. IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity
    Authors: Landoni, E;Woodcock, MG;Barragan, G;Casirati, G;Cinella, V;Stucchi, S;Flick, LM;Withers, TA;Hudson, H;Casorati, G;Dellabona, P;Genovese, P;Savoldo, B;Metelitsa, LS;Dotti, G;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells
    Authors: Su, HH;Cheng, CM;Yang, YN;Chang, YW;Li, CY;Wu, ST;Lin, CC;Wu, HE;Suen, JL;
    Mucosal immunology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
    Authors: Baumgartner, CK;Ebrahimi-Nik, H;Iracheta-Vellve, A;Hamel, KM;Olander, KE;Davis, TGR;McGuire, KA;Halvorsen, GT;Avila, OI;Patel, CH;Kim, SY;Kammula, AV;Muscato, AJ;Halliwill, K;Geda, P;Klinge, KL;Xiong, Z;Duggan, R;Mu, L;Yeary, MD;Patti, JC;Balon, TM;Mathew, R;Backus, C;Kennedy, DE;Chen, A;Longenecker, K;Klahn, JT;Hrusch, CL;Krishnan, N;Hutchins, CW;Dunning, JP;Bulic, M;Tiwari, P;Colvin, KJ;Chuong, CL;Kohnle, IC;Rees, MG;Boghossian, A;Ronan, M;Roth, JA;Wu, MJ;Suermondt, JSMT;Knudsen, NH;Cheruiyot, CK;Sen, DR;Griffin, GK;Golub, TR;El-Bardeesy, N;Decker, JH;Yang, Y;Guffroy, M;Fossey, S;Trusk, P;Sun, IM;Liu, Y;Qiu, W;Sun, Q;Paddock, MN;Farney, EP;Matulenko, MA;Beauregard, C;Frost, JM;Yates, KB;Kym, PR;Manguso, RT;
    Nature
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Lipid accumulation-mediated histone hypoacetylation drives persistent NK cell dysfunction in anti-tumor immunity
    Authors: Jiao, D;Sun, R;Ren, X;Wang, Y;Tian, P;Wang, Y;Yuan, D;Yue, X;Wu, Z;Li, C;Gao, L;Ma, C;Liang, X;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. CD40L modulates CD4+ T cell activation through receptor for activated C kinase 1
    Authors: van Os, BW;Vos, WG;Bosmans, LA;van Tiel, CM;Toom, MD;Beckers, L;Admiraal, M;Hoeksema, MA;de Winther, MP;Lutgens, E;
    European journal of immunology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Ligand-based adoptive T cell targeting CA125 in ovarian cancer
    Authors: Zhao, H;Wu, L;Dai, J;Sun, K;Zi, Z;Guan, J;Zhang, L;
    Journal of translational medicine
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  13. Type-2 CD8+ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations
    Authors: van der Ploeg, EK;Krabbendam, L;Vroman, H;van Nimwegen, M;de Bruijn, MJW;de Boer, GM;Bergen, IM;Kool, M;Tramper-Standers, GA;Braunstahl, GJ;Huylebroeck, D;Hendriks, RW;Stadhouders, R;
    Nature communications
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  14. Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity
    Authors: Tamura, S;Ishiguro, H;Suwabe, T;Katagiri, T;Cho, K;Fuse, K;Shibasaki, Y;Mikami, T;Shindo, T;Kitagawa, H;Igarashi, M;Sone, H;Masuko, M;Ushiki, T;
    Scientific reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Targeting the MR1-MAIT cell axis improves vaccine efficacy and affords protection against viral pathogens
    Authors: Rashu, R;Ninkov, M;Wardell, CM;Benoit, JM;Wang, NI;Meilleur, CE;D'Agostino, MR;Zhang, A;Feng, E;Saeedian, N;Bell, GI;Vahedi, F;Hess, DA;Barr, SD;Troyer, RM;Kang, CY;Ashkar, AA;Miller, MS;Haeryfar, SMM;
    PLoS pathogens
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Tumor-resident regulatory T cells in pancreatic cancer express the ?v?5 integrin as a targetable activation marker
    Authors: Suzuki, K;Kunisada, Y;Miyamura, N;Eikawa, S;Hurtado de Mendoza, T;Mose, ES;Lu, C;Kuroda, Y;Ruoslahti, E;Lowy, AM;Sugahara, KN;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8+ T cell cytotoxicity and proliferation
    Authors: Naito, Y;Koyama, S;Masuhiro, K;Hirai, T;Uenami, T;Inoue, T;Osa, A;Machiyama, H;Watanabe, G;Sax, N;Villa, J;Kinugasa-Katayama, Y;Nojima, S;Yaga, M;Hosono, Y;Okuzaki, D;Satoh, S;Tsuda, T;Nakanishi, Y;Suga, Y;Morita, T;Fukushima, K;Nishide, M;Shiroyama, T;Miyake, K;Iwahori, K;Hirata, H;Nagatomo, I;Yano, Y;Tamiya, M;Kumagai, T;Takemoto, N;Inohara, H;Yamasaki, S;Yamashita, K;Aoshi, T;Akbay, EA;Hosen, N;Shintani, Y;Takamatsu, H;Mori, M;Takeda, Y;Kumanogoh, A;
    Science advances
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Magnesium increases numbers of Foxp3+ Treg cells and reduces arthritis severity and joint damage in an IL-10-dependent manner mediated by the intestinal microbiome
    Authors: Laragione, T;Harris, C;Azizgolshani, N;Beeton, C;Bongers, G;Gulko, PS;
    EBioMedicine
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Hypoxia-inducible factor orchestrates adenosine metabolism to promote liver cancer development
    Authors: Cheu, JW;Chiu, DK;Kwan, KK;Yang, C;Yuen, VW;Goh, CC;Chui, NN;Shen, W;Law, CT;Li, Q;Zhang, MS;Bao, MH;Wong, BP;Chan, CY;Liu, CX;Sit, GF;Ooi, ZY;Deng, H;Tse, AP;Ng, IO;Wong, CC;
    Science advances
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. A dhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T�cells with enhanced tumor homing to improve cell therapy
    Authors: CP Camargo, AK Muhuri, Y Alapan, LF Sestito, M Khosla, MP Manspeaker, AS Smith, CM Paulos, SN Thomas
    Cell Reports, 2023-02-26;42(3):112175.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFbeta
    Authors: JA O'Sullivan, FJ Kohlhapp, A Zloza, L Plaza-Roja, B Burke, NO Dulin, JA Guevara-Pa
    International Journal of Molecular Sciences, 2023-02-15;24(4):.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Modulation of Skin Inflammatory Responses by Aluminum Adjuvant
    Authors: Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang
    Pharmaceutics, 2023-02-08;15(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Crosstalk between ILC2s and Th2 cells varies among mouse models
    Authors: RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu
    Cell Reports, 2023-02-02;42(2):112073.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway
    Authors: WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee
    International Journal of Molecular Sciences, 2023-01-29;24(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Tumor-intrinsic YTHDF1 drives immune evasion and resistance to immune checkpoint inhibitors via promoting MHC-I degradation
    Authors: W Lin, L Chen, H Zhang, X Qiu, Q Huang, F Wan, Z Le, S Geng, A Zhang, S Qiu, L Chen, L Kong, JJ Lu
    Nature Communications, 2023-01-17;14(1):265.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival
    Authors: T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan
    Mucosal Immunology, 2023-01-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. GPR68 limits the severity of chemical-induced oral epithelial dysplasia
    Authors: D Shore, N Griggs, V Graffeo, ARMR Amin, XM Zha, Y Xu, JP McAleer
    Scientific Reports, 2023-01-07;13(1):353.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  28. Insulin Receptor Substrate 1 Signaling Inhibits Foxp3 Expression and Suppressive Functions in Treg Cells through the mTORC1 Pathway
    Authors: WH Lee, GE Kim, KJ Hong, HS Kim, GR Lee
    International Journal of Molecular Sciences, 2023;24(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity
    Authors: M Scherlinge, W Pan, R Hisada, A Boulougour, N Yoshida, M Vukelic, M Umeda, S Krishfield, MG Tsokos, GC Tsokos
    Science Advances, 2022-11-30;8(48):eadc9657.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Intranasal nanoemulsion adjuvanted S-2P vaccine demonstrates protection in hamsters and induces systemic, cell-mediated and mucosal immunity in mice
    Authors: S Ganesan, H Acosta, C Brigolin, K Orange, K Trabbic, C Chen, CE Lien, YJ Lin, MY Lin, YS Chuang, A Fattom, V Bitko
    PLoS ONE, 2022-11-02;17(11):e0272594.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation
    Authors: SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen
    Nature Communications, 2022-10-14;13(1):6069.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Identification of human MHC-I HPV18 E6/E7-specific CD8?+?T cell epitopes and generation of an HPV18 E6/E7-expressing adenosquamous carcinoma in HLA-A2 transgenic mice
    Authors: S Peng, D Xing, L Ferrall, YC Tsai, CF Hung, TC Wu
    Journal of Biomedical Science, 2022-10-12;29(1):80.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  33. IL-3 regulates the differentiation of pathogenic Th17 cells
    Authors: L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani
    European Journal of Immunology, 2022-09-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R
    Authors: JH Badrani, AN Strohm, L Lacasa, B Civello, K Cavagnero, YA Haung, M Amadeo, LH Naji, SJ Lund, A Leng, H Kim, RE Baum, N Khorram, M Mondal, G Seumois, J Pilotte, PW Vanderklis, HM McGee, TA Doherty
    Nature Communications, 2022-07-30;13(1):4435.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. MAP4K3/GLK inhibits Treg differentiation by direct phosphorylating IKKbeta and inducing IKKbeta-mediated FoxO1 nuclear export and Foxp3 downregulation
    Authors: JN Chi, JY Yang, CH Hsueh, CY Tsai, HC Chuang, TH Tan
    Theranostics, 2022-07-18;12(13):5744-5760.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  36. IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation
    Authors: HS Lee, HW Park
    Journal of Cellular and Molecular Medicine, 2022-07-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Immuno-reactive cancer organoid model to assess effects of the microbiome on cancer immunotherapy
    Authors: E Shelkey, D Oommen, ER Stirling, DR Soto-Panto, KL Cook, Y Lu, KI Votanopoul, S Soker
    Scientific Reports, 2022-06-15;12(1):9983.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
    Authors: LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh
    Cell Reports, 2022-05-24;39(8):110838.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. RNA polymerase II pausing factor NELF in CD8+ T cells promotes antitumor immunity
    Authors: B Wu, X Zhang, HC Chiang, H Pan, B Yuan, P Mitra, L Qi, H Simonyan, CN Young, E Yvon, Y Hu, N Zhang, R Li
    Nature Communications, 2022-04-20;13(1):2155.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. A Mutated Prostatic Acid Phosphatase (PAP) Peptide-Based Vaccine Induces PAP-Specific CD8+ T Cells with Ex Vivo Cytotoxic Capacities in HHDII/DR1 Transgenic Mice
    Authors: PL Vu, J Vadakekola, S Idri, H Nicholls, M Cavaignac, S Reeder, MA Khan, D Christense, AG Pockley, SE McArdle
    Cancers, 2022-04-13;14(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. EBV+ tumors exploit tumor cell-intrinsic and -extrinsic mechanisms to produce regulatory T cell-recruiting chemokines CCL17 and CCL22
    Authors: A Jorapur, LA Marshall, S Jacobson, M Xu, S Marubayash, M Zibinsky, DX Hu, O Robles, JJ Jackson, V Baloche, P Busson, D Wustrow, DG Brockstedt, O Talay, PD Kassner, G Cutler
    PloS Pathogens, 2022-01-13;18(1):e1010200.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Development of a Spontaneous HPV16 E6/E7-Expressing Head and Neck Squamous Cell Carcinoma in HLA-A2 Transgenic Mice
    Authors: S Peng, D Xing, L Ferrall, YC Tsai, RBS Roden, CF Hung, TC Wu
    MBio, 2022-01-04;0(0):e0325221.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Partial STAT5 signaling is sufficient for CD4+ T cell priming but not memory formation
    Authors: M Fleury, C Vazquez-Ma, J Hernandez-, H Dooms
    Cytokine, 2021-11-26;150(0):155770.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Leukemic progenitor cells enable immunosuppression and post-chemotherapy relapse via IL-36-inflammatory monocyte axis
    Authors: HZ Guo, ZH Guo, SH Yu, LT Niu, WT Qiang, MM Huang, YY Tian, J Chen, H Yang, XQ Weng, Y Zhang, W Zhang, SY Hu, J Shi, J Zhu
    Science Advances, 2021-10-08;7(41):eabg4167.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Gold nanorods enhance different immune cells and allow for efficient targeting of CD4+ Foxp3+ Tregulatory cells
    Authors: I Safina, ZAN Al Sudani, A Hashoosh, E Darrigues, F Watanabe, AS Biris, RPM Dings, K Bao Vang
    PLoS ONE, 2021-08-30;16(8):e0241882.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Tumor cell-imposed iron restriction drives immunosuppressive polarization of tumor-associated macrophages
    Authors: JL Sun, NP Zhang, RC Xu, GC Zhang, ZY Liu, W Abuduwaili, F Wang, XN Yu, X Shi, GQ Song, H Wu, TT Liu, XZ Shen, B Deng, SQ Weng, L Dong, JM Zhu
    Journal of Translational Medicine, 2021-08-13;19(1):347.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. CISH constrains the tuft-ILC2 circuit to set epithelial and immune tone
    Authors: ME Kotas, NM Mroz, S Koga, HE Liang, AW Schroeder, RR Ricardo-Go, C Schneider, RM Locksley
    Mucosal Immunology, 2021-07-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Splicing factor SRSF1 is indispensable for regulatory T�cell homeostasis and function
    Authors: T Katsuyama, VR Moulton
    Cell Reports, 2021-07-06;36(1):109339.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. m6A demethylase ALKBH5 controls CD4+ T cell pathogenicity and promotes autoimmunity
    Authors: J Zhou, X Zhang, J Hu, R Qu, Z Yu, H Xu, H Chen, L Yan, C Ding, Q Zou, Y Ye, Z Wang, RA Flavell, HB Li
    Science Advances, 2021-06-16;7(25):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
    Authors: S Sheppard, EK Santosa, CM Lau, S Violante, P Giovanelli, H Kim, JR Cross, MO Li, JC Sun
    Cell Reports, 2021-06-01;35(9):109210.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. miR-20a suppresses Treg differentiation by targeting Map3k9 in experimental autoimmune encephalomyelitis
    Authors: Y Wang, C Xie, Y Song, W Xiang, J Peng, L Han, J Ding, Y Guan
    Journal of Translational Medicine, 2021-05-26;19(1):223.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment
    Authors: CH Hsieh, HC Hsieh, FS Shih, PW Wang, LX Yang, DB Shieh, YC Wang
    Theranostics, 2021-05-13;11(14):7072-7091.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Bach2 attenuates IL-2R signaling to control Treg homeostasis and Tfr development
    Authors: H Zhang, D Dai, Q Hu, F Yang, Y Xue, F Li, N Shen, M Zhang, C Huang
    Cell Reports, 2021-05-11;35(6):109096.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Bruton's tyrosine kinase regulates gut immune homeostasis through attenuating Th1 response
    Authors: D Guan, Z Wang, J Huo, S Xu, KP Lam
    Cell Death & Disease, 2021-04-30;12(5):431.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Declined miR-181a-5p expression is associated with impaired natural killer cell development and function with aging
    Authors: J Lu, S Li, X Li, W Zhao, X Duan, X Gu, J Xu, B Yu, LJ Sigal, Z Dong, L Xie, M Fang
    Aging Cell, 2021-03-29;0(0):e13353.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells
    Authors: SH Shin, KA Cho, HS Yoon, SY Kim, HY Kim, Y Pewzner-Ju, SA Jung, WJ Park, AH Futerman, JW Park
    International Journal of Molecular Sciences, 2021-03-08;22(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Circadian Clock Disruption Suppresses PDL1+ Intraepithelial B-cells in Experimental Colitis and Colitis Associated Colorectal Cancer
    Authors: JL Liu, CY Wang, TY Cheng, Youlutuzia, C Ji, M Deng, S Yao, LH Yuan, YY Zhao, T Shen, JM Li
    Cellular and Molecular Gastroenterology and Hepatology, 2021-02-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. The phenotypic and functional study of tissue B cells in respiratory system provided important information for diseases and development of vaccines
    Authors: L Fan, Q Wu, S Kang, B Yang, C Wu
    Journal of Cellular and Molecular Medicine, 2021-01-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. DNA Methylation Patterns in CD 4 + T Cells of Na�ve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand
    Authors: CG Burke, JR Myers, CM Post, LA Boulé, BP Lawrence
    Environmental health perspectives, 2021-01-15;129(1):17007.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  60. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
    Authors: J Yu, MD Green, S Li, Y Sun, SN Journey, JE Choi, SM Rizvi, A Qin, JJ Waninger, X Lang, Z Chopra, I El Naqa, J Zhou, Y Bian, L Jiang, A Tezel, J Skvarce, RK Achar, M Sitto, BS Rosen, F Su, SP Narayanan, X Cao, S Wei, W Szeliga, L Vatan, C Mayo, MA Morgan, CA Schonewolf, K Cuneo, I Kryczek, VT Ma, CD Lao, TS Lawrence, N Ramnath, F Wen, AM Chinnaiyan, M Cieslik, A Alva, W Zou
    Nature Medicine, 2021-01-04;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Airway-Associated Macrophages in Homeostasis and Repair
    Authors: AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock
    Cell Reports, 2020-12-29;33(13):108553.
    Species: Transgenic Mouse
    Sample Types: Spheroid
    Applications: Bioassay
  62. Chromatin Protein PC4 Orchestrates B Cell Differentiation by Collaborating with IKAROS and IRF4
    Authors: K Ochiai, M Yamaoka, A Swaminatha, H Shima, H Hiura, M Matsumoto, D Kurotaki, J Nakabayash, R Funayama, K Nakayama, T Arima, T Ikawa, T Tamura, R Sciammas, P Bouvet, TK Kundu, K Igarashi
    Cell Reports, 2020-12-22;33(12):108517.
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Eosinophils improve cardiac function after myocardial infarction
    Authors: J Liu, C Yang, T Liu, Z Deng, W Fang, X Zhang, J Li, Q Huang, C Liu, Y Wang, D Yang, GK Sukhova, JS Lindholt, A Diederichs, LM Rasmussen, D Li, G Newton, FW Luscinskas, L Liu, P Libby, J Wang, J Guo, GP Shi
    Nature Communications, 2020-12-16;11(1):6396.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells
    Authors: GM Wiedemann, S Grassmann, CM Lau, M Rapp, AV Villarino, C Friedrich, G Gasteiger, JJ O'Shea, JC Sun
    Cell Reports, 2020-12-15;33(11):108498.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation
    Authors: T Koga, F Sasaki, K Saeki, S Tsuchiya, T Okuno, M Ohba, T Ichiki, S Iwamoto, H Uzawa, K Kitajima, C Meno, E Nakamura, N Tada, Y Fukui, J Kikuta, M Ishii, Y Sugimoto, M Nakao, T Yokomizo
    Cell Mol Immunol, 2020-10-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division
    Authors: JH Kang, G Katsikis, Z Li, KM Sapp, MA Stockslage, D Lim, MG Vander Hei, MB Yaffe, SR Manalis, TP Miettinen
    Nat Commun, 2020-10-05;11(1):4983.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. PPP2R2D suppresses interleukin-2 production and regulatory T cell function
    Authors: W Pan, A Sharabi, AP Ferretti, Y Zhang, C Burbano, N Yoshida, MG Tsokos, GC Tsokos
    JCI Insight, 2020-10-02;5(19):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. TRI microparticles prevent inflammatory arthritis in a collagen-induced arthritis model
    Authors: EJ Bassin, AR Buckley, JD Piganelli, SR Little
    PLoS ONE, 2020-09-23;15(9):e0239396.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  69. Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity
    Authors: J Tur, S Pereira-Lo, T Vico, EA Marín, JP Muñoz, M Hernández-, PJ Cardona, A Zorzano, J Lloberas, A Celada
    Cell Rep, 2020-08-25;32(8):108079.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. E proteins orchestrate dynamic transcriptional cascades implicated in the suppression of the differentiation of group 2 innate lymphoid cells
    Authors: V Peng, C Georgescu, A Bakowska, A Pankow, L Qian, JD Wren, XH Sun
    J. Biol. Chem., 2020-08-19;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  71. Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
    Authors: JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa
    Nat. Immunol., 2020-08-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Exhausted CD4+ T Cells during Malaria Exhibit Reduced mTORc1 Activity Correlated with Loss of T-bet Expression
    Authors: A Villegas-M, G Khandelwal, LM McGowan, RS Dookie, MJ Haley, C George, D Sims, GM Lord, LV Sinclair, RG Jenner, KN Couper
    J. Immunol., 2020-08-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  73. Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice
    Authors: K Schmitt, J Curlin, L Remling-Mu, R Moriarty, K Goff, S O'Connor, M Stenglein, P Marx, R Akkina
    Front Microbiol, 2020-08-11;11(0):1889.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Trispecific natural killer cell nanoengagers for targeted chemoimmunotherapy
    Authors: KM Au, SI Park, AZ Wang
    Sci Adv, 2020-07-03;6(27):eaba8564.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  75. T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
    Authors: J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham
    Cell Rep, 2020-06-30;31(13):107820.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal
    Authors: MND Svensson, M Zoccheddu, S Yang, G Nygaard, C Secchi, KM Doody, K Slowikowsk, F Mizoguchi, F Humby, R Hands, E Santelli, C Sacchetti, K Wakabayash, DJ Wu, C Barback, R Ai, W Wang, GP Sims, P Mydel, T Kasama, DL Boyle, F Galimi, D Vera, ML Tremblay, S Raychaudhu, MB Brenner, GS Firestein, C Pitzalis, AH Ekwall, SM Stanford, N Bottini
    Sci Adv, 2020-06-26;6(26):eaba4353.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. T cells expressing the lupus susceptibility allele Pbx1d enhance autoimmunity and atherosclerosis in dyslipidemic mice
    Authors: W Li, AS Elshikha, C Cornaby, X Teng, G Abboud, J Brown, X Zou, L Zeumer-Spa, B Robusto, SC Choi, K Fredenburg, A Major, L Morel
    JCI Insight, 2020-06-04;5(11):.
    Species: Transgenic Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation
    Authors: CW Keller, MB Kotur, S Mundt, N Dokalis, LA Ligeon, AM Shah, M Prinz, B Becher, C Münz, JD Lünemann
    Autophagy, 2020-05-13;0(0):1-15.
    Species: Mouse
    Sample Types: Whole Cell, Whole Cells
    Applications: Bioassay
  79. Midkine activation of CD8+ T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth
    Authors: X Guo, Y Pan, M Xiong, S Sanapala, C Anastasaki, O Cobb, S Dahiya, DH Gutmann
    Nat Commun, 2020-05-01;11(1):2177.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  80. JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction
    Authors: L Simula, M Corrado, B Accordi, A Di Rita, F Nazio, Y Antonucci, A Di Daniele, F Caicci, I Caruana, ME Soriano, M Pigazzi, F Locatelli, F Cecconi, S Campello
    Cell Death Differ., 2020-04-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Commensal bacteria stimulate antitumor responses via T cell cross-reactivity
    Authors: CA Bessell, A Isser, JJ Havel, S Lee, DR Bell, JW Hickey, W Chaisawang, J Glick Biel, R Srivastava, F Kuo, T Purohit, R Zhou, TA Chan, JP Schneck
    JCI Insight, 2020-04-23;5(8):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  82. Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity
    Authors: W Seo, K Shimizu, S Kojo, A Okeke, T Kohwi-Shig, SI Fujii, I Taniuchi
    Nat Commun, 2020-03-26;11(1):1562.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  83. TLR4 abrogates the Th1 immune response through IRF1 and IFN-&beta to prevent immunopathology during L. infantum infection
    Authors: LA Sacramento, L Benevides, SR Maruyama, L Tavares, KF Fukutani, M Francozo, T Sparwasser, FQ Cunha, RP Almeida, JS da Silva, V Carregaro
    PLoS Pathog., 2020-03-25;16(3):e1008435.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Bee Venom Phospholipase A2 Induces Regulatory T Cell Populations by Suppressing Apoptotic Signaling Pathway
    Authors: H Baek, SY Park, SJ Ku, K Ryu, Y Kim, H Bae, YS Lee
    Toxins (Basel), 2020-03-22;12(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  85. The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation
    Authors: JL Galeano Ni, SS Tay, JLE Tearle, J Xie, MA Govendir, D Kempe, J Mazalo, AP Drew, F Colakoglu, SK Kummerfeld, CG Proud, M Biro
    J. Cell. Sci., 2020-03-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  86. Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s
    Authors: M Wagner, KN Ealey, H Tetsu, T Kiniwa, Y Motomura, K Moro, S Koyasu
    Cell Rep, 2020-02-25;30(8):2743-2757.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Immune cell landscaping reveals a protective role for regulatory T cells during kidney injury and fibrosis
    Authors: F do Valle D, A Lafont, M Beibel, K Martin, K Darribat, R Cuttat, A Waldt, U Naumann, G Wieczorek, S Gaulis, S Pfister, KD Mertz, J Li, G Roma, M Warncke
    JCI Insight, 2020-02-13;5(3):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  88. Hepatic ILC2 activity is regulated by liver inflammation-induced cytokines and effector CD4+ T cells
    Authors: S Steinmann, M Schoedsack, F Heinrich, PC Breda, A Ochel, G Tiegs, K Neumann
    Sci Rep, 2020-01-23;10(1):1071.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  89. Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes
    Authors: P Obeidy, LA Ju, SH Oehlers, NS Zulkhernai, Q Lee, JL Galeano, Niño, R Kwan, S Tikoo, LL Cavanagh, P Mrass, A Cook, SP Jackson, M Biro, B Roediger, M Sixt, W Weninger
    Immunol. Cell Biol., 2019-12-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  90. CD226 deficiency on regulatory T cells aggravates renal fibrosis via up-regulation of Th2 cytokines through miR-340
    Authors: Y Mu, J Zhang, Y Liu, J Ma, D Jiang, X Zhang, X Yi, K Cheng, S Shen, Y Yang, R Zhuang, Y Zhang
    J. Leukoc. Biol., 2019-12-04;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Amplification of tumor antigen presentation by NLGplatin to improve chemoimmunotherapy
    Authors: Y Zhu, L Xing, X Zheng, CX Yang, YJ He, TJ Zhou, QR Jin, HL Jiang
    Int J Pharm, 2019-11-19;0(0):118736.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  92. IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis
    Authors: A Rose, C von Spee-M, L Kloke, K Wu, A Kühl, P Enghard, GR Burmester, G Riemekaste, JY Humrich
    Cells, 2019-10-11;8(10):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  93. Simulated microgravity-mediated reversion of murine lymphoma immune evasion
    Authors: JH Bradley, S Barwick, GQ Horn, E Ullrich, B Best, JP Arnold, RK Gregg
    Sci Rep, 2019-10-10;9(1):14623.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development
    Authors: X Qu, J Han, Y Zhang, X Wang, H Fan, F Hua, R Yao
    J Neuroinflammation, 2019-09-27;16(1):183.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Prolonged exposure to simulated microgravity diminishes dendritic cell immunogenicity
    Authors: N Tackett, JH Bradley, EK Moore, SH Baker, SL Minter, B DiGiacinto, JP Arnold, RK Gregg
    Sci Rep, 2019-09-25;9(1):13825.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells
    Authors: LP Araujo, JT Maricato, MG Guereschi, MC Takenaka, VM Nascimento, FM de Melo, FJ Quintana, PC Brum, AS Basso
    Cell Rep, 2019-09-17;28(12):3120-3130.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  97. Innate Lymphoid Cells in the Induction of Obesity
    Authors: T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu
    Cell Rep, 2019-07-02;28(1):202-217.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Ablation of RhoA impairs Th17 cell differentiation and alleviates house dust mite-triggered allergic airway inflammation
    Authors: JQ Yang, KW Kalim, Y Li, Y Zheng, F Guo
    J. Leukoc. Biol., 2019-07-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer
    Authors: L Racioppi, ER Nelson, W Huang, D Mukherjee, SA Lawrence, W Lento, AM Masci, Y Jiao, S Park, B York, Y Liu, AE Baek, DH Drewry, WJ Zuercher, FR Bertani, L Businaro, J Geradts, A Hall, AR Means, N Chao, CY Chang, DP McDonnell
    Nat Commun, 2019-06-04;10(1):2450.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death
    Authors: K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess
    J. Immunol., 2019-05-31;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. CD45Rb-low effector T cells require IL-4 to induce IL-10 in FoxP3 Tregs and to protect mice from inflammation
    Authors: MB Jones, CA Alvarez, JL Johnson, JY Zhou, N Morris, BA Cobb
    PLoS ONE, 2019-05-23;14(5):e0216893.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
    Authors: H Dong, NM Adams, Y Xu, J Cao, DSJ Allan, JR Carlyle, X Chen, JC Sun, LH Glimcher
    Nat. Immunol., 2019-05-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Stimulation
  103. Pharmacological inhibition of ?-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells
    Authors: M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, C Chen, S Rafi, AX Zhu, YX Feng, D Zhu
    Sci Adv, 2019-05-08;5(5):eaau5240.
    Species: Human, Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Pan-cancer genomic analysis links 3'UTR DNA methylation with increased gene expression in T cells
    Authors: MH McGuire, SM Herbrich, SK Dasari, SY Wu, Y Wang, R Rupaimoole, G Lopez-Bere, KA Baggerly, AK Sood
    EBioMedicine, 2019-05-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism
    Authors: C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella
    Cell Rep, 2019-04-30;27(5):1434-1445.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
    Authors: A Abdullah, M Maged, I Hairul-Isl, A Osama I, H Maha, A Manal, H Hamza
    PLoS ONE, 2019-04-26;14(4):e0215981.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity
    Authors: M Ott, E Avendaño-G, E Ullrich, C Dreyer, J Strauss, M Harden, M Schön, MP Schön, G Bernhardt, C Stadelmann, C Wegner, W Brück, S Nessler
    J Neuroinflammation, 2019-02-26;16(1):49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Rab4b Deficiency in T Cells Promotes Adipose Treg/Th17 Imbalance, Adipose Tissue Dysfunction, and Insulin Resistance
    Authors: J Gilleron, G Bouget, S Ivanov, C Meziat, F Ceppo, B Vergoni, M Djedaini, A Soprani, K Dumas, A Jacquel, L Yvan-Charv, N Venteclef, JF Tanti, M Cormont
    Cell Rep, 2018-12-18;25(12):3329-3341.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming
    Authors: L Simula, I Pacella, A Colamatteo, C Procaccini, V Cancila, M Bordi, C Tregnago, M Corrado, M Pigazzi, V Barnaba, C Tripodo, G Matarese, S Piconese, S Campello
    Cell Rep, 2018-12-11;25(11):3059-3073.e10.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
    Authors: AM Falcão, D van Brugge, S Marques, M Meijer, S Jäkel, E Agirre, Samudyata, EM Floriddia, DP Vanichkina, C Ffrench-Co, A Williams, AO Guerreiro-, G Castelo-Br
    Nat. Med., 2018-11-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Taste Receptor T1R1/T1R3 Promotes the Tumoricidal Activity of Hepatic CD49a+CD49b- Natural Killer Cells
    Authors: S Liu, M Xu, C Zhu, Q Zhao, F Zhou
    Eur. J. Immunol., 2018-10-10;0(0):.
    Species: Mouse
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  112. NK cell receptor NKG2D sets activation threshold for the NCR1 receptor early in NK cell development
    Authors: V Jelen?i?, M Šestan, I Kavazovi?, M Lenarti?, S Marinovi?, TD Holmes, M Prchal-Mur, B Lisni?, V Sexl, YT Bryceson, FM Wensveen, B Poli?
    Nat. Immunol., 2018-09-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene
    Authors: S Kojo, N Yasmin, S Muroi, M Tenno, I Taniuchi
    Nat Commun, 2018-09-05;9(1):3593.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  114. Non-redundant ISGF3 Components Promote NK Cell Survival in an Auto-regulatory Manner during Viral Infection
    Authors: CD Geary, C Krishna, CM Lau, NM Adams, SV Gearty, Y Pritykin, AR Thomsen, CS Leslie, JC Sun
    Cell Rep, 2018-08-21;24(8):1949-1957.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
    Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
    Mucosal Immunol, 2018-08-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function
    Authors: J Wu, J Gu, S Zhou, H Lu, Y Lu, L Lu, X Wang
    J Immunol Res, 2018-08-07;2018(0):1605341.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
    Authors: HA Ting, D de Almeida, AJ Rasky, CA Malinczak, IP Maillard, MA Schaller, NW Lukacs
    Mucosal Immunol, 2018-07-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms
    Authors: X Zhang, X Xiao, P Lan, J Li, Y Dou, W Chen, N Ishii, S Chen, B Xia, K Chen, E Taparowsky, XC Li
    Cell Rep, 2018-07-17;24(3):607-618.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice
    Authors: Y Omata, M Frech, T Primbs, S Lucas, D Andreev, C Scholtysek, K Sarter, M Kindermann, N Yeremenko, DL Baeten, N Andreas, T Kamradt, A Bozec, A Ramming, G Krönke, S Wirtz, G Schett, MM Zaiss
    Cell Rep, 2018-07-03;24(1):169-180.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  120. Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency
    Authors: HH Abdul-Raza, CJ Rocca, SJ Howe, ME Alonso-Fer, J Wang, R Gabriel, CC Bartholoma, CHV Gan, MI Garín, A Roberts, MP Blundell, V Prakash, FJ Molina-Est, J Pantoglou, G Guenechea, MC Holmes, PD Gregory, C Kinnon, C von Kalle, M Schmidt, JA Bueren, AJ Thrasher, RJ Yáñez-Muño
    Sci Rep, 2018-05-29;8(1):8214.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cells
    Authors: S Teruya, T Okamura, T Komai, M Inoue, Y Iwasaki, S Sumitomo, H Shoda, K Yamamoto, K Fujio
    Sci Rep, 2018-05-04;8(1):7021.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing
    Authors: Y Ouchi, A Patil, Y Tamura, H Nishimasu, A Negishi, SK Paul, N Takemura, T Satoh, Y Kimura, M Kurachi, O Nureki, K Nakai, H Kiyono, S Uematsu
    Int. Immunol., 2018-04-03;30(4):141-154.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. KLRG1+Effector CD8+T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity
    Authors: D Herndler-B, H Ishigame, R Shinnakasu, V Plajer, C Stecher, J Zhao, M Lietzenmay, L Kroehling, A Takumi, K Kometani, T Inoue, Y Kluger, SM Kaech, T Kurosaki, T Okada, RA Flavell
    Immunity, 2018-04-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Dual Modifications of ?-Galactosylceramide Synergize to Promote Activation of Human Invariant Natural Killer T Cells and Stimulate Anti-tumor Immunity
    Authors: D Chennamadh, NA Saavedra-A, LJ Carreño, MJ Guberman-P, P Arora, T Yongqing, HF Koay, DI Godfrey, S Keshipeddy, SK Richardson, S Sundararaj, JH Lo, X Wen, JA Gascón, W Yuan, J Rossjohn, J Le Nours, SA Porcelli, AR Howell
    Cell Chem Biol, 2018-03-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway
    Authors: R Yang, T Yu, D Liu, S Shi, Y Zhou
    Stem Cell Res Ther, 2018-03-09;9(1):62.
    Species: Mouse
    Sample Types: Whole Cells
  126. PD-L1 in tumor microenvironment mediates resistance to oncolytic immunotherapy
    Authors: D Zamarin, JM Ricca, S Sadekova, A Oseledchyk, Y Yu, WM Blumensche, J Wong, M Gigoux, T Merghoub, JD Wolchok
    J. Clin. Invest., 2018-03-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3K? inhibitors and VIP antagonists
    Authors: CT Petersen, M Hassan, AB Morris, J Jeffery, K Lee, N Jagirdar, AD Staton, SS Raikar, HT Spencer, T Sulchek, CR Flowers, EK Waller
    Blood Adv, 2018-02-13;2(3):210-223.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells
    Authors: A Seki, S Rutz
    J. Exp. Med., 2018-02-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  129. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis
    Authors: S Cosenza, K Toupet, M Maumus, P Luz-Crawfo, O Blanc-Brud, C Jorgensen, D Noël
    Theranostics, 2018-02-03;8(5):1399-1410.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. TGF-?-Induced CD8CD103Regulatory T Cells Show Potent Therapeutic Effect on Chronic Graft-versus-Host Disease Lupus by Suppressing B Cells
    Authors: H Zhong, Y Liu, Z Xu, P Liang, H Yang, X Zhang, J Zhao, J Chen, S Fu, Y Tang, J Lv, J Wang, N Olsen, A Xu, SG Zheng
    Front Immunol, 2018-01-30;9(0):35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  131. Kbtbd2 inhibits the cytotoxic activity of immortalized NK cells through down-regulating mTOR signaling in a mouse hepatocellular carcinoma model
    Authors: K Dai, Y Huang, Z Chen, X Sun, L Yang, Y Jiang
    Eur. J. Immunol., 2018-01-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection
    Authors: SK Varanasi, U Jaggi, N Hay, BT Rouse
    PLoS ONE, 2018-01-19;13(1):e0191533.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Crucial role of OX40/OX40L signaling in a murine model of asthma
    Authors: W Lei, D Zeng, G Liu, Y Zhu, J Wang, H Wu, J Jiang, J Huang
    Mol Med Rep, 2018-01-18;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  134. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
    Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
    Mucosal Immunol, 2017-12-20;11(3):615-626.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  135. NK cells are negatively regulated by sCD83 in experimental autoimmune uveitis
    Authors: W Lin, X Man, P Li, N Song, Y Yue, B Li, Y Li, Y Sun, Q Fu
    Sci Rep, 2017-10-16;7(1):12895.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression
    Authors: X Fu, F Sun, F Wang, J Zhang, B Zheng, J Zhong, T Yue, X Zheng, JF Xu, CY Wang
    Mediators Inflamm., 2017-09-19;2017(0):5706152.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Manipulating Glucose Metabolism during Different Stages of Viral Pathogenesis Can Have either Detrimental or Beneficial Effects
    Authors: SK Varanasi, D Donohoe, U Jaggi, BT Rouse
    J. Immunol., 2017-08-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Lamtor1 Is Critically Required for CD4(+) T Cell Proliferation and Regulatory T Cell Suppressive Function
    Authors: T Hosokawa, T Kimura, S Nada, T Okuno, D Ito, S Kang, S Nojima, K Yamashita, T Nakatani, Y Hayama, Y Kato, Y Kinehara, M Nishide, N Mikami, S Koyama, H Takamatsu, D Okuzaki, N Ohkura, S Sakaguchi, M Okada, A Kumanogoh
    J. Immunol., 2017-08-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis-Induced Inflammation
    Authors: G Nagalingam, CG Vinuesa, WJ Britton, BM Saunders
    J. Immunol., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  140. BJ-2266 ameliorates experimental autoimmune encephalomyelitis through down-regulation of the JAK/STAT signaling pathway
    Authors: Z You, M Timilshina, BS Jeong, JH Chang
    Eur. J. Immunol., 2017-07-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. The excretory-secretory products of Echinococcus granulosus protoscoleces directly regulate the differentiation of B10, B17 and Th17 cells
    Authors: W Pan, WT Hao, YJ Shen, XY Li, YJ Wang, FF Sun, JH Yin, J Zhang, RX Tang, JP Cao, KY Zheng
    Parasit Vectors, 2017-07-21;10(1):348.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Transcription factor RBP-J-mediated signaling regulates Basophil's immunoregulatory function in mouse asthma model
    Authors: SY Qu, YL He, J Zhang, CG Wu
    Immunology, 2017-07-19;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  143. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017-07-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis
    Authors: LT McDonald, SD Johnson, DL Russell, MRI Young, AC LaRue
    PLoS ONE, 2017-07-10;12(7):e0180724.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
    Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
    Eur. J. Immunol., 2017-06-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  146. The frequency of Th17�cells in the small intestine exhibits a day-night variation dependent on circadian clock activity
    Authors: HP Thu Le, Y Nakamura, K Oh-Oka, K Ishimaru, S Nakajima, A Nakao
    Biochem. Biophys. Res. Commun., 2017-06-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance
    Authors: H Yang, HZ Guo, XY Li, J Lin, W Zhang, JM Zhao, HX Zhang, SJ Chen, Z Chen, J Zhu
    J. Immunol., 2017-05-26;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  148. The microRNA miR-31 inhibits CD8(+) T cell function in chronic viral infection
    Authors: HF Moffett, ANR Cartwright, HJ Kim, J Godec, J Pyrdol, T Äijö, GJ Martinez, A Rao, J Lu, TR Golub, H Cantor, AH Sharpe, CD Novina, KW Wucherpfen
    Nat. Immunol., 2017-05-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths
    Authors: VS Pelly, SM Coomes, Y Kannan, M Gialitakis, LJ Entwistle, J Perez-Llor, S Czieso, IS Okoye, D Rückerl, JE Allen, F Brombacher, MS Wilson
    J. Exp. Med., 2017-05-15;214(6):1809-1826.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  150. Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells
    Authors: R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang
    J. Immunol., 2017-04-28;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Induction of Colonic Regulatory T Cells by Mesalamine by Activating the Aryl Hydrocarbon Receptor
    Authors: K Oh-Oka, Y Kojima, K Uchida, K Yoda, K Ishimaru, S Nakajima, J Hemmi, H Kano, Y Fujii-Kuri, R Katoh, H Ito, A Nakao
    Cell Mol Gastroenterol Hepatol, 2017-04-11;4(1):135-151.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  152. IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
    Authors: DC Nascimento, PH Melo, AR Piñeros, RG Ferreira, DF Colón, PB Donate, FV Castanheir, A Gozzi, PG Czaikoski, W Niedbala, MC Borges, DS Zamboni, FY Liew, FQ Cunha, JC Alves-Filh
    Nat Commun, 2017-04-04;8(0):14919.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
    Authors: L Tian, A Goldstein, H Wang, H Ching Lo, I Sun Kim, T Welte, K Sheng, LE Dobrolecki, X Zhang, N Putluri, TL Phung, SA Mani, F Stossi, A Sreekumar, MA Mancini, WK Decker, C Zong, MT Lewis, XH Zhang
    Nature, 2017-04-03;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  154. MiR-384 Regulates the Th17/Treg Ratio during Experimental Autoimmune Encephalomyelitis Pathogenesis
    Authors: X Qu, J Han, Y Zhang, Y Wang, J Zhou, H Fan, R Yao
    Front Cell Neurosci, 2017-03-28;11(0):88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy
    Authors: E Oh, JE Oh, J Hong, Y Chung, Y Lee, KD Park, S Kim, CO Yun
    J Control Release, 2017-03-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity
    Authors: C Plaza-Sirv, M Schuster, Y Neumann, U Heise, MC Pils, K Schulze-Os, I Schmitz
    Cell Rep, 2017-01-03;18(1):22-Dec.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation
    Sci Rep, 2016-12-08;6(0):38387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCR? Repertoire
    Authors: David A Hildeman
    J. Immunol., 2016-11-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse
    Authors: John A Hammer
    J. Cell Biol., 2016-10-31;215(3):383-399.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  160. BPTF Depletion Enhances T Cell Mediated Antitumor Immunity
    Cancer Res, 2016-09-20;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  161. Premalignant Oral Lesion Cells Elicit Increased Cytokine Production and Activation of T-cells
    Authors: M Rita I Young
    Anticancer Res., 2016-07-01;36(7):3261-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  162. Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells
    Authors: Nimi Marcel
    Elife, 2016-06-06;5(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Cancer stem cell-secreted macrophage migration inhibitory factor stimulates myeloid derived suppressor cell function and facilitates glioblastoma immune evasion
    Stem Cells, 2016-05-27;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  164. T cells are necessary for ILC2 activation in house dust mite-induced allergic airway inflammation in mice
    Authors: BW Li, MJ de Bruijn, I Tindemans, M Lukkes, A KleinJan, HC Hoogsteden, RW Hendriks
    Eur J Immunol, 2016-05-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  165. IL-12p40/IL-10 Producing preCD8?/Clec9A+ Dendritic Cells Are Induced in Neonates upon Listeria monocytogenes Infection
    Authors: D Torres, A Köhler, S Delbauve, I Caminschi, MH Lahoud, K Shortman, V Flamand
    PLoS Pathog, 2016-04-13;12(4):e1005561.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  166. Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide
    Authors: K Szklany, E Ruiter, F Mian, W Kunze, J Bienenstoc, P Forsythe, K Karimi
    PLoS ONE, 2016-03-29;11(3):e0152443.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
    Authors: Shweta Pasi
    J Biol Chem, 2016-03-28;291(23):12358-69.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Distinct Roles of Cytoskeletal Components in Immunological Synapse Formation and Directed Secretion.
    Authors: Ueda H, Zhou J, Xie J, Davis M
    J Immunol, 2015-09-21;195(9):4117-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  169. Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
    Authors: Lubeck B, Lapinski P, Oliver J, Ksionda O, Parada L, Zhu Y, Maillard I, Chiang M, Roose J, King P
    J Immunol, 2015-05-22;195(1):31-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Dynamics of Circulating gammadelta T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma.
    Authors: Beck B, Kim H, O'Brien R, Jadus M, Gillespie G, Cloud G, Hoa N, Langford C, Lopez R, Harkins L, Lamb L
    PLoS ONE, 2015-05-08;10(5):e0122387.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  171. A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity.
    Authors: Shibuya M, Fujio K, Shoda H, Okamura T, Okamoto A, Sumitomo S, Yamamoto K
    Eur J Immunol, 2015-04-28;45(6):1643-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  172. TCR sequences and tissue distribution discriminate the subsets of naive and activated/memory Treg cells in mice.
    Authors: Bergot A, Chaara W, Ruggiero E, Mariotti-Ferrandiz E, Dulauroy S, Schmidt M, von Kalle C, Six A, Klatzmann D
    Eur J Immunol, 2015-04-07;45(5):1524-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  173. mTORC2 Deficiency in Myeloid Dendritic Cells Enhances Their Allogeneic Th1 and Th17 Stimulatory Ability after TLR4 Ligation In Vitro and In Vivo.
    Authors: Raich-Regue D, Rosborough B, Watson A, McGeachy M, Turnquist H, Thomson A
    J Immunol, 2015-04-03;194(10):4767-76.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Impaired dendritic cell function in a spontaneous autoimmune polyneuropathy.
    Authors: Quan S, Kim H, Dukala D, Sheng J, Soliven B
    J Immunol, 2015-03-30;194(9):4175-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  175. TGF-beta3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
    Authors: Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
    Nat Commun, 2015-02-19;6(0):6329.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  176. CXCL13 antibody for the treatment of autoimmune disorders.
    Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
    BMC Immunol, 2015-02-12;16(0):6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Anti-CD40-induced inflammatory E-cadherin+ dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma.
    Authors: Zhang Y, Hu X, Hu Y, Teng K, Zhang K, Zheng Y, Hong X, Yu K, Wang Y, Liu L
    J Exp Clin Cancer Res, 2015-02-05;34(0):11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  178. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction.
    Authors: Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan D, Wu C, Rangachari M, Pertel T, Jin H, Ahmed R, Anderson A, Kuchroo V
    Nat Commun, 2015-01-23;6(0):6072.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  179. Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse.
    Authors: Karsten C, Laumonnier Y, Eurich B, Ender F, Broker K, Roy S, Czabanska A, Vollbrandt T, Figge J, Kohl J
    J Immunol, 2015-01-14;194(4):1841-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  180. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.
    Authors: Solt L, Banerjee S, Campbell S, Kamenecka T, Burris T
    Endocrinology, 2015-01-05;156(3):869-81.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells.
    Authors: Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V
    Nature, 2014-12-03;518(7539):417-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.
    Authors: Benkhoucha M, Molnarfi N, Dunand-Sauthier I, Merkler D, Schneiter G, Bruscoli S, Riccardi C, Tabata Y, Funakoshi H, Nakamura T, Reith W, Santiago-Raber M, Lalive P
    J Immunol, 2014-08-11;193(6):2743-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis.
    Authors: Hagemann U, Gunnarsson L, Geraudie S, Scheffler U, Griep R, Reiersen H, Duncan A, Kiprijanov S
    PLoS ONE, 2014-07-31;9(7):e103776.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  184. Role of Blimp-1 in programing Th effector cells into IL-10 producers.
    Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
    J Exp Med, 2014-07-29;211(9):1807-19.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10.
    Authors: Engler D, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover T, Taube C, Muller A
    Proc Natl Acad Sci U S A, 2014-07-29;111(32):11810-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Adipocyte IL-15 regulates local and systemic NK cell development.
    Authors: Liou Y, Wang S, Chang C, Huang P, Hou M, Lai Y, Lee G, Jiang S, Tsai C, Liao N
    J Immunol, 2014-07-09;193(4):1747-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Embryonic stem cell-derived haematopoietic progenitor cells down-regulate the CD3 xi chain on T cells, abrogating alloreactive T cells.
    Authors: Kim E, Miyake B, Aggarwal M, Voetlause R, Griffith M, Zavazava N
    Immunology, 2014-07-01;142(3):421-30.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation.
    Authors: Liu C, Wang H, Yu S, Jin R, Tang H, Liu Y, Ge Q, Sun X, Zhang Y
    J Immunol, 2014-06-11;193(2):663-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  189. Basophils as a primary inducer of the T helper type 2 immunity in ovalbumin-induced allergic airway inflammation.
    Authors: Zhong W, Su W, Zhang Y, Liu Q, Wu J, Di C, Zhang Z, Xia Z
    Immunology, 2014-06-01;142(2):202-15.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  190. miR-20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting RORgammat and STAT3.
    Authors: Zhu E, Wang X, Zheng B, Wang Q, Hao J, Chen S, Zhao Q, Zhao L, Wu Z, Yin Z
    J Immunol, 2014-05-19;192(12):5599-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Timed action of IL-27 protects from immunopathology while preserving defense in influenza.
    Authors: Liu F, Kenngott E, Schroter M, Kuhl A, Jennrich S, Watzlawick R, Hoffmann U, Wolff T, Norley S, Scheffold A, Stumhofer J, Saris C, Schwab J, Hunter C, Debes G, Hamann A
    PLoS Pathog, 2014-05-08;10(5):e1004110.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  192. Dynamic Treg interactions with intratumoral APCs promote local CTL dysfunction.
    Authors: Bauer, Christia, Kim, Edward Y, Marangoni, Francesc, Carrizosa, Esteban, Claudio, Natalie, Mempel, Thorsten
    J Clin Invest, 2014-05-08;124(6):2425-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  193. The transcription factor Zbtb32 controls the proliferative burst of virus-specific natural killer cells responding to infection.
    Authors: Beaulieu A, Zawislak C, Nakayama T, Sun J
    Nat Immunol, 2014-04-20;15(6):546-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Galectin-9 induced myeloid suppressor cells expand regulatory T cells in an IL-10-dependent manner in CVB3-induced acute myocarditis.
    Authors: Zhang Y, Jiang L, Zhang M, Lv K
    Int J Mol Sci, 2014-02-25;15(3):3356-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells.
    Authors: VanGundy, Zachary, Guerau-de-Arellano, Mireia, Baker, Julie D, Strange, Heather, Olivo-Marston, Susan, Muth, Dillon C, Papenfuss, Tracey L
    BMC Immunol, 2014-02-18;15(0):8.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  196. Critical role of microRNA-155 in herpes simplex encephalitis.
    Authors: Bhela S, Mulik S, Reddy P, Richardson R, Gimenez F, Rajasagi N, Veiga-Parga T, Osmand A, Rouse B
    J Immunol, 2014-02-10;192(6):2734-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Upregulation of GRAIL is associated with impaired CD4 T cell proliferation in sepsis.
    Authors: Aziz M, Yang W, Matsuo S, Sharma A, Zhou M, Wang P
    J Immunol, 2014-01-29;192(5):2305-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Mesenchymal stem cells use IDO to regulate immunity in tumor microenvironment.
    Authors: Ling W, Zhang J, Yuan Z, Ren G, Zhang L, Chen X, Rabson A, Roberts A, Wang Y, Shi Y
    Cancer Res, 2014-01-22;74(5):1576-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL.
    Authors: Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T
    J Immunol, 2014-01-10;192(4):1512-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
    Authors: Yang C, Li J, Chiu L, Lan J, Chen D, Chuang H, Huang C, Tan T
    J Immunol, 2014-01-08;192(4):1547-57.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression.
    Authors: Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, Zhao Y, Shi S
    EMBO Mol Med, 2014-01-08;6(3):322-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. iNKT cell production of GM-CSF controls Mycobacterium tuberculosis.
    Authors: Rothchild A, Jayaraman P, Nunes-Alves C, Behar S
    PLoS Pathog, 2014-01-02;10(1):e1003805.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
    Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
    Nat Med, 2013-12-22;20(1):62-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  204. Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses.
    Authors: Ashino S, Takeda K, Li H, Taylor V, Joetham A, Pine P, Gelfand E
    J Allergy Clin Immunol, 2013-12-22;133(4):1162-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Moesin controls clathrin-mediated S1PR1 internalization in T cells.
    Authors: Nomachi, Akira, Yoshinaga, Masanori, Liu, Jaron, Kanchanawong, Pakorn, Tohyama, Kiyoshi, Thumkeo, Dean, Watanabe, Takeshi, Narumiya, Shuh, Hirata, Takako
    PLoS ONE, 2013-12-16;8(12):e82590.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  206. Mammalian diaphanous-related formin 1 regulates GSK3beta-dependent microtubule dynamics required for T cell migratory polarization.
    Authors: Dong B, Zhang S, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts A, Zhang J, Siminovitch K
    PLoS ONE, 2013-11-18;8(11):e80500.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  207. TLR1/2 ligand-stimulated mouse liver endothelial cells secrete IL-12 and trigger CD8+ T cell immunity in vitro.
    Authors: Liu, Jia, Jiang, Min, Ma, Zhiyong, Dietze, Kirsten, Zelinskyy, Gennadiy, Yang, Donglian, Dittmer, Ulf, Schlaak, Joerg F, Roggendorf, Michael, Lu, Mengji
    J Immunol, 2013-11-13;191(12):6178-90.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Stimulation
  208. Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo.
    Authors: Rojo J, Ojeda G, Acosta Y, Montes-Casado M, Criado G, Portoles P
    J Leukoc Biol, 2013-11-08;95(3):441-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  209. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.
    Authors: Jiang E, Perrard X, Yang D, Khan I, Perrard J, Smith C, Ballantyne C, Wu H
    Arterioscler Thromb Vasc Biol, 2013-10-24;34(1):34-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  210. Regulation and migratory role of P-selectin ligands during intestinal inflammation.
    Authors: Hoffmann U, Pink M, Lauer U, Heimesaat M, Winsauer C, Kruglov A, Schlawe K, Leichsenring C, Liesenfeld O, Hamann A, Syrbe U
    PLoS ONE, 2013-04-22;8(4):e62055.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  211. MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
    Authors: Dudda J, Salaun B, Ji Y, Palmer D, Monnot G, Merck E, Boudousquie C, Utzschneider D, Escobar T, Perret R, Muljo S, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo N, Held W, Gattinoni L, Romero P
    Immunity, 2013-04-18;38(4):742-53.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  212. Prostate cancer stem cells are targets of both innate and adaptive immunity and elicit tumor-specific immune responses.
    Authors: Jachetti, Elena, Mazzoleni, Stefania, Grioni, Matteo, Ricupito, Alessia, Brambillasca, Chiara, Generoso, Luca, Calcinotto, Arianna, Freschi, Massimo, Mondino, Anna, Galli, Rossella, Bellone, Matteo
    Oncoimmunology, 2013-04-16;2(5):e24520.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  213. The survival of memory CD8 T cells that is mediated by IL-15 correlates with sustained protection against malaria.
    Authors: Zarling S, Berenzon D, Dalai S, Liepinsh D, Steers N, Krzych U
    J Immunol, 2013-04-15;190(10):5128-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  214. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity.
    Authors: Kidani, Yoko, Elsaesser, Heidi, Hock, M Benjam, Vergnes, Laurent, Williams, Kevin J, Argus, Joseph P, Marbois, Beth N, Komisopoulou, Evangeli, Wilson, Elizabet, Osborne, Timothy, Graeber, Thomas G, Reue, Karen, Brooks, David G, Bensinger, Steven J
    Nat Immunol, 2013-04-07;14(5):489-99.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  215. Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells.
    Authors: Carey, Kirstyn, Tan, Kheng H, Ng, Judy, Liddicoat, Douglas, Godfrey, Dale I, Cole, Timothy
    Endocrinology, 2013-02-20;154(4):1540-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  216. Galectin-9 functionally impairs natural killer cells in humans and mice.
    Authors: Golden-Mason L, McMahan R, Strong M, Reisdorph R, Mahaffey S, Palmer B, Cheng L, Kulesza C, Hirashima M, Niki T, Rosen H
    J Virol, 2013-02-13;87(9):4835-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  217. Apoptotic programs are determined during lineage commitment of CD4+ T effectors: selective regulation of T effector-memory apoptosis by inducible nitric oxide synthase.
    Authors: Purushothaman D, Marcel N, Garg M, Venkataraman R, Sarin A
    J Immunol, 2012-12-05;190(1):97-105.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  218. Glucopyranosyl Lipid Adjuvant (GLA), a Synthetic TLR4 agonist, promotes potent systemic and mucosal responses to intranasal immunization with HIVgp140.
    Authors: Arias, Mauricio, Van Roey, Griet A, Tregoning, John S, Moutaftsi, Magdalin, Coler, Rhea N, Windish, Hillarie, Reed, Steven G, Carter, Darrick, Shattock, Robin J
    PLoS ONE, 2012-07-19;7(7):e41144.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  219. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  220. Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair.
    Authors: Yoshida S, Mohamed RH, Kajikawa M, Koizumi J, Tanaka M, Fugo K, Otsuka N, Maenaka K, Yagita H, Chiba H, Kasahara M
    J. Immunol., 2012-03-07;188(8):3972-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  221. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer.
    Authors: Zhao E, Wang L, Dai J, Kryczek I, Wei S, Vatan L, Altuwaijri S, Sparwasser T, Wang G, Keller E, Zou W
    Oncoimmunology, 2012-03-01;1(2):152-161.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  222. CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
    Authors: Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
    J. Immunol., 2012-01-16;188(4):2001-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  223. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011-12-23;188(3):1503-13.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  224. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
    Authors: Monticelli LA, Sonnenberg GF, Abt MC
    Nat. Immunol., 2011-11-01;12(11):1045-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  225. Influence of galectin-9/Tim-3 interaction on herpes simplex virus-1 latency.
    Authors: Reddy PB, Sehrawat S, Suryawanshi A
    J. Immunol., 2011-10-21;187(11):5745-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  226. Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease.
    Authors: Cao W, Yang Y, Wang Z, Liu A, Fang L, Wu F, Hong J, Shi Y, Leung S, Dong C, Zhang JZ
    Immunity, 2011-08-11;35(2):273-84.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  227. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
    Authors: El-Behi M, Ciric B, Dai H
    Nat. Immunol., 2011-04-24;12(6):568-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  228. NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
    Authors: Kashiwada M, Cassel SL, Colgan JD
    EMBO J., 2011-04-15;30(10):2071-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  229. Differential outcome of IL-2/anti-IL-2 complex therapy on effector and memory CD8+ T cells following vaccination with an adenoviral vector encoding EBV epitopes.
    Authors: Smith C, Martinez M, Peet J, Khanna R
    J. Immunol., 2011-04-11;186(10):5784-90.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  230. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010-09-29;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  231. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages.
    Authors: Filardy AA, Pires DR, Nunes MP, Takiya CM, Freire-de-Lima CG, Ribeiro-Gomes FL, DosReis GA
    J. Immunol., 2010-07-21;185(4):2044-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  232. Antigen-specific CD25- Foxp3- IFN-gamma(high) CD4+ T cells restrain the development of experimental allergic encephalomyelitis by suppressing Th17.
    Authors: Wildbaum G, Zohar Y, Karin N
    Am. J. Pathol., 2010-04-09;176(6):2764-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  233. Dissociated expression of natural killer 1.1 and T-cell receptor by invariant natural killer T cells after interleukin-12 receptor and T-cell receptor signalling.
    Authors: Emoto M, Shimizu T, Koike H, Yoshizawa I, Hurwitz R, Kaufmann SH, Emoto Y
    Immunology, 2010-01-01;129(1):62-74.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  234. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus.
    Authors: Humrich JY, Morbach H, Undeutsch R, Enghard P, Rosenberger S, Weigert O, Kloke L, Heimann J, Gaber T, Brandenburg S, Scheffold A, Huehn J, Radbruch A, Burmester GR, Riemekasten G
    Proc. Natl. Acad. Sci. U.S.A., 2009-12-14;107(1):204-9.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  235. CD94 defines phenotypically and functionally distinct mouse NK cell subsets.
    Authors: Yu J, Wei M, Mao H, Zhang J, Hughes T, Mitsui T, Park IK, Hwang C, Liu S, Marcucci G, Trotta R, Benson DM, Caligiuri MA
    J. Immunol., 2009-10-15;183(8):4968-74.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  236. Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis.
    Authors: Purushothaman D, Sarin A
    J. Exp. Med., 2009-06-22;206(7):1515-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  237. The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.
    Authors: Dienz O, Eaton SM, Bond JP, Neveu W, Moquin D, Noubade R, Briso EM, Charland C, Leonard WJ, Ciliberto G, Teuscher C, Haynes L, Rincon M
    J. Exp. Med., 2009-01-12;206(1):69-78.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  238. Identification of cardiac troponin I sequence motifs leading to heart failure by induction of myocardial inflammation and fibrosis.
    Authors: Kaya Z, Goser S, Buss SJ, Leuschner F, Ottl R, Li J, Volkers M, Zittrich S, Pfitzer G, Rose NR, Katus HA
    Circulation, 2008-10-27;118(20):2063-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  239. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice.
    Authors: McKinley L, Alcorn JF, Peterson A, Dupont RB, Kapadia S, Logar A, Henry A, Irvin CG, Piganelli JD, Ray A, Kolls JK
    J. Immunol., 2008-09-15;181(6):4089-97.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  240. Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells.
    Authors: Jacobsen EA, Ochkur SI, Pero RS, Taranova AG, Protheroe CA, Colbert DC, Lee NA, Lee JJ
    J. Exp. Med., 2008-03-03;205(3):699-710.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  241. Two novel NKG2D ligands of the mouse H60 family with differential expression patterns and binding affinities to NKG2D.
    Authors: Takada A, Yoshida S, Kajikawa M, Miyatake Y, Tomaru U, Sakai M, Chiba H, Maenaka K, Kohda D, Fugo K, Kasahara M
    J. Immunol., 2008-02-01;180(3):1678-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  242. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.
    Authors: Seshasayee D, Lee WP, Zhou M, Shu J, Suto E, Zhang J, Diehl L, Austin CD, Meng YG, Tan M, Bullens SL, Seeber S, Fuentes ME, Labrijn AF, Graus YM, Miller LA, Schelegle ES, Hyde DM, Wu LC, Hymowitz SG, Martin F
    J. Clin. Invest., 2007-12-01;117(12):3868-3878.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  243. Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo.
    Authors: Ruzek MC, Waire JS, Hopkins D, Lacorcia G, Sullivan J, Roberts BL, Richards SM, Nahill SR, Williams JM, Scaria A, Dzuris J, Shankara S, Garman RD
    Blood, 2007-11-19;111(3):1726-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  244. Protection of CD8+ T cells from activation-induced cell death by IL-18.
    Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
    J. Leukoc. Biol., 2007-03-30;82(1):142-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  245. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
    Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
    J. Allergy Clin. Immunol., 2007-03-01;119(3):662-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  246. IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells.
    Authors: Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA
    J. Immunol., 2007-02-15;178(4):2018-27.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  247. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity.
    Authors: Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner VE, Gonzalez-Munoz A, Clark J, Veijola R, Cubbon R, Chen SL, Rosa R, Cumiskey AM, Serreze DV, Gregory S, Rogers J, Lyons PA, Healy B, Smink LJ, Todd JA, Peterson LB, Wicker LS, Santamaria P
    Nat. Genet., 2007-02-04;39(3):329-37.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  248. Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages.
    Authors: Ogawa K, Funaba M, Chen Y, Tsujimoto M
    J. Immunol., 2006-11-15;177(10):6787-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  249. Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator.
    Authors: Chiang YM, Chang CL, Chang SL, Yang WC, Shyur LF
    J Ethnopharmacol, 2006-10-19;110(3):532-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  250. Evidence for a role for notch signaling in the cytokine-dependent survival of activated T cells.
    Authors: Bheeshmachar G, Purushotaman D, Sade H, Gunasekharan V, Rangarajan A, Sarin A
    J. Immunol., 2006-10-15;177(8):5041-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  251. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation.
    Authors: de la Fuente MA, Kumar L, Lu B, Geha RS
    Mol. Cell. Biol., 2006-07-01;26(14):5214-25.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  252. CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system.
    Authors: Christensen JE, de Lemos C, Moos T, Christensen JP, Thomsen AR
    J. Immunol., 2006-04-01;176(7):4235-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  253. A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys.
    Authors: Vugmeyster Y, Seshasayee D, Chang W, Storn A, Howell K, Sa S, Nelson T, Martin F, Grewal I, Gilkerson E, Wu B, Thompson J, Ehrenfels BN, Ren S, Song A, Gelzleichter TR, Danilenko DM
    Am. J. Pathol., 2006-02-01;168(2):476-89.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  254. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.
    Authors: Harrington, Laurie E, Hatton, Robin D, Mangan, Paul R, Turner, Henriett, Murphy, Theresa, Murphy, Kenneth, Weaver, Casey T
    Nat Immunol, 2005-10-02;6(11):1123-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  255. Ig-reactive CD4+CD25+ T cells from tolerized (New Zealand Black x New Zealand White)F1 mice suppress in vitro production of antibodies to DNA.
    Authors: La Cava A, Ebling FM, Hahn BH
    J. Immunol., 2004-09-01;173(5):3542-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  256. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration.
    Authors: Kipnis J, Cardon M, Avidan H, Lewitus GM, Mordechay S, Rolls A, Shani Y, Schwartz M
    J. Neurosci., 2004-07-07;24(27):6133-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  257. Atherogenic effect of interleukin-2 and antiatherogenic effect of interleukin-2 antibody in apo-E-deficient mice.
    Authors: Upadhya S, Mooteri S, Peckham N, Pai RG
    Angiology, 2004-05-01;55(3):289-94.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  258. IL-21 induces the functional maturation of murine NK cells.
    Authors: Brady J, Hayakawa Y, Smyth MJ, Nutt SL
    J. Immunol., 2004-02-15;172(4):2048-58.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  259. Control of Leishmania major in the absence of Tyk2 kinase.
    Authors: Schleicher U, Mattner J, Blos M, Schindler H, Rollinghoff M, Karaghiosoff M, Muller M, Werner-Felmayer G, Bogdan C
    Eur. J. Immunol., 2004-02-01;34(2):519-29.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  260. Identification of a murine CD28 dileucine motif that suppresses single-chain chimeric T-cell receptor expression and function.
    Authors: Nguyen P, Moisini I, Geiger TL
    Blood, 2003-08-28;102(13):4320-5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  261. Ultraviolet radiation inhibits interleukin-2-induced tyrosine phosphorylation and the activation of STAT5 in T lymphocytes.
    Authors: Kulms D, Schwarz T
    J. Biol. Chem., 2001-01-23;276(16):12849-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. The source information for Recombinant Mouse IL-2 Protein (Catalog# 402-ML) states "Ala21-Gln169, with and without an N-terminal Met". What does "with and without an N-terminal Met" mean?

    • When the signal peptide gets cleaved off during post-translational modification, sometimes the N-terminal methionine also gets cleaved off. This does not affect protein function.

View all Proteins and Enzyme FAQs

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Recombinant Mouse IL-2 Protein
By Anonymous on 06/17/2021
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-2 Protein
By Anonymous on 02/20/2021
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-2 Protein
By Anonymous on 05/23/2020
Application: CellProlif
Cell Proliferation Recombinant Mouse IL-2 Protein 402-ML
Recombinant Mouse IL-2 Protein
By Anonymous on 09/16/2019
Application: In vitro bioactivity in cell culture
In vitro bioactivity in cell culture Recombinant Mouse IL-2 Protein 402-ML
Recombinant Mouse IL-2 Protein
By Anonymous on 05/03/2018
Application: Cell migration/motility
Recombinant Mouse IL-2 Protein
By Anonymous on 04/26/2018
Application: CellProlif
Recombinant Mouse IL-2 Protein
By Anonymous on 04/22/2018
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-2 Protein
By Tima Thomas on 01/21/2016
Application: In vitro bioactivity in cell culture
Recombinant Mouse IL-2 Protein
By SOjan Abraham on 01/21/2016
Application: In vitro bioactivity in cell culture