Recombinant Human TNF-alpha Protein Summary
Product Specifications
Val77-Leu233, with and without an N-terminal Met
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
210-TA
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
Reconstitution | Reconstitute at 0.1-1 mg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
210-TA/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. *Small pack size (5 & 20 µg) is supplied as a 0.2 µm filtered solution in PBS. |
Reconstitution | Reconstitute at 0.1-1 mg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (5 & 20 µg) is shipped with dry ice or equivalent. Upon receipt, store it immediately at -20 to -70 °C. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Scientific Data
Recombinant Human TNF-alpha (Catalog # 210-TA) has a molecular weight (MW) of 53.1 kDa as analyzed by SEC-MALS, suggesting that this protein is a homotrimer. MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).
Recombinant Human TNF-alpha (Catalog # 210‑TA) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is 25‑100 pg/mL.
1 µg/lane of Recombinant Human TNF-alpha was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.
Reconstitution Calculator
Background: TNF-alpha
Tumor necrosis factor alpha (TNF-alpha ), also known as cachectin and TNFSF2, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (1, 2). Human TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD) (3). Within the ECD, human TNF-alpha shares 97% aa sequence identity with rhesus and 71%-92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-alpha. TNF-alpha is produced by a wide variety of immune, epithelial, endothelial, and tumor cells (1, 2). TNF-alpha is assembled intracellularly to form a noncovalently linked homotrimer which is expressed on the cell surface (4). Cell surface TNF-alpha can induce the lysis of neighboring tumor cells and virus infected cells, and it can generate its own downstream cell signaling following ligation by soluble TNFR I (2, 5). Shedding of membrane bound TNF-alpha by TACE/ADAM17 releases the bioactive cytokine, a 55 kDa soluble trimer of the TNF-alpha extracellular domain (6-8). TNF-alpha binds the ubiquitous 55-60 kDa TNF RI (9, 10) and the hematopoietic cell-restricted 80 kDa TNF RII (11, 12), both of which are also expressed as homotrimers (1, 2, 13). Both type I and type II receptors bind TNF-alpha with comparable affinity (14), although only TNF RI contains a cytoplasmic death domain which triggers the activation of apoptosis. Soluble forms of both types of receptors are released and can neutralize the biological activity of TNF-alpha (15).
- Zelova, H. and J. Hosek (2013) Inflamm. Res. 62:641.
- Juhasz, K. et al. (2013) Expert Rev. Clin. Immunol. 9:335.
- Pennica, D. et al. (1984) Nature 312:724.
- Tang, P. et al. (1996) Biochemistry 35:8216.
- Perez, C. et al. (1990) Cell 63:251.
- Black, R.A. et al. (1997) Nature 385:729.
- Moss, M.L. et al. (1997) Nature 385:733.
- Gearing, A.J.H. et al. (1994) Nature 370:555.
- Schall, T.J. et al. (1990) Cell 61:361.
- Loetscher, H. et al. (1990) Cell 61:351.
- Dembic, Z. et al. (1990) Cytokine 2:231.
- Smith, C.A. et al. (1990) Science 248:1019.
- Loetscher, H. et al. (1991) J. Biol. Chem. 266:18324.
- Pinckard, J.K. et al. (1997) J. Biol. Chem. 272:10784.
- Engelmann, H. et al. (1990) J. Biol. Chem. 265:1531.
Citations for Recombinant Human TNF-alpha Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
811
Citations: Showing 1 - 10
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Tuberculosis in otherwise healthy adults with inherited TNF deficiency
Authors: Arias, AA;Neehus, AL;Ogishi, M;Meynier, V;Krebs, A;Lazarov, T;Lee, AM;Arango-Franco, CA;Yang, R;Orrego, J;Corcini Berndt, M;Rojas, J;Li, H;Rinchai, D;Erazo-Borrás, L;Han, JE;Pillay, B;Ponsin, K;Chaldebas, M;Philippot, Q;Bohlen, J;Rosain, J;Le Voyer, T;Janotte, T;Amarajeeva, K;Soudée, C;Brollo, M;Wiegmann, K;Marquant, Q;Seeleuthner, Y;Lee, D;Lainé, C;Kloos, D;Bailey, R;Bastard, P;Keating, N;Rapaport, F;Khan, T;Moncada-Vélez, M;Carmona, MC;Obando, C;Alvarez, J;Cataño, JC;Martínez-Rosado, LL;Sanchez, JP;Tejada-Giraldo, M;L'Honneur, AS;Agudelo, ML;Perez-Zapata, LJ;Arboleda, DM;Alzate, JF;Cabarcas, F;Zuluaga, A;Pelham, SJ;Ensser, A;Schmidt, M;Velásquez-Lopera, MM;Jouanguy, E;Puel, A;Krönke, M;Ghirardello, S;Borghesi, A;Pahari, S;Boisson, B;Pittaluga, S;Ma, CS;Emile, JF;Notarangelo, LD;Tangye, SG;Marr, N;Lachmann, N;Salvator, H;Schlesinger, LS;Zhang, P;Glickman, MS;Nathan, CF;Geissmann, F;Abel, L;Franco, JL;Bustamante, J;Casanova, JL;Boisson-Dupuis, S;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
EGFR inhibits TNF-?-mediated pathway by phosphorylating TNFR1 at tyrosine 360 and 401
Authors: Nam, YW;Shin, JH;Kim, S;Hwang, CH;Lee, CS;Hwang, G;Kim, HR;Roe, JS;Song, J;
Cell death and differentiation
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Select DYRK1A Inhibitors Enhance Both Proliferation and Differentiation in Human Pancreatic Beta Cells
Authors: Wang, P;Wood, O;Choleva, L;Liu, H;Karakose, E;Lambertini, L;Pillard, A;Wu, V;Garcia-Ocana, A;Scott, DK;Kumar, K;DeVita, RJ;Stewart, AF;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Authors: Cacho-Navas, C;López-Pujante, C;Reglero-Real, N;Colás-Algora, N;Cuervo, A;Conesa, JJ;Barroso, S;de Rivas, G;Ciordia, S;Paradela, A;D'Agostino, G;Manzo, C;Feito, J;Andrés, G;Molina-Jiménez, F;Majano, P;Correas, I;Carazo, JM;Nourshargh, S;Huch, M;Millán, J;
eLife
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Necroptosis blockade prevents lung injury in severe influenza
Authors: Gautam, A;Boyd, DF;Nikhar, S;Zhang, T;Siokas, I;Van de Velde, LA;Gaevert, J;Meliopoulos, V;Thapa, B;Rodriguez, DA;Cai, KQ;Yin, C;Schnepf, D;Beer, J;DeAntoneo, C;Williams, RM;Shubina, M;Livingston, B;Zhang, D;Andrake, MD;Lee, S;Boda, R;Duddupudi, AL;Crawford, JC;Vogel, P;Loch, C;Schwemmle, M;Fritz, LC;Schultz-Cherry, S;Green, DR;Cuny, GD;Thomas, PG;Degterev, A;Balachandran, S;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis
Authors: Caratis, F;Opie?ka, M;Hausmann, M;Velasco-Estevez, M;Rojek, B;de Vallière, C;Seuwen, K;Rogler, G;Karaszewski, B;Rutkowska, A;
PloS one
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB dependent IFITM3 expression
Authors: Munir, M;Embry, A;Doench, JG;Heaton, NS;Wilen, CB;Orchard, RC;
The Journal of biological chemistry
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay -
Logical design of synthetic cis-regulatory DNA for genetic tracing of cell identities and state changes
Authors: Company, C;Schmitt, MJ;Dramaretska, Y;Serresi, M;Kertalli, S;Jiang, B;Yin, JA;Aguzzi, A;Barozzi, I;Gargiulo, G;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
VEXAS syndrome is characterized by inflammasome activation and monocyte dysregulation
Authors: Kosmider, O;Possémé, C;Templé, M;Corneau, A;Carbone, F;Duroyon, E;Breillat, P;Chirayath, TW;Oules, B;Sohier, P;Luka, M;Gobeaux, C;Lazaro, E;Outh, R;Le Guenno, G;Lifermann, F;Berleur, M;Le Mene, M;Friedrich, C;Lenormand, C;Weitten, T;Guillotin, V;Burroni, B;Boussier, J;Willems, L;Aractingi, S;Dionet, L;Tharaux, PL;Vergier, B;Raynaud, P;Ea, HK;Ménager, M;Duffy, D;Terrier, B;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BAFF deficiency aggravated optic nerve crush-induced retinal ganglion cells damage by regulating apoptosis and neuroinflammation via NF-?B-I?B? signaling
Authors: Lin, J;Deng, W;Liao, J;Ke, D;Cui, L;Zhong, H;Huang, K;Jiang, L;Chen, Q;Xu, F;Tang, F;
International immunopharmacology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of the cAMP-PKA-NF-?B pathway in Mucin1 over-expression in A549 cells during Respiratory syncytial virus infection
Authors: Jin, Y;Zhang, D;Deng, K;Wu, P;Yang, D;Xie, Z;Qiu, W;Yu, G;
BMC infectious diseases
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis
Authors: Kang, P;Dong, P;
International immunopharmacology
Species: Human
Sample Types:
Applications: Cell Culture -
Effects of tumor necrosis factor-? and interleukin-1? on human retinal endothelial cells
Authors: Barros Ferreira, L;Ashander, LM;Ma, Y;Appukuttan, B;Williams, KA;Best, G;Smith, JR;
Cytokine
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
CD40 Ligand-CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy
Authors: Abu El-Asrar, AM;Nawaz, MI;Ahmad, A;Dillemans, L;Siddiquei, M;Allegaert, E;Gikandi, PW;De Hertogh, G;Opdenakker, G;Struyf, S;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts
Authors: Wright, CW;Li, N;Shaffer, L;Hill, A;Boyer, N;Alves, SE;Venkataraman, S;Biswas, K;Lieberman, LA;Mohammadi, S;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB
Authors: Munir, M;Embry, A;Doench, JG;Heaton, NS;Wilen, CB;Orchard, RC;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils
Authors: Britt, EC;Qing, X;Votava, JA;Lika, J;Wagner, A;Shen, S;Arp, NL;Khan, H;Schieke, SM;Fletcher, CD;Huttenlocher, A;Fan, J;
bioRxiv : the preprint server for biology
Species: Human
Sample Types:
Applications: Cell Culture -
Characterization and optimization of variability in a human colonic epithelium culture model
Authors: Pike, CM;Zwarycz, B;McQueen, BE;Castillo, M;Barron, C;Morowitz, JM;Levi, JA;Phadke, D;Balik-Meisner, M;Mav, D;Shah, R;Glasspoole, DLC;Laetham, R;Thelin, W;Bunger, MK;Boazak, EM;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-1 protects the endothelium in acute lung injury
Authors: Korde, A;Haslip, M;Pednekar, P;Khan, A;Chioccioli, M;Mehta, S;Lopez-Giraldez, F;Bermejo, S;Rojas, M;Dela Cruz, C;Matthay, MA;Pober, JS;Pierce, RW;Takyar, SS;
JCI insight
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells
Authors: Yoshida, K;Suzuki, S;Yuan, H;Sato, A;Hirata-Tsuchiya, S;Saito, M;Yamada, S;Shiba, H;
Scientific reports
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Human cardiovascular disease model predicts xanthine oxidase inhibitor cardiovascular risk
Authors: Feaver, RE;Bowers, MS;Cole, BK;Hoang, S;Lawson, MJ;Taylor, J;LaMoreaux, BD;Zhao, L;Henke, BR;Johns, BA;Nyborg, AC;Wamhoff, BR;Figler, RA;
PloS one
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
AAV-Mediated Targeting of the Activin A-ACVR1R206H Signaling in Fibrodysplasia Ossificans Progressiva
Authors: Yang, YS;Lin, C;Ma, H;Xie, J;Kaplan, FS;Gao, G;Shim, JH;
Biomolecules
Species: Human, Transgenic Mouse
Sample Types: Transduced Whole Cells, Whole Cells
Applications: Bioassay -
TNF? induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
Authors: Twarog, M;Schustak, J;Xu, Y;Coble, M;Dolan, K;Esterberg, R;Huang, Q;Saint-Geniez, M;Bao, Y;
Scientific reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Repurposing Fc gamma receptor I (Fc?RI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -?)
Authors: Çapk?n, E;Kutlu, A;Yüce, M;
Heliyon
Species: N/A
Sample Types: Recombinant Protein
Applications: Bioassay -
Acylation of MLKL impacts its function in necroptosis
Authors: Pradhan, AJ;Chitkara, S;Ramirez, RX;Monje-Galvan, V;Sancak, Y;Atilla-Gokcumen, GE;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory effects of Arnica montana (mother tincture and homeopathic dilutions) in various cell models
Authors: Verre, J;Boisson, M;Paumier, A;Tribolo, S;Boujedaini, N;
Journal of ethnopharmacology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plug-and-play protein biosensors using aptamer-regulated in vitro transcription
Authors: Lee, H;Xie, T;Yu, X;Schaffter, SW;Schulman, R;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction
Authors: Shimizu, K;Kikuta, J;Ohta, Y;Uchida, Y;Miyamoto, Y;Morimoto, A;Yari, S;Sato, T;Kamakura, T;Oshima, K;Imai, R;Liu, YC;Okuzaki, D;Hara, T;Motooka, D;Emoto, N;Inohara, H;Ishii, M;
Nature communications
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
IMT504 protects beta cells against apoptosis and maintains beta cell identity, without modifying proliferation
Authors: Converti, A;Bianchi, MS;Martinez, MD;Montaner, AD;Lux-Lantos, V;Bonaventura, MM;
Physiological reports
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity
Authors: Boys, IN;Johnson, AG;Quinlan, MR;Kranzusch, PJ;Elde, NC;
Cell reports
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Authors: Xu, D;Jiang, W;Wu, L;Gaudet, RG;Park, ES;Su, M;Cheppali, SK;Cheemarla, NR;Kumar, P;Uchil, PD;Grover, JR;Foxman, EF;Brown, CM;Stansfeld, PJ;Bewersdorf, J;Mothes, W;Karatekin, E;Wilen, CB;MacMicking, JD;
Nature
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis
Authors: Ma, F;Plazyo, O;Billi, AC;Tsoi, LC;Xing, X;Wasikowski, R;Gharaee-Kermani, M;Hile, G;Jiang, Y;Harms, PW;Xing, E;Kirma, J;Xi, J;Hsu, JE;Sarkar, MK;Chung, Y;Di Domizio, J;Gilliet, M;Ward, NL;Maverakis, E;Klechevsky, E;Voorhees, JJ;Elder, JT;Lee, JH;Kahlenberg, JM;Pellegrini, M;Modlin, RL;Gudjonsson, JE;
Nature communications
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dynamics of Ex Vivo Mesenchymal Stromal Cell Potency under Continuous Perfusion
Authors: Doshi, A;Erickson, P;Teryek, M;Parekkadan, B;
International journal of molecular sciences
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation
Authors: Hong, SG;Ashby, JW;Kennelly, JP;Wu, M;Chattopadhyay, E;Foreman, R;Tontonoz, P;Turowski, P;Gallagher-Jones, M;Mack, JJ;
bioRxiv : the preprint server for biology
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4+ T cell arrest on the inflamed BBB under flow in vitro
Authors: Soldati, S;B�r, A;Vladymyrov, M;Glavin, D;McGrath, JL;Gosselet, F;Nishihara, H;Goelz, S;Engelhardt, B;
Journal of neuroinflammation
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis
Authors: Stavre, Z;Kim, JM;Yang, YS;N�ndel, K;Chaugule, S;Sato, T;Park, KH;Gao, G;Gravallese, EM;Shim, JH;
Proceedings of the National Academy of Sciences of the United States of America
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Altered Functionality of Lipoprotein(a) Impacts on Angiogenesis in Diabetic Retinopathy
Authors: Shariatzadeh, M;Nagtzaam, NMA;van Vark-van der Zee, L;van Holten-Neelen, C;Verhoeven, AJM;Dehairs, J;Swinnen, JV;Leijten, F;Ten Berge, JC;Ciriano, JPM;Wong, KT;Mulder, M;Leenen, PJM;Dik, WA;
Investigative ophthalmology & visual science
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells
Authors: M Krizanac, PB Mass Sanch, SK Schröder, R Weiskirche, A Asimakopou
International Journal of Molecular Sciences, 2023-04-13;24(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Primary role of type I interferons for the induction of functionally optimal antigen-specific CD8+ T cells in HIV infection
Authors: MP Cabral-Pic, L Papagno, X Lahaye, F Perdomo-Ce, S Volant, E White, V Monceaux, S Llewellyn-, R Fromentin, DA Price, N Chomont, N Manel, A Saez-Cirio, V Appay
EBioMedicine, 2023-04-12;91(0):104557.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells
Authors: P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner
Heliyon, 2023-04-10;9(4):e15202.
Species: Porcine
Sample Types: Whole Cells
Applications: Cell Culture -
Pomegranate Extract Affects Gut Biofilm Forming Bacteria and Promotes Intestinal Mucosal Healing Regulating the Crosstalk between Epithelial Cells and Intestinal Fibroblasts
Authors: G Rizzo, SE Pineda Cha, E Vandenkoor, CL Cárdenas R, V Cento, V Garlatti, M Wozny, G Sammarco, A Di Claudio, L Meanti, S Elangovan, A Romano, G Roda, L Loy, A Dal Buono, R Gabbiadini, S Lovisa, R Rusconi, A Repici, A Armuzzi, S Vetrano
Nutrients, 2023-04-05;15(7):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses
Authors: IN Boys, AG Johnson, M Quinlan, PJ Kranzusch, NC Elde
bioRxiv : the preprint server for biology, 2023-04-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
SARS-CoV-2 ORF3a positively regulates NF-kappaB activity by enhancing IKKbeta-NEMO interaction
Authors: Y Nie, L Mou, Q Long, D Deng, R Hu, J Cheng, J Wu
Virus research, 2023-03-13;328(0):199086.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of Endothelial Large Conductance Potassium Channels Protects against TNF-alpha-Induced Inflammation
Authors: T Zyrianova, K Zou, B Lopez, A Liao, C Gu, R Olcese, A Schwingsha
International Journal of Molecular Sciences, 2023-02-17;24(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Authors: DI Cho, MJ Ahn, HH Cho, M Cho, JH Jun, BG Kang, SY Lim, SJ Yoo, MR Kim, HS Kim, SJ Lee, LT Dat, C Lee, YS Kim, Y Ahn
Experimental & Molecular Medicine, 2023-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
Authors: F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber
bioRxiv : the preprint server for biology, 2023-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis
Authors: J Nassour, LG Aguiar, A Correia, TT Schmidt, L Mainz, S Przetocka, C Haggblom, N Tadepalle, A Williams, MN Shokhirev, SC Akincilar, V Tergaonkar, GS Shadel, J Karlseder
Nature, 2023-02-08;614(7949):767-773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TGF-Beta Induces Activin A Production in Dermal Fibroblasts Derived from Patients with Fibrodysplasia Ossificans Progressiva
Authors: RD de Ruiter, LE Wisse, T Schoenmake, M Yaqub, G Sánchez-Du, EMW Eekhoff, D Micha
International Journal of Molecular Sciences, 2023-01-24;24(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fructose-1,6-bisphosphatase 1 dephosphorylates IkappaBalpha and suppresses colorectal tumorigenesis
Authors: W Zhu, H Chu, Y Zhang, T Luo, H Yu, H Zhu, Y Liu, H Gao, Y Zhao, Q Li, X Wang, G Li, W Yang
Cell Research, 2023-01-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells
Authors: P Dörschmann, C Seeba, T Thalenhors, J Roider, A Klettner
Heliyon, 2023;9(4):e15202.
Species: Porcine
Sample Types: Whole Cells
Applications: Cell Culture -
NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes
Authors: DR Calabrese, T Tsao, M Magnen, C Valet, Y Gao, B Mallavia, JJ Tian, EA Aminian, KM Wang, A Shemesh, EB Punzalan, A Sarma, CS Calfee, SA Christenso, CR Langelier, SR Hays, JA Golden, LE Leard, ME Kleinhenz, NA Kolaitis, RJ Shah, A Venado, LL Lanier, JR Greenland, DM Sayah, A Ardehali, J Kukreja, SS Weigt, JA Belperio, JP Singer, MR Looney
JCI Insight, 2022-12-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Novel Cortisol Immunosensor Based on a Hafnium Oxide/Silicon Structure for Heart Failure Diagnosis
Authors: H Ben Halima, N Zine, J Bausells, N Jaffrezic-, A Errachid
Micromachines, 2022-12-16;13(12):.
Species: Human
Sample Types: Recombinanat Protein
Applications: Bioassay -
Intestinal epithelial BLT1 promotes mucosal repair
Authors: S Hayashi, CK Muraleedha, M Oku, S Tomar, SP Hogan, M Quiros, CA Parkos, A Nusrat
JCI Insight, 2022-12-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Blood serum analysis: A modified sandwich enzyme-linked immunosorbent assay protocol
Authors: D Cai, M Fraunfelde, SY Chen
MethodsX, 2022-11-22;9(0):101923.
Species: Human
Sample Types: Serum
Applications: ELISA Control -
Dienogest May Reduce Estradiol- and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture- and Mouse Model-Based Study
Authors: HJ Kim, SH Kim, YS Oh, SR Lee, HD Chae
Biomedicines, 2022-11-21;10(11):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Anti-inflammatory and pro-anabolic effects of 5-aminosalicylic acid on human inflammatory osteoarthritis models
Authors: K Li, Y Zhu, P Zhang, M Alini, S Grad, Z Li
Journal of Orthopaedic Translation, 2022-10-29;38(0):106-116.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
In Vitro Characterization of a Tissue Renin-Angiotensin System in Human Nucleus Pulposus Cells
Authors: B Saravi, Z Li, V Basoli, S Grad, S Häckel, CE Albers, M Alini, H Schmal, P Obid, G Lang
Cells, 2022-10-28;11(21):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting hypoxia-induced tumor stemness by activating pathogen-induced stem cell niche defense.
Authors: Bhuyan S, Pal B, Pathak L, Saikia P, Mitra S, Gayan S, Mokhtari R, Li H, Ramana C, Baishya D, Das B
Front Immunol, 2022-09-29;13(0):933329.
Species: Complex Species Category
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine responsive networks in human colonic epithelial organoids unveil a molecular classification of inflammatory bowel disease
Authors: P Pavlidis, A Tsakmaki, A Treveil, K Li, D Cozzetto, F Yang, U Niazi, BH Hayee, M Saqi, J Friedman, T Korcsmaros, G Bewick, N Powell
Cell Reports, 2022-09-27;40(13):111439.
Species: Human
Sample Types: Organoid
Applications: Bioassay -
Delayed regression of laser-induced choroidal neovascularization in TNFalpha-null mice
Authors: H Iwanishi, O Yamanaka, T Sumioka, S Yasuda, M Miyajima, S Saika
Journal of Cellular and Molecular Medicine, 2022-09-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Improved immunoassay sensitivity and specificity using single-molecule colocalization
Authors: AA Hariri, SS Newman, S Tan, D Mamerow, AM Adams, N Maganzini, BL Zhong, M Eisenstein, AR Dunn, HT Soh
Nature Communications, 2022-09-12;13(1):5359.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
Science Advances, 2022-08-24;8(34):eabn5522.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
STUB1 is an intracellular checkpoint for interferon gamma sensing
Authors: S Ng, S Lim, ACN Sim, R Mangadu, A Lau, C Zhang, SB Martinez, A Chandramoh, UM Lim, SSW Ho, SC Chang, P Gopal, LZ Hong, A Schwaid, AZ Fernandis, A Loboda, C Li, U Phan, B Henry, AW Partridge
Scientific Reports, 2022-08-18;12(1):14087.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins
Authors: V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck
International Journal of Molecular Sciences, 2022-08-17;23(16):.
Species: Human
Sample Types: Whole Cells
Applications: Stimulation -
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Authors: DC Humphries, R Mills, C Boz, BJ McHugh, N Hirani, AG Rossi, A Pedersen, HT Schambye, RJ Slack, H Leffler, UJ Nilsson, W Wang, T Sethi, AC Mackinnon
Frontiers in Pharmacology, 2022-08-08;13(0):949264.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Ralpha
Authors: Z Cai, S Tian, T Klein, L Tu, LW Geenen, T Koudstaal, AE van den Bo, YB de Rijke, IKM Reiss, E Boersma, C van der Le, M Van Faasse, I Kema, DJ Duncker, KA Boomars, K Tran-Lundm, C Guignabert, D Merkus
Scientific Reports, 2022-07-19;12(1):12326.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hypo-osmotic stress induces the epithelial alarmin IL-33 in the colonic barrier of ulcerative colitis
Authors: MD Gundersen, KB Larsen, KM Johnsen, R Goll, J Florholmen, G Haraldsen
Scientific Reports, 2022-07-07;12(1):11550.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
In vitro assessment of the anti-inflammatory and skin-moisturizing effects of Filipendula palmata (Pall.) Maxim. On human keratinocytes and identification of its bioactive phytochemicals
Authors: XJ Mi, JK Kim, S Lee, SK Moon, YJ Kim, H Kim
Journal of ethnopharmacology, 2022-07-07;296(0):115523.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Authors: S Wang, B Li, V Solomon, A Fonteh, SI Rapoport, DA Bennett, Z Arvanitaki, HC Chui, PM Sullivan, HN Yassine
Molecular Neurodegeneration, 2022-06-15;17(1):42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Membrane-Tethered Mucin 1 Is Stimulated by Interferon and Virus Infection in Multiple Cell Types and Inhibits Influenza A Virus Infection in Human Airway Epithelium
Authors: E Iverson, K Griswold, D Song, TB Gagliardi, K Hamidzadeh, M Kesimer, S Sinha, M Perry, GA Duncan, MA Scull
MBio, 2022-06-14;0(0):e0105522.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells
Authors: S Hong, EY Kim, SE Lim, JH Kim, Y Sohn, HS Jung
International Journal of Molecular Sciences, 2022-04-18;23(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Secreted NF-kappaB suppressive microbial metabolites modulate gut inflammation
Authors: R Giri, EC Hoedt, S Khushi, AA Salim, AS Bergot, V Schreiber, R Thomas, MA McGuckin, TH Florin, M Morrison, RJ Capon, P Ó Cuív, J Begun
Cell Reports, 2022-04-12;39(2):110646.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of probiotic Lactobacillus paracasei on tumor necrosis factor-alpha level in gingival crevicular fluid of patients undergoing impacted third molar removal
Authors: S Banjonjit, M Taweechoti, S Rungsiyano
Journal of oral science, 2022-04-08;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Standard -
The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells
Authors: P Sekhri, DK Ledezma, A Shukla, EE Sweeney, R Fernandes
Cancers, 2022-03-11;14(6):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Synoviocytes from pigmented villonodular synovitis are less sensitive to cadmium-induced cell death than synoviocytes from rheumatoid arthritis.
Authors: H Farese, Farese H, M Noack, Noack M, P Miossec
Sci Rep, 2022-03-09;12(1):3832.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus
Authors: D Stacey, L Chen, PJ Stanczyk, JMM Howson, AM Mason, S Burgess, S MacDonald, J Langdown, H McKinney, K Downes, N Farahi, JE Peters, S Basu, JS Pankow, W Tang, N Pankratz, M Sabater-Ll, PS de Vries, NL Smith, CHARGE Hem, AD Gelinas, DJ Schneider, N Janjic, NJ Samani, S Ye, C Summers, ER Chilvers, J Danesh, DS Paul
Nature Communications, 2022-03-09;13(1):1222.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Administration of probiotics to healthy volunteers: effects on reactivity of intestinal mucosa and systemic leukocytes
Authors: C Stene, A Röme, I Palmquist, C Linninge, G Molin, S Ahrné, LB Johnson, B Jeppsson
BMC gastroenterology, 2022-03-05;22(1):100.
Species: Human
Sample Types: Whole Tissue
Applications: Cell Culture -
5,8-Dihydroxy-4 ', 7-dimethoxyflavone Attenuates TNF-alpha-Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKCalpha/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts
Authors: CC Yang, LD Hsiao, YF Shih, HH Lin, CM Yang
Oxidative Medicine and Cellular Longevity, 2022-03-04;2022(0):1372958.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling
Authors: C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu
Redox Biology, 2022-02-24;51(0):102274.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MG132 Induces Progerin Clearance and Improves Disease Phenotypes in HGPS-like Patients' Cells
Authors: K Harhouri, P Cau, F Casey, KM Guedenon, Y Doubaj, L Van Malder, G Mejia-Balt, C Bartoli, A De Sandre-, N Lévy
Cells, 2022-02-10;11(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of the Na+/K+-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation
Authors: MA Shandell, AL Capatina, SM Lawrence, WJ Brackenbur, D Lagos
The Journal of Biological Chemistry, 2022-02-09;0(0):101707.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble PD-L1 through alternative polyadenylation works as a decoy in lung cancer immunotherapy
Authors: R Sagawa, S Sakata, B Gong, Y Seto, A Takemoto, S Takagi, H Ninomiya, N Yanagitani, M Nakao, M Mun, K Uchibori, M Nishio, Y Miyazaki, Y Shiraishi, S Ogawa, K Kataoka, N Fujita, K Takeuchi, R Katayama
JCI Insight, 2022-01-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation
Authors: AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf
Frontiers in Physiology, 2022-01-10;12(0):807747.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-kappaB activation
Authors: JJ Lenoir, JP Parisien, CM Horvath
Cell Reports, 2021-12-28;37(13):110175.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1
Authors: Y Hu, H Zhang, N Xie, D Liu, Y Jiang, Z Liu, D Ye, S Liu, X Chen, C Li, Q Wang, X Huang, Y Liu, Y Shi, X Zhang
Cell Death and Differentiation, 2021-12-01;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Bioassay -
CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction
Authors: L Toma, T Barb?lat?, GM Sanda, LS Niculescu, AV Sima, CS Stancu
Biomolecules, 2021-11-25;11(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets
Authors: A Fu, L van Rooyen, L Evans, N Armstrong, D Avizonis, T Kin, GH Bird, A Reddy, ET Chouchani, M Liesa-Roig, LD Walensky, AMJ Shapiro, NN Danial
Cell Reports, 2021-11-23;37(8):110037.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Demystifying the long noncoding RNA landscape of small EVs derived from human mesenchymal stromal cells
Authors: CW Lee, YF Chen, AW Hsiao, AY Wang, OY Shen, BY Wang, LWC Ho, WT Lin, CHJ Choi, OK Lee
Journal of advanced research, 2021-11-19;39(0):73-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-kappaB signaling
Authors: C Xu, J Tang, Q Yang, H Zhao, Y Liu, J Cao, Y Zhou, X Chen, J Chen
The Journal of Biological Chemistry, 2021-11-03;0(0):101380.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients
Authors: M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass
Molecular and Cellular Biology, 2021-11-01;0(0):MCB0046721.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Novel cytoplasmic lncRNA IKBKBAS promotes lung adenocarcinoma metastasis by upregulating IKKbeta and consequential activation of NF-kappaB signaling pathway
Authors: Y Xing, Y Lin, Y Zhang, J Hu, J Liu, Y Tian, J Zhao, W Chen, B Han
Cell Death & Disease, 2021-10-26;12(11):1004.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Diverse inflammatory threats modulate astrocytes Ca2+ signaling via connexin43 hemichannels in organotypic spinal slices
Authors: G Panattoni, R Amoriello, C Memo, A Thalhammer, C Ballerini, L Ballerini
Molecular Brain, 2021-10-25;14(1):159.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris
Authors: S Shao, J Chen, WR Swindell, LC Tsoi, X Xing, F Ma, R Uppala, MK Sarkar, O Plazyo, AC Billi, R Wasikowski, KM Smith, P Honore, VE Scott, E Maverakis, JM Kahlenberg, G Wang, NL Ward, PW Harms, JE Gudjonsson
JCI Insight, 2021-10-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiotensin II-Induced Long Non-Coding RNA Alivec Regulates Chondrogenesis in Vascular Smooth Muscle Cells
Authors: VA Samara, S Das, MA Reddy, VS Tanwar, K Stapleton, A Leung, M Abdollahi, R Ganguly, L Lanting, R Natarajan
Cells, 2021-10-09;10(10):.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture -
Fundamentally different roles of neuronal TNF receptors in CNS pathology: TNFR1 and IKKbeta promote microglial responses and tissue injury in demyelination while TNFR2 protects against excitotoxicity in mice
Authors: I Papazian, E Tsoukala, A Boutou, M Karamita, K Kambas, L Iliopoulou, R Fischer, RE Kontermann, MC Denis, G Kollias, H Lassmann, L Probert
Journal of Neuroinflammation, 2021-09-26;18(1):222.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TNF-alpha Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways
Authors: S Kochumon, A Al-Sayyar, T Jacob, A Hasan, F Al-Mulla, S Sindhu, R Ahmad
Biomolecules, 2021-09-13;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Correction: Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome
Authors: S Vangeti, T Strandin, S Liu, J Tauriainen, A Räisänen-S, LE Cabrera, A Hassinen, S Mäkelä, J Mustonen, A Vaheri, O Vapalahti, J Klingström, A Smed-Sören
PloS Pathogens, 2021-08-25;17(8):e1009876.
Species: Human
Sample Types:
Applications: Bioassay -
Pro-inflammatory beta cell small extracellular vesicles induce beta cell failure through activation of the CXCL10/CXCR3 axis in diabetes
Authors: N Javeed, TK Her, MR Brown, P Vanderboom, K Rakshit, AM Egan, A Vella, I Lanza, AV Matveyenko
Cell Reports, 2021-08-24;36(8):109613.
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation -
Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model
Authors: T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker
Scientific Reports, 2021-08-23;11(1):17028.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
Authors: R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini
Nature Communications, 2021-07-27;12(1):4559.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis
Authors: S Honda, K Ikeda, R Urata, E Yamazaki, N Emoto, S Matoba
Scientific Reports, 2021-07-16;11(1):14608.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-378a-3p is overexpressed in psoriasis and modulates cell cycle arrest in keratinocytes via targeting BMP2 gene
Authors: W Soonthornc, P Tangtanata, K Meesilpavi, V Dalm, P Kueanjinda, J Wongpiyabo
Scientific Reports, 2021-07-09;11(1):14186.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Protective effects of the knockdown of lncRNA AK139328 against oxygen glucose deprivation/reoxygenation-induced injury in PC12 cells
Authors: L Liu, B Zheng, Z Wang
Molecular Medicine Reports, 2021-07-02;24(3):.
Species: Rat
Sample Types: Cell Culture Supernates
-
CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy
Authors: AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker
Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transdifferentiation of Human Fibroblasts into Skeletal Muscle Cells: Optimization and Assembly into Engineered Tissue Constructs through Biological Ligands
Authors: KMA Abdel-Raou, R Rezgui, C Stefanini, JCM Teo, N Christofor
Biology, 2021-06-16;10(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lung macrophages drive mucus production and steroid-resistant inflammation in chronic bronchitis
Authors: K Andelid, K Öst, A Andersson, E Mohamed, Z Jevnikar, LEGW Vanfletere, M Göransson
Respiratory Research, 2021-06-07;22(1):172.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Induction of OCT2 contributes to regulate the gene expression program in human neutrophils activated via TLR8
Authors: N Tamassia, F Bianchetto, S Gasperini, S Polletti, E Gardiman, R Ostuni, G Natoli, MA Cassatella
Cell Reports, 2021-05-18;35(7):109143.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells
Authors: S Yan, Q Li, D Zhang, X Wang, Y Xu, C Zhang, D Guo, Y Bao
American journal of cancer research, 2021-05-15;11(5):2062-2080.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RIPK1 activation mediates neuroinflammation and disease progression in multiple sclerosis
Authors: M Zelic, F Pontarelli, L Woodworth, C Zhu, A Mahan, Y Ren, M LaMorte, R Gruber, A Keane, P Loring, L Guo, TH Xia, B Zhang, P Orning, E Lien, A Degterev, T Hammond, D Ofengeim
Cell Reports, 2021-05-11;35(6):109112.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IkB
Authors: B Galinski, M Luxemburg, Y Landesman, B Pawel, KJ Johnson, SR Master, KW Freeman, DM Loeb, JM Hébert, DA Weiser
Translational Oncology, 2021-05-09;14(8):101114.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4
Authors: S Wang, B Li, V Solomon, A Fonteh, SI Rapoport, DA Bennett, Z Arvanitaki, HC Chui, C Miller, PM Sullivan, HY Wang, HN Yassine
Molecular Neurodegeneration, 2021-04-16;16(1):26.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell-Derived RPE
Authors: SR Sripathi, MW Hu, MM Liu, J Wan, J Cheng, Y Duan, JL Mertz, KJ Wahlin, J Maruotti, CA Berlinicke, J Qian, DJ Zack
Investigative Ophthalmology & Visual Science, 2021-04-01;62(4):1.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure
Authors: P Rueda, J Merlin, S Chimenti, M Feletou, J Paysant, PJ White, A Christopou, PM Sexton, RJ Summers, WN Charman, LT May, CJ Langmead
Frontiers in Pharmacology, 2021-03-11;12(0):628060.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
LL-37-mediated activation of host receptors is critical for defense against group A streptococcal infection
Authors: D Biswas, P Ambalavana, M Ravins, A Anand, A Sharma, KXZ Lim, RYM Tan, HY Lim, A Sol, G Bachrach, V Angeli, E Hanski
Cell Reports, 2021-03-02;34(9):108766.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm
Authors: P Gao, P Gao, J Zhao, S Shan, W Luo, OJ Slivano, W Zhang, A Tabuchi, SA LeMaire, L Maegdefess, YH Shen, JM Miano, HA Singer, X Long
Redox Biology, 2021-02-20;41(0):101903.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ABIN-1 is a key regulator in RIPK1-dependent apoptosis (RDA) and necroptosis, and ABIN-1 deficiency potentiates necroptosis-based cancer therapy in colorectal cancer
Authors: J Cai, D Hu, J Sakya, T Sun, D Wang, L Wang, X Mao, Z Su
Cell Death & Disease, 2021-02-01;12(2):140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The inflammatory kinase IKK&alpha phosphorylates and stabilizes c-Myc and enhances its activity
Authors: B Moser, B Hochreiter, J Basílio, V Gleitsmann, A Panhuber, A Pardo-Garc, B Hoesel, M Salzmann, U Resch, M Noreen, JA Schmid
Molecular Cancer, 2021-01-18;20(1):16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes
Authors: TM Garcia-Bat, ML Palma, RR Anderko, DC Hsu, J Ananworani, BT Korber, GD Gaiha, N Phanuphak, R Thomas, S Tovanabutr, BD Walker, JW Mellors, PA Piazza, E Kroon, SA Riddler, NL Michael, CR Rinaldo, RB Mailliard, I4C and RV
EBioMedicine, 2021-01-12;63(0):103175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial ERp72 is involved in the inflammatory response in a rat model of skeletal muscle injury
Authors: NB Khalaf, D Al-?ehatab, DM Fathallah
Molecular Medicine Reports, 2021-01-05;23(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
Authors: J Stebbing, G Sánchez Ni, M Falcone, S Youhanna, P Richardson, S Ottaviani, JX Shen, C Sommerauer, G Tiseo, L Ghiadoni, A Virdis, F Monzani, LR Rizos, F Forfori, A Avendaño-C, S De Marco, L Carrozzi, F Lena, PM Sánchez-Ju, LG Lacerenza, N Cesira, D Caldevilla, A Perrella, L Niccoli, LS Méndez, D Matarrese, D Goletti, YJ Tan, V Monteil, G Dranitsari, F Cantini, A Farcomeni, S Dutta, SK Burley, H Zhang, M Pistello, W Li, M Mas Romero, F Andrés Pre, RS Simón-Tale, R García-Mol, C Kutter, JH Felce, ZF Nizami, AG Miklosi, JM Penninger, F Menichetti, A Mirazimi, P Abizanda, VM Lauschke
Sci Adv, 2021-01-01;0(0):.
Species: Human
Sample Types: Spheroid
Applications: Spheroid Culture -
Acadesine suppresses TNF-&alpha induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells
Authors: NE Efstathiou, GA Moustafa, DE Maidana, EK Konstantin, S Notomi, PRT Barbisan, CD Georgakopo, JW Miller, DG Vavvas
PLoS ONE, 2020-12-23;15(12):e0244307.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway
Authors: Q Dai, Y Zhang, X Liao, Y Jiang, X Lv, X Yuan, J Meng, Y Xie, Z Peng, Q Yuan, L Tao, L Huang
Frontiers in Pharmacology, 2020-12-16;11(0):534775.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation
Authors: A Dorronsoro, V Lang, I Ferrin, J Fernández-, L Zabaleta, E Pérez-Ruiz, P Sepúlveda, C Trigueros
Scientific Reports, 2020-12-14;10(1):21853.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus
Authors: V Simion, H Zhou, S Haemmig, JB Pierce, S Mendes, Y Tesmenitsk, D Pérez-Crem, JF Lee, AF Chen, N Ronda, B Papotti, JA Marto, MW Feinberg
Nature Communications, 2020-12-01;11(1):6135.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Red-COLA1: a human fibroblast reporter cell line for type I collagen transcription
Authors: HH Wong, SH Seet, CC Bascom, RJ Isfort, F Bard
Sci Rep, 2020-11-12;10(1):19723.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
CD4 T-cell immune stimulation of HER2?+?breast cancer cells alters response to trastuzumab in vitro
Authors: PN Song, A Mansur, KJ Dugger, TR Davis, G Howard, TE Yankeelov, AG Sorace
Cancer Cell International, 2020-11-10;20(1):544.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
&beta-Catenin Regulates Wound Healing and IL-6 Expression in Activated Human Astrocytes
Authors: VV Edara, S Nooka, J Proulx, S Stacy, A Ghorpade, K Borgmann
Biomedicines, 2020-11-06;8(11):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Relative Deficiency of Anti-Inflammatory N-Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus
Authors: L Rankin, S Gouveia-Fi, KP Danielsson, CJ Fowler
Biomedicines, 2020-11-06;8(11):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Preclinical validation of therapeutic targets predicted by tensor factorization on heterogeneous graphs
Authors: S Paliwal, A de Giorgio, D Neil, JB Michel, AM Lacoste
Sci Rep, 2020-10-26;10(1):18250.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG
Authors: K Landgraf, N Klöting, M Gericke, N Maixner, E Guiu-Jurad, M Scholz, AV Witte, F Beyer, JT Schwartze, M Lacher, A Villringer, P Kovacs, A Rudich, M Blüher, W Kiess, A Körner
Cell Rep, 2020-10-20;33(3):108295.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1
Authors: F Al-Rashed, R Thomas, A Al-Roub, F Al-Mulla, R Ahmad
Molecules, 2020-10-14;25(20):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia
Authors: S Nagel, C Pommerenke, C Meyer, RAF MacLeod, HG Drexler
PLoS ONE, 2020-10-13;15(10):e0240120.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Stearic Acid and TNF-&alpha Co-Operatively Potentiate MIP-1&alpha Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway
Authors: S Kochumon, H Arefanian, R Azim, S Shenouda, T Jacob, N Abu Khalaf, F Al-Rashed, A Hasan, S Sindhu, F Al-Mulla, R Ahmad
Biomedicines, 2020-10-09;8(10):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation
Authors: EM Wilfong, R Croze, X Fang, M Schwede, E Niemi, GY López, JW Lee, MC Nakamura, MA Matthay
PLoS ONE, 2020-10-06;15(10):e0240319.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis
Authors: S Panigrahi, B Chen, M Fang, D Potashniko, AA Komissarov, A Lebedeva, GM Michaelson, JM Wyrick, SR Morris, SF Sieg, M Paiardini, FJ Villinger, K Harth, VS Kashyap, MJ Cameron, CM Cameron, E Vasilieva, L Margolis, SA Younes, NT Funderburg, DA Zidar, MM Lederman, ML Freeman
PLoS Pathog, 2020-09-25;16(9):e1008885.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Association of tricellulin expression with poor colorectal cancer prognosis and metastasis
Authors: JX Zhang, MB Qin, Z Ye, P Peng, SM Li, Q Song, L Lin, SQ Liu, LH Xie, Y Zhu, JA Huang
Oncology reports, 2020-09-17;44(5):2174-2184.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Circulating miRNAs Associated with Dysregulated Vascular and Trophoblast Function as Target-Based Diagnostic Biomarkers for Preeclampsia
Authors: S Kim, M Park, JY Kim, T Kim, JY Hwang, KS Ha, MH Won, S Ryoo, YG Kwon, YM Kim
Cells, 2020-08-31;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Expressions of TSLP, IL-33, and IL-17A in Monocyte Derived Dendritic Cells from Asthma and COPD Patients are Related to Epithelial-Macrophage Interactions
Authors: M Paplinska-, P Misiukiewi, M Proboszcz, P Nejman-Gry, K Gorska, R Krenke
Cells, 2020-08-22;9(9):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model
Authors: T Bluhmki, S Bitzer, JA Gindele, E Schruf, T Kiechle, M Webster, J Schymeinsk, R Ries, F Gantner, D Bischoff, J Garnett, R Heilker
Sci Rep, 2020-08-03;10(1):13022.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MIP-1alpha Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-alpha Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress
Authors: S Sindhu, N Akhter, A Wilson, R Thomas, H Arefanian, A Al Madhoun, F Al-Mulla, R Ahmad
Cells, 2020-07-29;9(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications
Authors: D Jian, Y Wang, L Jian, H Tang, L Rao, K Chen, Z Jia, W Zhang, Y Liu, X Chen, X Shen, C Gao, S Wang, M Li
Theranostics, 2020-07-11;10(20):8939-8956.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke
Authors: BH Clausen, M Wirenfeldt, SS Høgedal, LH Frich, HH Nielsen, HD Schrøder, K Østergaard, B Finsen, BW Kristensen, KL Lambertsen
Acta Neuropathol Commun, 2020-06-05;8(1):81.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Group V secreted phospholipase A2 plays a protective role against aortic dissection
Authors: K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami
J. Biol. Chem., 2020-06-01;295(30):10092-10111.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES)
Authors: MY Hsieh, JJ Lin, SH Hsia, JL Huang, KW Yeh, KW Chang, WI Lee
Biomed J, 2020-05-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor-&alpha regulates skeletal myogenesis by inhibiting SP1 interaction with cis-acting regulatory elements within the Fbxl2 gene promoter
Authors: ME O'Brien, J Londino, M McGinnis, N Weathingto, J Adair, T Suber, V Kagan, K Chen, C Zou, B Chen, J Bon, RK Mallampall
Mol. Cell. Biol., 2020-05-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Beclin 1 functions as a negative modulator of MLKL oligomerisation by integrating into the necrosome complex
Authors: J Seo, D Seong, YW Nam, CH Hwang, SR Lee, CS Lee, Y Jin, HW Lee, DB Oh, P Vandenabee, J Song
Cell Death Differ., 2020-05-26;0(0):.
Applications: Cell Culture -
Ultrasensitive digital quantification of cytokines and bacteria predicts septic shock outcomes
Authors: MF Abas?yan?k, K Wolfe, H Van Phan, J Lin, B Laxman, SR White, PA Verhoef, GM Mutlu, B Patel, S Tay
Nat Commun, 2020-05-25;11(1):2607.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the interleukin-17 effect on articular cartilage in a translational model: an explorative study
Authors: D Sinkeviciu, A Aspberg, Y He, AC Bay-Jensen, P Önnerfjord
BMC Rheumatol, 2020-05-12;4(0):30.
Species: Bovine
Sample Types: Whole Tissue
Applications: Bioassay -
Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins
Authors: RA Lu, AA Zeki, S Ram-Mohan, N Nguyen, Y Bai, K Chmiel, S Pecic, X Ai, R Krishnan, CC Ghosh
Front Pharmacol, 2020-05-06;11(0):469.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaB Signaling Pathway through Stabilization of p62
Authors: J Ha, M Kim, D Seo, JS Park, J Lee, J Lee, SH Park
Int J Mol Sci, 2020-04-28;21(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synergistic activation of NF-&kappaB by TNFAIP3 (A20) reduction and UBE2L3 (UBCH7) augment that synergistically elevate lupus risk
Authors: T Kim, SC Bae, C Kang
Arthritis Res. Ther., 2020-04-25;22(1):93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Baicalin Inhibits Cell Proliferation and Inflammatory Cytokines Induced by Tumor Necrosis Factor &alpha (TNF-&alpha) in Human Immortalized Keratinocytes (HaCaT) Human Keratinocytes by Inhibiting the STAT3/Nuclear Factor kappa B (NF-?B) Signaling Pathway
Authors: X Wu, X Deng, J Wang, Q Li
Med. Sci. Monit., 2020-04-23;26(0):e919392.
Species: Human
Sample Types: Whole Cells
-
Cellular Importin-&alpha3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection
Authors: S Thiele, S Stanelle-B, S Beck, NM Kouassi, M Zickler, M Müller, B Tuku, P Resa-Infan, D van Riel, M Alawi, T Günther, F Rother, S Hügel, S Reimering, A McHardy, A Grundhoff, W Brune, A Osterhaus, M Bader, E Hartmann, G Gabriel
Cell Rep, 2020-04-21;31(3):107549.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
M1-like macrophages are potent producers of anti-viral interferons and M1-associated marker-positive lung macrophages are decreased during rhinovirus-induced asthma exacerbations
Authors: A Nikonova, M Khaitov, DJ Jackson, S Traub, MB Trujillo-T, DA Kudlay, AS Dvornikov, A Del-Rosari, R Valenta, LA Stanciu, R Khaitov, SL Johnston
EBioMedicine, 2020-04-09;54(0):102734.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration
Authors: Y Wooff, N Fernando, JHC Wong, C Dietrich, R Aggio-Bruc, JA Chu-Tan, AAB Robertson, SL Doyle, SM Man, R Natoli
Sci Rep, 2020-02-10;10(1):2263.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Monocyte chemoattractant protein?1 promotes the proliferation, migration and differentiation potential of fibroblast?like synoviocytes via the PI3K/P38 cellular signaling pathway
Authors: X Tong, H Zeng, P Gu, K Wang, H Zhang, X Lin
Mol Med Rep, 2020-01-29;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Cell Culture -
Increasing the Medium Osmolarity Reduces the Inflammatory Status of Human OA Chondrocytes and Increases Their Responsiveness to GDF-5
Authors: T Mang, S Lindemann, A Gigout
Int J Mol Sci, 2020-01-14;21(2):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma
Authors: M Tochimoto, Y Oguri, M Hashimura, R Konno, T Matsumoto, A Yokoi, Y Kodera, M Saegusa
Lab. Invest., 2019-12-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome
Authors: CC Gross, C Meyer, U Bhatia, L Yshii, I Kleffner, J Bauer, AR Tröscher, A Schulte-Me, S Herich, T Schneider-, H Plate, T Kuhlmann, M Schwaninge, W Brück, M Pawlitzki, DA Laplaud, D Loussouarn, J Parratt, M Barnett, ME Buckland, TA Hardy, SW Reddel, M Ringelstei, J Dörr, B Wildemann, M Kraemer, H Lassmann, R Höftberger, E Beltrán, K Dornmair, N Schwab, L Klotz, SG Meuth, G Martin-Blo, H Wiendl, R Liblau
Nat Commun, 2019-12-18;10(1):5779.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NF-kappaB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells
Authors: K Hübner, D Karwelat, E Pietsch, I Beinborn, S Winterberg, K Bedenbende, BJ Benedikter, B Schmeck, E Vollmeiste
Cell. Signal., 2019-12-16;67(0):109498.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The role of endothelial MERTK during the inflammatory response in lungs
Authors: Y Li, ES Wittchen, E Monaghan-B, C Hahn, HS Earp, CM Doerschuk, K Burridge
PLoS ONE, 2019-12-05;14(12):e0225051.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Hydrogel based protein biochip for parallel detection of biomarkers for diagnosis of a Systemic Inflammatory Response Syndrome (SIRS) in human serum
Authors: A Stumpf, T Brandstett, J Hübner, J Rühe
PLoS ONE, 2019-12-02;14(12):e0225525.
Species: Human
Sample Types: Serum
Applications: ELISA Standard -
Intervention for early diabetic nephropathy by mesenchymal stem cells in a preclinical nonhuman primate model
Authors: X An, G Liao, Y Chen, A Luo, J Liu, Y Yuan, L Li, L Yang, H Wang, F Liu, G Yang, S Yi, Y Li, J Cheng, Y Lu
Stem Cell Res Ther, 2019-12-02;10(1):363.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients
Authors: D Deli?, K Wolk, R Schmid, O Gabrielyan, D Christou, K Rieber, M Rolser, I Jakob, F Wiech, M Griesser, C Wohnhaas, G Kokolakis, E Witte-Händ, P Baum, R Sabat
J. Dermatol. Sci., 2019-11-30;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation
Authors: N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto
Sci Rep, 2019-11-26;9(1):17558.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles
Authors: B Khiatah, M Qi, W Du, K T-Chen, KM van Megen, RG Perez, JS Isenberg, F Kandeel, BO Roep, HT Ku, IH Al-Abdulla
Stem Cell Res Ther, 2019-11-15;10(1):322.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Iguratimod Inhibits the Aggressiveness of Rheumatoid Fibroblast-Like Synoviocytes
Authors: J Lin, Y Yu, X Wang, Y Ke, C Sun, L Yue, G Xu, B Xu, L Xu, H Cao, D Xu, N Olsen, W Chen
J Immunol Res, 2019-11-14;2019(0):6929286.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TSG-6 in conditioned media from adipose mesenchymal stem cells protects against visual deficits in mild traumatic brain injury model through neurovascular modulation
Authors: KA Jha, M Pentecost, R Lenin, J Gentry, L Klaic, N Del Mar, A Reiner, CH Yang, LM Pfeffer, N Sohl, R Gangaraju
Stem Cell Res Ther, 2019-11-05;10(1):318.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE
Authors: H Wang, E Kunz, GJ Stoddard, WW Hauswirth, ME Hartnett
Sci Rep, 2019-10-31;9(1):15732.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Anti-inflammatory mechanisms of the novel cytokine interleukin-38 in allergic asthma
Authors: X Sun, T Hou, E Cheung, TN Iu, VW Tam, IM Chu, MS Tsang, PK Chan, CW Lam, CK Wong
Cell. Mol. Immunol., 2019-10-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression
Authors: J Merola, M Reschke, RW Pierce, L Qin, S Spindler, T Baltazar, TD Manes, F Lopez-Gira, G Li, LG Bracaglia, C Xie, N Kirkiles-S, WM Saltzman, GT Tietjen, G Tellides, JS Pober
JCI Insight, 2019-10-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals
Authors: ER Wonderlich, K Subramania, B Cox, A Wiegand, C Lackman-Sm, MJ Bale, M Stone, R Hoh, MF Kearney, F Maldarelli, SG Deeks, MP Busch, RG Ptak, DA Kulpa
PLoS Pathog., 2019-10-14;15(10):e1008074.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele
Authors: H Al-Mossawi, N Yager, CA Taylor, E Lau, S Danielli, J de Wit, J Gilchrist, I Nassiri, EA Mahe, W Lee, L Rizvi, S Makino, J Cheeseman, M Neville, JC Knight, P Bowness, BP Fairfax
Nat Commun, 2019-10-08;10(1):4575.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress
Authors: C Merriman, D Fu
J. Biol. Chem., 2019-10-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Progranulin attenuates liver fibrosis by downregulating the inflammatory response
Authors: W Yoo, J Lee, KH Noh, S Lee, D Jung, MH Kabir, D Park, C Lee, KS Kwon, JS Kim, S Kim
Cell Death Dis, 2019-10-07;10(10):758.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma
Authors: A Shimbo, H Kajiyama, S Tamauchi, N Yoshikawa, Y Ikeda, K Nishino, S Suzuki, K Niimi, J Sakata, F Kikkawa
Oncol. Rep., 2019-10-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue-regenerative potential of the secretome of gamma-irradiated peripheral blood mononuclear cells is mediated via TNFRSF1B-induced necroptosis
Authors: E Simader, L Beer, M Laggner, V Vorstandle, A Gugerell, M Erb, P Kalinina, D Copic, D Moser, A Spittler, E Tschachler, H Jan Ankers, M Mildner
Cell Death Dis, 2019-09-30;10(10):729.
Species: Human
Sample Types: Recombinant Protein
Applications: Bioassay -
Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression
Authors: J Ren, M Smid, J Iaria, DCF Salvatori, H van Dam, HJ Zhu, JWM Martens, P Ten Dijke
Breast Cancer Res., 2019-09-18;21(1):109.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity
Authors: NW Zammit, OM Siggs, PE Gray, K Horikawa, DB Langley, SN Walters, SR Daley, C Loetsch, J Warren, JY Yap, D Cultrone, A Russell, EK Malle, JE Villanueva, MJ Cowley, V Gayevskiy, ME Dinger, R Brink, D Zahra, G Chaudhri, G Karupiah, B Whittle, C Roots, E Bertram, M Yamada, Y Jeelall, A Enders, BE Clifton, PD Mabbitt, CJ Jackson, SR Watson, CN Jenne, LL Lanier, T Wiltshire, MH Spitzer, GP Nolan, F Schmitz, A Aderem, BT Porebski, AM Buckle, DW Abbott, JB Ziegler, ME Craig, P Benitez-Ag, J Teo, SG Tangye, C King, M Wong, MP Cox, W Phung, J Tang, W Sandoval, IE Wertz, D Christ, CC Goodnow, ST Grey
Nat. Immunol., 2019-09-18;20(10):1299-1310.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Possible Role of Neutrophils in the Induction of Osteoclastogenesis
Authors: CGJ Moonen, TJ de Vries, P Rijkschroe, PE Poubelle, EA Nicu, BG Loos
J Immunol Res, 2019-09-15;2019(0):8672604.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fisetin, a 3,7,3',4'-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models
Authors: JC Chamcheu, S Esnault, VM Adhami, AL Noll, S Banang-Mbe, T Roy, SS Singh, S Huang, KG Kousoulas, H Mukhtar
Cells, 2019-09-15;8(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An Autocrine Wnt5a Loop Promotes NF-kappaB Pathway Activation and Cytokine/Chemokine Secretion in Melanoma
Authors: G Barbero, MV Castro, MB Villanueva, MJ Quezada, NB Fernández, S DeMorrow, P Lopez-Berg
Cells, 2019-09-10;8(9):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Melatonin Rescued Reactive Oxygen Species-Impaired Osteogenesis of Human Bone Marrow Mesenchymal Stem Cells in the Presence of Tumor Necrosis Factor-Alpha
Authors: X Qiu, X Wang, J Qiu, Y Zhu, T Liang, B Gao, Z Wu, C Lian, Y Peng, A Liang, P Su, D Huang
Stem Cells Int, 2019-09-05;2019(0):6403967.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of Ionizing Radiation on Human EA.hy926 Endothelial Cells under Inflammatory Conditions and Their Interactions with A549 Tumour Cells
Authors: S Schröder, S Broese, J Baake, D Juer beta, S Kriesen, G Hildebrand, K Manda
J Immunol Res, 2019-09-02;2019(0):9645481.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CRISPR/Cas9 Screens Reveal Multiple Layers of B cell CD40 Regulation
Authors: C Jiang, SJ Trudeau, TC Cheong, R Guo, M Teng, LW Wang, Z Wang, C Pighi, C Gautier-Co, Y Ma, S Jiang, C Wang, B Zhao, L Paillard, JG Doench, R Chiarle, BE Gewurz
Cell Rep, 2019-07-30;28(5):1307-1322.e8.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Low concentration flufenamic acid enhances osteogenic differentiation of mesenchymal stem cells and suppresses bone loss by inhibition of the NF-κB signaling pathway
Authors: X Liu, Z Li, H Liu, Y Zhu, D Xia, S Wang, R Gu, W Wu, P Zhang, Y Liu, Y Zhou
Stem Cell Res Ther, 2019-07-19;10(1):213.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The P-selectin and PSGL-1 axis accelerates atherosclerosis via activation of dendritic cells by the TLR4 signaling pathway
Authors: Z Ye, L Zhong, S Zhu, Y Wang, J Zheng, S Wang, J Zhang, R Huang
Cell Death Dis, 2019-07-01;10(7):507.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The expression of NOD2, NLRP3 and NLRC5 and renal injury in anti-neutrophil cytoplasmic antibody-associated vasculitis
Authors: LY Wang, XJ Sun, M Chen, MH Zhao
J Transl Med, 2019-06-11;17(1):197.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis
Authors: BD Bryson, TR Rosebrock, FG Tafesse, CY Itoh, A Nibasumba, GH Babunovic, B Corleis, C Martin, C Keegan, P Andrade, S Realegeno, D Kwon, RL Modlin, SM Fortune
Nat Commun, 2019-05-27;10(1):2329.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses
Authors: R van Dalen, JS De La Cruz, M Rumpret, FF Fuchsberge, NH van Teijli, J Hanske, C Rademacher, TBH Geijtenbee, JAG van Strijp, C Weidenmaie, A Peschel, DH Kaplan, NM van Sorge
MBio, 2019-05-14;10(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional characterization of SLC26A3 c.392C>G (p.P131R) mutation in intestinal barrier function using CRISPR/CAS9-created cell models
Authors: N Zhang, DP Heruth, W Wu, LQ Zhang, MN Nsumu, K Shortt, K Li, X Jiang, B Wang, C Friesen, DY Li, SQ Ye
Cell Biosci, 2019-05-14;9(0):40.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Differential modulation of CXCL8 versus CXCL10, by cytokines, PPAR-gamma, or PPAR-alpha agonists, in primary cells from Graves' disease and ophthalmopathy
Authors: SM Ferrari, F Ragusa, SR Paparo, F Nasini, M Nardi, SS Franceschi, P Fallahi, A Antonelli
Autoimmun Rev, 2019-05-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of a New Member of Alphacoronavirus with Unique Genomic Features in Rhinolophus Bats
Authors: N Wang, C Luo, H Liu, X Yang, B Hu, W Zhang, B Li, Y Zhu, G Zhu, X Shen, C Peng, Z Shi
Viruses, 2019-04-24;11(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Xanthatin inhibits STAT3 and NF-?B signalling by covalently binding to JAK and IKK kinases
Authors: M Liu, CQ Xiao, MW Sun, MJ Tan, LH Hu, Q Yu
J. Cell. Mol. Med., 2019-04-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis
Authors: MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay
Sci Rep, 2019-04-15;9(1):6020.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells
Authors: IB Mitre-Agui, T Barrios-Ga, VM Ruiz-Lopez, AJ Cabrera-Qu, NR Mejia-Domi, JL Ventura-Ga, D Moreno-Mit, A Aranda-Gut, J Mejia-Rang, AR Escalona-G, Y Chavarri-G, A Leon-Del-R, A Zentella-D
BMC Cancer, 2019-04-15;19(1):356.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neutrophil GM-CSF receptor dynamics in acute lung injury
Authors: S De Alessan, GJ Ferguson, AJ Dodd, JK Juss, A Devaprasad, S Piper, O Wyatt, H Killick, DJ Corkill, ES Cohen, A Pandit, TRDJ Radstake, R Simmonds, AM Condliffe, MA Sleeman, AS Cowburn, DK Finch, ER Chilvers
J. Leukoc. Biol., 2019-04-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1
Authors: J Kristoff, ML Palma, TM Garcia-Bat, C Shen, N Sluis-Crem, P Gupta, CR Rinaldo, RB Mailliard
EBioMedicine, 2019-04-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TGF-?1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM
Authors: K Wang, S Fang, Q Liu, J Gao, X Wang, H Zhu, Z Zhu, F Ji, J Wu, Y Ma, L Hu, X Shen, D Gao, J Zhu, P Liu, H Zhou
EBioMedicine, 2019-03-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome
Authors: T Liu, Q Zeng, X Zhao, W Wei, Y Li, H Deng, D Song
Molecules, 2019-03-23;24(6):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system
Authors: Q An, Y Zheng, Y Zhao, T Liu, H Guo, D Zhang, W Qian, H Wang, Y Guo, S Hou, J Li
Drug Des Devel Ther, 2019-03-12;13(0):791-805.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TAK1 suppresses RIPK1-dependent cell death and is associated with disease progression in melanoma
Authors: B Podder, C Guttà, J Rožanc, E Gerlach, M Feoktistov, D Panayotova, LG Alexopoulo, M Leverkus, M Rehm
Cell Death Differ., 2019-03-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility
Authors: H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta
Cell Stem Cell, 2019-03-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cortistatin binds to TNF-? receptors and protects against osteoarthritis
Authors: Y Zhao, Y Li, R Qu, X Chen, W Wang, C Qiu, B Liu, X Pan, L Liu, K Vasilev, J Hayball, S Dong, W Li
EBioMedicine, 2019-02-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Novel TNF-?-Targeting Aptamer for TNF-?-Mediated Acute Lung Injury and Acute Liver Failure
Authors: WY Lai, JW Wang, BT Huang, EP Lin, PC Yang
Theranostics, 2019-02-28;9(6):1741-1751.
Species: Human
Sample Types: DNA
Applications: Bioassay -
Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: A new link between trimethylamine N-oxide and atherosclerotic thrombosis
Authors: X Cheng, X Qiu, Y Liu, C Yuan, X Yang
Thromb. Res., 2019-02-23;177(0):110-116.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LncRNA Meg3 protects endothelial function by regulating the DNA damage response
Authors: MS Shihabudee, X Cheng, M Moran, S Haemmig, MJ Naldrett, S Alvarez, MW Feinberg, X Sun
Nucleic Acids Res., 2019-02-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery
Authors: V Laubach, R Kaufmann, A Bernd, S Kippenberg, N Zöller
Int J Mol Sci, 2019-02-19;20(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
hCMV-Mediated Immune Escape Mechanisms Favor Pathogen Growth and Disturb the Immune Privilege of the Eye
Authors: K Spekker-Bo, CM Ufermann, M Maywald, A Zimmermann, A Domröse, C Woite, W Däubener, SK Eller
Int J Mol Sci, 2019-02-16;20(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ornithine decarboxylase antizyme inhibitor 2 (AZIN2) is a signature of secretory phenotype and independent predictor of adverse prognosis in colorectal cancer
Authors: T Kaprio, T Rasila, J Hagström, H Mustonen, P Lankila, C Haglund, LC Andersson
PLoS ONE, 2019-02-15;14(2):e0211564.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of PTGS1 promotes osteogenic differentiation of adipose-derived stem cells by suppressing NF-kB signaling
Authors: Y Wang, Y Liu, M Zhang, L Lv, X Zhang, P Zhang, Y Zhou
Stem Cell Res Ther, 2019-02-13;10(1):57.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis
Authors: JC de Quaglia, AM Della Cole, TP Gardizani, GG Romagnoli, R Kaneno, LA Dias-Melic
J Immunol Res, 2019-02-06;2019(0):1529189.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autoimmune rheumatic disease IgG has differential effects upon neutrophil integrin activation that is modulated by the endothelium
Authors: AA Khawaja, C Pericleous, VM Ripoll, JC Porter, IP Giles
Sci Rep, 2019-02-04;9(1):1283.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential expression and regulation of the non-integrin 37/67-kDa laminin receptor on peripheral blood leukocytes of healthy individuals and patients with rheumatoid arthritis
Authors: BA Kane, H An, P Rajasekari, HP McNeil, K Bryant, N Tedla
Sci Rep, 2019-02-04;9(1):1149.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate
Authors: M Bobardt, J Kuo, U Chatterji, S Chanda, SJ Little, N Wiedemann, G Vuagniaux, PA Gallay
PLoS ONE, 2019-02-04;14(2):e0211746.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CCL27/CCL28-CCR10 CHEMOKINE SIGNALING MEDIATES MIGRATION OF LYMPHATIC ENDOTHELIAL CELLS
Authors: T Karnezis, R Farnsworth, NC Harris, SP Williams, C Caesar, DJ Byrne, P Herle, ML Macheda, R Shayan, YF Zhang, S Yazar, SJ Takouridis, C Gerard, S Fox, MG Achen, SA Stacker
Cancer Res., 2019-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Constructive approach for synthesis of a functional IgG using a reconstituted cell-free protein synthesis system
Authors: S Murakami, R Matsumoto, T Kanamori
Sci Rep, 2019-01-24;9(1):671.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Capture) -
Rifamycin SV exhibits strong anti-inflammatory in�vitro activity through pregnane X receptor stimulation and NF?B inhibition
Authors: C Rosette, FJ Agan, N Rosette, L Moro, A Mazzetti, C Hassan, M Gerloni
Drug Metab. Pharmacokinet., 2019-01-17;34(3):172-180.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Allergic and Anti-Inflammatory Effects of Kuwanon G and Morusin on MC/9 Mast Cells and HaCaT Keratinocytes
Authors: SE Jin, H Ha, HK Shin, CS Seo
Molecules, 2019-01-11;24(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory Skin
Authors: Y Zhang, Q Xia, Y Li, Z He, Z Li, T Guo, Z Wu, N Feng
Theranostics, 2019-01-01;9(1):48-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intravascular heavy chain-modification of hyaluronan during endotoxic shock
Authors: K Ni, A Gill, D Cao, K Koike, KS Schweitzer, S Garantziot, I Petrache
Biochem Biophys Rep, 2018-12-26;17(0):114-121.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cell Size-Based Decision-Making of a Viral Gene Circuit
Authors: K Bohn-Wippe, EN Tevonian, Y Lu, MY Huang, MR Megaridis, RD Dar
Cell Rep, 2018-12-26;25(13):3844-3857.e5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor-like weak inducer of apoptosis induces inflammation in Graves' orbital fibroblasts
Authors: SJ Lee, J Kim, J Ko, EJ Lee, HJ Koh, JS Yoon
PLoS ONE, 2018-12-21;13(12):e0209583.
Species: Human
Sample Types: Whole Cells
-
Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182
Authors: Q Li, W Xing, X Gong, Y Wang
Cell. Physiol. Biochem., 2018-11-27;51(3):1149-1163.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence
Authors: M Rentschler, Y Chen, J Pahl, L Soria-Mart, H Braumüller, E Brenner, O Bischof, M Röcken, T Wieder
Cell. Physiol. Biochem., 2018-11-26;51(3):1103-1118.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Agrimonia procera exerts antimicrobial effects, modulates the expression of defensins and cytokines in colonocytes and increases the immune response in lipopolysaccharide-challenged piglets
Authors: T Gräber, H Kluge, S Granica, G Horn, J Kalbitz, C Brandsch, A Breitenste, C Brütting, GI Stangl
BMC Vet. Res., 2018-11-15;14(1):346.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Astrocyte expression of the Drosophila TNF-alpha homologue, Eiger, regulates sleep in flies
Authors: WM Vanderheyd, AG Goodman, RH Taylor, MG Frank, HPA Van Dongen, JR Gerstner
PLoS Genet., 2018-10-31;14(10):e1007724.
Species: Drosophila
Sample Types: In Vivo
Applications: In Vivo -
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment
Authors: L Mercurio, M Morelli, C Scarponi, EZ Eisenmesse, N Doti, G Pagnanelli, E Gubinelli, C Mazzanti, A Cavani, M Ruvo, CA Dinarello, C Albanesi, S Madonna
Cell Death Dis, 2018-10-30;9(11):1104.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Protective mechanisms of resveratrol derivatives against TNF-?-induced inflammatory responses in rat mesangial cells
Authors: IT Lee, CF Lin, YL Huang, KY Chong, MF Hsieh, TH Huang, CY Cheng
Cytokine, 2018-10-30;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines
Authors: S Perriot, A Mathias, G Perriard, M Canales, N Jonkmans, N Merienne, C Meunier, L El Kassar, AL Perrier, DA Laplaud, M Schluep, N Déglon, R Du Pasquie
Stem Cell Reports, 2018-10-25;11(5):1199-1210.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Divergent TCR-Initiated Calcium Signals Govern Recruitment versus Activation of Human Alloreactive Effector Memory T Cells by Endothelial Cells
Authors: TD Manes, V Wang, JS Pober
J. Immunol., 2018-10-19;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anacardic acid suppresses fibroblast-like synoviocyte proliferation and invasion and ameliorates collagen-induced arthritis in a mouse model
Authors: GH Yang, C Zhang, N Wang, Y Meng, YS Wang
Cytokine, 2018-09-28;111(0):350-356.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Catalase Enhances Viability of Human Chondrocytes in Culture by Reducing Reactive Oxygen Species and Counteracting Tumor Necrosis Factor-?-Induced Apoptosis
Authors: S Li, X Yang, Z Feng, P Wang, W Zhu, S Cui
Cell. Physiol. Biochem., 2018-09-27;49(6):2427-2442.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of calcium-sensing receptor by allosteric agonists cinacalcet and AC-265347 abolishes the 1,25(OH)2D3-induced Ca2+ transport: Evidence that explains how the intestine prevents excessive Ca2+ absorption
Authors: K Wongdee, M Rodrat, C Keadsai, W Jantarajit, J Teerapornp, J Thongbunch, N Charoenpha
Arch. Biochem. Biophys., 2018-09-11;657(0):15-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Presenilin 1 Regulates NF-?B Activation via Association with Breakpoint Cluster Region and Casein Kinase II
Authors: Y Tanaka, L Sabharwal, M Ota, I Nakagawa, JJ Jiang, Y Arima, H Ogura, M Okochi, M Ishii, D Kamimura, M Murakami
J. Immunol., 2018-09-10;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ICAM1 expression is induced by proinflammatory cytokines and associated with TLS formation in aggressive breast cancer subtypes
Authors: SL Figenschau, E Knutsen, I Urbarova, C Fenton, B Elston, M Perander, ES Mortensen, KA Fenton
Sci Rep, 2018-08-06;8(1):11720.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion
Authors: S Ishii, T Isozaki, H Furuya, H Takeuchi, Y Tsubokura, K Inagaki, T Kasama
Arthritis Res. Ther., 2018-08-02;20(1):159.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-?, IL-1?, and IFN-?
Authors: M Schwede, EM Wilfong, RL Zemans, PJ Lee, C Dos Santos, X Fang, MA Matthay
Physiol Rep, 2018-08-01;6(16):e13831.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TRAIL and Ceruloplasmin Inverse Correlation as a Representative Crosstalk between Inflammation and Oxidative Stress
Authors: V Tisato, S Gallo, E Melloni, C Celeghini, A Passaro, G Zauli, P Secchiero, C Bergamini, A Trentini, G Bonaccorsi, G Valacchi, G Zuliani, C Cervellati
Mediators Inflamm., 2018-07-26;2018(0):9629537.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis
Authors: SI Jeong, JW Kim, KP Ko, BK Ryu, MG Lee, HJ Kim, SG Chi
Cell Death Dis, 2018-07-24;9(8):806.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Elevated Expression of AXL May Contribute to the Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease Patients
Authors: É Boros, Z Kellermaye, P Balogh, G Strifler, A Vörös, P Sarlós, Á Vincze, C Varga, I Nagy
Mediators Inflamm., 2018-07-22;2018(0):3241406.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proton irradiation orchestrates macrophage reprogramming through NF?B signaling
Authors: G Genard, AC Wera, C Huart, B Le Calve, S Penninckx, A Fattacciol, T Tabarrant, C Demazy, N Ninane, AC Heuskin, S Lucas, C Michiels
Cell Death Dis, 2018-06-27;9(7):728.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sodium Butyrate Attenuates Diarrhea in Weaned Piglets and Promotes Tight Junction Protein Expression in Colon in a GPR109A-Dependent Manner
Authors: W Feng, Y Wu, G Chen, S Fu, B Li, B Huang, D Wang, W Wang, J Liu
Cell. Physiol. Biochem., 2018-06-27;47(4):1617-1629.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Induction of innate immune memory via microRNA targeting of chromatin remodelling factors
Authors: JJ Seeley, RG Baker, G Mohamed, T Bruns, MS Hayden, SD Deshmukh, DE Freedberg, S Ghosh
Nature, 2018-06-27;559(7712):114-119.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2
Authors: A Gaudin, M Tolar, OA Peters
Sci Rep, 2018-06-11;8(1):8921.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-?B activation
Authors: JA Marwick, R Mills, O Kay, K Michail, J Stephen, AG Rossi, I Dransfield, N Hirani
Cell Death Dis, 2018-06-04;9(6):665.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways
Authors: A Beringer, N Thiam, J Molle, B Bartosch, P Miossec
Clin. Exp. Immunol., 2018-05-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
Authors: SU Seo, SM Woo, HS Lee, SH Kim, KJ Min, TK Kwon
Oncogene, 2018-05-30;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer
Authors: AL Means, TJ Freeman, J Zhu, LG Woodbury, P Marincola-, C Wu, AR Meyer, CJ Weaver, C Padmanabha, H An, J Zi, BC Wessinger, R Chaturvedi, TD Brown, NG Deane, RJ Coffey, KT Wilson, JJ Smith, CL Sawyers, JR Goldenring, SV Novitskiy, MK Washington, C Shi, RD Beauchamp
Cell Mol Gastroenterol Hepatol, 2018-05-24;6(3):257-276.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Hyaluronic Acid Influence on Normal and Osteoarthritic Tissue-Engineered Cartilage
Authors: S Hemmati-Sa, J Ringe, T Dehne, R Haag, M Sittinger
Int J Mol Sci, 2018-05-19;19(5):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli
Authors: AE Dodi, IO Ajayi, C Chang, M Beard, SL Ashley, SK Huang, VJ Thannickal, DJ Tschumperl, TH Sisson, JC Horowitz
Respir. Res., 2018-05-10;19(1):91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A20 regulates canonical wnt-signaling through an interaction with RIPK4
Authors: BN Nakamura, A Glazier, MG Kattah, B Duong, Y Jia, D Campo, L Shao
PLoS ONE, 2018-05-02;13(5):e0195893.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anisakis pegreffii impacts differentiation and function of human dendritic cells
Authors: C Napoletano, S Mattiucci, A Colantoni, F Battisti, IG Zizzari, H Rahimi, M Nuti, A Rughetti
Parasite Immunol., 2018-05-01;0(0):e12527.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of osteoprotegerin/TNFRSF11B in two models of abdominal aortic aneurysms
Authors: E Vorkapic, A Kunath, D Wågsäter
Mol Med Rep, 2018-04-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
Authors: M Boyd, M Thodberg, M Vitezic, J Bornholdt, K Vitting-Se, Y Chen, M Coskun, Y Li, BZS Lo, P Klausen, P Jan Schwei, AG Pedersen, N Rapin, K Skovgaard, K Dahlgaard, R Andersson, TB Terkelsen, B Lilje, JT Troelsen, AM Petersen, KB Jensen, I Gögenur, P Thielsen, JB Seidelin, OH Nielsen, JT Bjerrum, A Sandelin
Nat Commun, 2018-04-25;9(1):1661.
Species: Human
Sample Types: Organoids
Applications: Bioassay -
The proximal tubular ?7 nicotinic acetylcholine receptor attenuates ischemic acute kidney injury through Akt/PKC signaling-mediated HO-1 induction
Authors: H Kim, SR Kim, J Je, K Jeong, S Kim, HJ Kim, KC Chang, SW Park
Exp. Mol. Med., 2018-04-20;50(4):40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling
Authors: JP Parisien, JJ Lenoir, R Mandhana, KR Rodriguez, K Qian, AM Bruns, CM Horvath
EMBO Rep., 2018-04-16;0(0):.
Species: Human
Sample Types: Transfected Whole Cells
Applications: Bioassay -
Lymphatic exosomes promote dendritic cell migration along guidance cues
Authors: M Brown, LA Johnson, DA Leone, P Majek, K Vaahtomeri, D Senfter, N Bukosza, H Schachner, G Asfour, B Langer, R Hauschild, K Parapatics, YK Hong, KL Bennett, R Kain, M Detmar, M Sixt, DG Jackson, D Kerjaschki
J. Cell Biol., 2018-04-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Matrix metalloproteinase-9 (MMP9) is involved in the TNF-α-induced fusion of human M13SV1-Cre breast epithelial cells and human MDA-MB-435-pFDR1 cancer cells
Authors: J Weiler, M Mohr, KS Zänker, T Dittmar
Cell Commun. Signal, 2018-04-10;16(1):14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation
Authors: R Drolia, S Tenguria, AC Durkes, JR Turner, AK Bhunia
Cell Host Microbe, 2018-04-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High-Mobility Group Box 1 in Dry Eye Inflammation
Authors: C Lema, RY Reins, RL Redfern
Invest. Ophthalmol. Vis. Sci., 2018-04-01;59(5):1741-1750.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties
Authors: M Gabl, M Sundqvist, A Holdfeldt, S Lind, J Mårtensson, K Christenso, T Marutani, C Dahlgren, H Mukai, H Forsman
J. Immunol., 2018-03-30;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death
Authors: L Gao, MM Liu, HM Zang, QY Ma, Q Yang, L Jiang, GL Ren, HD Li, WF Wu, JN Wang, B Wei, XQ Liu, C Jiang, C Huang, J Li, XM Meng
Lab. Invest., 2018-03-26;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus
Authors: D Sireesh, U Dhamodhara, K Ezhilarasi, V Vijay, KM Ramkumar
Sci Rep, 2018-03-23;8(1):5126.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation
Authors: S Ikeya, JI Sakabe, T Yamada, T Naito, Y Tokura
Sci Rep, 2018-03-22;8(1):5050.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes
Authors: S Modi, N Yaluri, T Kokkola
Biochem. Biophys. Res. Commun., 2018-03-21;0(0):.
Species: Mouse
Sample Types: 3T3-L1 adipocytes
Applications: Bioassay -
Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients
Authors: CM Dickinson, BW LeBlanc, MM Edhi, DS Heffernan, MH Faridi, V Gupta, WG Cioffi, X O'Brien, JS Reichner
J Intensive Care, 2018-03-15;6(0):19.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Unraveling the interplay between senescent dermal fibroblasts and cutaneous squamous cell carcinoma cell lines at different stages of tumorigenesis
Authors: M Toutfaire, E Dumortier, A Fattacciol, MV Steenbrugg, CM Proby, F Debacq-Cha
Int. J. Biochem. Cell Biol., 2018-03-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sulforaphane rescues amyloid-? peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages
Authors: KA Jhang, JS Park, HS Kim, YH Chong
J Neuroinflammation, 2018-03-12;15(1):75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NF-?B Activation
Authors: K Flentie, C Gonzalez, B Kocher, Y Wang, H Zhu, J Marasa, D Piwnica-Wo
Mol. Cancer Res., 2018-03-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation
Authors: Y Wang, Y Liu, M Zhang, L Lv, X Zhang, P Zhang, Y Zhou
Stem Cell Res Ther, 2018-03-09;9(1):65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The induced RNA-binding protein, HuR targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis
Authors: K Ouhara, S Munenaga, M Kajiya, K Takeda, S Matsuda, Y Sato, Y Hamamoto, T Iwata, S Yamasaki, K Akutagawa, N Mizuno, T Fujita, E Sugiyama, H Kurihara
Clin. Exp. Immunol., 2018-03-08;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients
Authors: E Canto, N Isobe, A Didonna, SL Hauser, JR Oksenberg
J Neuroinflammation, 2018-03-07;15(1):72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease
Authors: AW Clarke, L Poulton, D Shim, D Mabon, D Butt, M Pollard, V Pande, J Husten, J Lyons, C Tian, AG Doyle
MAbs, 2018-03-05;0(0):1-43.
Species: Human
Sample Types: Recombinant Protein
Applications: Surface Plasmon Resonance (SPR -
Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury
Authors: S Wink, SW Hiemstra, S Huppelscho, JE Klip, B van de Wat
Arch. Toxicol., 2018-03-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
Blood, 2018-03-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Class 1-selective histone deacetylase inhibitors enhance HIV latency reversal while preserving the activity of HDAC isoforms necessary for maximal HIV gene expression
Authors: TD Zaikos, MM Painter, NT Sebastian, VH Terry, KL Collins
J. Virol., 2018-02-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
Authors: CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
Elife, 2018-02-22;7(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiokine Wisp-1 is increased in myocardial infarction and regulates cardiac endothelial signaling
Authors: LH Wright, DJ Herr, SS Brown, H Kasiganesa, DR Menick
JCI Insight, 2018-02-22;3(4):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interactome analysis of transforming growth factor-?-activated kinase 1 inHelicobacter pylori-infected cells revealed novel regulators tripartite motif 28 and CDC37
Authors: O Sokolova, T Kähne, K Bryan, M Naumann
Oncotarget, 2018-02-21;9(18):14366-14381.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Progesterone Inhibits Apoptosis in Fetal Membranes by Altering Expression of Both Pro- and Antiapoptotic Proteins
Authors: Y Wang, VM Abrahams, G Luo, NG Norwitz, VV Snegovskik, SW Ng, ER Norwitz
Reprod Sci, 2018-02-20;0(0):1933719118759.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
LAIR-1 shedding from human fibroblast-like synoviocytes in rheumatoid arthritis following TNF-? stimulation
Authors: Y Zhang, S Wang, H Dong, X Yi, J Zhang, X Liu, R Zhuang, Y Ding
Clin. Exp. Immunol., 2018-02-20;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human iPS-Derived Astroglia from a Stable Neural Precursor State Show Improved Functionality Compared with Conventional Astrocytic Models
Authors: A Lundin, L Delsing, M Clausen, P Ricchiuto, J Sanchez, A Sabirsh, M Ding, J Synnergren, H Zetterberg, G Brolén, R Hicks, A Herland, A Falk
Stem Cell Reports, 2018-02-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
Authors: AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims
Diabetologia, 2018-02-14;0(0):.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Changes in the Anti-Allergic Activities of Sesame by Bioconversion
Authors: TD Jung, SI Choi, SH Choi, BY Cho, WS Sim, SJ Lee, SJ Park, DB Kim, YC Kim, JH Lee, OH Lee
Nutrients, 2018-02-14;10(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Filifactor alocis modulates human neutrophil antimicrobial functional responses
Authors: JS Edmisson, S Tian, CL Armstrong, A Vashishta, CK Klaes, I Miralda, E Jimenez-Fl, J Le, Q Wang, RJ Lamont, SM Uriarte
Cell. Microbiol., 2018-02-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
Authors: M Armaka, C Ospelt, M Pasparakis, G Kollias
Nat Commun, 2018-02-12;9(1):618.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CellCycleTRACER accounts for cell cycle and volume in mass cytometry data
Authors: MA Rapsomanik, XK Lun, S Woerner, M Laumanns, B Bodenmille, MR Martínez
Nat Commun, 2018-02-12;9(1):632.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Galectin-3 Plays an Important Role in Preterm Birth Caused by Dental Infection of Porphyromonas gingivalis
Authors: M Miyauchi, M Ao, H Furusho, C Chea, A Nagasaki, S Sakamoto, T Ando, T Inubushi, K Kozai, T Takata
Sci Rep, 2018-02-12;8(1):2867.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature
Authors: W Klement, R Garbelli, E Zub, L Rossini, L Tassi, B Girard, M Blaquiere, F Bertaso, J Perroy, F de Bock, N Marchi
Neurobiol. Dis., 2018-02-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Virus-like infection induces human ? cell dedifferentiation
Authors: M Oshima, KP Knoch, M Diedisheim, A Petzold, P Cattan, M Bugliani, P Marchetti, P Choudhary, GC Huang, SR Bornstein, M Solimena, O Albagli-Cu, R Scharfmann
JCI Insight, 2018-02-08;3(3):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown
Authors: G Bi, L Wu, P Huang, S Islam, DP Heruth, LQ Zhang, DY Li, V Sampath, W Huang, BA Simon, RB Easley, SQ Ye
FASEB J., 2018-02-08;0(0):fj201701059R.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells
Authors: L Chung, ET Orberg, AL Geis, JL Chan, K Fu, CED Shields, CM Dejea, P Fathi, J Chen, BB Finard, AJ Tam, FM McAllister, H Fan, X Wu, S Ganguly, A Lebid, P Metz, SW Van Meerbe, DL Huso, EC Wick, DM Pardoll, F Wan, S Wu, CL Sears, F Housseau
Cell Host Microbe, 2018-02-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ANKRD1 regulates innate immune responses against herpes simplex virus 1: A potential role in eczema herpeticum
Authors: L Bin, X Li, B Richers, JE Streib, JW Hu, P Taylor, DYM Leung
J. Allergy Clin. Immunol., 2018-01-31;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Authors: A Rutkowska, DR Shimshek, AW Sailer, KK Dev
Neuropharmacology, 2018-01-31;133(0):121-128.
Species: Human, Mouse, Rat
Sample Types: Whole Cells
Applications: Bioassay -
DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway
Authors: F Zhang, G Liu, D Li, C Wei, J Hao
J. Immunol., 2018-01-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature
Authors: WR Swindell, MA Beamer, MK Sarkar, S Loftus, J Fullmer, X Xing, NL Ward, LC Tsoi, MJ Kahlenberg, Y Liang, JE Gudjonsson
Front Immunol, 2018-01-29;9(0):80.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles
Authors: M Frank-Bert, DS Pisetsky, C Kolling, BA Michel, RE Gay, A Jüngel, S Gay
Front Immunol, 2018-01-29;9(0):28.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps
Authors: L Tengroth, J Arebro, O Larsson, C Bachert, SK Georén, LO Cardell
Sci Rep, 2018-01-24;8(1):1561.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The IL20 Genetic Polymorphism Is Associated with Altered Clinical Outcome in Septic Shock
Authors: TA Nakada, P Wacharasin, JA Russell, JH Boyd, E Nakada, SA Thair, T Shimada, KR Walley
J Innate Immun, 2018-01-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Streamlined circular proximity ligation assay provides high stringency and compatibility with low-affinity antibodies
Authors: R Jalili, J Horecka, JR Swartz, RW Davis, HHJ Persson
Proc. Natl. Acad. Sci. U.S.A., 2018-01-16;0(0):.
Applications: Bioassay -
Bridging pro-inflammatory signals, synaptic transmission and protection in spinal explants in vitro
Authors: M Medelin, V Giacco, A Aldinucci, G Castronovo, E Bonechi, A Sibilla, M Tanturli, M Torcia, L Ballerini, F Cozzolino, C Ballerini
Mol Brain, 2018-01-15;11(1):3.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
NF-?B inducing kinase is a therapeutic target for systemic lupus erythematosus
Authors: HD Brightbill, E Suto, N Blaquiere, N Ramamoorth, S Sujatha-Bh, EB Gogol, GM Castanedo, BT Jackson, YC Kwon, S Haller, J Lesch, K Bents, C Everett, PB Kohli, S Linge, L Christian, K Barrett, A Jaochico, LM Berezhkovs, PW Fan, Z Modrusan, K Veliz, MJ Townsend, J DeVoss, AR Johnson, R Godemann, WP Lee, CD Austin, BS McKenzie, JA Hackney, JJ Crawford, ST Staben, MH Alaoui Ism, LC Wu, N Ghilardi
Nat Commun, 2018-01-12;9(1):179.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1
Authors: B Jeong, HR Kim, NS Choi, BS Park, H Eom, JW Park, JG Kim, BJ Lee
Biochem. Biophys. Res. Commun., 2018-01-04;0(0):.
Species: Mouse, Rat
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
EpCAM peptide-primed dendritic cell vaccination confers significant anti-tumor immunity in hepatocellular carcinoma cells
Authors: YJ Choi, SJ Park, YS Park, HS Park, KM Yang, K Heo
PLoS ONE, 2018-01-03;13(1):e0190638.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RvD1 inhibits TNF?-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells
Authors: X Zhong, HN Lee, YJ Surh
Biochem. Biophys. Res. Commun., 2018-01-03;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antigen presentation of the Oct4 and Sox2 peptides by CD154-activated B lymphocytes enhances the killing effect of cytotoxic T lymphocytes on tumor stem-like cells derived from cisplatin-resistant lung cancer cells
Authors: X Zhang, Y Zhang, J Xu, H Wang, X Zheng, Y Lou, B Han
J Cancer, 2018-01-01;9(2):367-374.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Arsenite exposure potentiates apoptosis-inducing effects of tumor necrosis factor-alpha- through reactive oxygen species
Authors: P Singhirunn, B Moolmuang, K Lirdprapam, M Ruchirawat
J Toxicol Sci, 2018-01-01;43(2):159-169.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X.
Species: Human
Sample Types:
Applications: Bioassay -
Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation
Authors: T Tanaka, Y Zhou, T Ozawa, R Okizono, A Banba, T Yamamura, E Oga, A Muraguchi, H Sakurai
J. Biol. Chem., 2017-12-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor
Authors: AT Holdbrooks, CM Britain, SL Bellis
J. Biol. Chem., 2017-12-12;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long noncoding RNA NEAT1 promotes nasopharyngeal carcinoma progression through regulation of miR-124/NF-?B pathway
Authors: N Cheng, Y Guo
Onco Targets Ther, 2017-12-11;10(0):5843-5853.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Association of HMGB1 with oxidative stress markers and regulators in PDR
Authors: AM Abu El-Asr, K Alam, M Garcia-Ram, A Ahmad, MM Siddiquei, G Mohammad, A Mousa, G De Hertogh, G Opdenakker, R Simó
Mol. Vis., 2017-12-05;23(0):853-871.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis
Authors: Y Xu, S Xu, P Liu, M Koroleva, S Zhang, S Si, ZG Jin
J Am Heart Assoc, 2017-11-30;6(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Diosgenin, an Activator of 1,25D3-MARRS Receptor/ERp57, Attenuates the Effects of TNF-? by Causing ADAM10-Dependent Ectodomain Shedding of TNF Receptor 1
Authors: WS Yang, SY Moon, MJ Lee, EK Lee, SK Park
Cell. Physiol. Biochem., 2017-10-27;43(6):2434-2445.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-155 induction via TNF-? and IFN-? suppresses expression of programmed death ligand-1 (PD-L1) in human primary cells
Authors: D Yee, KM Shah, MC Coles, TV Sharp, D Lagos
J. Biol. Chem., 2017-10-24;292(50):20683-20693.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN-? and TNF-? synergism may provide a link between psoriasis and inflammatory atherogenesis
Authors: NN Mehta, HL Teague, WR Swindell, Y Baumer, NL Ward, X Xing, B Baugous, A Johnston, AA Joshi, J Silverman, DH Barnes, L Wolterink, RP Nair, PE Stuart, M Playford, JJ Voorhees, MK Sarkar, JT Elder, K Gallagher, SK Ganesh, JE Gudjonsson
Sci Rep, 2017-10-23;7(1):13831.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of calcium in regulating the intra- and extracellular cleavage of von Willebrand factor by the protease ADAMTS13
Authors: S Gogia, A Kelkar, C Zhang, KM Dayananda, S Neelamegha
Blood Adv, 2017-10-20;1(23):2063-2074.
Applications: Western Blot -
Tumor necrosis factor ? decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription
Authors: MA Peplowski, AJ Vegso, V Iablokov, M Dicay, RS Zaheer, B Renaux, D Proud, MD Hollenberg, PL Beck, WK MacNaughto
Physiol Rep, 2017-10-16;5(19):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Healing of Preterm Ruptured Fetal Membranes
Authors: H Mogami, A Hari Kisho, Y Akgul, RA Word
Sci Rep, 2017-10-13;7(1):13139.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation
Authors: S Ebtehaj, EG Gruppen, M Parvizi, UJF Tietge, RPF Dullaart
Cardiovasc Diabetol, 2017-10-12;16(1):132.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HAT1 induces lung cancer cell apoptosis via up regulating Fas
Authors: N Han, L Shi, Q Guo, W Sun, Y Yu, L Yang, X Zhang, M Zhang
Oncotarget, 2017-09-23;8(52):89970-89977.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A type of human skin dendritic cell marked by CD5 is associated with the development of inflammatory skin disease
Authors: D Korenfeld, L Gorvel, A Munk, J Man, A Schaffer, T Tung, C Mann, E Klechevsky
JCI Insight, 2017-09-21;2(18):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer
Authors: ML Palisoul, JM Quinn, E Schepers, IS Hagemann, L Guo, K Reger, AR Hagemann, CK McCourt, PH Thaker, MA Powell, DG Mutch, KC Fuh
Mol. Cancer Ther., 2017-09-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction
Authors: N Akbar, JE Digby, TJ Cahill, AN Tavare, AL Corbin, S Saluja, S Dawkins, L Edgar, N Rawlings, K Ziberna, E McNeill, E Johnson, AA Aljabali, RA Dragovic, M Rohling, TG Belgard, IA Udalova, DR Greaves, KM Channon, PR Riley, DC Anthony, RP Choudhury
JCI Insight, 2017-09-07;2(17):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients
Authors: M Matsushita, K Ozawa, T Suzuki, M Nakamura, N Nakano, S Kanchi, D Ichikawa, E Matsuki, M Sakurai, D Karigane, H Kasahara, N Tsukamoto, T Shimizu, T Mori, H Nakajima, S Okamoto, Y Kawakami, Y Hattori
Blood Cancer J, 2017-09-01;7(9):e601.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency
Authors: N Starc, D Ingo, A Conforti, V Rossella, L Tomao, A Pitisci, F De Mattia, I Brigida, M Algeri, M Montanari, G Palumbo, P Merli, P Rossi, A Aiuti, F Locatelli, ME Bernardo
Sci Rep, 2017-08-15;7(1):8153.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation
Authors: KA Bailey, FG Haj, SI Simon, AG Passerini
Sci Rep, 2017-08-15;7(1):8196.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential
Authors: YK Lee, SW Kim, JY Park, WC Kang, YJ Kang, D Khang
Int J Nanomedicine, 2017-08-10;12(0):5761-5779.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-143 and -145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis
Authors: BK Hong, S You, SA Yoo, D Park, D Hwang, CS Cho, WU Kim
Exp. Mol. Med., 2017-08-04;49(8):e363.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mollugin Has an Anti-Cancer Therapeutic Effect by Inhibiting TNF-?-Induced NF-?B Activation
Authors: Z Wang, MY Li, C Mi, KS Wang, J Ma, X Jin
Int J Mol Sci, 2017-07-26;18(8):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
Authors: E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron
PLoS ONE, 2017-07-14;12(7):e0181486.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching
Authors: R Ahmad, B Rah, D Bastola, P Dhawan, AB Singh
Sci Rep, 2017-07-11;7(1):5125.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterisation of preproendothelin-1 derived peptides identifies Endothelin-Like Domain Peptide as a modulator of Endothelin-1
Authors: J Yuzugulen, JA Douthwaite, EG Wood, IC Villar, NSA Patel, J Jegard, H Gaertner, I Rossitto-B, K Rose, O Hartley, PR Cutillas, A Ahluwalia, R Corder
Sci Rep, 2017-07-10;7(1):4956.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF?-Induced Disruption of the Blood-Retinal Barrier In Vitro Is Regulated by Intracellular 3',5'-Cyclic Adenosine Monophosphate Levels
Authors: AE van der Wi, IMC Vogels, CJF van Noorde, I Klaassen, RO Schlingema
Invest. Ophthalmol. Vis. Sci., 2017-07-01;58(9):3496-3505.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection
Authors: R Connor, LD Jones, X Qiu, J Thakar, SB Maggirwar
J. Leukoc. Biol., 2017-06-29;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of benzazole compounds that induce HIV-1 transcription
Authors: JD Graci, D Michaels, G Chen, GM Schiralli, S Nodder, M Weetall, GM Karp, Z Gu, JM Colacino, AJ Henderson
PLoS ONE, 2017-06-28;12(6):e0179100.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis
Authors: L Šenolt, K Prajzlerov, H Hulejová, B Šumová, M Filková, D Veigl, K Pavelka, J Vencovský
Cytokine, 2017-06-26;97(0):187-192.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Upregulation of circulating microRNA-134 in adult-onset Still's disease and its use as potential biomarker
Authors: TL Liao, YM Chen, CW Hsieh, HH Chen, HC Lee, WT Hung, KT Tang, DY Chen
Sci Rep, 2017-06-23;7(1):4214.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors
Authors: A Pavesi, AT Tan, S Koh, A Chia, M Colombo, E Antonecchi, C Miccolis, E Ceccarello, G Adriani, MT Raimondi, RD Kamm, A Bertoletti
JCI Insight, 2017-06-15;2(12):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Metabolic Adaptation Establishes Disease Tolerance to Sepsis
Authors: S Weis, AR Carlos, MR Moita, S Singh, B Blankenhau, S Cardoso, R Larsen, S Rebelo, S Schäuble, L Del Barrio, G Mithieux, F Rajas, S Lindig, M Bauer, MP Soares
Cell, 2017-06-15;169(7):1263-1275.e14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration
Authors: JS Reyat, M Chimen, PJ Noy, J Szyroka, GE Rainger, MG Tomlinson
J. Immunol., 2017-06-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proinflammatory Cytokines IL-6 and TNF-? Increased Telomerase Activity through NF-?B/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells
Authors: SS Chung, Y Wu, Q Okobi, D Adekoya, M Atefi, O Clarke, P Dutta, JV Vadgama
Mediators Inflamm., 2017-06-06;2017(0):5958429.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells
Authors: R Santos, KC Vadodaria, BN Jaeger, A Mei, S Lefcochilo, APD Mendes, G Erikson, M Shokhirev, L Randolph-M, C Fredlender, S Dave, R Oefner, C Fitzpatric, M Pena, JJ Barron, M Ku, AM Denli, BE Kerman, P Charnay, JR Kelsoe, MC Marchetto, FH Gage
Stem Cell Reports, 2017-06-06;8(6):1757-1769.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells
Authors: NT Hogan, MB Whalen, LK Stolze, NK Hadeli, MT Lam, JR Springstea, CK Glass, CE Romanoski
Elife, 2017-06-06;6(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
AAV-based dual-reporter circuit for monitoring cell signaling in living human cells
Authors: Z Zhang, Z Stickney, N Duong, K Curley, B Lu
J Biol Eng, 2017-06-05;11(0):18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity
Authors: D Sagar, NP Singh, R Ginwala, X Huang, R Philip, M Nagarkatti, P Nagarkatti, K Neumann, J Ruland, AM Andrews, SH Ramirez, ZK Khan, P Jain
Sci Rep, 2017-06-02;7(1):2707.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The involvement and possible mechanism of pro-inflammatory tumor necrosis factor alpha (TNF-?) in thoracic ossification of the ligamentum flavum
Authors: C Zhang, Z Chen, X Meng, M Li, L Zhang, A Huang
PLoS ONE, 2017-06-02;12(6):e0178986.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis
Authors: F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai
Scand. J. Immunol., 2017-06-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of a small molecule that primes the type I interferon response to cytosolic DNA
Authors: S Khiar, M Lucas-Hour, S Nisole, N Smith, O Helynck, M Bourgine, C Ruffié, JP Herbeuval, H Munier-Leh, F Tangy, PO Vidalain
Sci Rep, 2017-05-31;7(1):2561.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RalBP1 and p19-VHL play an oncogenic role, and p30-VHL plays a tumor suppressor role during the blebbishield emergency program
Authors: GG Jinesh, AM Kamat
Cell Death Discov, 2017-05-29;3(0):17023.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lysosomal destabilization activates the NLRP3 inflammasome in human umbilical vein endothelial cells (HUVECs)
Authors: K Kinnunen, N Piippo, S Loukovaara, M Hytti, K Kaarnirant, A Kauppinen
J Cell Commun Signal, 2017-05-25;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors
Authors: CH Lo, N Vunnam, AK Lewis, TL Chiu, BE Brummel, TM Schaaf, BD Grant, P Bawaskar, DD Thomas, JN Sachs
SLAS Discov, 2017-05-22;0(0):2472555217706.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF? promotes proliferation of human synovial MSCs while maintaining chondrogenic potential
Authors: M Shioda, T Muneta, K Tsuji, M Mizuno, K Komori, H Koga, I Sekiya
PLoS ONE, 2017-05-18;12(5):e0177771.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4.
Authors: Yunbo Ke, Noureddine Zebda, Olga Oskolkova, Taras Afonyushk, Evgeny Berdyshev, Yufeng Tian, Fanyong Meng, Nicolene Sarich, Valery N Bochkov, Ji Ming Wang, Anna A Birukova, Konstantin G Birukov
Circulation Research, 2017-05-18;0(0):1524-4571.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
Authors: M Fardoun, T Al-Shehabi, A El-Yazbi, K Issa, F Zouein, D Maaliki, R Iratni, AH Eid
Oxid Med Cell Longev, 2017-05-15;2017(0):4134093.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
Authors: A Alquraini, M Jamal, L Zhang, T Schmidt, GD Jay, KA Elsaid
Arthritis Res. Ther., 2017-05-08;19(1):89.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ASK1 (MAP3K5) is transcriptionally upregulated by E2F1 in adipose tissue in obesity, molecularly defining a human dys-metabolic obese phenotype
Authors: Y Haim, M Blüher, D Konrad, N Goldstein, N Klöting, I Harman-Boe, B Kirshtein, D Ginsberg, T Tarnovscki, Y Gepner, I Shai, A Rudich
Mol Metab, 2017-05-06;6(7):725-736.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice
Authors: GW He, C Günther, V Thonn, YQ Yu, E Martini, B Buchen, MF Neurath, M Stürzl, C Becker
J. Exp. Med., 2017-05-05;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Apomorphine suppresses TNF-?-induced MMP-9 expression and cell invasion through inhibition of ERK/AP-1 signaling pathway in MCF-7 cells
Authors: YS Jung, SO Lee
Biochem. Biophys. Res. Commun., 2017-05-02;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
iTRAQ quantitative proteomic study in patients with thoracic ossification of the ligamentum flavum
Authors: B Wang, Z Chen, X Meng, M Li, X Yang, C Zhang
Biochem. Biophys. Res. Commun., 2017-04-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adipogenic differentiation of MSC alters their immunomodulatory properties in a tissue-specific manner
Authors: H Munir, LS Ward, L Sheriff, S Kemble, S Nayar, F Barone, GB Nash, HM McGettrick
Stem Cells, 2017-04-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Unique molecular profile of exosomes derived from primary human proximal tubular epithelial cells under diseased conditions
Authors: X Wang, R Wilkinson, K Kildey, J Potriquet, J Mulvenna, RJ Lobb, A Möller, N Cloonan, P Mukhopadhy, AJ Kassianos, H Healy
J Extracell Vesicles, 2017-04-21;6(1):1314073.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Augmented Serum Amyloid A1/2 Mediated by TNF-induced NF-?B in Human Serous Ovarian Epithelial Tumors
Authors: H Choi, RMC Ignacio, ES Lee, AJ Wilson, D Khabele, DS Son
Immune Netw, 2017-04-20;17(2):121-127.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis
Authors: H Al Faruque, JH Kang, SR Hwang, S Sung, MM Alam, KH Sa, EJ Nam, YR Byun, YM Kang
PLoS ONE, 2017-04-18;12(4):e0176110.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity
Authors: KJ Chung, A Chatzigeor, M Economopou, R Garcia-Mar, VI Alexaki, I Mitroulis, M Nati, J Gebler, T Ziemssen, SE Goelz, J Phieler, JH Lim, KP Karalis, T Papayannop, M Blüher, G Hajishenga, T Chavakis
Nat. Immunol., 2017-04-17;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
Stem Cell Res Ther, 2017-04-17;8(1):79.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Doxofylline does not increase formoterol-induced cAMP nor MKP-1 expression in ASM cells resulting in lack of anti-inflammatory effect
Authors: BS Patel, MJ Kugel, G Baehring, AJ Ammit
Pulm Pharmacol Ther, 2017-04-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synovial cell death is regulated by TNF-?-induced expression of B-cell activating factor through an ERK-dependent increase in hypoxia-inducible factor-1?
Authors: JW Lee, J Lee, SH Um, EY Moon
Cell Death Dis, 2017-04-06;8(4):e2727.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-? induced insufficient autophagy contributes to p62-dependent apoptosis of epithelial cells in chronic rhinosinusitis with nasal polyps
Authors: BF Wang, PP Cao, ZC Wang, ZY Li, ZZ Wang, J Ma, B Liao, YK Deng, XB Long, K Xu, H Wang, H Wang, M Zeng, X Lu, Z Liu
Allergy, 2017-04-04;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Roflumilast N-oxide in Combination with Formoterol Enhances the Anti-inflammatory Effect of Dexamethasone in ASM Cells
Authors: Brijeshkumar S Patel
Am. J. Respir. Cell Mol. Biol, 2017-04-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of 6-phosphofructo-2-kinase suppresses fibroblast-like synoviocytes- mediated synovial inflammation and joint destruction in rheumatoid arthritis
Authors: Y Zou, S Zeng, M Huang, Q Qiu, Y Xiao, M Shi, Z Zhan, L Liang, X Yang, H Xu
Br. J. Pharmacol, 2017-03-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
Authors: M Frank-Bert, M Trenkmann, K Klein, E Karouzakis, H Rehrauer, A Bratus, C Kolling, M Armaka, A Filer, BA Michel, RE Gay, CD Buckley, G Kollias, S Gay, C Ospelt
Nat Commun, 2017-03-23;8(0):14852.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cell-Specific Variation in E-Selectin Ligand Expression among Human Peripheral Blood Mononuclear Cells: Implications for Immunosurveillance and Pathobiology
Authors: M Silva, RK Fung, CB Donnelly, PA Videira, R Sackstein
J. Immunol, 2017-03-22;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In�vitro model of cerebral ischemia by using brain microvascular endothelial cells derived from human induced pluripotent stem cells
Authors: Y Kokubu, T Yamaguchi, K Kawabata
Biochem. Biophys. Res. Commun, 2017-03-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: A pilot study
Authors: HA Ebhardt, S Degen, V Tadini, A Schilb, N Johns, CA Greig, KC Fearon, R Aebersold, C Jacobi
J Cachexia Sarcopenia Muscle, 2017-03-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
Oncotarget, 2017-03-14;0(0):1949-2553.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autophagy Impairment by Helicobacter pylori-induced Methylation Silencing of MAP1LC3Av1 Promotes Gastric Carcinogenesis
Authors: JS Muhammad, S Nanjo, T Ando, S Yamashita, T Maekita, T Ushijima, Y Tabuchi, T Sugiyama
Int. J. Cancer, 2017-03-14;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36?
Authors: JS Ainscough, T Macleod, D McGonagle, R Brakefield, JM Baron, A Alase, M Wittmann, M Stacey
Proc. Natl. Acad. Sci. U.S.A, 2017-03-13;114(13):E2748-E2757.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis
Authors: J Retzlaff, K Thamm, CC Ghosh, W Ziegler, H Haller, SM Parikh, S David
Sci Rep, 2017-03-09;7(0):44113.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A possible role for neutrophils in allergic rhinitis revealed after cellular subclassification
Authors: J Arebro, S Ekstedt, E Hjalmarsso, O Winqvist, S Kumlien Ge, LO Cardell
Sci Rep, 2017-03-08;7(0):43568.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-?B-Activating Factors through Direct Downregulation of IKK? and IKK?
Authors: MH Hancock, LM Hook, J Mitchell, JA Nelson
MBio, 2017-03-07;8(2):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9
Authors: JA Schwartz, KL Clayton, S Mujib, H Zhang, AK Rahman, J Liu, FY Yue, E Benko, C Kovacs, MA Ostrowski
J. Immunol, 2017-03-06;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Analytical ultracentrifugation with fluorescence detection system reveals differences in complex formation between recombinant human TNF and different biological TNF antagonists in various environments
Authors: E Krayukhina, M Noda, K Ishii, T Maruno, H Wakabayash, M Tada, T Suzuki, A Ishii-Wata, M Kato, S Uchiyama
MAbs, 2017-03-03;9(4):664-679.
Applications: Bioassay -
MC-PPEA as a new and more potent inhibitor of CLP-induced sepsis and pulmonary inflammation than FK866
Authors: P Huang, MW Lee, K Sadrerafi, DP Heruth, LQ Zhang, D Maulik, SQ Ye
Drug Des Devel Ther, 2017-03-03;11(0):629-641.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs
Authors: F Salazar, D Awuah, OH Negm, F Shakib, AM Ghaemmagha
Sci Rep, 2017-03-03;7(0):43337.
Species: Complex Species Category
Sample Types: Plasma
Applications: Bioassay -
Tissue-resident macrophages can contain replication-competent virus in antiretroviral-naive, SIV-infected Asian macaques
Authors: SR DiNapoli, AM Ortiz, F Wu, K Matsuda, HL Twigg, VM Hirsch, K Knox, JM Brenchley
JCI Insight, 2017-02-23;2(4):e91214.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity
Authors: L Israel, Y Wang, K Bulek, E Della Mina, Z Zhang, V Pedergnana, M Chrabieh, NA Lemmens, V Sancho-Shi, M Descatoire, T Lasseau, E Israelsson, L Lorenzo, L Yun, A Belkadi, A Moran, LE Weisman, F Vandenesch, F Batteux, S Weller, M Levin, J Herberg, A Abhyankar, C Prando, Y Itan, WJB van Wamel, C Picard, L Abel, D Chaussabel, X Li, B Beutler, PD Arkwright, JL Casanova, A Puel
Cell, 2017-02-23;168(5):789-800.e10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture -
Decitabine treatment sensitizes tumor cells to T-cell-mediated cytotoxicity in patients with myelodysplastic syndromes
Authors: Z Zhang, Q He, Y Tao, J Guo, F Xu, LY Wu, YS Zhao, D Wu, LY Zhou, JY Su, LX Song, C Xiao, X Li, CK Chang
Am J Transl Res, 2017-02-15;9(2):454-465.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial-mesenchymal transition in cancer
Authors: NV Sankpal, TP Fleming, PK Sharma, HJ Wiedner, WE Gillanders
Oncogene, 2017-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Substance P enhances proliferation and paracrine potential of adipose-derived stem cells in�vitro
Authors: S Kim, J Piao, Y Son, HS Hong
Biochem. Biophys. Res. Commun, 2017-02-10;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vaccination targeting native receptors to enhance the function and proliferation of chimeric antigen receptor (CAR)-modified T cells
Authors: M Tanaka, H Tashiro, B Omer, N Lapteva, J Ando, M Ngo, B Mehta, G Dotti, PR Kinchingto, AM Leen, C Rossig, CM Rooney
Clin. Cancer Res, 2017-02-09;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells
Authors: S Zhu, Q Zhang, X Sun, HJ Zeh, MT Lotze, R Kang, D Tang
Cancer Res, 2017-01-27;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
STAT3/NF-?B-Regulated Lentiviral TK/GCV Suicide Gene Therapy for Cisplatin-Resistant Triple-Negative Breast Cancer
Authors: WY Kuo, L Hwu, CY Wu, JS Lee, CW Chang, RS Liu
Theranostics, 2017-01-15;7(3):647-663.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN type I and II induce BAFF secretion from human decidual stromal cells
Authors: AC Lundell, I Nordstr”m, K Andersson, C Lundqvist, E Telemo, S Nava, H Kaipe, A Rudin
Sci Rep, 2017-01-06;7(0):39904.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Synthetic Mammalian Therapeutic Gene Circuit for Sensing and Suppressing Inflammation
Authors: A Smole, D Lain??ek, U Bezeljak, S Horvat, R Jerala
Mol. Ther, 2017-01-04;25(1):102-119.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Identificaiton of Novel Immunogenic Human Papillomavirus Type 16 E7-Specific Epitopes Restricted to HLA-A*33;03 for Cervical Cancer Immunotherapy
Authors: Jong Baeck Lim
Yonsei Med. J., 2017-01-01;58(1):43-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
Authors: L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
Autophagy, 2017-01-01;0(0):0.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy
Authors: R Havunen, M Siurala, S Sorsa, S Grönberg-V, M Behr, S Tähtinen, JM Santos, P Karell, J Rusanen, DM Nettelbeck, A Ehrhardt, A Kanerva, A Hemminki
Mol Ther Oncolytics, 2016-12-31;4(0):77-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis
Authors: Anja Kerstein
J. Autoimmun, 2016-12-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity
Authors: Shailesh Dudhgaonka
J. Immunol, 2016-12-21;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-37 suppresses hepatocellular carcinoma growth by converting pSmad3 signaling from JNK/pSmad3L/c-Myc oncogenic signaling to pSmad3C/P21 tumor-suppressive signaling
Authors: R Liu, C Tang, A Shen, H Luo, X Wei, D Zheng, C Sun, Z Li, D Zhu, T Li, Z Wu
Oncotarget, 2016-12-20;7(51):85079-85096.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling
Sci Rep, 2016-12-19;6(0):39190.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency
Proc. Natl. Acad. Sci. U.S.A, 2016-12-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adsorption as a Contributor for Inflammatory Mediators Removal by Different Hemofiltration Membranes: A Pilot Study
Authors: Benjamin Malard
Artif Organs, 2016-12-02;0(0):.
Species: Human
Sample Types: Plasma
Applications: Hemofiltration Procedure -
P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression
Stem Cell Res Ther, 2016-12-01;7(1):175.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Bioequivalence, safety and immunogenicity of BI 695501, an adalimumab biosimilar candidate, compared with the reference biologic in a randomized, double-blind, active-comparator Phase I clinical study (VOLTAIRE�-PK) in healthy subjects
Authors: Niklas Czeloth
Expert Opin Investig Drugs, 2016-12-01;0(0):.
Applications: Bioassay -
Growth Differentiation Factor-15-Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells
Invest. Ophthalmol. Vis. Sci, 2016-12-01;57(15):6482-6495.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Prenylated Polyphenols from Clusiaceae and Calophyllaceae with Immunomodulatory Activity on Endothelial Cells
PLoS ONE, 2016-12-01;11(12):e0167361.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation and function of Bone Morphogenetic Protein signaling in colonic injury and inflammation
Authors: Andrea Todisco
Am. J. Physiol. Gastrointest. Liver Physiol., 2016-11-17;0(0):ajpgi.00169.2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory treatment improves high-density lipoprotein function in rheumatoid arthritis
Authors: John Deanfield
Heart, 2016-11-16;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression
Authors: Martin F Reiner
Cardiovasc. Res, 2016-11-15;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Analysis of CD83 Expression on Human Immune Cells Identifies a Unique CD83+-Activated T Cell Population
Authors: Derek N J Hart
J. Immunol., 2016-11-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-inflammatory and immunomodulatory effects of Aquaphilus dolomiae extract on in vitro models
Authors: Nathalie Castex-Riz
Clin Cosmet Investig Dermatol, 2016-11-10;9(0):421-434.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme
Authors: Joan W Conaway
J. Biol. Chem., 2016-11-07;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Extracellular Microvesicle Production by Human Eosinophils Activated by Inflammatory Stimuli
Authors: Rossana C N Melo
Front Cell Dev Biol, 2016-10-27;4(0):117.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
Authors: Robert Sabat
Mediators Inflamm., 2016-10-23;2016(0):4097574.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bradykinin stimulates protein kinase D-mediated colonic myofibroblast migration via cyclooxygenase-2 and heat shock protein 27
Authors: Eric Chu
J. Surg. Res, 2016-10-20;209(0):191-198.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Serum YKL-40 as a marker of liver fibrosis in patients with non-alcoholic fatty liver disease
Sci Rep, 2016-10-14;6(0):35282.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue engineering of acellular vascular grafts capable of somatic growth in young lambs
Nat Commun, 2016-09-27;7(0):12951.
Species: Ovine
Sample Types: Whole Tissue
Applications: Bioassay -
Endothelial Cell Activation is Regulated by Epidermal Growth Factor-Like Domain 7 (Egfl7) during Inflammation
J Biol Chem, 2016-09-20;0(0):.
Species: Human, Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
Cytokines TNF-?, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells.
Authors: Angela P Bastidas-C, Astrid D Bakker, Behrouz Zandieh-D, Cornelis J Kleverlaa, Nathalie Bravenboe, Tim Forouzanf, Jenneke Klein-Nul
Stem Cells International, 2016-09-07;0(0):1687-966X.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17
PLoS ONE, 2016-09-02;11(9):e0161759.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization
Mol Ther Methods Clin Dev, 2016-08-24;3(0):16056.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Negative regulation of NF-?B p65 activity by serine 536 phosphorylation.
Authors: Jean-Philippe Pradère, Céline Hernandez, Christiane Koppe, Richard A Friedman, Tom Luedde, Robert F Schwabe
Science Signaling, 2016-08-23;0(0):1937-9145.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HDL function is impaired in acute myocardial infarction independent of plasma HDL cholesterol levels
Authors: Wijtske Annema
J Clin Lipidol, 2016-08-17;10(6):1318-1328.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IRAK1, a Target of miR-146b, Reduces Cell Aggressiveness of Human Papillary Thyroid Carcinoma
J Clin Endocrinol Metab, 2016-08-17;0(0):jc20162276.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity
Cell, 2016-08-11;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis
Cell Death Dis, 2016-06-30;7(6):e2287.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Mosquito Saliva Increases Endothelial Permeability in the Skin, Immune Cell Migration, and Dengue Pathogenesis during Antibody-Dependent Enhancement
Authors: Michael A Schmid
PLoS Pathog, 2016-06-16;12(6):e1005676.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-? and Tumor Necrosis Factor-? Polarize Bone Marrow Stromal Cells Uniformly to a Th1 Phenotype
Sci Rep, 2016-05-23;6(0):26345.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells
PLoS ONE, 2016-05-20;11(5):e0156145.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium massiliense Induces Macrophage Extracellular Traps with Facilitating Bacterial Growth
PLoS ONE, 2016-05-18;11(5):e0155685.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-3 Decreases Cartilage Degeneration by Downregulating Matrix Metalloproteinases and Reduces Joint Destruction in Osteoarthritic Mice
J Immunol, 2016-05-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7
Authors: MM Halpert, V Konduri, D Liang, Y Chen, JB Wing, S Paust, JM Levitt, WK Decker
Stem Cells Dev., 2016-05-02;25(10):774-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Authors: R Yosef, N Pilpel, R Tokarsky-A, A Biran, Y Ovadya, S Cohen, E Vadai, L Dassa, E Shahar, R Condiotti, I Ben-Porath, V Krizhanovs
Nat Commun, 2016-04-06;7(0):11190.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human lung fibroblasts may modulate dendritic cell phenotype and function: results from a pilot in vitro study
Authors: O Freynet, J Marchal-So, F Jean-Louis, A Mailleux, B Crestani, P Soler, L Michel
Respir Res, 2016-04-04;17(1):36.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial Surface Protrusion by a Point Force
Authors: Y Chen, L Lu, JY Shao
Biophys. J, 2016-03-08;110(5):1150-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis.
Authors: Lu W, Sun J, Yoon J, Zhang Y, Zheng L, Murphy E, Mattson M, Lenardo M
PLoS ONE, 2016-01-25;11(1):e0147792.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Up-Regulation of Human Inducible Nitric Oxide Synthase by p300 Transcriptional Complex.
Authors: Guo Z, Zheng L, Liao X, Geller D
PLoS ONE, 2016-01-11;11(1):e0146640.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Common Genetic Variant in TLR1 Enhances Human Neutrophil Priming and Impacts Length of Intensive Care Stay in Pediatric Sepsis.
Authors: Whitmore L, Hook J, Philiph A, Hilkin B, Bing X, Ahn C, Wong H, Ferguson P, Moreland J
J Immunol, 2016-01-04;196(3):1376-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tissue Inhibitor of Metalloproteinase-4 Triggers Apoptosis in Cervical Cancer Cells.
Authors: Lizarraga F, Ceballos-Cancino G, Espinosa M, Vazquez-Santillan K, Maldonado V, Melendez-Zajgla J
PLoS ONE, 2015-08-20;10(8):e0135929.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome.
Authors: Fairclough L, Stoop A, Negm O, Radford P, Tighe P, Todd I
Eur J Immunol, 2015-08-17;45(10):2937-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CYLD and the NEMO Zinc Finger Regulate Tumor Necrosis Factor Signaling and Early Embryogenesis.
Authors: Zhao Y, Ma C, Wu L, Iwai K, Ashwell J, Oltz E, Ballard D, Jain A
J Biol Chem, 2015-07-29;290(36):22076-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dual inhibition of CDK4/Rb and PI3K/AKT/mTOR pathways by ON123300 induces synthetic lethality in mantle cell lymphomas.
Authors: Divakar S, Ramana Reddy M, Cosenza S, Baker S, Perumal D, Antonelli A, Brody J, Akula B, Parekh S, Premkumar Reddy E
Leukemia, 2015-07-15;30(1):86-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-4 Downregulates IL-1beta and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine.
Authors: Onderdijk A, Baerveldt E, Kurek D, Kant M, Florencia E, Debets R, Prens E
J Immunol, 2015-07-13;195(4):1744-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia.
Authors: Southcombe J, Redman C, Sargent I, Granne I
Clin Exp Immunol, 2015-06-29;181(3):480-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.
Authors: Watson R, Buck J, Levin L, Winger R, Wang J, Arase H, Muller W
J Exp Med, 2015-06-22;212(7):1021-41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cancer-testis antigen SLLP1 represents a promising target for the immunotherapy of multiple myeloma.
Authors: Yousef S, Heise J, Lajmi N, Bartels K, Kroger N, Luetkens T, Atanackovic D
J Transl Med, 2015-06-20;13(0):197.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFkappaB activation in airway epithelial cells.
Authors: Kurakula K, Hamers A, van Loenen P, de Vries C
Respir Res, 2015-06-19;16(0):73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes.
Authors: Perriard G, Mathias A, Enz L, Canales M, Schluep M, Gentner M, Schaeren-Wiemers N, Du Pasquier R
J Neuroinflammation, 2015-06-16;12(0):119.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure.
Authors: Miranda A, Funes J, Sanchez N, Limia C, Mesa M, Quezada S, Perez R, de Leon J
Cancer Res, 2015-06-11;75(15):3032-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia.
Authors: Boisson B, Laplantine E, Dobbs K, Cobat A, Tarantino N, Hazen M, Lidov H, Hopkins G, DU L, Belkadi A, Chrabieh M, Itan Y, Picard C, Fournet J, Eibel H, Tsitsikov E, Pai S, Abel L, Al-Herz W, Casanova J, Israel A, Notarangelo L
J Exp Med, 2015-05-25;212(6):939-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage.
Authors: Catanzaro D, Rancan S, Orso G, Dall'Acqua S, Brun P, Giron M, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M
PLoS ONE, 2015-05-08;10(5):e0125375.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.
Authors: He Y, Zheng Q, Jiang M, Sun S, Christiansen T, Kassem M, Karsdal M, Bay-Jensen A
PLoS ONE, 2015-04-24;10(0):.
Species: Bovine
Sample Types: Whole Tissue
Applications: Bioassay -
Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes.
Authors: Sommerfelt R, Feuerherm A, Skuland T, Johansen B
PLoS ONE, 2015-04-20;10(4):e0119088.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Facile supermolecular aptamer inhibitors of L-selectin.
Authors: Chang, Elizabet, Eckert, Mark A, Ali, M Monsur, Riazifar, Hamidrez, Pone, Egest J, Liu, Linan, Zhao, Weian
PLoS ONE, 2015-03-31;10(3):e0123034.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Molecular mechanisms linking high dose medroxyprogesterone with HIV-1 risk.
Authors: Irvin S, Herold B
PLoS ONE, 2015-03-23;10(3):e0121135.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of pancreatic NMDA receptors as possible drug targets for diabetes treatment.
Authors: Marquard J, Otter S, Welters A, Stirban A, Fischer A, Eglinger J, Herebian D, Kletke O, Klemen M, Stozer A, Wnendt S, Piemonti L, Kohler M, Ferrer J, Thorens B, Schliess F, Rupnik M, Heise T, Berggren P, Klocker N, Meissner T, Mayatepek E, Eberhard D, Kragl M, Lammert E
Nat Med, 2015-03-16;21(4):363-72.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro.
Authors: Rzeniewicz K, Newe A, Rey Gallardo A, Davies J, Holt M, Patel A, Charras G, Stramer B, Molenaar C, Tedder T, Parsons M, Ivetic A
Proc Natl Acad Sci U S A, 2015-03-09;112(12):E1461-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.
Authors: Gentilini M, Velasquez L, Barrionuevo P, Arriola Benitez P, Giambartolomei G, Delpino M
Infect Immun, 2015-03-02;83(5):1973-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RIP1 Kinase Is an Oncogenic Driver in Melanoma.
Authors: Liu X, Lai F, Yan X, Jiang C, Guo S, Wang C, Croft A, Tseng H, Wilmott J, Scolyer R, Jin L, Zhang X
Cancer Res, 2015-02-27;75(8):1736-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammation and hypoxia linked to renal injury by CCAAT/enhancer-binding protein delta.
Authors: Yamaguchi J, Tanaka T, Eto N, Nangaku M
Kidney Int, 2015-02-18;88(2):262-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor kappaB (NF-kappaB) signaling.
Authors: Wang Y, Tan B, Mu R, Chang Y, Wu M, Tu H, Zhang Y, Guo S, Qin X, Li T, Li W, Li A, Zhang X, Li H
J Biol Chem, 2015-02-13;290(16):10395-405.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
RelB/p50 complexes regulate cytokine-induced YKL-40 expression.
Authors: Bhardwaj R, Yester J, Singh S, Biswas D, Surace M, Waters M, Hauser K, Yao Z, Boyce B, Kordula T
J Immunol, 2015-02-13;194(6):2862-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The cerebral cavernous malformation 3 gene is necessary for senescence induction.
Authors: Guerrero A, Iglesias C, Raguz S, Floridia E, Gil J, Pombo C, Zalvide J
Aging Cell, 2015-02-05;14(2):274-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages.
Authors: Herova M, Schmid M, Gemperle C, Hersberger M
J Immunol, 2015-01-30;194(5):2330-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine-induced loss of glucocorticoid function: effect of kinase inhibitors, long-acting beta(2)-adrenoceptor [corrected] agonist and glucocorticoid receptor ligands.
Authors: Rider C, Shah S, Miller-Larsson A, Giembycz M, Newton R
PLoS ONE, 2015-01-27;10(1):e0116773.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells.
Authors: Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M
Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment.
Authors: Rousseau M, Belleannee C, Duchez A, Cloutier N, Levesque T, Jacques F, Perron J, Nigrovic P, Dieude M, Hebert M, Gelb M, Boilard E
PLoS ONE, 2015-01-14;10(1):e0116812.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of transforming growth factor-activated kinase-1 on tumor necrosis factor-alpha actions in human adipose tissue-derived stromal cells.
Authors: Lee S, Lee J, Shin K, Kim D, Kim Y, Bae Y, Jung J
Stem Cells Dev, 2014-12-31;24(7):836-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.
Authors: Chan C, Fang C, Qiao Y, Yarilina A, Prinjha R, Ivashkiv L
Eur J Immunol, 2014-12-01;45(1):287-97.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nuclear FAM21 participates in NF-kappaB-dependent gene regulation in pancreatic cancer cells.
Authors: Deng Z, Gomez T, Osborne D, Phillips-Krawczak C, Zhang J, Billadeau D
J Cell Sci, 2014-11-27;128(2):373-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Anti-apoptotic NF-kappaB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production.
Authors: Muller I, Beissert S, Kulms D
J Invest Dermatol, 2014-11-07;135(3):851-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy.
Authors: Lam, Sharon, Sung, Julia, Cruz, Conrad, Castillo-Caro, Paul, Ngo, Minhtran, Garrido, Carolina, Kuruc, Joann, Archin, Nancie, Rooney, Cliona, Margolis, David, Bollard, Catherin
Mol Ther, 2014-11-04;23(2):387-95.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
Infect Immun, 2014-10-13;83(1):138-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Restoring Akt1 activity in outgrowth endothelial cells from South Asian men rescues vascular reparative potential.
Authors: Cubbon R, Yuldasheva N, Viswambharan H, Mercer B, Baliga V, Stephen S, Askham J, Sukumar P, Skromna A, Mughal R, Walker A, Bruns A, Bailey M, Galloway S, Imrie H, Gage M, Rakobowchuk M, Li J, Porter K, Ponnambalam S, Wheatcroft S, Beech D, Kearney M
Stem Cells, 2014-10-01;32(10):2714-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Family with sequence similarity 5, member C (FAM5C) increases leukocyte adhesion molecules in vascular endothelial cells: implication in vascular inflammation.
Authors: Sato J, Kinugasa M, Satomi-Kobayashi S, Hatakeyama K, Knox A, Asada Y, Wierman M, Hirata K, Rikitake Y
PLoS ONE, 2014-09-24;9(9):e107236.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion.
Authors: Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L
PLoS ONE, 2014-09-03;9(9):e106673.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Th17-type cytokines, IL-6 and TNF-alpha synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth.
Authors: De Simone V, Franze E, Ronchetti G, Colantoni A, Fantini M, Di Fusco D, Sica G, Sileri P, MacDonald T, Pallone F, Monteleone G, Stolfi C
Oncogene, 2014-09-01;34(27):3493-503.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
DeltaNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis.
Authors: Kubo T, Kamekura R, Kumagai A, Kawata K, Yamashita K, Mitsuhashi Y, Kojima T, Sugimoto K, Yoneta A, Sumikawa Y, Yamashita T, Sato N, Himi T, Ichimiya S
PLoS ONE, 2014-08-29;9(8):e105498.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Membrane type 1-matrix metalloproteinase/Akt signaling axis modulates TNF-alpha-induced procoagulant activity and apoptosis in endothelial cells.
Authors: Ohkawara H, Ishibashi T, Sugimoto K, Ikeda K, Ogawa K, Takeishi Y
PLoS ONE, 2014-08-27;9(8):e105697.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Identification of novel epitopes from human papillomavirus type 18 E7 that can sensitize PBMCs of multiple HLA class I against human cervical cancer.
Authors: Kim S, Chung H, Lee K, Lim J
J Transl Med, 2014-08-21;12(0):229.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.
Authors: Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri K, Sahaf B, Herzenberg L, Herzenberg L, Mullen L, Ghezzi P
Proc Natl Acad Sci U S A, 2014-08-05;111(33):12157-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen.
Authors: Bailon E, Ugarte-Berzal E, Amigo-Jimenez I, Van den Steen P, Opdenakker G, Garcia-Marco J, Garcia-Pardo A
J Leukoc Biol, 2014-08-01;96(2):185-99.
Species: Human
Sample Types: N/A
-
Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk.
Authors: Sehgal K, Ragheb R, Fahmy T, Dhodapkar M, Dhodapkar K
J Immunol, 2014-07-30;193(5):2297-305.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plasticity-related gene 5 promotes spine formation in murine hippocampal neurons.
Authors: Coiro P, Stoenica L, Strauss U, Brauer A
J Biol Chem, 2014-07-29;289(36):24956-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
p300-mediated acetylation of COMMD1 regulates its stability, and the ubiquitylation and nucleolar translocation of the RelA NF-kappaB subunit.
Authors: O'Hara A, Simpson J, Morin P, Loveridge C, Williams A, Novo S, Stark L
J Cell Sci, 2014-07-29;127(0):3659-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Carbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell death.
Authors: Ji, Weidong, Yang, Mei, Praggastis, Alexandr, Li, Yonghao, Zhou, Huanjiao, He, Yun, Ghazvinian, Roxanne, Cincotta, Dylan J, Rice, Kevin P, Min, Wang
PLoS ONE, 2014-07-28;9(7):e103224.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay -
Extrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.
Authors: Chattopadhyay A, Hood B, Conrads T, Redner R
Mol Cancer Res, 2014-07-17;12(9):1283-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A20 deficiency causes spontaneous neuroinflammation in mice.
Authors: Guedes R, Csizmadia E, Moll H, Ma A, Ferran C, da Silva C
J Neuroinflammation, 2014-07-16;11(0):122.
Species: Mouse
Sample Types: Whole Cells
Applications: Stimulation -
The differential regulation of human ACT1 isoforms by Hsp90 in IL-17 signaling.
Authors: Wu L, Wang C, Boisson B, Misra S, Rayman P, Finke J, Puel A, Casanova J, Li X
J Immunol, 2014-07-14;193(4):1590-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M.
Authors: Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F
PLoS ONE, 2014-07-10;9(7):e101937.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB231 partly through suppression of the Akt pathway.
Authors: Jin H, Lee W, Eun S, Jung J, Park H, Kim G, Choi Y, Ryu C, Jung J, Hong S, Shin S, Kim H
Int J Oncol, 2014-07-04;45(4):1629-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Authors: Lewis, Nuruddee, Patnaude, Lori A, Pelletier, Josephin, Souza, Donald J, Lukas, Susan M, King, F James, Hill, Jonathan, Stefanopoulos, Dimitria, Ryan, Kelli, Desai, Sudha, Skow, Donna, Kauschke, Stefan G, Broermann, Andre, Kuzmich, Daniel, Harcken, Christia, Hickey, Eugene R, Modis, Louise K
PLoS ONE, 2014-06-26;9(6):e100883.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Caffeic acid derivatives inhibit the growth of colon cancer: involvement of the PI3-K/Akt and AMPK signaling pathways.
Authors: Chiang, En-Pei I, Tsai, Shu-Yao, Kuo, Yueh-Hsi, Pai, Man-Hui, Chiu, Hsi-Lin, Rodriguez, Raymond, Tang, Feng-Yao
PLoS ONE, 2014-06-24;9(6):e99631.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
PHLDA1 expression is controlled by an estrogen receptor-NFkappaB-miR-181 regulatory loop and is essential for formation of ER+ mammospheres.
Authors: Kastrati I, Canestrari E, Frasor J
Oncogene, 2014-06-23;34(18):2309-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Adoptive immunotherapy with MUC1-mRNA transfected dendritic cells and cytotoxic lymphocytes plus gemcitabine for unresectable pancreatic cancer.
Authors: Shindo Y, Hazama S, Maeda Y, Matsui H, Iida M, Suzuki N, Yoshimura K, Ueno T, Yoshino S, Sakai K, Suehiro Y, Yamasaki T, Hinoda Y, Oka M
J Transl Med, 2014-06-19;12(0):175.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.
Authors: Mimura N, Hideshima T, Shimomura T, Suzuki R, Ohguchi H, Rizq O, Kikuchi S, Yoshida Y, Cottini F, Jakubikova J, Cirstea D, Gorgun G, Minami J, Tai Y, Richardson P, Utsugi T, Iwama A, Anderson K
Cancer Res, 2014-06-16;74(16):4458-69.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1.
Authors: Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T
J Immunol, 2014-06-11;193(2):879-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A pro-inflammatory signalome is constitutively activated by C33Y mutant TNF receptor 1 in TNF receptor-associated periodic syndrome (TRAPS).
Authors: Negm O, Mannsperger H, McDermott E, Drewe E, Powell R, Todd I, Fairclough L, Tighe P
Eur J Immunol, 2014-06-10;44(7):2096-110.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis.
Authors: Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu M, Bogiatzi S, Fernandez M, Touzot M, Bichet J, Reyal F, Paronetto M, Chiricozzi A, Chimenti S, Nasorri F, Cavani A, Kislat A, Homey B, Soumelis V
J Allergy Clin Immunol, 2014-06-06;134(2):373-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-alpha, and IL-1beta.
Authors: Zhao Y, Xiao X, Frank S, Lin H, Xia Y
Am J Physiol Endocrinol Metab, 2014-06-03;307(2):E186-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells.
Authors: Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georen S, Latif L, Cardell L
PLoS ONE, 2014-06-02;9(6):e98239.
Species: Human
Sample Types: Whole Tissue
Applications: Bioassay -
Neutrophils from vasculitis patients exhibit an increased propensity for activation by anti-neutrophil cytoplasmic antibodies.
Authors: Ohlsson S, Ohlsson S, Soderberg D, Gunnarsson L, Pettersson A, Segelmark M, Hellmark T
Clin Exp Immunol, 2014-06-01;176(3):363-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity.
Authors: Schafer P, Parton A, Capone L, Cedzik D, Brady H, Evans J, Man H, Muller G, Stirling D, Chopra R
Cell Signal, 2014-05-29;26(9):2016-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Glucocorticoid-induced reversal of interleukin-1beta-stimulated inflammatory gene expression in human oviductal cells.
Authors: Backman S, Kollara A, Haw R, Stein L, Brown T
PLoS ONE, 2014-05-21;9(5):e97997.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Plasma cells in the mucosa of patients with inflammatory bowel disease produce granzyme B and possess cytotoxic activities.
Authors: Cupi M, Sarra M, Marafini I, Monteleone I, Franze E, Ortenzi A, Colantoni A, Sica G, Sileri P, Rosado M, Carsetti R, MacDonald T, Pallone F, Monteleone G
J Immunol, 2014-05-16;192(12):6083-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-2 phosphorylates STAT5 to drive IFN-gamma production and activation of human dendritic cells.
Authors: Herr F, Lemoine R, Gouilleux F, Meley D, Kazma I, Heraud A, Velge-Roussel F, Baron C, Lebranchu Y
J Immunol, 2014-05-14;192(12):5660-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TL1A increased the differentiation of peripheral Th17 in rheumatoid arthritis.
Authors: Zhou M, Liu R, Su D, Feng X, Li X
Cytokine, 2014-05-13;69(1):125-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A splicing variant of NME1 negatively regulates NF-kappaB signaling and inhibits cancer metastasis by interacting with IKKbeta.
Authors: You D, Park C, Lee H, Moon M, Kang J, Lee C, Oh S, Ahn C, Seong J, Hwang J
J Biol Chem, 2014-05-08;289(25):17709-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells.
Authors: Kim, Dae Won, Zloza, Andrew, Broucek, Joseph, Schenkel, Jason M, Ruby, Carl, Samaha, Georges, Kaufman, Howard L
J Transl Med, 2014-05-06;12(0):113.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Osteodifferentiated mesenchymal stem cells from bone marrow and adipose tissue express HLA-G and display immunomodulatory properties in HLA-mismatched settings: implications in bone repair therapy.
Authors: Montespan F, Deschaseaux F, Sensebe L, Carosella E, Rouas-Freiss N
J Immunol Res, 2014-04-30;2014(0):230346.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4.
Authors: Catanzaro J, Sheshadri N, Pan J, Sun Y, Shi C, Li J, Powers R, Crawford H, Zong W
Nat Commun, 2014-04-23;5(0):3729.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor (TNF)-alpha induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-kappaB p65 methylation.
Authors: Harris D, Bandyopadhyay S, Maxwell T, Willard B, DiCorleto P
J Biol Chem, 2014-04-21;289(22):15328-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
Authors: Singer B, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza L, Heyl K, Muller M, Weimann A, Zweigner J, Slevogt H
PLoS ONE, 2014-04-17;9(4):e94106.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel CD44-binding peptide from the pro-matrix metalloproteinase-9 hemopexin domain impairs adhesion and migration of chronic lymphocytic leukemia (CLL) cells.
Authors: Ugarte-Berzal E, Bailon E, Amigo-Jimenez I, Albar J, Garcia-Marco J, Garcia-Pardo A
J Biol Chem, 2014-04-16;289(22):15340-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stiffness-activated GEF-H1 expression exacerbates LPS-induced lung inflammation.
Authors: Mambetsariev I, Tian Y, Wu T, Lavoie T, Solway J, Birukov K, Birukova A
PLoS ONE, 2014-04-16;9(4):e92670.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Characterization of platelet-monocyte complexes in HIV-1-infected individuals: possible role in HIV-associated neuroinflammation.
Authors: Singh, Meera V, Davidson, Donna C, Jackson, Joseph W, Singh, Vir B, Silva, Jharon, Ramirez, Servio H, Maggirwar, Sanjay B
J Immunol, 2014-04-11;192(10):4674-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Overexpression of CCN3 inhibits inflammation and progression of atherosclerosis in apolipoprotein E-deficient mice.
Authors: Liu J, Ren Y, Kang L, Zhang L
PLoS ONE, 2014-04-10;9(4):e94912.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members.
Authors: Beigel F, Friedrich M, Probst C, Sotlar K, Goke B, Diegelmann J, Brand S
PLoS ONE, 2014-04-07;9(4):e93498.
Applications: Western Blot -
Cell density impacts epigenetic regulation of cytokine-induced E-selectin gene expression in vascular endothelium.
Authors: Hamada K, Osaka M, Yoshida M
PLoS ONE, 2014-04-01;9(4):e90502.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Toxoplasma gondii virulence factor ROP18 inhibits the host NF-kappaB pathway by promoting p65 degradation.
Authors: Du J, An R, Chen L, Shen Y, Chen Y, Cheng L, Jiang Z, Zhang A, Yu L, Chu D, Shen Y, Luo Q, Chen H, Wan L, Li M, Xu X, Shen J
J Biol Chem, 2014-03-19;289(18):12578-92.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids.
Authors: Rahman M, Alkhouri H, Tang F, Che W, Ge Q, Ammit A
PLoS ONE, 2014-03-19;9(3):e92466.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rad GTPase inhibits the NFkappaB pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Authors: Hsiao B, Chang T, Wu I, Chen M
Cell Signal, 2014-03-13;26(7):1437-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014-03-12;44(5):1745-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation.
Authors: Lopez-Ramirez M, Wu D, Pryce G, Simpson J, Reijerkerk A, King-Robson J, Kay O, de Vries H, Hirst M, Sharrack B, Baker D, Male D, Michael G, Romero I
FASEB J, 2014-03-06;28(6):2551-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumour necrosis factor-alpha regulates human eosinophil apoptosis via ligation of TNF-receptor 1 and balance between NF-kappaB and AP-1.
Authors: Kankaanranta H, Ilmarinen P, Zhang X, Adcock I, Lahti A, Barnes P, Giembycz M, Lindsay M, Moilanen E
PLoS ONE, 2014-02-28;9(2):e90298.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The RhoA guanine nucleotide exchange factor, LARG, mediates ICAM-1-dependent mechanotransduction in endothelial cells to stimulate transendothelial migration.
Authors: Lessey-Morillon E, Osborne L, Monaghan-Benson E, Guilluy C, O'Brien E, Superfine R, Burridge K
J Immunol, 2014-02-28;192(7):3390-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Luteolin inhibits human keratinocyte activation and decreases NF-kappaB induction that is increased in psoriatic skin.
Authors: Weng Z, Patel A, Vasiadi M, Therianou A, Theoharides T
PLoS ONE, 2014-02-28;9(2):e90739.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The multifunctional growth factor midkine promotes proliferation and migration in pancreatic cancer.
Authors: Rawnaq T, Dietrich L, Wolters-Eisfeld G, Uzunoglu F, Vashist Y, Bachmann K, Simon R, Izbicki J, Bockhorn M, Gungor C
Mol Cancer Res, 2014-02-24;12(5):670-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
MicroRNA-26b suppresses the NF-kappaB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3.
Authors: Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang S
Mol Cancer, 2014-02-24;13(0):35.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Innate lymphoid cells integrate stromal and immunological signals to enhance antibody production by splenic marginal zone B cells.
Authors: Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra C, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Arostegui J, Juan M, Yague J, Merad M, Fagarasan S, Cerutti A
Nat Immunol, 2014-02-23;15(4):354-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.
Authors: Llop-Guevara A, Chu D, Walker T, Goncharova S, Fattouh R, Silver J, Moore C, Xie J, O'Byrne P, Coyle A, Kolbeck R, Humbles A, Stampfli M, Jordana M
PLoS ONE, 2014-02-14;9(2):e88714.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial activation by platelets from sickle cell anemia patients.
Authors: Proenca-Ferreira R, Brugnerotto A, Garrido V, Dominical V, Vital D, Ribeiro M, dos Santos M, Traina F, Olalla-Saad S, Costa F, Conran N
PLoS ONE, 2014-02-13;9(2):e89012.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vaspin inhibits cytokine-induced nuclear factor-kappa B activation and adhesion molecule expression via AMP-activated protein kinase activation in vascular endothelial cells.
Authors: Jung C, Lee M, Kang Y, Lee Y, Yoon H, Kang S, Lee W, Park J
Cardiovasc Diabetol, 2014-02-12;13(0):41.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The in vitro pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long acting beta2-adrenoceptor agonist.
Authors: Tannheimer S, Sorensen E, Cui Z, Kim M, Patel L, Baker W, Phillips G, Wright C, Salmon M
J Pharmacol Exp Ther, 2014-02-10;349(1):85-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF-alpha induces matrix metalloproteinase-9-dependent soluble intercellular adhesion molecule-1 release via TRAF2-mediated MAPKs and NF-kappaB activation in osteoblast-like MC3T3-E1 cells.
Authors: Tsai C, Chen W, Hsieh H, Chi P, Hsiao L, Yang C
J Biomed Sci, 2014-02-05;21(0):12.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CD24-triggered caspase-dependent apoptosis via mitochondrial membrane depolarization and reactive oxygen species production of human neutrophils is impaired in sepsis.
Authors: Parlato M, Souza-Fonseca-Guimaraes F, Philippart F, Misset B, Adib-Conquy M, Cavaillon J
J Immunol, 2014-02-05;192(5):2449-59.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enriched protein screening of human bone marrow mesenchymal stromal cell secretions reveals MFAP5 and PENK as novel IL-10 modulators.
Authors: Milwid, Jack M, Elman, Jessica, Li, Matthew, Shen, Keyue, Manrai, Arjun, Gabow, Aaron, Yarmush, Joshua, Jiao, Yunxin, Fletcher, Anne, Lee, Jungwoo, Cima, Michael, Yarmush, Martin L, Parekkadan, Biju
Mol Ther, 2014-02-05;22(5):999-1007.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity.
Authors: Morlino G, Barreiro O, Baixauli F, Robles-Valero J, Gonzalez-Granado J, Villa-Bellosta R, Cuenca J, Sanchez-Sorzano C, Veiga E, Martin-Cofreces N, Sanchez-Madrid F
Mol Cell Biol, 2014-02-03;34(8):1412-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways.
Authors: Lo H, Lai T, Li C, Wu W
Acta Pharmacol Sin, 2014-02-03;35(3):339-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Absence of a role for interleukin-13 in inflammatory bowel disease.
Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
Eur J Immunol, 2014-02-01;44(2):370-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA.
Authors: Chiliveru S, Rahbek S, Jensen S, Jorgensen S, Nissen S, Christiansen S, Mogensen T, Jakobsen M, Iversen L, Johansen C, Paludan S
J Immunol, 2014-01-31;192(5):2395-404.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of ten-eleven translocation 1 (TET1), Isocitrate Dehydrogenase (IDH) expression, alpha-Ketoglutarate (alpha-KG), and DNA hydroxymethylation levels by interleukin-1beta in primary human chondrocytes.
Authors: Haseeb A, Makki M, Haqqi T
J Biol Chem, 2014-01-27;289(10):6877-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Comparison of osteogenic differentiation of embryonic stem cells and primary osteoblasts revealed by responses to IL-1beta, TNF-alpha, and IFN-gamma.
Authors: Sidney L, Kirkham G, Buttery L
Stem Cells Dev, 2014-01-23;23(6):605-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
TRAIL/DR5 signaling promotes macrophage foam cell formation by modulating scavenger receptor expression.
Authors: Liu F, Wu X, Zhang Y, Wang Y, Jiang F
PLoS ONE, 2014-01-22;9(1):e87059.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Transcriptional repression of the transforming growth factor beta (TGF-beta) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor kappaB (NF-kappaB) p50 enhances TGF-beta signaling in hepatic stellate cells.
Authors: Liu C, Chen X, Yang L, Kisseleva T, Brenner D, Seki E
J Biol Chem, 2014-01-21;289(10):7082-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Reduced BMPR2 expression induces GM-CSF translation and macrophage recruitment in humans and mice to exacerbate pulmonary hypertension.
Authors: Sawada H, Saito T, Nickel N, Alastalo T, Glotzbach J, Chan R, Haghighat L, Fuchs G, Januszyk M, Cao A, Lai Y, Perez V, Kim Y, Wang L, Chen P, Spiekerkoetter E, Mitani Y, Gurtner G, Sarnow P, Rabinovitch M
J Exp Med, 2014-01-20;211(2):263-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Durable remission of renal cell carcinoma in conjuncture with graft versus host disease following allogeneic stem cell transplantation and donor lymphocyte infusion: rule or exception?
Authors: van Bergen, Cornelis, Verdegaal, Elisabet, Honders, M Wilhel, Hoogstraten, Conny, Steijn-van Tol, A Q M Je, de Quartel, Linda, de Jong, Joan, Meyering, Maaike, Falkenburg, J H Fred, Griffioen, Marieke, Osanto, Susanne
PLoS ONE, 2014-01-15;9(1):e85198.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy.
Authors: Ahmad T, Mukherjee S, Pattnaik B, Kumar M, Singh S, Kumar M, Rehman R, Tiwari B, Jha K, Barhanpurkar A, Wani M, Roy S, Mabalirajan U, Ghosh B, Agrawal A
EMBO J, 2014-01-15;33(9):994-1010.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TRIM38 inhibits TNFalpha- and IL-1beta-triggered NF-kappaB activation by mediating lysosome-dependent degradation of TAB2/3.
Authors: Hu M, Yang Q, Zhang J, Liu S, Zhang Y, Lin H, Huang Z, Wang Y, Zhang X, Zhong B, Shu H
Proc Natl Acad Sci U S A, 2014-01-13;111(4):1509-14.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pharmacologic IKK/NF-kappaB inhibition causes antigen presenting cells to undergo TNFalpha dependent ROS-mediated programmed cell death.
Authors: Tilstra J, Gaddy D, Zhao J, Dave S, Niedernhofer L, Plevy S, Robbins P
Sci Rep, 2014-01-10;4(0):3631.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IDO-independent suppression of T cell effector function by IFN-gamma-licensed human mesenchymal stromal cells.
Authors: Chinnadurai R, Copland I, Patel S, Galipeau J
J Immunol, 2014-01-08;192(4):1491-501.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokines alter IgA1 O-glycosylation by dysregulating C1GalT1 and ST6GalNAc-II enzymes.
Authors: Suzuki, Hitoshi, Raska, Milan, Yamada, Koshi, Moldoveanu, Zina, Julian, Bruce A, Wyatt, Robert J, Tomino, Yasuhiko, Gharavi, Ali G, Novak, Jan
J Biol Chem, 2014-01-07;289(8):5330-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High activities of BACE1 in brains with mild cognitive impairment.
Authors: Cheng X, He P, Lee T, Yao H, Li R, Shen Y
Am J Pathol, 2014-01-01;184(1):141-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay, Cell Culture -
TNF-alpha blockade induces IL-10 expression in human CD4+ T cells.
Authors: Evans H, Roostalu U, Walter G, Gullick N, Frederiksen K, Roberts C, Sumner J, Baeten D, Gerwien J, Cope A, Geissmann F, Kirkham B, Taams L
Nat Commun, 2014-01-01;5(0):3199.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Discovery and preclinical characterization of novel small molecule TRK and ROS1 tyrosine kinase inhibitors for the treatment of cancer and inflammation.
Authors: Narayanan R, Yepuru M, Coss C, Wu Z, Bauler M, Barrett C, Mohler M, Wang Y, Kim J, Snyder L, He Y, Levy N, Miller D, Dalton J
PLoS ONE, 2013-12-26;8(12):e83380.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells.
Authors: Fiorcari S, Brown W, McIntyre B, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda W, Keating M, Ding W, Kay N, Lannutti B, Marasca R, Burger J
PLoS ONE, 2013-12-23;8(12):e83830.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18.
Authors: Li W, Okuda A, Yamamoto H, Yamanishi K, Terada N, Yamanishi H, Tanaka Y, Okamura H
PLoS ONE, 2013-12-20;8(12):e82586.
Species: Human
Sample Types: N/A
-
Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions.
Authors: Nomura T, Aoyama M, Waguri-Nagaya Y, Goto Y, Suzuki M, Miyazawa K, Asai K, Goto S
Exp Cell Res, 2013-12-17;321(2):167-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis.
Authors: Dalli, Jesmond, Norling, Lucy V, Montero-Melendez, Trinidad, Federici Canova, Donata, Lashin, Hazem, Pavlov, Anton M, Sukhorukov, Gleb B, Hinds, Charles, Perretti, Mauro
EMBO Mol Med, 2013-12-15;6(1):27-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytosolic phospholipase A2 regulates TNF-induced production of joint destructive effectors in synoviocytes.
Authors: Sommerfelt R, Feuerherm A, Jones K, Johansen B
PLoS ONE, 2013-12-12;8(12):e83555.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A composite model of the human postcapillary venule for investigation of microvascular leukocyte recruitment.
Authors: Lauridsen H, Pober J, Gonzalez A
FASEB J, 2013-12-02;28(3):1166-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.
Authors: Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H
FEBS Lett, 2013-11-21;588(1):131-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis.
Authors: Cucchiarini M, Madry H, Terwilliger E
J Cell Mol Med, 2013-11-17;18(1):115-24.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
NF-kappaB-induced IL-6 ensures STAT3 activation and tumor aggressiveness in glioblastoma.
Authors: McFarland B, Hong S, Rajbhandari R, Twitty G, Gray G, Yu H, Benveniste E, Nozell S
PLoS ONE, 2013-11-11;8(11):e78728.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Influence of proinflammatory stimuli on the expression of vascular ribonuclease 1 in endothelial cells.
Authors: Gansler J, Preissner K, Fischer S
FASEB J, 2013-10-30;28(2):752-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.
Authors: Duverger, Alexandr, Wolschendorf, Frank, Anderson, Joshua C, Wagner, Frederic, Bosque, Alberto, Shishido, Takao, Jones, Jennifer, Planelles, Vicente, Willey, Christop, Cron, Randall, Kutsch, Olaf
J Virol, 2013-10-23;88(1):364-76.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
Authors: Mercier S, Donaghy H, Botting R, Turville S, Harman A, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson R, Moritz R, Cunningham A
PLoS Pathog, 2013-10-17;9(10):e1003700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Reference range and short- and long-term biological variation of interleukin (IL)-6, IL-17A and tissue necrosis factor-alpha using high sensitivity assays.
Authors: Todd J, Simpson P, Estis J, Torres V, Wub A
Cytokine, 2013-10-12;64(3):660-5.
Species: Human
Sample Types: Plasma
Applications: ELISA (Standard) -
Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.
Authors: Fraietta J, Mueller Y, Yang G, Boesteanu A, Gracias D, Do D, Hope J, Kathuria N, McGettigan S, Lewis M, Giavedoni L, Jacobson J, Katsikis P
PLoS Pathog, 2013-10-10;9(10):e1003658.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Long-term incubation with proteasome inhibitors (PIs) induces IkappaBalpha degradation via the lysosomal pathway in an IkappaB kinase (IKK)-dependent and IKK-independent manner.
Authors: Lee K, Jeong J, Yoo C
J Biol Chem, 2013-10-01;288(45):32777-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
Authors: Han B, You B, Park W
Oncol Rep, 2013-09-20;30(6):2999-3005.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting protein kinase CK2 suppresses prosurvival signaling pathways and growth of glioblastoma.
Authors: Zheng Y, McFarland B, Drygin D, Yu H, Bellis S, Kim H, Bredel M, Benveniste E
Clin Cancer Res, 2013-09-13;19(23):6484-94.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
Novel ex vivo culture method for human monocytes uses shear flow to prevent total loss of transendothelial diapedesis function.
Authors: Tsubota Y, Frey J, Raines E
J Leukoc Biol, 2013-09-04;95(1):191-5.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Magnolol inhibits migration of vascular smooth muscle cells via cytoskeletal remodeling pathway to attenuate neointima formation.
Authors: Karki R, Kim S, Kim D
Exp Cell Res, 2013-07-29;319(20):3238-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
Authors: Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Muller I
Eur J Immunol, 2013-07-23;43(10):2741-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.
Authors: Rapicavoli N, Qu K, Zhang J, Mikhail M, Laberge R, Chang H
Elife, 2013-07-23;2(0):e00762.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tumor cell-macrophage interactions increase angiogenesis through secretion of EMMPRIN.
Authors: Amit-Cohen B, Rahat M, Rahat M
Front Physiol, 2013-07-12;4(0):178.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A Lectin-EGF antibody promotes regulatory T cells and attenuates nephrotoxic nephritis via DC-SIGN on dendritic cells.
Authors: Cai, Minchao, Wu, Jing, Mao, Chaoming, Ren, Jianmin, Li, Pu, Li, Xiao, Zhong, Jiuchang, Xu, Chundi, Zhou, Tong
J Transl Med, 2013-04-29;11(0):103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-beta induces distinct gene expression response patterns in human monocytes versus T cells.
Authors: Henig N, Avidan N, Mandel I, Staun-Ram E, Ginzburg E, Paperna T, Pinter R, Miller A
PLoS ONE, 2013-04-23;8(4):e62366.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Comparison of drug and cell-based delivery: engineered adult mesenchymal stem cells expressing soluble tumor necrosis factor receptor II prevent arthritis in mouse and rat animal models.
Authors: Liu L, Wang G, Hendricks K, Lee K, Bohnlein E, Junker U, Mosca J
Stem Cells Transl Med, 2013-04-16;2(5):362-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Attenuated TGF-beta1 responsiveness of dendritic cells and their precursors in atopic dermatitis.
Authors: Peng W, Maintz L, Allam J, Novak N
Eur J Immunol, 2013-04-09;43(5):1374-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor alpha-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-kappaB signaling.
Authors: Trenkmann M, Brock M, Gay R, Michel B, Gay S, Huber L
Arthritis Rheum, 2013-04-01;65(4):916-27.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.
Authors: Melo, Rossana, Paganoti, Guillher, Dvorak, Ann M, Weller, Peter F
PLoS ONE, 2013-03-26;8(3):e59578.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role and regulation of PDGFRalpha signaling in liver development and regeneration.
Authors: Awuah P, Nejak-Bowen K, Monga S
Am J Pathol, 2013-03-23;182(5):1648-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo.
Authors: Kim J, Yoon Y, Lee J, Choi E, Yi N, Park K, Park J, Lotvall J, Kim Y, Gho Y
PLoS ONE, 2013-03-14;8(3):e59276.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Integration and regression of implanted engineered human vascular networks during deep wound healing.
Authors: Hanjaya-Putra D, Shen Y, Wilson A, Fox-Talbot K, Khetan S, Burdick J, Steenbergen C, Gerecht S
Stem Cells Transl Med, 2013-03-13;2(4):297-306.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-1beta promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.
Authors: Jayaraman P, Sada-Ovalle I, Nishimura T, Anderson A, Kuchroo V, Remold H, Behar S
J Immunol, 2013-03-13;190(8):4196-204.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Protein carbamylation predicts mortality in ESRD.
Authors: Koeth R, Kalantar-Zadeh K, Wang Z, Fu X, Tang W, Hazen S
2013-02-21;0(0):.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Standard) -
IFN-alpha induces APOBEC3G, F, and A in immature dendritic cells and limits HIV-1 spread to CD4+ T cells.
Authors: Mohanram V, Skold A, Bachle S, Pathak S, Spetz A
J Immunol, 2013-02-20;190(7):3346-53.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA.
Authors: Manes, Thomas D, Pober, Jordan S
J Immunol, 2013-02-18;190(7):3079-88.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Keratinocyte overexpression of IL-17C promotes psoriasiform skin inflammation.
Authors: Johnston A, Fritz Y, Dawes S, Diaconu D, Al-Attar P, Guzman A, Chen C, Fu W, Gudjonsson J, McCormick T, Ward N
J Immunol, 2013-01-28;190(5):2252-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
12/15-lipoxygenase expressed in non-epithelial cells causes airway epithelial injury in asthma.
Authors: Mabalirajan U, Rehman R, Ahmad T, Kumar S, Leishangthem G, Singh S, Dinda A, Biswal S, Agrawal A, Ghosh B
Sci Rep, 2013-01-01;3(0):1540.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice.
Authors: Mogami H, Kishore A, Shi H, Keller P, Akgul Y, Word R
J Biol Chem, 2012-11-26;288(3):1953-66.
Species: Human
Sample Types: Whole Cells
Applications: Cell Culture -
MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli.
Authors: Sheng Y, Triyana S, Wang R, Das I, Gerloff K, Florin T, Sutton P, McGuckin M
Mucosal Immunol, 2012-11-14;6(3):557-68.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency.
Authors: Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika A, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin H, Bossuyt X, Rambaud C, Facchetti F, Bonnet D, Quartier P, Fournet J, Pascual V, Chaussabel D, Notarangelo L, Puel A, Israel A, Casanova J, Picard C
Nat Immunol, 2012-10-28;13(12):1178-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
In vivo modulation of the inflammatory response by nonsteroidal antiinflammatory drug-related compounds that trigger L-selectin shedding.
Authors: Herrera-Garcia A, Dominguez-Luis M, Arce-Franco M, Lopez-Fernandez J, Feria M, Barreiro O, Sanchez-Madrid F, Diaz-Gonzalez F
Eur J Immunol, 2012-10-26;43(1):55-64.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Notch is active in Langerhans cell histiocytosis and confers pathognomonic features on dendritic cells.
Authors: Hutter, Caroline, Kauer, Max, Simonitsch-Klupp, Ingrid, Jug, Gunhild, Schwentner, Raphaela, Leitner, Judith, Bock, Peter, Steinberger, Peter, Bauer, Wolfgang, Carlesso, Nadia, Minkov, Milen, Gadner, Helmut, Stingl, Georg, Kovar, Heinrich, Kriehuber, Ernst
Blood, 2012-10-16;120(26):5199-208.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endothelial endoglin is involved in inflammation: role in leukocyte adhesion and transmigration.
Authors: Rossi E, Sanz-Rodriguez F, Eleno N, Duwell A, Blanco F, Langa C, Botella L, Cabanas C, Lopez-Novoa J, Bernabeu C
Blood, 2012-10-16;121(2):403-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Detecting T-cell reactivity to whole cell vaccines: Proof of concept analysis of T-cell response to K562 cell antigens in CML patients.
Authors: Brusic, Ana, Hainz, Ursula, Wadleigh, Martha, Neuberg, Donna, Su, Mei, Canning, Christin, Deangelo, Daniel J, Stone, Richard, Lee, Jeng-Shi, Mulligan, Richard, Ritz, Jerome, Dranoff, Glenn, Sasada, Tetsuro, Wu, Catherin
Oncoimmunology, 2012-10-01;1(7):1095-1103.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mycobacterium tuberculosis infection and tissue factor expression in macrophages.
Authors: Kothari H, Rao L, Vankayalapati R, Pendurthi U
PLoS ONE, 2012-09-24;7(9):e45700.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC.
Authors: You C, Shi M, Liu Y, Cao M, Luo R, Hermonat P
Oncoimmunology, 2012-09-01;1(6):847-855.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.
Authors: Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K
Infect Immun, 2012-08-13;80(11):3795-803.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Osteoblast-like differentiation of cultured human coronary artery smooth muscle cells by bone morphogenetic protein endothelial cell precursor-derived regulator (BMPER).
Authors: Satomi-Kobayashi S, Kinugasa M, Kobayashi R, Hatakeyama K, Kurogane Y, Ishida T, Emoto N, Asada Y, Takai Y, Hirata K, Rikitake Y
J Biol Chem, 2012-07-09;287(36):30336-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The SDF-1α/CXCR4 Axis is Required for Proliferation and Maturation of Human Fetal Pancreatic Endocrine Progenitor Cells.
Authors: Kayali AG, Lopez AD, Hao E, Hinton A, Hayek A, King CC
PLoS ONE, 2012-06-22;7(6):e38721.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E-selectin expression in human squamous cell carcinomas.
J. Invest. Dermatol., 2012-06-21;132(11):2642-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The C-type Lectin Receptor CLECSF8 (CLEC4D) Is Expressed by Myeloid Cells and Triggers Cellular Activation through Syk Kinase.
Authors: Graham LM, Gupta V, Schafer G, Reid DM, Kimberg M, Dennehy KM, Hornsell WG, Guler R, Campanero-Rhodes MA, Palma AS, Feizi T, Kim SK, Sobieszczuk P, Willment JA, Brown GD
J. Biol. Chem., 2012-06-11;287(31):25964-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of IL-33 expression by IFN-gamma and tumor necrosis factor-alpha in normal human epidermal keratinocytes.
J. Invest. Dermatol., 2012-06-07;132(11):2593-600.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A20/TNFAIP3 inhibits NF-kappaB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein.
Authors: Sakakibara S, Espigol-Frigole G, Gasperini P, Uldrick T, Yarchoan R, Tosato G
Oncogene, 2012-04-23;32(10):1223-32.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Pentraxin 3 (PTX3) expression in allergic asthmatic airways: role in airway smooth muscle migration and chemokine production.
Authors: Zhang J, Shan L, Koussih L, Redhu NS, Halayko AJ, Chakir J, Gounni AS
PLoS ONE, 2012-04-18;7(4):e34965.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation.
Authors: Napoletano C, Zizzari IG, Rughetti A, Rahimi H, Irimura T, Clausen H, Wandall HH, Belleudi F, Bellati F, Pierelli L, Frati L, Nuti M
Eur. J. Immunol., 2012-04-01;42(4):936-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
Authors: Wilde S, Geiger C, Milosevic S, Mosetter B, Eichenlaub S, Schendel D
Oncoimmunology, 2012-03-01;1(2):129-140.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Constitutive expression of inter-alpha-inhibitor (IalphaI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex.
Authors: Zhang S, He H, Day AJ, Tseng SC
J. Biol. Chem., 2012-02-20;287(15):12433-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Daily exposure to dust alters innate immunity.
Authors: Sahlander K, Larsson K, Palmberg L
PLoS ONE, 2012-02-15;7(2):e31646.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Kinome-wide functional genomics screen reveals a novel mechanism of TNFα-induced nuclear accumulation of the HIF-1α transcription factor in cancer cells.
Authors: Schoolmeesters A, Brown DD, Fedorov Y
PLoS ONE, 2012-02-15;7(2):e31270.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Authors: Sancho-Shimizu V, Perez de Diego R, Lorenzo L, Halwani R, Alangari A, Israelsson E, Fabrega S, Cardon A, Maluenda J, Tatematsu M, Mahvelati F, Herman M, Ciancanelli M, Guo Y, AlSum Z, Alkhamis N, Al-Makadma AS, Ghadiri A, Boucherit S, Plancoulaine S, Picard C, Rozenberg F, Tardieu M, Lebon P, Jouanguy E, Rezaei N, Seya T, Matsumoto M, Chaussabel D, Puel A, Zhang SY, Abel L, Al-Muhsen S, Casanova JL
J. Clin. Invest., 2011-11-21;121(12):4889-902.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cross-presentation of tumour antigens by human induced pluripotent stem cell-derived CD141(+)XCR1+ dendritic cells.
Gene Ther, 2011-11-10;19(10):1035-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and regulation of CCL15 by human airway smooth muscle cells.
Authors: Joubert P, Lajoie-Kadoch S, Wellemans V, Létuvé S, Tulic MK, Halayko AJ, Hamid Q
Clin. Exp. Allergy, 2011-11-09;42(1):85-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1.
Authors: Wang R, Jaw JJ, Jaw J, Stutzman NC, Stutzman N, Zou Z, Sun PD
J Leukoc Biol, 2011-11-01;91(2):299-309.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Authors: Ramirez-Carrozzi V, Sambandam A, Luis E
Nat. Immunol., 2011-10-12;12(12):1159-66.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.
Authors: Cross SA, Cook DR, Chi AW, Vance PJ, Kolson LL, Wong BJ, Jordan-Sciutto KL, Kolson DL
J. Immunol., 2011-10-05;187(10):5015-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effects of TLR agonists on maturation and function of 3-day dendritic cells from AML patients in complete remission.
Authors: Beck B, Dorfel D, Lichtenegger FS, Geiger C, Lindner L, Merk M, Schendel DJ, Subklewe M
J Transl Med, 2011-09-13;9(0):151.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium.
Authors: Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, Duerschmied D, Patterson C, Bode C, Moser M
Blood, 2011-09-07;118(18):5040-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis.
Authors: Carrier Y, Ma HL, Ramon HE, Napierata L, Small C, O'Toole M, Young DA, Fouser LA, Nickerson-Nutter C, Collins M, Dunussi-Joannopoulos K, Medley QG
J. Invest. Dermatol., 2011-09-01;131(12):2428-37.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Authors: Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia, 2011-07-09;54(10):2713-23.
Applications: ELISA (Standard) -
Monocytic microparticles activate endothelial cells in an IL-1{beta}-dependent manner.
Authors: Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N
Blood, 2011-06-23;118(8):2366-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cadherin-11 regulates fibroblast inflammation.
Authors: Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB
Proc. Natl. Acad. Sci. U.S.A., 2011-05-02;108(20):8402-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17A and TNF-alpha Exert Synergistic Effects on Expression of CXCL5 by Alveolar Type II Cells In Vivo and In Vitro.
Authors: Liu Y, Mei J, Gonzales L, Yang G, Dai N, Wang P, Zhang P, Favara M, Malcolm KC, Guttentag S, Worthen GS
J. Immunol., 2011-01-31;186(5):3197-205.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-1F5, -F6, -F8, and -F9: A Novel IL-1 Family Signaling System That Is Active in Psoriasis and Promotes Keratinocyte Antimicrobial Peptide Expression.
Authors: Johnston A, Xing X, Guzman AM, Riblett M, Loyd CM, Ward NL, Wohn C, Prens EP, Wang F, Maier LE, Kang S, Voorhees JJ, Elder JT, Gudjonsson JE
J. Immunol., 2011-01-17;186(4):2613-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
T-helper cell type 2 (Th2) memory T cell-potentiating cytokine IL-25 has the potential to promote angiogenesis in asthma.
Authors: Corrigan CJ, Wang W, Meng Q, Fang C, Wu H, Reay V, Lv Z, Fan Y, An Y, Wang YH, Liu YJ, Lee TH, Ying S
Proc. Natl. Acad. Sci. U.S.A., 2011-01-04;108(4):1579-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Complement Receptor Mac-1 Is an Adaptor for NB1 (CD177)-mediated PR3-ANCA Neutrophil Activation.
Authors: Jerke U, Rolle S, Dittmar G, Bayat B, Santoso S, Sporbert A, Luft F, Kettritz R
J. Biol. Chem., 2010-12-30;286(9):7070-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased expression of matrix metalloproteinase-1 in systemic vessels of preeclamptic women: a critical mediator of vascular dysfunction.
Authors: Estrada-Gutierrez G, Cappello RE, Mishra N, Romero R, Strauss JF, Walsh SW
Am. J. Pathol., 2010-12-23;178(1):451-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bacterial lipoprotein TLR2 agonists broadly modulate endothelial function and coagulation pathways in vitro and in vivo.
Authors: Shin HS, Xu F, Bagchi A, Herrup E, Wilhelmsen K
J. Immunol., 2010-12-17;186(2):1119-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Focal increases of fetal macrophages in placentas from pregnancies with histological chorioamnionitis: potential role of fibroblast monocyte chemotactic protein-1.
Authors: Toti P, Arcuri F, Tang Z, Schatz F, Zambrano E, Mor G, Niven-Fairchild T, Abrahams VM, Krikun G, Lockwood CJ, Guller S
Am. J. Reprod. Immunol., 2010-11-19;65(5):470-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies.
Authors: Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C
J. Virol., 2010-11-17;85(2):1077-85.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased B7-H1 expression on dendritic cells correlates with programmed death 1 expression on T cells in simian immunodeficiency virus-infected macaques and may contribute to T cell dysfunction and disease progression.
Authors: Xu H, Wang X, Pahar B
J. Immunol., 2010-11-08;185(12):7340-8.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD.
Authors: Hindryckx P, De Vos M, Jacques P, Ferdinande L, Peeters H, Olievier K, Bogaert S, Brinkman B, Vandenabeele P, Elewaut D, Laukens D
J. Immunol., 2010-10-13;185(10):6306-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Authors: Johnson LA, Jackson DG
Int. Immunol., 2010-08-25;22(10):839-49.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
B7-h3 augments the inflammatory response and is associated with human sepsis.
Authors: Zhang G, Wang J, Kelly J
J. Immunol., 2010-08-09;185(6):3677-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LIGHT (TNFSF14) inhibits adipose differentiation without affecting adipocyte metabolism.
Authors: Tiller G, Laumen H, Fischer-Posovszky P, Finck A, Skurk T, Keuper M, Brinkmann U, Wabitsch M, Link D, Hauner H
Int J Obes (Lond), 2010-06-15;35(2):208-16.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN-gamma generates maturation-arrested dendritic cells that induce T cell hyporesponsiveness independent of Foxp3+ T-regulatory cell generation.
Authors: Rojas D, Krishnan R
Immunol. Lett., 2010-05-24;132(1):31-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evidence for altered Wnt signaling in psoriatic skin.
Authors: Gudjonsson JE, Johnston A, Stoll SW
J. Invest. Dermatol., 2010-04-08;130(7):1849-59.
Species: Human
Sample Types: Whole Cells
-
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010-03-31;184(9):4880-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
J. Immunol., 2010-03-24;184(0):5263-70.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
Eur. J. Immunol., 2009-12-01;39(12):3570-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-10 suppresses Th17 cells and promotes regulatory T cells in the CD4+ T cell population of rheumatoid arthritis patients.
Authors: Heo YJ, Joo YB, Oh HJ, Park MK, Heo YM, Cho ML, Kwok SK, Ju JH, Park KS, Cho SG, Park SH, Kim HY, Min JK
Immunol. Lett., 2009-11-04;127(2):150-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.
Authors: Kotarsky K, Sitnik KM, Stenstad H, Kotarsky H, Schmidtchen A, Koslowski M, Wehkamp J, Agace WW
Mucosal Immunol, 2009-10-07;3(1):40-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses.
Authors: Duraisingham SS, Hornig J, Gotch F, Patterson S
J. Immunol., 2009-07-22;183(4):2242-51.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.
Authors: Babelova A, Moreth K, Tsalastra-Greul W, Zeng-Brouwers J, Eickelberg O, Young MF, Bruckner P, Pfeilschifter J, Schaefer RM, Schaefer R, Grone HJ, Schaefer L
J Biol Chem, 2009-07-15;284(36):24035-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases.
Authors: Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT
J. Immunol., 2009-07-10;183(3):1739-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients.
Authors: Colucci S, Brunetti G, Mori G, Oranger A, Centonze M, Mori C, Cantatore FP, Tamma R, Rizzi R, Liso V, Zallone A, Grano M
Leukemia, 2009-07-09;23(11):2139-46.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells.
Authors: Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F
Nat. Immunol., 2009-07-05;10(8):857-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009-06-25;133(1):27-44.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.
Authors: Dave SH, Tilstra JS, Matsuoka K, Li F, DeMarco RA, Beer-Stolz D, Sepulveda AR, Fink MP, Lotze MT, Plevy SE
J. Leukoc. Biol., 2009-05-19;86(3):633-43.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The E-selectin ligand basigin/CD147 is responsible for neutrophil recruitment in renal ischemia/reperfusion.
Authors: Kato N, Yuzawa Y, Kosugi T
J. Am. Soc. Nephrol., 2009-05-14;20(7):1565-76.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
Authors: Le TA, Takai T, Kinoshita H, Suto H, Ikeda S, Okumura K, Ogawa H
Allergy, 2009-03-27;64(8):1231-2.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts.
Authors: Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C
Bone, 2009-03-02;44(6):1143-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Vascular endothelial growth factor induces protein kinase D-dependent production of proinflammatory cytokines in endothelial cells.
Authors: Hao Q, Wang L, Tang H
Am. J. Physiol., Cell Physiol., 2009-01-28;296(4):C821-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
Authors: Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ
Invest. Ophthalmol. Vis. Sci., 2009-01-17;50(6):2702-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
Authors: Mabilleau G, Sabokbar A
PLoS ONE, 2009-01-12;4(1):e4173.
Species: Human
Sample Types:
-
Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease.
Authors: Miller M, Cho JY, Pham A, Ramsdell J, Broide DH
J. Immunol., 2009-01-01;182(1):684-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment.
Authors: Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S
J. Exp. Med., 2008-12-29;206(1):249-58.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA.
Authors: Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H
J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nitric oxide attenuates vascular endothelial cadherin-mediated vascular integrity in human chronic inflammation.
Authors: Hama S, Takeichi O, Fujisaki K, Tanabe N, Maeno M, Ochiai K
Clin. Exp. Immunol., 2008-12-01;154(3):384-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts.
Authors: Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lajeunesse D, Duval N, Martel-Pelletier J
Arthritis Rheum., 2008-12-01;58(12):3820-30.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human bronchial intraepithelial T cells produce interferon-gamma and stimulate epithelial cells.
Authors: Hirosako S, Goto E, Fujii K, Tsumori K, Hirata N, Tsumura S, Kamohara H, Kohrogi H
Clin. Exp. Immunol., 2008-11-26;155(2):266-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis.
Authors: Sandberg WJ, Halvorsen B, Yndestad A, Smith C, Otterdal K, Brosstad FR, Froland SS, Olofsson PS, Damas JK, Gullestad L, Hansson GK, Oie E, Aukrust P
Circ. Res., 2008-11-20;104(1):60-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ectopic expression of interleukin-1 receptor type II enhances cell migration through activation of the pre-interleukin 1alpha pathway.
Authors: Chang SY, Su PF, Lee TC
Cytokine, 2008-11-20;45(1):32-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Functional characterization of IL-17F as a selective neutrophil attractant in psoriasis.
Authors: Watanabe H, Kawaguchi M, Fujishima S, Ogura M, Matsukura S, Takeuchi H, Ohba M, Sueki H, Kokubu F, Hizawa N, Adachi M, Huang SK, Iijima M
J. Invest. Dermatol., 2008-10-02;129(3):650-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
Stem Cells, 2008-09-04;26(11):2955-63.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel method to establish microglia-free astrocyte cultures: comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia.
Authors: Crocker SJ, Frausto RF, Whitton JL, Milner R
Glia, 2008-08-15;56(0):1187-98.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and potential function of the CXC chemokine CXCL16 in pancreatic ductal adenocarcinoma.
Authors: Wente MN, Gaida MM, Mayer C, Michalski CW, Haag N, Giese T, Felix K, Bergmann F, Giese NA, Friess H
Int. J. Oncol., 2008-08-01;33(2):297-308.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells.
Authors: Gerber SA, Pober JS
J. Immunol., 2008-07-15;181(2):1052-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation.
Authors: Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW
J. Immunol., 2008-07-15;181(2):1103-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Effect of fudosteine on mucin production.
Authors: Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, Moon HS, Park SH, Song JS
Eur. Respir. J., 2008-06-25;32(5):1195-202.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils.
Authors: Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H
J. Allergy Clin. Immunol., 2008-06-01;121(6):1484-90.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation.
Authors: Jasny E, Eisenblatter M, Matz-Rensing K, Tenner-Racz K, Tenbusch M, Schrod A, Stahl-Hennig C, Moos V, Schneider T, Racz P, Uberla K, Kaup FJ, Ignatius R
J. Immunol., 2008-05-15;180(10):6629-39.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Development and validation of sandwich ELISA microarrays with minimal assay interference.
Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
J. Proteome Res., 2008-04-19;7(6):2406-14.
Applications: ELISA (Standard) -
Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps.
Authors: Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP
J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
p38 mitogen-activated protein kinase inhibitor LY2228820 enhances bortezomib-induced cytotoxicity and inhibits osteoclastogenesis in multiple myeloma; therapeutic implications.
Authors: Ishitsuka K, Hideshima T, Neri P, Vallet S, Shiraishi N, Okawa Y, Shen Z, Raje N, Kiziltepe T, Ocio EM, Chauhan D, Tassone P, Munshi N, Campbell RM, Dios AD, Shih C, Starling JJ, Tamura K, Anderson KC
Br. J. Haematol., 2008-04-07;141(5):598-606.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis.
Authors: Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D
Arthritis Rheum., 2008-04-01;58(4):1001-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
Applications: ELISA (Standard) -
Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes.
Authors: Wolk K, Witte K, Witte E, Proesch S, Schulze-Tanzil G, Nasilowska K, Thilo J, Asadullah K, Sterry W, Volk HD, Sabat R
J. Leukoc. Biol., 2008-02-15;83(5):1181-93.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and regulation of CCR1 by airway smooth muscle cells in asthma.
Authors: Joubert P, Lajoie-Kadoch S, Welman M, Dragon S, Letuvee S, Tolloczko B, Halayko AJ, Gounni AS, Maghni K, Hamid Q
J. Immunol., 2008-01-15;180(2):1268-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes.
Authors: Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Herve C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P, Dahlback B, Carmeliet P, Hoylaerts MF, Moons L
Blood, 2007-12-21;111(8):4096-105.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Mitochondrially targeted ceramide LCL-30 inhibits colorectal cancer in mice.
Authors: Dahm F, Bielawska A, Nocito A, Georgiev P, Szulc ZM, Bielawski J, Jochum W, Dindo D, Hannun YA, Clavien PA
Br. J. Cancer, 2007-11-20;98(1):98-105.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.
Authors: Rao DA, Tracey KJ, Pober JS
J. Immunol., 2007-11-15;179(10):6536-46.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells.
Authors: Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G, Zauli G
Blood, 2007-11-13;111(3):1287-94.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Fluorescence single-molecule counting assays for high-sensitivity detection of cytokines and chemokines.
Authors: Qui H, Ferrell EP, Nolan N, Phelps BH, Tabibiazar R, Whitney DH, Naelfski EA
Clin. Chem., 2007-11-01;53(11):2010-2.
Applications: ELISA (Standard) -
Substance P regulates macrophage inflammatory protein 3alpha/chemokine C-C ligand 20 (CCL20) with heme oxygenase-1 in human periodontal ligament cells.
Authors: Lee SK, Pi SH, Kim SH, Min KS, Lee HJ, Chang HS, Kang KH, Kim HR, Shin HI, Lee SK, Kim EC
Clin. Exp. Immunol., 2007-10-09;150(3):567-75.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Ultrasensitive flow-based immunoassays using single-molecule counting.
Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
Clin. Chem., 2007-09-21;53(11):1990-5.
Applications: ELISA (Standard) -
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
Authors: Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, Seidl KJ, Winkler A, Hu Y, Green N, Askew GR, Tam S, Clark JD, Lin LL
J. Biol. Chem., 2007-09-11;282(46):33295-304.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
J. Biol. Chem., 2007-08-24;282(43):31643-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis.
Authors: Wosik K, Cayrol R, Dodelet-Devillers A, Berthelet F, Bernard M, Moumdjian R, Bouthillier A, Reudelhuber TL, Prat A
J. Neurosci., 2007-08-22;27(34):9032-42.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection.
Authors: Zalevsky J, Secher T, Ezhevsky SA, Janot L, Steed PM, O'Brien C, Eivazi A, Kung J, Nguyen DH, Doberstein SK, Erard F, Ryffel B, Szymkowski DE
J. Immunol., 2007-08-01;179(3):1872-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Infusion of stably immature monocyte-derived dendritic cells plus CTLA4Ig modulates alloimmune reactivity in rhesus macaques.
Authors: Zahorchak AF, Kean LS, Tokita D, Turnquist HR, Abe M, Finke J, Hamby K, Rigby MR, Larsen CP, Thomson AW
Transplantation, 2007-07-27;84(2):196-206.
Species: Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells.
Authors: Kato A, Favoreto S, Avila PC, Schleimer RP
J. Immunol., 2007-07-15;179(2):1080-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates.
Authors: Luty WH, Rodeberg D, Parness J, Vyas YM
J. Immunol., 2007-07-15;179(2):819-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression and role of CCR6/CCL20 chemokine axis in pulmonary sarcoidosis.
Authors: Facco M, Baesso I, Miorin M, Bortoli M, Cabrelle A, Boscaro E, Gurrieri C, Trentin L, Zambello R, Calabrese F, Cassatella MA, Semenzato G, Agostini C
J. Leukoc. Biol., 2007-07-05;82(4):946-55.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease.
Authors: Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S
J. Clin. Invest., 2007-07-01;117(7):1951-60.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Calcineurin modulates the catabolic and anabolic activity of chondrocytes and participates in the progression of experimental osteoarthritis.
Authors: Yoo SA, Park BH, Yoon HJ, Lee JY, Song JH, Kim HA, Cho CS, Kim WU
Arthritis Rheum., 2007-07-01;56(7):2299-311.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.
Authors: Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A
J. Immunol., 2007-06-15;178(12):8064-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium.
Authors: Silverman MD, Haas CS, Rad AM, Arbab AS, Koch AE
Arthritis Rheum., 2007-06-01;56(6):1817-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43.
Species: Human, Porcine
Sample Types: Whole Cells
Applications: Bioassay -
Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease.
Authors: Zhang K, Shan L, Rahman MS, Unruh H, Halayko AJ, Gounni AS
Am. J. Physiol. Lung Cell Mol. Physiol., 2007-05-18;293(2):L375-82.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
J. Immunol., 2007-05-01;178(9):5973-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.
Authors: Caruso R, Fina D, Peluso I, Fantini MC, Tosti C, Del Vecchio Blanco G, Paoluzi OA, Caprioli F, Andrei F, Stolfi C, Romano M, Ricci V, MacDonald TT, Pallone F, Monteleone G
J. Immunol., 2007-05-01;178(9):5957-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease.
Authors: Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, Auernhammer CJ, Brand S
Gut, 2007-04-20;56(9):1257-65.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells.
Authors: Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B
Dig. Dis. Sci., 2007-04-06;52(12):3404-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Leukemia inhibitory factor functions as a growth factor in pancreas carcinoma cells: Involvement of regulation of LIF and its receptor expression.
Authors: Kamohara H, Ogawa M, Ishiko T, Sakamoto K, Baba H
Int. J. Oncol., 2007-04-01;30(4):977-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Authors: Kang YM, Kim SY, Kang JH
Arthritis Rheum., 2007-04-01;56(4):1106-17.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inflammatory cytokines stimulate the adhesion of colon carcinoma cells to mesothelial monolayers.
Authors: van Grevenstein WM, Hofland LJ, van Rossen ME, van Koetsveld PM, Jeekel J, van Eijck CH
Dig. Dis. Sci., 2007-03-30;52(10):2775-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Authors: Ponte AL, Marais E, Gallay N, Langonne A, Delorme B, Herault O, Charbord P, Domenech J
Stem Cells, 2007-03-29;25(7):1737-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of neuronal pituitary adenylate cyclase-activating polypeptide expression during culture of guinea-pig cardiac ganglia.
Authors: Girard BM, Young BA, Buttolph TR, White SL, Parsons RL
Neuroscience, 2007-03-23;146(2):584-93.
Species: Guinea Pig
Sample Types: Whole Cells
Applications: Bioassay -
Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
Authors: Brechter AB, Lerner UH
Arthritis Rheum., 2007-03-01;56(3):910-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CD28-mediated regulation of multiple myeloma cell proliferation and survival.
Authors: Bahlis NJ, King AM, Kolonias D, Carlson LM, Liu HY, Hussein MA, Terebelo HR, Byrne GE, Levine BL, Boise LH, Lee KP
Blood, 2007-02-20;109(11):5002-10.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
Authors: Sa SM, Valdez PA, Wu J
J. Immunol., 2007-02-15;178(4):2229-40.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood, 2007-02-08;109(10):4272-9.
Applications: ELISA (Standard) -
Guinea pig neutrophils infected with Mycobacterium tuberculosis produce cytokines which activate alveolar macrophages in noncontact cultures.
Authors: Sawant KV, McMurray DN
Infect. Immun., 2007-02-05;75(4):1870-7.
Applications: ELISA (Standard) -
The F11 receptor (F11R/JAM-A) in atherothrombosis: overexpression of F11R in atherosclerotic plaques.
Authors: Babinska A, Azari BM, Salifu MO, Liu R, Jiang XC, Sobocka MB, Boo D, Al Khoury G, Deitch JS, Marmur JD, Ehrlich YH, Kornecki E
Thromb. Haemost., 2007-02-01;97(2):272-81.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Role of mesothelial cell-derived granulocyte colony-stimulating factor in interleukin-17-induced neutrophil accumulation in the peritoneum.
Authors: Witowski J, Ksiazek K, Warnecke C, Kuzlan M, Korybalska K, Tayama H, Wisniewska-Elnur J, Pawlaczyk K, Trominska J, Breborowicz A, Jorres A
Kidney Int., 2007-01-17;71(6):514-25.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IFN-gamma alters the response of Borrelia burgdorferi-activated endothelium to favor chronic inflammation.
Authors: Dame TM, Orenzoff BL, Palmer LE, Furie MB
J. Immunol., 2007-01-15;178(2):1172-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Tumour necrosis factor-alpha (TNF-alpha) increases nuclear factor kappaB (NFkappaB) activity in and interleukin-8 (IL-8) release from bovine mammary epithelial cells.
Authors: Fitzgerald DC, Meade KG, McEvoy AN, Lillis L, Murphy EP, Machugh DE, Baird AW
Vet. Immunol. Immunopathol., 2007-01-09;116(1):59-68.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Angiopoietin-2 is increased in severe sepsis: correlation with inflammatory mediators.
Authors: Orfanos SE, Kotanidou A, Glynos C, Athanasiou C, Tsigkos S, Dimopoulou I, Sotiropoulou C, Zakynthinos S, Armaganidis A, Papapetropoulos A, Roussos C
Crit. Care Med., 2007-01-01;35(1):199-206.
Species: Bovine, Human
Sample Types: Whole Cells
Applications: Bioassay -
Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.
Authors: Pietila TE, Veckman V, Lehtonen A, Lin R, Hiscott J, Julkunen I
J. Immunol., 2007-01-01;178(1):253-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway.
Authors: Nagineni CN, Cherukuri KS, Kutty V, Detrick B, Hooks JJ
J. Cell. Physiol., 2007-01-01;210(1):192-200.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.
Authors: Grivel JC, Elliott J, Lisco A, Biancotto A, Condack C, Shattock RJ, McGowan I, Margolis L, Anton P
AIDS, 2007;21(10):1263-72.
Species: N/A
Sample Types: N/A
Applications: ELISA (Standard) -
Simultaneous induction of apoptotic and survival signaling pathways in macrophage-like THP-1 cells by Shiga toxin 1.
Authors: Lee SY, Cherla RP, Tesh VL
Infect. Immun., 2006-12-28;75(3):1291-302.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
Authors: Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R
J. Leukoc. Biol., 2006-12-18;81(3):748-56.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Aberrant regulation of synovial T cell activation by soluble costimulatory molecules in rheumatoid arthritis.
Authors: Wan B, Nie H, Liu A, Feng G, He D, Xu R, Zhang Q, Dong C, Zhang JZ
J. Immunol., 2006-12-15;177(12):8844-50.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes.
Authors: Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST
J. Immunol., 2006-12-01;177(11):7665-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
J. Exp. Med., 2006-11-20;203(12):2763-77.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.
Authors: Peng H, Erdmann N, Whitney N, Dou H, Gorantla S, Gendelman HE, Ghorpade A, Zheng J
Glia, 2006-11-01;54(6):619-29.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Shear flow-dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm.
Authors: Schreiber TH, Shinder V, Cain DW, Alon R, Sackstein R
Blood, 2006-10-12;109(4):1381-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia.
Authors: Pontikoglou C, Liapakis G, Pyrovolaki K, Papadakis M, Bux J, Eliopoulos GD, Papadaki HA
Exp. Hematol., 2006-10-01;34(10):1312-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
J. Endocrinol., 2006-10-01;191(1):65-81.
Species: Hamster
Sample Types: Whole Cells
Applications: Bioassay -
Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways.
Authors: Hunter I, Nixon GF
J. Biol. Chem., 2006-09-18;281(45):34705-15.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The ascochlorin derivative, AS-6, inhibits TNF-alpha-induced adhesion molecule and chemokine expression in rat vascular smooth muscle cells.
Authors: Park KG, Lee KM, Magae J, Kim YN, Lee KU, Lee IK
Life Sci., 2006-09-01;80(2):120-6.
Species: Rat
Sample Types: Whole Cells
Applications: Bioassay -
Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
Authors: Ebert EC, Mehta V
Cell. Immunol., 2006-08-17;241(1):7-13.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Sepsis and pathophysiology of anthrax in a nonhuman primate model.
Authors: Stearns-Kurosawa DJ, Lupu F, Taylor FB, Kinasewitz G, Kurosawa S
Am. J. Pathol., 2006-08-01;169(2):433-44.
Applications: ELISA (Standard) -
Dendritic cells can turn CD4+ T lymphocytes into vascular endothelial growth factor-carrying cells by intercellular neuropilin-1 transfer.
Authors: Bourbie-Vaudaine S, Blanchard N, Hivroz C, Romeo PH
J. Immunol., 2006-08-01;177(3):1460-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function.
Authors: Rebelo SL, Bainbridge SE, Amel-Kashipaz MR, Radford PM, Powell RJ, Todd I, Tighe PJ
Arthritis Rheum., 2006-08-01;54(8):2674-87.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Apoptotic neutrophils release macrophage migration inhibitory factor upon stimulation with tumor necrosis factor-alpha.
Authors: Daryadel A, Grifone RF, Simon HU, Yousefi S
J. Biol. Chem., 2006-07-21;281(37):27653-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.
Authors: Filer A, Parsonage G, Smith E, Osborne C, Thomas AM, Curnow SJ, Rainger GE, Raza K, Nash GB, Lord J, Salmon M, Buckley CD
Arthritis Rheum., 2006-07-01;54(7):2096-108.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Control of matrix metalloproteinase production in human intestinal fibroblasts by interleukin 21.
Authors: Monteleone G, Caruso R, Fina D, Peluso I, Gioia V, Stolfi C, Fantini MC, Caprioli F, Tersigni R, Alessandroni L, MacDonald TT, Pallone F
Gut, 2006-05-08;55(12):1774-80.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
LIGHT (TNFSF14), a novel mediator of bone resorption, is elevated in rheumatoid arthritis.
Authors: Edwards JR, Sun SG, Locklin R, Shipman CM, Adamopoulos IE, Athanasou NA, Sabokbar A
Arthritis Rheum., 2006-05-01;54(5):1451-62.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis.
Authors: Makrygiannakis D, af Klint E, Catrina SB, Botusan IR, Klareskog E, Klareskog L, Ulfgren AK, Catrina AI
Arthritis Rheum., 2006-05-01;54(5):1463-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Selective regulation of IL-10 signaling and function by zymosan.
Authors: Du Z, Kelly E, Mecklenbrauker I, Agle L, Herrero C, Paik P, Ivashkiv LB
J. Immunol., 2006-04-15;176(8):4785-92.
Applications: ELISA (Standard) -
Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation.
Authors: Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS
Exp. Cell Res., 2006-04-04;312(10):1909-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression.
Authors: Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH
Mol. Cell. Biol., 2006-04-01;26(8):3071-84.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
Authors: Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S
J. Clin. Invest., 2006-04-01;116(4):984-95.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Dehydroepiandrosterone inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells.
Authors: Gutierrez G, Mendoza C, Zapata E, Montiel A, Reyes E, Montano LF, Lopez-Marure R
Atherosclerosis, 2006-03-30;190(1):90-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Cigarette smoke synergistically enhances respiratory mucin induction by proinflammatory stimuli.
Authors: Baginski TK, Dabbagh K, Satjawatcharaphong C, Swinney DC
Am. J. Respir. Cell Mol. Biol., 2006-03-16;35(2):165-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
J. Immunol., 2006-03-15;176(6):3742-52.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Expression of B7-H1 on gastric epithelial cells: its potential role in regulating T cells during Helicobacter pylori infection.
Authors: Das S, Suarez G, Beswick EJ, Sierra JC, Graham DY, Reyes VE
J. Immunol., 2006-03-01;176(5):3000-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts.
Authors: Létuvé S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q
J. Allergy Clin. Immunol., 2006-02-08;117(3):590-6.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL).
Authors: Hanabuchi S, Watanabe N, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ
Blood, 2006-01-05;107(9):3617-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Increased ENA-78 in the follicular fluid of patients with endometriosis.
Authors: Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA
Acta Obstet Gynecol Scand, 2006-01-01;85(3):336-42.
Applications: ELISA (Standard) -
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing.
Authors: Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS
Bone, 2005-12-05;38(4):497-508.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Phenotype and function of myeloid dendritic cells derived from African green monkey blood monocytes.
Authors: Mortara L, Ploquin MJ, Faye A, Scott-Algara D, Vaslin B, Butor C, Hosmalin A, Barre-Sinoussi F, Diop OM, Muller-Trutwin MC
J. Immunol. Methods, 2005-11-21;308(1):138-55.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Bioassay -
Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-alpha and its possible role in hemophagocytic syndrome.
Authors: Saito K, Hirokawa M, Inaba K, Fukaya H, Kawabata Y, Komatsuda A, Yamashita J, Sawada K
Blood, 2005-10-18;107(4):1366-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
J. Virol., 2005-10-01;79(20):12828-39.
Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
Sample Types: Whole Cells
Applications: Bioassay -
Tumor necrosis factor alpha and adiponectin in bone marrow interstitial fluid from patients with acute myeloid leukemia inhibit normal hematopoiesis.
Authors: Iversen PO, Wiig H
Clin. Cancer Res., 2005-10-01;11(19):6793-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Generation of feline dendritic cells derived from peripheral blood monocytes for in vivo use.
Authors: Freer G, Matteucci D, Mazzetti P, Bozzacco L, Bendinelli M
Clin. Diagn. Lab. Immunol., 2005-10-01;12(10):1202-8.
Species: Feline
Sample Types: Whole Cells
Applications: Bioassay -
Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
Authors: Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B
Cytokine, 2005-09-07;31(5):335-48.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of GM-CSF release by enantiomers of beta-agonists in human airway smooth muscle.
Authors: Ameredes BT, Calhoun WJ
J. Allergy Clin. Immunol., 2005-07-01;116(1):65-72.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interface tissue fibroblasts from loose total hip replacement prosthesis produce receptor activator of nuclear factor-kappaB ligand, osteoprotegerin, and cathepsin K.
Authors: Mandelin J, Li TF, Hukkanen M, Liljestrom M, Salo J, Santavirta S, Konttinen YT
J. Rheumatol., 2005-04-01;32(4):713-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Dendritic cells induce MUC1 expression and polarization on human T cells by an IL-7-dependent mechanism.
Authors: Vasir B, Avigan D, Wu Z, Crawford K, Turnquist S, Ren J, Kufe D
J. Immunol., 2005-02-15;174(4):2376-86.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CC chemokines and transmigration of eosinophils in the presence of vascular cell adhesion molecule 1.
Authors: Yamamoto H, Nagata M, Sakamoto Y
Ann. Allergy Asthma Immunol., 2005-02-01;94(2):292-300.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Bioassay -
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rheumatoid arthritis synovial fibroblast proliferation through mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt.
Authors: Morel J, Audo R, Hahne M, Combe B
J. Biol. Chem., 2005-01-31;280(16):15709-18.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNFalpha increases the inflammatory response to vascular balloon injury without accelerating neointimal formation.
Authors: Miller AM, McPhaden AR, Preston A, Wadsworth RM, Wainwright CL
Atherosclerosis, 2004-12-23;179(1):51-9.
Species: Rabbit
Sample Types: Whole Cells
Applications: Bioassay -
trans fatty acids and systemic inflammation in heart failure.
Authors: Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
Am. J. Clin. Nutr., 2004-12-01;80(6):1521-5.
Applications: ELISA (Standard) -
A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis.
Authors: Gibot S, Kolopp-Sarda MN, Bollaert PE, Lozniewski A, Mory F, Levy B, Faure GC
J. Exp. Med., 2004-11-22;200(11):1419-26.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Human bronchial epithelial cells express and secrete MMP-12.
Authors: Lavigne MC, Thakker P, Gunn J, Miyashiro JS, Wasserman AM, Wei SQ, Pelker JW
Biochem. Biophys. Res. Commun., 2004-11-12;324(2):534-46.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.
Authors: Ferlazzo G, Pack M, Thomas D, Paludan C, Schmid D, Strowig T, Bougras G, Muller WA, Moretta L, Munz C
Proc. Natl. Acad. Sci. U.S.A., 2004-11-09;101(47):16606-11.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
J. Immunol., 2004-11-01;173(9):5810-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TARC augments TNF-alpha-induced CTACK production in keratinocytes.
Authors: Vestergaard C, Johansen C, Christensen U, Just H, Hohwy T, Deleuran M
Exp. Dermatol., 2004-09-01;13(9):551-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
J. Immunol., 2004-09-01;173(5):3482-91.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Impact of fibronectin fragments on the transendothelial migration of HIV-infected leukocytes and the development of subendothelial foci of infectious leukocytes.
Authors: Birdsall HH, Porter WJ, Green DM, Rubio J, Trial J, Rossen RD
J. Immunol., 2004-08-15;173(4):2746-54.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).
Authors: Chopin V, Slomianny C, Hondermarck H, Le Bourhis X
Exp. Cell Res., 2004-08-15;298(2):560-73.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The effect of inflammatory cytokines on secretion of macrophage colony-stimulating factor and monocyte chemoattractant protein-1 in human granulosa cells.
Authors: Kawano Y, Fukuda J, Itoh H, Takai N, Nasu K, Miyakawa I
Am. J. Reprod. Immunol., 2004-08-01;52(2):124-8.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes.
Authors: Johansson MW, Lye MH, Barthel SR, Duffy AK, Annis DS, Mosher DF
Am. J. Respir. Cell Mol. Biol., 2004-06-25;31(4):413-22.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor.
Authors: Wang P, Zhang J, Bian H, Wu P, Kuvelkar R, Kung TT, Crawley Y, Egan RW, Billah MM
Biochem. J., 2004-06-01;380(0):425-33.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells.
Authors: Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, Qiuping Z, Junyan L, Zhang X, Jinquan T
Immunology, 2004-06-01;112(2):274-89.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
Authors: Phillips TM
Electrophoresis, 2004-06-01;25(10):1652-9.
-
KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation.
Authors: SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, Garcia-Cardena G, Jain MK
J. Exp. Med., 2004-05-10;199(10):1305-15.
Species: Bovine
Sample Types: Whole Cells
Applications: Bioassay -
Activation of primary porcine endothelial cells induces release of porcine endogenous retroviruses.
Authors: Cunningham DA, Dos Santos Cruz GJ, Fernandez-Suarez XM, Whittam AJ, Herring C, Copeman L, Richards A, Langford GA
Transplantation, 2004-04-15;77(7):1071-9.
Species: Porcine
Sample Types: Whole Cells
Applications: Bioassay -
CD14 is an acute-phase protein.
Authors: Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C
J. Immunol., 2004-04-01;172(7):4470-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments.
Authors: Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G
Blood, 2004-03-25;104(2):314-20.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia.
Authors: Ryan LA, Peng H, Erichsen DA, Huang Y, Persidsky Y, Zhou Y, Gendelman HE, Zheng J
J. Neuroimmunol., 2004-03-01;148(1):127-39.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Angiopoietin 1 and vascular endothelial growth factor modulate human glomerular endothelial cell barrier properties.
Authors: Satchell SC, Anderson KL, Mathieson PW
J. Am. Soc. Nephrol., 2004-03-01;15(3):566-74.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines.
Authors: Copeland S, Siddiqui J, Remick D
J. Immunol. Methods, 2004-01-01;284(1):99-106.
Applications: ELISA (Standard) -
The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt/PKB-mediated signaling in T cells.
Authors: Sade H, Krishna S, Sarin A
J. Biol. Chem., 2003-10-28;279(4):2937-44.
Species: Human, Mouse
Sample Types: Whole Cells
Applications: Bioassay -
CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
Authors: Cardones AR, Murakami T, Hwang ST
Cancer Res., 2003-10-15;63(20):6751-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis.
Authors: Uchida K, Nakata K, Trapnell BC, Terakawa T, Hamano E, Mikami A, Matsushita I, Seymour JF, Oh-Eda M, Ishige I, Eishi Y, Kitamura T, Yamada Y, Hanaoka K, Keicho N
Blood, 2003-09-25;103(3):1089-98.
Species: Human
Sample Types: Serum
Applications: SDS-Page -
Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation.
Authors: McLoughlin RM, Witowski J, Robson RL, Wilkinson TS, Hurst SM, Williams AS, Williams JD, Rose-John S, Jones SA, Topley N
J. Clin. Invest., 2003-08-01;112(4):598-607.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
Authors: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
Proc. Natl. Acad. Sci. U.S.A., 2003-07-23;100(16):9452-7.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-8 production in tuberculous pleurisy: role of mesothelial cells stimulated by cytokine network involving tumour necrosis factor-alpha and interleukin-1 beta.
Authors: Park JS, 107290, Kim YS, Jee YK, Myong NH, Lee KY
Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models, 2003-05-01;57(5):463-9.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus.
Authors: Favre D, Blouin V, Provost N, Spisek R, Porrot F, Bohl D, Marme F, Cherel Y, Salvetti A, Hurtrel B, Heard JM, Riviere Y, Moullier P
J. Virol., 2002-11-01;76(22):11605-11.
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
LIGHT, a member of the tumor necrosis factor ligand superfamily, prevents tumor necrosis factor-alpha-mediated human primary hepatocyte apoptosis, but not Fas-mediated apoptosis.
Authors: Hikichi Y, Tsuji I, Shintani Y
J. Biol. Chem., 2002-10-18;277(51):50054-61.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Endogenously expressed nef uncouples cytokine and chemokine production from membrane phenotypic maturation in dendritic cells.
Authors: Messmer D, Jacque JM, Santisteban C, Bristow C, Han SY, Villamide-Herrera L, Mehlhop E, Marx PA, Steinman RM, Gettie A, Pope M
J. Immunol., 2002-10-15;169(8):4172-82.
Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
Sample Types: Whole Cells
Applications: Bioassay -
Acute topical application of tumor necrosis factor alpha evokes protein kinase A-dependent responses in rat sensory neurons.
Authors: Zhang JM, Li H, Liu B, Brull SJ
J. Neurophysiol., 2002-09-01;88(3):1387-92.
Species: Rat
Sample Types: In Vivo
Applications: In Vivo -
Activation of NF-kappaB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma cells: therapeutic implications.
Authors: Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akiyama M, Chauhan D, Hideshima T, Treon SP, Munshi NC, Richardson PG, Anderson KC
Oncogene, 2002-08-22;21(37):5673-83.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
The correlation of adhesions and peritoneal fluid cytokine concentrations: a pilot study.
Authors: Cheong YC, Laird SM, Shelton JB, Ledger WL, Li TC, Cooke ID
Hum. Reprod., 2002-04-01;17(4):1039-45.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
IL-1, IL-6 and TNF-alpha concentrations in the peritoneal fluid of women with pelvic adhesions.
Authors: Cheong YC, Shelton JB, Laird SM, Richmond M, Kudesia G, Li TC, Ledger WL
Hum. Reprod., 2002-01-01;17(1):69-75.
Species: Human
Sample Types: Buffer
Applications: Bioassay -
A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases.
Authors: Albanesi C, Scarponi C, Sebastiani S, Cavani A, Federici M, Sozzani S, Girolomoni G
J. Leukoc. Biol., 2001-10-01;70(4):617-23.
Species: Human
Sample Types: Whole Cells
Applications: Bioassay -
Perfusion-contraction mismatch with coronary microvascular obstruction: role of inflammation.
Authors: Dorge H, Neumann T, Behrends M, Skyschally A, Schulz R, Kasper C, Erbel R, Heusch G
Am. J. Physiol. Heart Circ. Physiol., 2000-12-01;279(6):H2587-92.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay -
Tumour necrosis factor-alpha- and interleukin-1beta-stimulated cell proliferation through activation of mitogen-activated protein kinase in canine tracheal smooth muscle cells.
Authors: Yang CM, Luo SF, Wang CC, Chiu CT, Chien CS, Lin CC, Hsiao LD
Br. J. Pharmacol., 2000-06-01;130(4):891-9.
Species: Canine
Sample Types: Whole Cells
Applications: Bioassay -
Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver.
Authors: Barcena A, Park SW, Banapour B, Muench MO, Mechetner E
Blood, 1996-09-15;88(6):2013-25.
Species: Human
Sample Types:
Applications: Bioassay
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Average Rating: 4.8 (Based on 35 Reviews)
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Reason for Rating: We use this product to activate immature dendritic cells and have consistently seen activation and maturation.
Reason for Rating: TNF-a dilution and using was very easy, results were very replicable and induce a very strong pro-inflammatory response.
Human TNF-a was used to induce pro-inflammatory responses in an in vivo model of arthritis using male C57BL/6J mice. rhTNF-a was able to increase accumulation of immune cells in the pannus area, and increased bone loss in the model
Reason for Rating: The protein provided reliable results in stimulating inflammation in PBMC cells treated with the protein. We obtained high IL-6 levels as a response to the TNF-a treatment (in a time-dependent manner)
Reason for Rating: Worked great
Reason for Rating: Analysed the expression levels of control protein on treating with TNF-a for 1 hour and western blotting of whole cell lysates with control specific antibody. Observed an increased control protein levels in the TNF-a treated sample compared to untreated
Reason for Rating: Works as expected.
300 micron thick slices were preincubated in TNF-alpha (100 ng/ml) for 1 h before whole-cell recordings were performed from female mice. TNF alpha reduced excitability of neurons compared to control.
Reason for Rating: We always get great maturation of our dendritic cells using R&Ds TNF-alpha cytokine
Reason for Rating: Nice standard curve generated for cytotoxicity analysis on L929 cells.
Reason for Rating: Was used to stimulate human aortic endothelial cells.
Reason for Rating: Works very well to induce NF-KB. Used it in our publications
We tried it for induction of NF-KB detected with luciferase and immunoblot
Reason for Rating: Consistent and expect bioactive in our cell culture assays
We used TNF-a to stimulation macrophages and myofibroblast
Reason for Rating: Functioned well and reproducible data with TNF from another company.
Rat primary embryonic cortical culture stimulated with TNFa (10, 50, 100 ng/ml), PBS+BSA (negative stimulation control), or Okadaic Acid (OA; positive phosphorylation control) for 30 minutes. Protein isolated for western blot analysis of phospho-Akt.
Cultured endothelial cells were pre-treated (or not) with 1mg/mL HDL, then treated for 6 hours with 10ng/mL TNFa. TNFa treatment caused a massive upregulation of ICAM1 and E-Selectin versus control cells (untreated); HDL pre-treatment partially reversed this response.
Reason for Rating: At equal concentrations this protein supplied by R and D systems showed biological activity in our assay system (induction of known downstream genes) when the same protein from two other suppliers failed in all but the positive control condition.
Reason for Rating: This has worked well in WB
Reason for Rating: the band is strong and clear.
Reason for Rating: stable cheap and convenience