Recombinant Mouse IL-1 beta/IL-1F2 Protein

Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xC
Authors: Aboushousha, R;van der Velden, J;Hamilton, N;Peng, Z;MacPherson, M;Erickson, C;White, S;Wouters, EFM;Reynaert, NL;Seward, DJ;Li, J;Janssen-Heininger, YMW;
Science advances
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition
Authors: Shearn, CT;Anderson, AL;Devereaux, MW;El Kasmi, KC;Orlicky, DJ;Sokol, RJ;
PloS one
Species: Mouse
Sample Types: In Vivo
Applications: In vivo assay

Pyruvate dehydrogenase operates as an intramolecular nitroxyl generator during macrophage metabolic reprogramming
Authors: Palmieri, EM;Holewinski, R;McGinity, CL;Pierri, CL;Maio, N;Weiss, JM;Tragni, V;Miranda, KM;Rouault, TA;Andresson, T;Wink, DA;McVicar, DW;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

An in vitro and in vivo study: Valencene protects cartilage and alleviates the progression of osteoarthritis by anti-oxidative stress and anti-inflammatory effects
Authors: Chen, S;Meng, C;He, Y;Xu, H;Qu, Y;Wang, Y;Fan, Y;Huang, X;You, H;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The TRIM37 variants in Mulibrey nanism patients paralyze follicular helper T cell differentiation
Authors: Gu, W;Zhang, J;Li, Q;Zhang, Y;Lin, X;Wu, B;Yin, Q;Sun, J;Lu, Y;Sun, X;Jia, C;Li, C;Zhang, Y;Wang, M;Yin, X;Wang, S;Xu, J;Wang, R;Zhu, S;Cheng, S;Chen, S;Liu, L;Zhu, L;Yan, C;Yi, C;Li, X;Lian, Q;Lin, G;Ling, Z;Ma, L;Zhou, M;Xiao, K;Wei, H;Hu, R;Zhou, W;Ye, L;Wang, H;Li, J;Sun, B;
Cell discovery
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protection of pancreatic islets from oxidative cell death by a peripherally-active morphinan with increased drug safety
Authors: Scholz, O;Hu beta, E;Otter, S;Herebian, D;Hamacher, A;Levy, LM;Hristeva, S;Sanz, M;Ajani, H;Puentes, AR;Hoffmann, T;Hogeback, J;Unger, A;Terheyden, S;Reina do Fundo, M;Dewidar, B;Roden, M;Lammert, E;
Molecular metabolism
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome
Authors: Zhai, R;Lenga Ma Bonda, W;Leclaire, C;Saint-Béat, C;Theilliere, C;Belville, C;Coupet, R;Blondonnet, R;Bouvier, D;Blanchon, L;Sapin, V;Jabaudon, M;
Journal of translational medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
Authors: Sun, L;Zhang, X;Wu, S;Liu, Y;Guerrero-Juarez, CF;Liu, W;Huang, J;Yao, Q;Yin, M;Li, J;Ramos, R;Liao, Y;Wu, R;Xia, T;Zhang, X;Yang, Y;Li, F;Heng, S;Zhang, W;Yang, M;Tzeng, CM;Ji, C;Plikus, MV;Gallo, RL;Zhang, LJ;
Cell reports

Inflammatory mediators act at renal pericytes to elicit contraction of vasa recta and reduce pericyte density along the kidney medullary vascular network
Authors: Lilley, RJ;Taylor, KD;Wildman, SSP;Peppiatt-Wildman, CM;
Frontiers in physiology
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Stevioside protects primary articular chondrocytes against IL-1?-induced inflammation and catabolism by targeting integrin
Authors: Wan, J;Zhu, Z;He, Z;Wu, H;Chen, A;Zhu, W;Cheng, P;
International immunopharmacology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A comprehensive analysis of single-cell RNA transcriptome reveals unique SPP1+ chondrocytes in human osteoarthritis
Authors: Qu, Y;Wang, Y;Wang, S;Yu, X;He, Y;Lu, R;Chen, S;Meng, C;Xu, H;Pei, W;Ni, B;Zhang, R;Huang, X;You, H;
Computers in biology and medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-Induced Myeloid-Derived Suppressor Cells Demonstrate Their Immunoregulatory Functions to Prolong the Survival of Diabetic Mice
Authors: Li, TT;Lin, CL;Chiang, M;He, JT;Hung, CH;Hsieh, CC;
Cells
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
Authors: Lu, Y;Zhang, H;Pan, H;Zhang, Z;Zeng, H;Xie, H;Yin, J;Tang, W;Lin, R;Zeng, C;Cai, D;
Journal of translational medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Distinct Th17 effector cytokines differentially promote microglial and blood-brain barrier inflammatory responses during post-infectious encephalitis
Authors: Wayne, CR;Bremner, L;Faust, TE;Dur�n-Laforet, V;Ampatey, N;Ho, SJ;Feinberg, PA;Arvanitis, P;Ciric, B;Ruan, C;Elyaman, W;Delaney, SL;Vargas, WS;Swedo, S;Menon, V;Schafer, DP;Cutforth, T;Agalliu, D;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification of biomarkers for glycaemic deterioration in type 2 diabetes
Authors: Slieker, RC;Donnelly, LA;Akalestou, E;Lopez-Noriega, L;Melhem, R;G�ne?, A;Abou Azar, F;Efanov, A;Georgiadou, E;Muniangi-Muhitu, H;Sheikh, M;Giordano, GN;�kerlund, M;Ahlqvist, E;Ali, A;Banasik, K;Brunak, S;Barovic, M;Bouland, GA;Burdet, F;Canouil, M;Dragan, I;Elders, PJM;Fernandez, C;Festa, A;Fitipaldi, H;Froguel, P;Gudmundsdottir, V;Gudnason, V;Gerl, MJ;van der Heijden, AA;Jennings, LL;Hansen, MK;Kim, M;Leclerc, I;Klose, C;Kuznetsov, D;Mansour Aly, D;Mehl, F;Marek, D;Melander, O;Niknejad, A;Ottosson, F;Pavo, I;Duffin, K;Syed, SK;Shaw, JL;Cabrera, O;Pullen, TJ;Simons, K;Solimena, M;Suvitaival, T;Wretlind, A;Rossing, P;Lyssenko, V;Legido Quigley, C;Groop, L;Thorens, B;Franks, PW;Lim, GE;Estall, J;Ibberson, M;Beulens, JWJ;'t Hart, LM;Pearson, ER;Rutter, GA;
Nature communications
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis
Authors: Cho, MJ;Lee, HG;Yoon, JW;Kim, GR;Koo, JH;Taneja, R;Edelson, BT;Lee, YJ;Choi, JM;
Experimental & molecular medicine
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cbfbeta Is a Novel Modulator against Osteoarthritis by Maintaining Articular Cartilage Homeostasis through TGF-beta Signaling
Authors: X Che, X Jin, NR Park, HJ Kim, HS Kyung, HJ Kim, JB Lian, JL Stein, GS Stein, JY Choi
Cells, 2023-03-31;12(7):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inhibition of Histone Lysine Demethylase 6A Promotes Chondrocytic Activity and Attenuates Osteoarthritis Development through Repressing H3K27me3 Enhancement of Wnt10a
Authors: WS Lian, RW Wu, JY Ko, YS Chen, SY Wang, H Jahr, FS Wang
The international journal of biochemistry & cell biology, 2023-03-05;0(0):106394.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge
Authors: CM Schafer, S Martin-Alm, K Kurylowicz, N Dufton, L Osuna-Alma, ML Wu, CF Johnson, AV Shah, DO Haskard, A Buxton, E Willis, K Wheeler, S Turner, M Chlebicz, RP Scott, S Kovats, A Cleuren, GM Birdsey, AM Randi, CT Griffin
bioRxiv : the preprint server for biology, 2023-02-11;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Modulation of Skin Inflammatory Responses by Aluminum Adjuvant
Authors: Y Liao, L Sun, M Nie, J Li, X Huang, S Heng, W Zhang, T Xia, Z Guo, Q Zhao, LJ Zhang
Pharmaceutics, 2023-02-08;15(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Crosstalk between ILC2s and Th2 cells varies among mouse models
Authors: RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu
Cell Reports, 2023-02-02;42(2):112073.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RBM43 links adipose inflammation and energy expenditure through translational regulation of PGC1alpha
Authors: PA Dumesic, SE Wilensky, S Bose, JG Van Vranke, SP Gygi, BM Spiegelman
bioRxiv : the preprint server for biology, 2023-01-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification of astrocyte regulators by nucleic acid cytometry
Authors: IC Clark, MA Wheeler, HG Lee, Z Li, LM Sanmarco, S Thaploo, CM Polonio, SW Shin, G Scalisi, AR Henry, JM Rone, F Giovannoni, M Charabati, CF Akl, DM Aleman, SEJ Zandee, A Prat, DC Douek, EA Boritz, FJ Quintana, AR Abate
Nature, 2023-01-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1alpha signaling and glutamine metabolism
Authors: G Wang, E Sweren, W Andrews, Y Li, J Chen, Y Xue, E Wier, MP Alphonse, L Luo, Y Miao, R Chen, D Zeng, S Lee, A Li, E Dare, D Kim, NK Archer, SK Reddy, L Resar, Z Hu, EA Grice, MA Kane, LA Garza
Science Advances, 2023-01-04;9(1):eabo7555.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance
Authors: S Zia, BP Hammond, M Zirngibl, A Sizov, CS Baaklini, SP Panda, MFS Ho, KV Lee, A Mainali, MK Burr, S Williams, AV Caprariell, C Power, T Simmen, BJ Kerr, JR Plemel
Molecular Neurodegeneration, 2022-12-13;17(1):82.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NR4A1 agonist cytosporone B attenuates neuroinflammation in a mouse model of multiple sclerosis
Authors: HZ Yu, BQ Zhu, L Zhu, S Li, LM Wang
Oncogene, 2022-12-01;17(12):2765-2770.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Zinc Transporter 8 Haploinsufficiency Protects Against Beta Cell Dysfunction in Type 1 Diabetes by Increasing Mitochondrial Respiration
Authors: YK Kim, JA Walters, ND Moss, KL Wells, R Sheridan, JG Miranda, RKP Benninger, LL Pyle, RM O'Brien, L Sussel, HW Davidson
Molecular Metabolism, 2022-11-05;66(0):101632.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Authors: AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp
Journal of Neuroinflammation, 2022-10-29;19(1):265.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Desmoglein-2 is important for islet function and beta-cell survival
Authors: KK Myo Min, D Rojas-Cana, D Penko, M DeNichilo, MP Cockshell, CB Ffrench, EJ Thompson, O Asplund, CJ Drogemulle, RB Prasad, L Groop, ST Grey, HE Thomas, T Loudovaris, TW Kay, MG Mahoney, CF Jessup, PT Coates, CS Bonder
Cell Death & Disease, 2022-10-29;13(10):911.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Authors: A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe
Nature, 2022-10-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-3 regulates the differentiation of pathogenic Th17 cells
Authors: L Rani, A Kumar, J Karhade, G Pandey, A Guha, GC Mishra, MR Wani
European Journal of Immunology, 2022-09-26;0(0):.
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

A cannabidiol aminoquinone derivative activates the PP2A/B55alpha/HIF pathway and shows protective effects in a murine model of traumatic brain injury
Authors: C Navarrete, A García-Mar, A Correa-Sáe, ME Prados, F Fernández, R Pineda, M Mazzone, M Álvarez-Be, MA Calzado, E Muñoz
Journal of Neuroinflammation, 2022-07-09;19(1):177.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
Authors: J Yin, H Zeng, K Fan, H Xie, Y Shao, Y Lu, J Zhu, Z Yao, L Liu, H Zhang, B Luo, X Wang, C Zeng, X Bai, H Zhang, D Cai
Cell Death & Disease, 2022-06-24;13(6):567.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement
Authors: H Kamei, T Ishii, Y Nishii
Oncogene, 2022-06-02;12(1):9243.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Brain Protective Effect of Resveratrol via Ameliorating Interleukin-1beta-Induced MMP-9-Mediated Disruption of ZO-1 Arranged Integrity
Authors: MM Tsai, JL Chen, TH Lee, H Liu, V Shanmugam, HL Hsieh
Biomedicines, 2022-05-29;10(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
Authors: LEA Damasceno, GCM Cebinelli, MF Fernandes, DC Nascimento, GA Públio, MAR Vinolo, SC Oliveira, T Sparwasser, TM Cunha, FQ Cunha, JC Alves-Filh
Cell Reports, 2022-05-24;39(8):110838.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function
Authors: HW Cheng, U Mörbe, M Lütge, C Engetschwi, L Onder, M Novkovic, C Gil-Cruz, C Perez-Shib, T Hehlgans, E Scandella, B Ludewig
Nature Communications, 2022-04-19;13(1):2027.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65
Authors: H Jiang, X Lin, W Liang, Y Li, X Yu
Nutrients, 2022-04-18;14(8):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CD4+ T-cell-derived IL-10 promotes CNS inflammation in mice by sustaining effector T�cell survival
Authors: N Yogev, T Bedke, Y Kobayashi, L Brockmann, D Lukas, T Regen, AL Croxford, A Nikolav, N Hövelmeyer, E von Stebut, M Prinz, C Ubeda, KJ Maloy, N Gagliani, RA Flavell, A Waisman, S Huber
Cell Reports, 2022-03-29;38(13):110565.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

RORgammat phosphorylation protects against T�cell-mediated inflammation
Authors: S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang
Cell Reports, 2022-03-15;38(11):110520.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Ferroptosis as a Novel Determinant of beta-Cell Death in Diabetic Conditions
Authors: A Stancic, T Saksida, M Markelic, M Vucetic, I Grigorov, V Martinovic, D Gajic, A Ivanovic, K Velickovic, N Savic, V Otasevic
Oxidative Medicine and Cellular Longevity, 2022-03-14;2022(0):3873420.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
Authors: Z Guo, J Lin, K Sun, J Guo, X Yao, G Wang, L Hou, J Xu, J Guo, F Guo
Frontiers in Pharmacology, 2022-03-14;13(0):791376.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

SOX4 is a novel phenotypic regulator of endothelial cells in atherosclerosis revealed by single-cell analysis
Authors: CK Cheng, X Lin, Y Pu, JKY Tse, Y Wang, CL Zhang, X Cao, CW Lau, J Huang, L He, JY Luo, YT Shih, S Wan, CF Ng, L Wang, RCW Ma, JJ Chiu, TF Chan, X Yu Tian, Y Huang
Journal of advanced research, 2022-03-01;43(0):187-203.
Species: Mouse
Sample Types: Whole Tissue
Applications: Organ Culture

Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2
Authors: AS Wilson, KL Randall, JA Pettitt, JI Ellyard, A Blumenthal, A Enders, BJ Quah, T Bopp, CR Parish, A Brüstle
Nature Communications, 2022-01-26;13(1):528.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Dynamic changes in beta-cell [Ca2+] regulates NFAT activation, gene transcription and islet gap junction communication
Authors: JG Miranda, WE Schleicher, KL Wells, DG Ramirez, SP Landgrave, RK Benninger
Oncogene, 2021-12-31;0(0):101430.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pericytes as mediators of infiltration of macrophages in multiple sclerosis
Authors: DK Kaushik, A Bhattachar, BM Lozinski, V Wee Yong
Journal of Neuroinflammation, 2021-12-24;18(1):301.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease
Authors: Y Duan, H Chu, K Brandl, L Jiang, S Zeng, N Meshgin, E Papachrist, J Argemi, BG Mendes, Y Wang, H Su, W Sun, C Llorente, T Hendrikx, X Liu, M Hosseini, T Kisseleva, DA Brenner, R Bataller, P Ramachandr, M Karin, W Fu, B Schnabl
Nature Communications, 2021-12-09;12(1):7172.
Species: Mouse, Transgenic Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
Authors: A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial
Cell Reports, 2021-11-23;37(8):110037.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Differential Cytokine-Induced Responses of Polarized Microglia
Authors: P Chauhan, WS Sheng, S Hu, S Prasad, JR Lokensgard
Brain sciences, 2021-11-10;11(11):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The effect of macrophage polarization on the expression of the oxytocin signalling system in enteric neurons
Authors: Y Shi, S Li, H Zhang, J Zhu, T Che, B Yan, J Li, C Liu
Journal of Neuroinflammation, 2021-11-08;18(1):261.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2
Authors: C van de Wet, AM Manuel, M Sharafi, R Aboushoush, X Qian, C Erickson, M MacPherson, G Chan, IM Adcock, N ZounematKe, F Schleich, R Louis, E Bohrnsen, A D'Alessand, EF Wouters, NL Reynaert, J Li, CR Wolf, CJ Henderson, LKA Lundblad, ME Poynter, AE Dixon, CG Irvin, A van der Vl, JL van der Ve, YM Janssen-He
Redox Biology, 2021-10-03;47(0):102160.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes
Authors: S Lee, A Ishitsuka, T Kuroki, YH Lin, A Shibuya, T Hongu, Y Funakoshi, Y Kanaho, K Nagata, A Kawaguchi
JCI Insight, 2021-08-23;6(16):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice
Authors: M Han, T Ishikawa, CC Stroupe, HA Breckenrid, JK Bentley, MB Hershenson
Mucosal Immunology, 2021-08-05;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal &gamma&delta T�cells
Authors: L Dupraz, A Magniez, N Rolhion, ML Richard, G Da Costa, S Touch, C Mayeur, J Planchais, A Agus, C Danne, C Michaudel, M Spatz, F Trottein, P Langella, H Sokol, ML Michel
Cell Reports, 2021-07-06;36(1):109332.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Ontogenic timing, T�cell receptor signal strength, and Notch signaling direct &gamma&delta T�cell functional differentiation in�vivo
Authors: ELY Chen, CR Lee, PK Thompson, DL Wiest, MK Anderson, JC Zúñiga-Pfl
Cell Reports, 2021-06-08;35(10):109227.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells
Authors: A Singh, M Dashynam, B Chim, TM Escobar, X Liu, X Hu, S Patnaik, X Xu, N Southall, J Marugan, A Jadhav, V Lazarevic, SA Muljo, M Ferrer
Scientific Reports, 2021-06-01;11(1):11498.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients
Authors: V Farré-Alin, A Palomino-A, P Narros-Fer, AB Lopez-Rodr, C Decouty-Pe, A Muñoz-Mont, J Zamorano-F, B Mansilla-F, J Giner-Garc, P García-Fei, M Sáez-Alegr, AJ Palpán-Flo, JM Roda-Frade, CS Carabias, JM Rosa, B Civantos-M, S Yus-Teruel, L Gandía, A Lagares, BJ Hernández-, J Egea
Biomedicines, 2021-05-25;9(6):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-&kappaB pathway
Authors: Y Lu, L Liu, J Pan, B Luo, H Zeng, Y Shao, H Zhang, H Guan, D Guo, C Zeng, R Zhang, X Bai, H Zhang, D Cai
Cell Death & Disease, 2021-05-25;12(6):533.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

NLRP1 acts as a negative regulator of Th17 cell programming in mice and humans with autoimmune diabetes
Authors: FRC Costa, JA Leite, DM Rassi, JF da Silva, J Elias-Oliv, JB Guimarães, MC Foss-Freit, NOS Câmara, A Pontillo, RC Tostes, JS Silva, D Carlos
Cell Reports, 2021-05-25;35(8):109176.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
Authors: X Han, T Xu, Q Fang, H Zhang, L Yue, G Hu, L Sun
Redox Biology, 2021-05-25;44(0):102010.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1
Authors: J Zhao, B Cai, Z Shao, L Zhang, Y Zheng, C Ma, F Yi, B Liu, C Gao
Cell Death and Differentiation, 2021-05-20;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Authors: R Grieshaber, FA Radtke, P Cunin, G Stifano, A Levescot, B Vijaykumar, N Nelson-Man, RB Blaustein, PA Monach, PA Nigrovic, ImmGen Con
Nature Communications, 2021-05-17;12(1):2856.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Leukotriene B4 Receptors Are Necessary for the Stimulation of NLRP3 Inflammasome and IL-1&beta Synthesis in Neutrophil-Dominant Asthmatic Airway Inflammation
Authors: DW Kwak, D Park, JH Kim
Biomedicines, 2021-05-11;9(5):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Neuromodulatory effect of interleukin 1&beta in the dorsal raphe nucleus on individual differences in aggression
Authors: A Takahashi, H Aleyasin, MA Stavarache, L Li, F Cathomas, LF Parise, HY Lin, CJ Burnett, A Aubry, ME Flanigan, A Brancato, C Menard, ML Pfau, V Kana, J Wang, GE Hodes, T Sasaki, MG Kaplitt, S Ogawa, BS McEwen, SJ Russo
Molecular Psychiatry, 2021-04-30;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level
Authors: HR Clark, C McKenney, NM Livingston, A Gershman, S Sajjan, IS Chan, AJ Ewald, W Timp, B Wu, A Singh, S Regot
Nature Communications, 2021-03-23;12(1):1836.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay

N4BP1 negatively regulates NF-&kappaB by binding and inhibiting NEMO oligomerization
Authors: H Shi, L Sun, Y Wang, A Liu, X Zhan, X Li, M Tang, P Anderton, S Hildebrand, J Quan, S Ludwig, EMY Moresco, B Beutler
Nature Communications, 2021-03-02;12(1):1379.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress
Authors: M Ichii, K Oritani, J Toda, H Saito, H Shi, H Shibayama, D Motooka, Y Kitai, R Muromoto, JI Kashiwakur, K Saitoh, D Okuzaki, T Matsuda, Y Kanakura
Haematologica, 2021-02-01;0(0):.
Species: Mouse
Sample Types: Whole Cell
Applications: Cell Culture

Efficacy of Posidonia oceanica Extract against Inflammatory Pain: In Vivo Studies in Mice
Authors: L Micheli, M Vasarri, E Barletta, E Lucarini, C Ghelardini, D Degl'Innoc, L Di Cesare
Marine Drugs, 2021-01-21;19(2):.
Species: Mouse
Sample Types: In Vitro
Applications: Bioassay

Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
Nature, 2021-01-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress
Authors: Y Yang, P Shen, T Yao, J Ma, Z Chen, J Zhu, Z Gong, S Shen, X Fang
Theranostics, 2021-01-01;11(4):1877-1900.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Airway-Associated Macrophages in Homeostasis and Repair
Authors: AE Engler, AB Ysasi, RMF Pihl, C Villacorta, HM Heston, HMK Richardson, BR Thapa, NR Moniz, AC Belkina, SA Mazzilli, JR Rock
Cell Reports, 2020-12-29;33(13):108553.
Species: Transgenic Mouse
Sample Types: Spheroid
Applications: Bioassay

Transient Receptor Potential Ankyrin 1 (TRPA1) Is Involved in Upregulating Interleukin-6 Expression in Osteoarthritic Chondrocyte Models
Authors: E Nummenmaa, M Hämäläinen, A Pemmari, LJ Moilanen, L Tuure, RM Nieminen, T Moilanen, K Vuolteenah, E Moilanen
International Journal of Molecular Sciences, 2020-12-23;22(1):.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: Cell Culture, Tissue Culture

Chondrocyte ferroptosis contribute to the progression of osteoarthritis
Authors: X Yao, K Sun, S Yu, J Luo, J Guo, J Lin, G Wang, Z Guo, Y Ye, F Guo
Journal of Orthopaedic Translation, 2020-12-17;27(0):33-43.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Heparan sulfate functions are altered in the osteoarthritic cartilage
Authors: S Shamdani, S Chantepie, C Flageollet, N Henni-Cheb, Y Jouan, F Eymard, E Hay, M Cohen-Sola, D Papy-Garci, X Chevalier, P Albanese
Arthritis Research & Therapy, 2020-12-07;22(1):283.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

EBV-induced gene 3 augments IL-23R&alpha protein expression through a chaperone calnexin
Authors: I Mizoguchi, M Ohashi, H Hasegawa, Y Chiba, N Orii, S Inoue, C Kawana, M Xu, K Sudo, K Fujita, M Kuroda, SI Hashimoto, K Matsushima, T Yoshimoto
J. Clin. Invest., 2020-11-02;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response
Authors: S Lee, S Kim, HY Kang, HR Lim, Y Kwon, M Jo, YM Jeon, SR Kim, K Kim, CM Ha, S Lee, HJ Kim
J Neuroinflammation, 2020-10-14;17(1):299.
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice
Authors: F Namai, S Shigemori, T Ogita, T Sato, T Shimosato
Exp Mol Med, 2020-09-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
Authors: V Grubiši?, JL McClain, DE Fried, I Grants, P Rajasekhar, E Csizmadia, OA Ajijola, RE Watson, DP Poole, SC Robson, FL Christofi, BD Gulbransen
Cell Rep, 2020-09-08;32(10):108100.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Alternative Enhancer Usage and Targeted Polycomb Marking Hallmark Promoter Choice during T Cell Differentiation
Authors: MA Maqbool, L Pioger, AZ El Aabidin, N Karasu, AM Molitor, LTM Dao, G Charbonnie, F van Laethe, R Fenouil, F Koch, G Lacaud, I Gut, M Gut, S Amigorena, O Joffre, T Sexton, S Spicuglia, JC Andrau
Cell Rep, 2020-08-18;32(7):108048.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture

Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells
Authors: J Jhun, HK Min, J Ryu, SY Lee, JG Ryu, JW Choi, HS Na, SY Lee, Y Jung, SJ Park, MS Park, B Kwon, GE Ji, ML Cho, SH Park
J Transl Med, 2020-08-15;18(1):317.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC

The methylation status of the chemerin promoter region located from -?252 to +?258�bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels
Authors: K Kwiecien, P Brzoza, M Bak, P Majewski, I Skulimowsk, K Bednarczyk, J Cichy, M Kwitniewsk
Sci Rep, 2020-08-13;10(1):13702.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo, Bioassay

Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis
Authors: M Liu, M Yan, H Lv, B Wang, X Lv, H Zhang, S Xiang, J Du, T Liu, Y Tian, X Zhang, F Zhou, T Cheng, Y Zhu, H Jiang, Y Cao, D Ai
Cell Rep, 2020-08-04;32(5):107990.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury
Authors: H Ito, H Kimura, T Karasawa, S Hisata, A Sadatomo, Y Inoue, N Yamada, E Aizawa, E Hishida, R Kamata, T Komada, S Watanabe, T Kasahara, T Suzuki, H Horie, J Kitayama, N Sata, K Yamaji-Keg, M Takahashi
J. Immunol., 2020-07-29;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot Control

The Lipid Receptor G2A (GPR132) Mediates Macrophage Migration in Nerve Injury-Induced Neuropathic Pain
Authors: T Osthues, B Zimmer, V Rimola, K Klann, K Schilling, P Mathoor, C Angioni, A Weigert, G Geisslinge, C Münch, K Scholich, M Sisignano
Cells, 2020-07-21;9(7):.
Species: Mouse
Sample Types: Cell Culture Lysates
Applications: Bioassay

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice
Authors: Y Dong, S Li, Y Lu, X Li, Y Liao, Z Peng, Y Li, L Hou, Z Yuan, J Cheng
J Neuroinflammation, 2020-07-07;17(1):205.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
Authors: J Kealy, C Murray, EW Griffin, AB Lopez-Rodr, D Healy, LS Tortorelli, JP Lowry, LO Watne, C Cunningham
J. Neurosci., 2020-06-08;0(0):.
Species: Mouse, Transgenic Mouse
Sample Types: In Vivo
Applications: In Vivo

gammadelta T cells compose a developmentally regulated intrauterine population and protect against vaginal candidiasis
Authors: L Monin, DS Ushakov, H Arnesen, N Bah, A Jandke, M Muñoz-Ruiz, J Carvalho, S Joseph, BC Almeida, MJ Green, E Nye, S Hatano, Y Yoshikai, M Curtis, H Carlsen, U Steinhoff, P Boysen, A Hayday
Mucosal Immunol, 2020-05-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Paracrine regulation and improvement of &beta-cell function by thioredoxin
Authors: EM Hanschmann, SF Petry, S Eitner, CC Maresch, N Lingwal, CH Lillig, T Linn
Redox Biol, 2020-05-16;34(0):101570.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype
Authors: B Hou, Y Zhang, P Liang, Y He, B Peng, W Liu, S Han, J Yin, X He
Cell Death Dis, 2020-05-15;11(5):377.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity
Authors: Y Huang, H Wang, Y Hao, H Lin, M Dong, J Ye, L Song, Y Wang, Q Li, B Shan, Y Jiang, H Li, Z Shao, G Kroemer, H Zhang, L Bai, T Jin, C Wang, Y Ma, Y Cai, C Ding, S Liu, Y Pan, W Jiang, R Zhou
Nat. Cell Biol., 2020-05-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1
Authors: S Ma, A Zhang, X Li, S Zhang, S Liu, H Zhao, S Wu, L Chen, C Ma, H Zhao
Arthritis Res. Ther., 2020-05-01;22(1):99.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Noggin Inhibits IL-1&beta and BMP-2 Expression, and Attenuates Cartilage Degeneration and Subchondral Bone Destruction in Experimental Osteoarthritis
Authors: SY Chien, CH Tsai, SC Liu, CC Huang, TH Lin, YZ Yang, CH Tang
Cells, 2020-04-10;9(4):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Expression and Role of IL-1&beta Signaling in Chondrocytes Associated with Retinoid Signaling during Fracture Healing
Authors: T Shimo, H Takebe, T Okui, Y Kunisada, S Ibaragi, K Obata, N Kurio, K Shamsoon, S Fujii, A Hosoya, K Irie, A Sasaki, M Iwamoto
Int J Mol Sci, 2020-03-29;21(7):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pro-inflammatory Cytokines Drive Deregulation of Potassium Channel Expression in Primary Synovial Fibroblasts
Authors: O Haidar, N O'Neill, CA Staunton, S Bavan, F O'Brien, S Zouggari, U Sharif, A Mobasheri, K Kumagai, R Barrett-Jo
Front Physiol, 2020-03-24;11(0):226.
Species: Mouse
Sample Types: Whole Cell
Applications: Bioassay

Exploration of metformin as novel therapy for osteoarthritis: preventing cartilage degeneration and reducing pain behavior
Authors: H Li, X Ding, R Terkeltaub, H Lin, Y Zhang, B Zhou, K He, K Li, Z Liu, J Wei, Y Yang, H Xie, C Zeng, G Lei
Arthritis Res. Ther., 2020-02-22;22(1):34.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

MAFG-driven astrocytes promote CNS inflammation
Authors: MA Wheeler, IC Clark, EC Tjon, Z Li, SEJ Zandee, CP Couturier, BR Watson, G Scalisi, S Alkwai, V Rothhammer, A Rotem, JA Heyman, S Thaploo, LM Sanmarco, J Ragoussis, DA Weitz, K Petrecca, JR Moffitt, B Becher, JP Antel, A Prat, FJ Quintana
Nature, 2020-02-12;0(0):.
Species: Transgenic Mouse
Sample Types: Whole Cells, In Vivo, Transfected Whole Cells
Applications: Bioassay, In vivo assay

Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair
Authors: FC Simões, TJ Cahill, A Kenyon, D Gavriouchk, JM Vieira, X Sun, D Pezzolla, C Ravaud, E Masmanian, M Weinberger, S Mayes, ME Lemieux, DN Barnette, M Gunadasa-R, RM Williams, DR Greaves, LA Trinh, SE Fraser, SL Dallas, RP Choudhury, T Sauka-Spen, PR Riley
Nat Commun, 2020-01-30;11(1):600.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1&beta Production
Authors: JH Jang, DH Kim, JM Lim, JW Lee, SJ Jeong, KP Kim, YJ Surh
Cancer Res, 2020-01-22;80(6):1342-1356.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay

Pyruvate Kinase M2 Promotes Expression of Proinflammatory Mediators in House Dust Mite-Induced Allergic Airways Disease
Authors: C van de Wet, R Aboushoush, AM Manuel, SB Chia, C Erickson, MB MacPherson, JL van der Ve, V Anathy, AE Dixon, CG Irvin, ME Poynter, A van der Vl, EFM Wouters, NL Reynaert, YMW Janssen-He
J. Immunol., 2020-01-10;204(4):763-774.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Cell Culture, In Vivo

Dengue Virus Infection Activates Interleukin-1beta to Induce Tissue Injury and Vascular Leakage
Authors: P Pan, Q Zhang, W Liu, W Wang, Z Yu, Z Lao, W Zhang, M Shen, P Wan, F Xiao, MA Shereen, W Zhang, Q Tan, Y Liu, X Liu, K Wu, Y Liu, G Li, J Wu
Front Microbiol, 2019-11-22;10(0):2637.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Benzydamine inhibits osteoclast differentiation and bone resorption via down-regulation of interleukin-1 &beta expression
Authors: HS Son, J Lee, HI Lee, N Kim, YJ Jo, GR Lee, SE Hong, M Kwon, NY Kim, HJ Kim, JH Park, SY Lee, W Jeong
Acta Pharm Sin B, 2019-11-08;10(3):462-474.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A20 as an immune tolerance factor can determine islet transplant outcomes
Authors: NW Zammit, SN Walters, KL Seeberger, PJ O'Connell, GS Korbutt, ST Grey
JCI Insight, 2019-11-01;4(21):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf
Authors: D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton
Cell Rep, 2019-10-29;29(5):1203-1220.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NFAT-Specific Inhibition by dNP2-VIVITAmeliorates Autoimmune Encephalomyelitisby Regulation of Th1 and Th17
Authors: HG Lee, LK Kim, JM Choi
Mol Ther Methods Clin Dev, 2019-10-23;16(0):32-41.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Authors: S Mahmoudi, E Mancini, L Xu, A Moore, F Jahanbani, K Hebestreit, R Srinivasan, X Li, K Devarajan, L Prélot, CE Ang, Y Shibuya, BA Benayoun, ALS Chang, M Wernig, J Wysocka, MT Longaker, MP Snyder, A Brunet
Nature, 2019-10-23;574(7779):553-558.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Serum amyloid A-mediated inflammasome activation of microglial cells in cerebral ischemia
Authors: J Yu, H Zhu, S Taheri, W Mondy, L Bonilha, GS Magwood, D Lackland, RJ Adams, MS Kindy
J. Neurosci., 2019-10-14;0(0):.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA Standard

Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
Authors: DX Ji, LH Yamashiro, KJ Chen, N Mukaida, I Kramnik, KH Darwin, RE Vance
Nat Microbiol, 2019-10-14;0(0):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Bioassay

Phlda3 regulates beta cell survival during stress
Authors: M Bensellam, JY Chan, K Lee, MV Joglekar, AA Hardikar, T Loudovaris, HE Thomas, JC Jonas, DR Laybutt
Sci Rep, 2019-09-06;9(1):12827.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Increased ILC3s associated with higher levels of IL-1? aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase
Authors: TY Chan, CL Yen, YF Huang, PC Lo, PA Nigrovic, CY Cheng, WZ Wang, SY Wu, CC Shieh
Eur. J. Immunol., 2019-08-06;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Differential Roles of Dendritic Cells in Expanding CD4 T Cells in Sepsis
Authors: S Darkwah, N Nago, MG Appiah, PK Myint, E Kawamoto, M Shimaoka, EJ Park
Biomedicines, 2019-07-18;7(3):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1? Promotes Schwann Cells De-Differentiation in Wallerian Degeneration via the c-JUN/AP-1 Pathway
Authors: G Chen, X Luo, W Wang, Y Wang, F Zhu, W Wang
Front Cell Neurosci, 2019-07-09;13(0):304.
Species: Rat
Sample Types: Whole Tissue
Applications: Tissue Culture

5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt
Authors: C Lao, X Zhou, H Chen, F Wei, Z Huang, C Bai
Bioorg. Chem., 2019-06-21;90(0):103077.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Reactive microglia and IL1?/IL-1R1-signaling mediate neuroprotection in excitotoxin-damaged mouse retina
Authors: L Todd, I Palazzo, L Suarez, X Liu, L Volkov, TV Hoang, WA Campbell, S Blackshaw, N Quan, AJ Fischer
J Neuroinflammation, 2019-06-06;16(1):118.
Species: Mouse, Transgenic Mouse
Sample Types: In Vivo
Applications: In Vivo

NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death
Authors: K Radulovic, CK Ayata, R Mak'Anyeng, K Lechner, P Wuggenig, B Kaya, P Hruz, M Gomez de A, P Broz, B Weigmann, JH Niess
J. Immunol., 2019-05-31;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

3?-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation
Authors: X Zhou, H Chen, F Wei, Q Zhao, Q Su, J Liang, M Yin, X Tian, Z Liu, B Yu, C Bai, X He, Z Huang
J Immunol Res, 2019-05-22;2019(0):2431617.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

? Cell Hypoxia-Inducible Factor-1? Is Required for the Prevention of Type 1 Diabetes
Authors: A Lalwani, J Warren, D Liuwantara, WJ Hawthorne, PJ O'Connell, FJ Gonzalez, RA Stokes, J Chen, DR Laybutt, ME Craig, MM Swarbrick, C King, JE Gunton
Cell Rep, 2019-05-21;27(8):2370-2384.e6.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Estrogen receptor ? in T cells suppresses follicular helper T cell responses and prevents autoimmunity
Authors: DH Kim, HJ Park, HS Park, JU Lee, C Ko, MC Gye, JM Choi
Exp. Mol. Med., 2019-04-15;51(4):41.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1?-dependent manner in macrophages
Authors: OM Finucane, J Sugrue, A Rubio-Arai, MV Guillot-Se, MA Lynch
Sci Rep, 2019-03-11;9(1):4034.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

NCR- group 3 innate lymphoid cells orchestrate IL-23/IL-17 axis to promote hepatocellular carcinoma development
Authors: Y Liu, Y Song, D Lin, L Lei, Y Mei, Z Jin, H Gong, Y Zhu, B Hu, Y Zhang, L Zhao, HY Teo, J Qiu, W Jiang, C Dong, D Wu, Y Huang, H Liu
EBioMedicine, 2019-03-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Frontline Science: Induction of experimental autoimmune encephalomyelitis mobilizes Th17-promoting myeloid derived suppressor cells to the lung
Authors: JD Glenn, C Liu, KA Whartenby
J. Leukoc. Biol., 2019-02-14;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Responses of perivascular macrophages to circulating lipopolysaccharides in the subfornical organ with special reference to endotoxin tolerance
Authors: S Morita-Tak, K Nakahara, S Hasegawa-I, A Isonishi, K Tatsumi, H Okuda, T Tanaka, M Kitabatake, T Ito, A Wanaka
J Neuroinflammation, 2019-02-14;16(1):39.
Species: Mouse
Sample Types: Protein

Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis
Authors: HG Lee, JU Lee, DH Kim, S Lim, I Kang, JM Choi
Nat Commun, 2019-02-12;10(1):709.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation
Authors: K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota
Nat Commun, 2019-02-01;10(1):549.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Memory-like Liver Natural Killer Cells are Responsible for Islet Destruction in Secondary Islet Transplantation
Authors: Y Saeki, K Ishiyama, N Ishida, Y Tanaka, H Ohdan
Sci Rep, 2019-01-31;9(1):1022.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Potential Novel Prediction of TMJ-OA: MiR-140-5p Regulates Inflammation Through Smad/TGF-? Signaling
Authors: W Li, S Zhao, H Yang, C Zhang, Q Kang, J Deng, Y Xu, Y Ding, S Li
Front Pharmacol, 2019-01-23;10(0):15.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis
Authors: S Das, D Bar-Sagi
Oncogene, 2019-01-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

REV-ERB? Regulates TH17 Cell Development and Autoimmunity
Authors: M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt
Cell Rep, 2018-12-26;25(13):3733-3749.e8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

EriB targeted inhibition of microglia activity attenuates MPP+ induced DA neuron injury through the NF-?B signaling pathway
Authors: F Dou, X Chu, B Zhang, L Liang, G Lu, J Ding, S Chen
Mol Brain, 2018-12-18;11(1):75.
Species: Mouse
Sample Types: Recombinant Protein
Applications: ELISA (Standard)

Obesity-associated inflammation promotes angiogenesis and breast cancer via angiopoietin-like 4
Authors: R Kolb, P Kluz, ZW Tan, N Borcherdin, N Bormann, A Vishwakarm, L Balcziak, P Zhu, BS Davies, F Gourronc, LZ Liu, X Ge, BH Jiang, K Gibson-Cor, A Klingelhut, NS Tan, Y Zhu, FS Sutterwala, X Shen, W Zhang
Oncogene, 2018-12-05;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-23R Signaling Plays No Role in Myocardial Infarction
Authors: E Engelowski, NF Modares, S Gorressen, P Bouvain, D Semmler, C Alter, Z Ding, U Flögel, J Schrader, H Xu, PA Lang, J Fischer, DM Floss, J Scheller
Sci Rep, 2018-11-20;8(1):17078.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Colitis Promotes a Pathological Condition of the Liver in the Absence of Foxp3+ Regulatory T Cells
Authors: F Mathies, N Steffens, D Kleinschmi, F Stuhlmann, FJ Huber, U Roy, T Meyer, M Luetgehetm, M von Peters, O Seiz, J Herkel, C Schramm, RA Flavell, N Gagliani, C Krebs, U Panzer, Z Abdullah, T Strowig, T Bedke, S Huber
J. Immunol., 2018-11-16;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Differentiation, Differentiation

TGF?1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of TH17 cells by an AHR-independent mechanism
Authors: KA de Lima, PB Donate, J Talbot, M Davoli-Fer, RS Peres, TM Cunha, JC Alves-Filh, FQ Cunha
Cell Death Dis, 2018-11-13;9(11):1130.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses
Authors: CN Berger, VF Crepin, TI Roumelioti, JC Wright, N Serafini, M Pevsner-Fi, L Yu, E Elinav, JP Di Santo, JS Choudhary, G Frankel
PLoS Pathog., 2018-10-26;14(10):e1007406.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Cutting Edge: IL-1? and Not IL-1? Drives IL-1R1-Dependent Neonatal Murine Sepsis Lethality
Authors: JT Benjamin, DJ Moore, C Bennett, R van der Me, A Royce, R Loveland, JL Wynn
J. Immunol., 2018-10-10;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice
Authors: HY Nam, JH Nam, G Yoon, JY Lee, Y Nam, HJ Kang, HJ Cho, J Kim, HS Hoe
J Neuroinflammation, 2018-09-19;15(1):271.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA (Standard)

Interleukin-37 Treatment of Mice with Metabolic Syndrome Improves Insulin Sensitivity and Reduces Pro-inflammatory Cytokine Production in Adipose Tissue
Authors: DB Ballak, S Li, G Cavalli, JL Stahl, IW Tengesdal, JA van Diepen, V Kluck, B Swartzwelt, T Azam, CJ Tack, R Stienstra, T Mandrup-Po, DR Seals, CA Dinarello
J. Biol. Chem., 2018-07-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice
Authors: CC Hsieh, CL Lin, JT He, M Chiang, Y Wang, YC Tsai, CH Hung, PJ Chang
Stem Cell Res Ther, 2018-07-04;9(1):183.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors
Authors: JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh
Nature, 2018-06-27;559(7712):114-119.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
Authors: DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham
Mol. Psychiatry, 2018-06-06;24(10):1533-1548.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1?
Authors: HM Hsiao, R Fernandez, S Tanaka, W Li, JH Spahn, S Chiu, M Akbarpour, D Ruiz-Perez, Q Wu, C Turam, D Scozzi, T Takahashi, HP Luehmann, V Puri, GRS Budinger, AS Krupnick, AV Misharin, KJ Lavine, Y Liu, AE Gelman, A Bharat, D Kreisel
J. Clin. Invest., 2018-05-21;128(7):2833-2847.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts
Authors: H Kuwata, C Yuzurihara, N Kinoshita, Y Taki, Y Ikegami, S Washio, Y Hirakawa, E Yoda, T Aiuchi, H Itabe, Y Nakatani, S Hara
FEBS J., 2018-04-18;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay

Role of IL-23 signaling in the progression of premalignant oral lesions to cancer
Authors: B Caughron, Y Yang, MRI Young
PLoS ONE, 2018-04-17;13(4):e0196034.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Nonpyroptotic IFN-?-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo
Authors: JP Ingram, S Tursi, T Zhang, W Guo, C Yin, M A Wynosky-, J van der He, KQ Cai, M Yamamoto, BB Finlay, IE Brodsky, SI Grivenniko, Ç Tükel, S Balachandr
J. Immunol., 2018-04-13;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Fas Promotes T Helper 17 Cell Differentiation and Inhibits T Helper 1 Cell Development by Binding and Sequestering Transcription Factor STAT1
Authors: G Meyer Zu H, D Przybylski, MA Schramm, C Wang, A Schnell, Y Lee, R Sobel, A Regev, VK Kuchroo
Immunity, 2018-03-20;48(3):556-569.e7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection
Authors: AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi
J. Exp. Med., 2018-02-28;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

GPR142 prompts glucagon-like Peptide-1 release from islets to improve ? cell function
Authors: HV Lin, J Wang, J Wang, W Li, X Wang, JT Alston, MK Thomas, DA Briere, SK Syed, AM Efanov
Mol Metab, 2018-02-23;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
Authors: CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
Elife, 2018-02-22;7(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature
Authors: W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi
Neurobiol. Dis., 2018-02-09;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

Salient type 1 interleukin 1 receptor expression in peripheral non-immune cells
Authors: A Song, L Zhu, G Gorantla, O Berdysz, SA Amici, M Guerau-de-, KM Madalena, JK Lerch, X Liu, N Quan
Sci Rep, 2018-01-15;8(1):723.
Species: Mouse
Sample Types:
Applications: In Vivo

Microglial activation and the nitric oxide/cGMP/PKG pathway underlie enhanced neuronal vulnerability to mitochondrial dysfunction in experimental multiple sclerosis
Authors: A Mancini, M Tantucci, P Mazzocchet, A de Iure, V Durante, L Macchioni, C Giampà, A Alvino, L Gaetani, C Costa, A Tozzi, P Calabresi, M Di Filippo
Neurobiol. Dis., 2018-01-09;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Pharmacological Effect ofCaulophyllum robustumon Collagen-Induced Arthritis and Regulation of Nitric Oxide, NF-?B, and Proinflammatory Cytokines In Vivo and In Vitro
Authors: QH Wang, SW Lv, YY Guo, JX Duan, SY Dong, QS Wang, FM Yu, H Su, HX Kuang
Evid Based Complement Alternat Med, 2017-12-31;2017(0):8134321.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A selective inhibition of c-Fos/activator protein-1 as a potential therapeutic target for intervertebral disc degeneration and associated pain
Authors: H Makino, S Seki, Y Yahara, S Shiozawa, Y Aikawa, H Motomura, M Nogami, K Watanabe, T Sainoh, H Ito, N Tsumaki, Y Kawaguchi, M Yamazaki, T Kimura
Sci Rep, 2017-12-05;7(1):16983.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Anti-inflammatory effects of a traditional Korean medicine: Ojayeonjonghwan
Authors: SY Nam, KY Kim, MH Kim, JB Jang, SY Rah, HJ Chae, JM Lee, HM Kim, HJ Jeong
Pharm Biol, 2017-12-01;55(1):1856-1862.
Species: Mouse
Sample Types:
Applications: ELISA (Standard)

IL-1? and IL-23 Promote Extrathymic Commitment of CD27(+)CD122(-) ?? T Cells to ??T17 Cells
Authors: A Muschaweck, F Petermann, T Korn
J. Immunol., 2017-08-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle
Authors: K Kamizaki, R Doi, M Hayashi, T Saji, M Kanagawa, T Toda, SI Fukada, HH Ho, ME Greenberg, M Endo, Y Minami
J. Biol. Chem., 2017-08-08;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

The Role of Inflammation in ?-cell Dedifferentiation
Authors: TM Nordmann, E Dror, F Schulze, S Traub, E Berishvili, C Barbieux, M Böni-Schne, MY Donath
Sci Rep, 2017-07-24;7(1):6285.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells
Authors: C Wang, CX Xu, Y Alippe, C Qu, J Xiao, E Schipani, R Civitelli, Y Abu-Amer, G Mbalaviele
Sci Rep, 2017-07-07;7(1):4880.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Balanced Bcl-3 expression in murine CD4(+) T cells is required for generation of encephalitogenic Th17 cells
Authors: IA Mufazalov, J Kuschmann, D Andruszews, J Masri, LA Gabriel, P Adams, S Reissig, N Hövelmeyer, A Waisman
Eur. J. Immunol., 2017-06-29;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota
Authors: Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson
J. Immunol., 2017-05-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Intestinal fungi contribute to development of alcoholic liver disease
Authors: AM Yang, T Inamine, K Hochrath, P Chen, L Wang, C Llorente, S Bluemel, P Hartmann, J Xu, Y Koyama, T Kisseleva, MG Torralba, K Moncera, K Beeri, CS Chen, K Freese, C Hellerbran, SM Lee, HM Hoffman, WZ Mehal, G Garcia-Tsa, EA Mutlu, A Keshavarzi, GD Brown, SB Ho, R Bataller, P Stärkel, DE Fouts, B Schnabl
J. Clin. Invest., 2017-05-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Prolactin blocks the expression of receptor activator of nuclear factor ?B ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis
Authors: MG Ledesma-Co, N Adán, G Ortiz, M Solís-Guti, F López-Barr, G Martínez d, C Clapp
Arthritis Res. Ther., 2017-05-15;19(1):93.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

TNF? drives mitochondrial stress in POMC neurons in obesity
Authors: CX Yi, M Walter, Y Gao, S Pitra, B Legutko, S Kälin, C Layritz, C García-Các, M Bielohuby, M Bidlingmai, SC Woods, A Ghanem, KK Conzelmann, JE Stern, M Jastroch, MH Tschöp
Nat Commun, 2017-05-10;8(0):15143.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Authors: Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich
Mol Metab, 2017-05-06;6(7):725-736.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay

IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
PLoS Pathog., 2017-04-27;13(4):e1006322.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TNF-? promotes extracellular vesicle release in mouse astrocytes through glutaminase
Authors: K Wang, L Ye, H Lu, H Chen, Y Zhang, Y Huang, JC Zheng
J Neuroinflammation, 2017-04-20;14(1):87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs
Authors: MX Li, HL Zheng, Y Luo, JG He, W Wang, J Han, L Zhang, X Wang, L Ni, HY Zhou, ZL Hu, PF Wu, Y Jin, LH Long, H Zhang, G Hu, JG Chen, F Wang
Mol. Psychiatry, 2017-04-18;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1
Authors: G Fu, Q Xu, Y Qiu, X Jin, T Xu, S Dong, J Wang, Y Ke, H Hu, X Cao, D Wang, H Cantor, X Gao, L Lu
J. Exp. Med., 2017-04-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease
Authors: MC Lee, JA McCubbin, AD Christense, DP Poole, P Rajasekhar, T Lieu, NW Bunnett, S Garcia-Car, A Erickson, SM Brierley, R Saleh, A Achuthan, AJ Fleetwood, RL Anderson, JA Hamilton, AD Cook
J. Immunol, 2017-03-20;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The symbiotic bacterial surface factor polysaccharide A on Bacteroides fragilis inhibits IL-1?-induced inflammation in human fetal enterocytes via toll receptors 2 and 4
Authors: F Jiang, D Meng, M Weng, W Zhu, W Wu, D Kasper, WA Walker
PLoS ONE, 2017-03-09;12(3):e0172738.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Role of pterostilbene in attenuating immune mediated devastation of pancreatic beta cells via Nrf2 signaling cascade
Authors: D Sireesh, MR Ganesh, U Dhamodhara, M Sakthivadi, S Sivasubram, P Gunasekara, KM Ramkumar
J. Nutr. Biochem, 2017-03-06;44(0):11-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4
Authors: L Di Candia, E Gomez, E Venereau, L Chachi, D Kaur, ME Bianchi, RA Challiss, CE Brightling, RM Saunders
J. Allergy Clin. Immunol, 2017-03-01;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis
Authors: L Franchi, I Monteleone, LY Hao, MA Spahr, W Zhao, X Liu, K Demock, A Kulkarni, CA Lesch, B Sanchez, L Carter, I Marafini, X Hu, O Mashadova, M Yuan, JM Asara, H Singh, CA Lyssiotis, G Monteleone, AW Opipari, GD Glick
J. Immunol, 2017-02-27;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway
Authors: W Huang, W Fan, Y Wang, D Han, X Li, S Li, C Li, B Xu, Y Huang, X Fu, F Cao
Cell Death Discov, 2017-02-27;3(0):16097.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis
Authors: S Choi, S You, D Kim, SY Choi, HM Kwon, HS Kim, D Hwang, YJ Park, CS Cho, WU Kim
J. Clin. Invest, 2017-02-13;127(3):954-969.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Early gene activation initiates neuroinflammation prior to VSV neuroinvasion: Impact on antiviral responses and sleep
Authors: Richard P Ciavarra
J. Neuroimmunol, 2016-12-29;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

NLRP3 inflammasome has a protective effect against oxazolone-induced colitis: a possible role in ulcerative colitis
Sci Rep, 2016-12-14;6(0):39075.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Pharmacologic modulation of ROR?t translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis
Sci Rep, 2016-12-01;6(0):37977.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis
Authors: Stephen J Galli
J. Clin. Invest., 2016-11-07;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels
PLoS ONE, 2016-09-23;11(9):e0163735.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A Critical Role for P2X7 Receptor-Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury
J Immunol, 2016-08-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-1? is an innate immune sensor of microbial proteolysis
Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
Sci Immunol, 2016-08-19;1(2):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TLR4-Upregulated IL-1? and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism
Sci Rep, 2016-08-16;6(0):31663.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

SLAM-associated protein favours the development of iNKT2 over iNKT17 cells
Authors: Marie-Laure Michel
Eur J Immunol, 2016-07-22;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Epidermal RAF prevents allergic skin disease
Elife, 2016-07-19;5(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
Nature, 2016-07-13;535(7612):440-3.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses
Authors: LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares
J. Biol. Chem., 2016-05-23;291(30):15830-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Platelets Guide Leukocytes to Their Sites of Extravasation
PLoS Biol, 2016-05-06;14(5):e1002459.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Phenotypic and Functional Plasticity of Murine Intestinal NKp46+ Group 3 Innate Lymphoid Cells
J Immunol, 2016-04-22;196(11):4731-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Toll/Interleukin-1 Receptor Domain Derived from TcpC (TIR-TcpC) Ameliorates Experimental Autoimmune Arthritis by Down-modulating Th17 Cell Response
Authors: Shweta Pasi
J Biol Chem, 2016-03-28;291(23):12358-69.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

HSP60 plays a regulatory role in IL-1beta-induced microglial inflammation via TLR4-p38 MAPK axis.
Authors: Swaroop S, Sengupta N, Suryawanshi A, Adlakha Y, Basu A
J Neuroinflammation, 2016-02-02;13(1):27.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TRIM38 Negatively Regulates TLR3/4-Mediated Innate Immune and Inflammatory Responses by Two Sequential and Distinct Mechanisms.
Authors: Hu M, Xie X, Yang Q, Liao C, Ye W, Lin H, Shu H
J Immunol, 2015-09-21;195(9):4415-25.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
Nat Med, 2015-03-16;21(4):363-72.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin 1 type 1 receptor restore: a genetic mouse model for studying interleukin 1 receptor-mediated effects in specific cell types.
Authors: Liu X, Yamashita T, Chen Q, Belevych N, Mckim D, Tarr A, Coppola V, Nath N, Nemeth D, Syed Z, Sheridan J, Godbout J, Zuo J, Quan N
J Neurosci, 2015-02-18;35(7):2860-70.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

IkappaBNS regulates murine Th17 differentiation during gut inflammation and infection.
Authors: Annemann M, Wang Z, Plaza-Sirvent C, Glauben R, Schuster M, Ewald Sander F, Mamareli P, Kuhl A, Siegmund B, Lochner M, Schmitz I
J Immunol, 2015-02-18;194(6):2888-98.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Testosterone suppresses hepatic inflammation by the downregulation of IL-17, CXCL-9, and CXCL-10 in a mouse model of experimental acute cholangitis.
Authors: Schwinge D, Carambia A, Quaas A, Krech T, Wegscheid C, Tiegs G, Prinz I, Lohse A, Herkel J, Schramm C
J Immunol, 2015-02-11;194(6):2522-30.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Authors: Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, Pear W, Hatton R, Weaver C
Nat Immunol, 2015-02-02;16(3):286-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile.
Authors: Cowardin C, Kuehne S, Buonomo E, Marie C, Minton N, Petri W
MBio, 2015-01-27;6(1):.
Species: Human, Mouse
Sample Types: Cell Culture Supernates, Whole Cells
Applications: Bioassay

Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
Authors: Moyon S, Dubessy A, Aigrot M, Trotter M, Huang J, Dauphinot L, Potier M, Kerninon C, Melik Parsadaniantz S, Franklin R, Lubetzki C
J Neurosci, 2015-01-07;35(1):4-20.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors.
Authors: Caiazzo M, Giannelli S, Valente P, Lignani G, Carissimo A, Sessa A, Colasante G, Bartolomeo R, Massimino L, Ferroni S, Settembre C, Benfenati F, Broccoli V
Stem Cell Reports, 2014-12-31;4(1):25-36.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1beta enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes.
Authors: Lutz A, Sanwald J, Thomas M, Feuer R, Sawodny O, Ederer M, Borner C, Humar M, Merfort I
PLoS ONE, 2014-12-31;9(12):e115603.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells.
Authors: Jin, Shijie, Sonobe, Yoshifum, Kawanokuchi, Jun, Horiuchi, Hiroshi, Cheng, Yi, Wang, Yue, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
PLoS ONE, 2014-12-23;9(12):e115981.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
Authors: Dunne A, Mielke L, Allen A, Sutton C, Higgs R, Cunningham C, Higgins S, Mills K
Mucosal Immunol, 2014-10-15;8(3):607-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Mesenchymal stem cells differentially modulate effector CD8+ T cell subsets and exacerbate experimental autoimmune encephalomyelitis.
Authors: Glenn J, Smith M, Calabresi P, Whartenby K
Stem Cells, 2014-10-01;32(10):2744-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Reversal of beta cell de-differentiation by a small molecule inhibitor of the TGFbeta pathway.
Authors: Blum B, Roose A, Barrandon O, Maehr R, Arvanites A, Davidow L, Davis J, Peterson Q, Rubin L, Melton D
Elife, 2014-09-16;3(0):e02809.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Role of Blimp-1 in programing Th effector cells into IL-10 producers.
Authors: Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A
J Exp Med, 2014-07-29;211(9):1807-19.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pseudomonas aeruginosa quorum-sensing molecule homoserine lactone modulates inflammatory signaling through PERK and eI-F2alpha.
Authors: Grabiner M, Fu Z, Wu T, Barry K, Schwarzer C, Machen T
J Immunol, 2014-07-02;193(3):1459-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Glimepiride reduces CD14 expression and cytokine secretion from macrophages.
Authors: Ingham V, Williams A, Bate C
J Neuroinflammation, 2014-06-21;11(0):115.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: ELISA (Standard)

A tissue-specific role for Nlrp3 in tubular epithelial repair after renal ischemia/reperfusion.
Authors: Bakker P, Butter L, Claessen N, Teske G, Sutterwala F, Florquin S, Leemans J
Am J Pathol, 2014-05-11;184(7):2013-22.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot

Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-alpha and interleukin-1beta but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
Authors: Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
J Biol Chem, 2014-04-22;289(22):15621-30.
Species: Bacteria - Porphyromonas gingivalis, Mouse
Sample Types: Protein, Whole Cells
Applications: Bioassay, Degradation

Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.
Authors: Jana M, Mondal S, Jana A, Pahan K
Immunology, 2014-04-01;141(4):549-63.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IFN-gamma or IFN-alpha ameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex.
Authors: Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, Iwai K
J Immunol, 2014-03-14;192(8):3793-804.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.
Authors: Hahn W, Kuzmicic J, Burrill J, Donoghue M, Foncea R, Jensen M, Lavandero S, Arriaga E, Bernlohr D
Am J Physiol Endocrinol Metab, 2014-03-04;306(9):E1033-45.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis.
Authors: Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H
Nat Med, 2013-12-22;20(1):62-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
Authors: Halai, Krishma, Whiteford, James, Ma, Bin, Nourshargh, Sussan, Woodfin, Abigail
J Cell Sci, 2013-12-06;127(0):620-9.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production.
Authors: Lee S, Lee K, Yi S, Kook S, Lee J
PLoS ONE, 2013-12-04;8(12):e80873.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture

A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
Authors: Zehendner, Christop, Wedler, Hannah E, Luhmann, Heiko J
PLoS ONE, 2013-11-21;8(11):e81637.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay

Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis.
Authors: Moon C, VanDussen K, Miyoshi H, Stappenbeck T
Mucosal Immunol, 2013-11-13;7(4):818-28.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-18 regulates melanoma VLA-4 integrin activation through a Hierarchized sequence of inflammatory factors.
Authors: Valcarcel M, Carrascal T, Crende O, Vidal-Vanaclocha F
J Invest Dermatol, 2013-08-12;134(2):470-80.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Galectin-9 protein is up-regulated in astrocytes by tumor necrosis factor and promotes encephalitogenic T-cell apoptosis.
Authors: Steelman A, Smith R, Welsh C, Li J
J Biol Chem, 2013-07-08;288(33):23776-87.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth.
Authors: Schmid M, Franco I, Kang S, Hirsch E, Quilliam L, Varner J
PLoS ONE, 2013-04-02;8(4):e60226.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
J Immunol, 2013-03-13;190(8):4196-204.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1beta-induced peritonitis.
Authors: Song J, Wu C, Zhang X, Sorokin L
J Immunol, 2012-12-07;190(1):401-10.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth.
Authors: Bruchard M, Mignot G, Derangere V, Chalmin F, Chevriaux A, Vegran F, Boireau W, Simon B, Ryffel B, Connat J, Kanellopoulos J, Martin F, Rebe C, Apetoh L, Ghiringhelli F
Nat Med, 2012-12-02;19(1):57-64.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
J. Exp. Med., 2012-07-16;209(8):1505-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS.
Authors: Flanagan K, Fitzgerald K, Baker J
PLoS ONE, 2012-07-06;7(7):e40443.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice.
Authors: Zhao H, Zhao X, Cao X, Wu G
Immun Ageing, 2012-05-28;9(1):12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
Authors: Proebstl D, Voisin MB, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S
J. Exp. Med., 2012-05-21;209(6):1219-34.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Hepatocarcinogenesis in FXR-/- mice mimics human HCC progression that operates through HNF1alpha regulation of FXR expression.
Authors: Liu N, Meng Z, Lou G, Zhou W, Wang X, Zhang Y, Zhang L, Liu X, Yen Y, Lai L, Forman BM, Xu Z, Xu R, Huang W
Mol. Endocrinol., 2012-04-02;26(5):775-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Hepatocyte-specific mutation of both NF-kappaB RelA and STAT3 abrogates the acute phase response in mice.
Authors: Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algul H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP
J. Clin. Invest., 2012-04-02;122(5):1758-63.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Interleukin-23-mediated inflammation in Pseudomonas aeruginosa pulmonary infection.
Authors: Dubin PJ, Martz A, Eisenstatt JR, Fox MD, Logar A, Kolls JK
Infect. Immun., 2011-10-24;80(1):398-409.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.
Authors: El-Behi M, Ciric B, Dai H
Nat. Immunol., 2011-04-24;12(6):568-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Authors: Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
J. Exp. Med., 2011-03-07;208(3):491-503.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Insulin-like Growth Factor 1-mediated Hyperthermia Involves Anterior Hypothalamic Insulin Receptors.
Authors: Sanchez-Alavez M, Osborn O, Tabarean IV
J. Biol. Chem., 2011-02-17;286(17):14983-90.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

XOMA 052, a potent, high-affinity monoclonal antibody for the treatment of IL-1beta-mediated diseases.
Authors: Owyang AM, Issafras H, Corbin J, Ahluwalia K, Larsen P, Pongo E, Handa M, Horwitz AH, Roell MK, Haak-Frendscho M, Masat L
MAbs, 2011-01-01;3(1):49-60.
Species: Mouse
Sample Types: Buffer
Applications: Binding Assay

Endothelial LSP1 is involved in endothelial dome formation, minimizing vascular permeability changes during neutrophil transmigration in vivo.
Authors: Petri B, Kaur J, Long EM, Li H, Parsons SA, Butz S, Phillipson M, Vestweber D, Patel KD, Robbins SM, Kubes P
Blood, 2010-10-28;117(3):942-52.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Tim3 binding to galectin-9 stimulates antimicrobial immunity.
Authors: Jayaraman P, Sada-Ovalle I, Beladi S, Anderson AC, Dardalhon V, Hotta C, Kuchroo VK, Behar SM
J. Exp. Med., 2010-10-11;207(11):2343-54.
Species: Mouse
Sample Types: Cell Culture Supernates
Applications: Bioassay

Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010-09-29;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis.
Authors: Chou RC, Kim ND, Sadik CD
Immunity, 2010-08-27;33(2):266-78.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo

IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
Authors: Cho JS, Pietras EM, Garcia NC, Ramos RI, Farzam DM, Monroe HR, Magorien JE, Blauvelt A, Kolls JK, Cheung AL, Cheng G, Modlin RL, Miller LS
J. Clin. Invest., 2010-04-01;120(5):1762-73.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.
Authors: Grossberg AJ, Scarlett JM, Zhu X, Bowe DD, Batra AK, Braun TP, Marks DL
Endocrinology, 2009-12-16;151(2):606-16.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
J. Immunol., 2009-12-15;183(12):7890-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept.
Authors: Aden U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, Lelievre V, Gressens P
Brain Behav. Immun., 2009-10-25;24(5):747-58.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Thymic regulation of autoimmune disease by accelerated differentiation of Foxp3+ regulatory T cells through IL-7 signaling pathway.
Authors: Chen X, Fang L, Song S, Guo TB, Liu A, Zhang JZ
J. Immunol., 2009-10-19;183(10):6135-44.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors.
Authors: Ghiringhelli F, Apetoh L, Tesniere A, Aymeric L, Ma Y, Ortiz C, Vermaelen K, Panaretakis T, Mignot G, Ullrich E, Perfettini JL, Schlemmer F, Tasdemir E, Uhl M, Genin P, Civas A, Ryffel B, Kanellopoulos J, Tschopp J, Andre F, Lidereau R, McLaughlin NM, Haynes NM, Smyth MJ, Kroemer G, Zitvogel L
Nat. Med., 2009-09-20;15(10):1170-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Externalization of the leaderless cytokine IL-1F6 occurs in response to lipopolysaccharide/ATP activation of transduced bone marrow macrophages.
Authors: Martin U, Scholler J, Gurgel J, Renshaw B, Sims JE, Gabel CA
J. Immunol., 2009-08-28;183(6):4021-30.
Applications: Western Blot

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.
Authors: Mizutani N, Nabe T, Yoshino S
J. Immunol., 2009-08-14;183(6):4039-46.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation.
Authors: Koziczak-Holbro M, Littlewood-Evans A, Pollinger B, Kovarik J, Dawson J, Zenke G, Burkhart C, Muller M, Gram H
Arthritis Rheum., 2009-06-01;60(6):1661-71.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

The role of interleukin-6 in lipopolysaccharide-induced fever by mechanisms independent of prostaglandin E2.
Authors: Nilsberth C, Elander L, Hamzic N, Norell M, Lonn J, Engstrom L, Blomqvist A
Endocrinology, 2008-11-20;150(4):1850-60.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs.
Authors: Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A
Arthritis Rheum., 2008-11-01;58(11):3510-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation.
Authors: Scarlett JM, Zhu X, Enriori PJ, Bowe DD, Batra AK, Levasseur PR, Grant WF, Meguid MM, Cowley MA, Marks DL
Endocrinology, 2008-06-26;149(10):4837-45.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Induction of IL-33 expression and activity in central nervous system glia.
Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
J. Leukoc. Biol., 2008-06-13;84(3):631-43.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
Authors: Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
Am. J. Pathol., 2008-06-05;173(1):57-67.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

In vivo efficacy of a phosphodiester TLR-9 aptamer and its beneficial effect in a pulmonary anthrax infection model.
Authors: Wu CC, Sabet M, Hayashi T, Tawatao R, Fierer J, Carson DA, Guiney DG, Corr M
Cell. Immunol., 2008-05-20;251(2):78-85.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Effects of i.c.v. administration of interleukin-1 on sleep and body temperature of interleukin-6-deficient mice.
Authors: Olivadoti MD, Opp MR
Neuroscience, 2008-02-19;153(1):338-48.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

IL-1F5 mediates anti-inflammatory activity in the brain through induction of IL-4 following interaction with SIGIRR/TIR8.
Authors: Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME, Garlanda C, Mantovani A, O'Neill LA, Mills KH, Lynch MA
J. Neurochem., 2008-02-18;105(5):1960-9.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis.
Authors: Antonopoulos C, Cumberbatch M, Mee JB, Dearman RJ, Wei XQ, Liew FY, Kimber I, Groves RW
J. Leukoc. Biol., 2007-11-05;83(2):361-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Cell surface 4-1BBL mediates sequential signaling pathways 'downstream' of TLR and is required for sustained TNF production in macrophages.
Authors: Kang YJ, Kim SO, Shimada S, Otsuka M, Seit-Nebi A, Kwon BS, Watts TH, Han J
Nat. Immunol., 2007-05-13;8(6):601-9.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Protection of CD8+ T cells from activation-induced cell death by IL-18.
Authors: Li W, Kashiwamura S, Ueda H, Sekiyama A, Okamura H
J. Leukoc. Biol., 2007-03-30;82(1):142-51.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Antiinflammatory effects of natural tetranortriterpenoids isolated from Carapa guianensis Aublet on zymosan-induced arthritis in mice.
Authors: Penido C, Conte FP, Chagas MS, Rodrigues CA, Pereira JF, Henriques MG
Inflamm. Res., 2006-11-01;55(11):457-64.
Applications: ELISA (Standard)

The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta.
Authors: Shchors K, Shchors E, Rostker F, Lawlor ER, Brown-Swigart L, Evan GI
Genes Dev., 2006-09-15;20(18):2527-38.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
Authors: Haraguchi G, Suzuki J, Kosuge H, Ogawa M, Koga N, Muto S, Itai A, Kagechika H, Shudo K, Isobe M
J. Mol. Cell. Cardiol., 2006-09-11;41(5):885-92.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality.
Authors: Osuchowski MF, Welch K, Siddiqui J, Remick DG
J. Immunol., 2006-08-01;177(3):1967-74.
Applications: ELISA (Standard)

Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide.
Authors: Vickers TA, Zhang H, Graham MJ, Lemonidis KM, Zhao C, Dean NM
J. Immunol., 2006-03-15;176(6):3652-61.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Shedding of soluble ICAM-1 into the alveolar space in murine models of acute lung injury.
Authors: Mendez MP, Morris SB, Wilcoxen S, Greeson E, Moore B, Paine R
Am. J. Physiol. Lung Cell Mol. Physiol., 2005-12-22;290(5):L962-70.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay

TLR-2 is upregulated and mobilized to the hepatocyte plasma membrane in the space of Disse and to the Kupffer cells TLR-4 dependently during acute endotoxemia in mice.
Authors: Ojaniemi M, Liljeroos M, Harju K, Sormunen R, Vuolteenaho R, Hallman M
Immunol. Lett., 2005-09-26;102(2):158-68.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Sequential ELISA to profile multiple cytokines from small volumes.
Authors: Osuchowski MF, Siddiqui J, Copeland S, Remick DG
J. Immunol. Methods, 2005-07-01;302(1):172-81.
Applications: ELISA (Standard)

IL-1 type I receptor plays a key role in mediating the recruitment of leukocytes into the central nervous system.
Authors: Ching S, He L, Lai W, Quan N
Brain Behav. Immun., 2005-03-01;19(2):127-37.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo

Selective macrophage suppression during sepsis.
Authors: Ellaban E, Bolgos G, Remick D
Cell. Immunol., 2005-02-26;231(1):103-11.
Applications: ELISA (Standard)

Involvement of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha and interleukin-1beta in Wallerian degeneration.
Authors: Perrin FE, Lacroix S, Aviles-Trigueros M, David S
Brain, 2005-02-02;128(0):854-66.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo