Home / HGF / Recombinant Human HGF Protein

Recombinant Human HGF Protein

Catalog #: 294-HG
111 Citations 6 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
294-HG-005/CF
294-HG-025/CF
294-HG-100/CF

With Carrier

Catalog # Availability Size / Price Qty
294-HG-005
294-HG-025
294-HG-250
Recombinant Human HGF Protein Bioactivity
2 Images
Product Details
Citations (111)
FAQs
Reviews (6)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human HGF Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells. Hjertner, O. et al. (1999) Blood 94:3883. The ED50 for this effect is equal to or less than 4.00 ng/mL.

Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human HGF protein
Gln32-Ser728 (Asp384Asn, Asp416Asn, Leu622Ser, His645Arg, Val678Ile)
Accession #
P14210.2
N-terminal Sequence
Analysis
alpha chain: No results obtained; Gln32 predicted
beta chain: Val495
Structure / Form
Disulfide-linked heterodimer
Predicted Molecular Mass
53.7 kDa ( alpha chain), 26 kDa ( beta chain)
SDS-PAGE
60-70 kDa, non-reducing conditions
60 kDa, and 33-34 kDa, reducing conditions

Product Datasheets

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294-HG (with carrier)

Product Datasheet
COA
SDS

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294-HG/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

294-HG

Formulation Lyophilized from a 0.2 μm filtered solution in NaH2PO4 and NaCl with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

294-HG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in NaH2PO4 and NaCl.
Reconstitution Reconstitute at 100 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human HGF Protein Bioactivity View Larger

Recombinant Human HGF (294-HG) induces IL-11 secretion in Saos-2 human osteosarcoma cells. The ED50 for this effect is equal to less than 4.00 ng/mL.

Cell Culture View Larger

Adult stem cell-derived liver organoids were cultured using Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and liver organoid initiation medium, which includes Recombinant Human HGF (Catalog # 294-HG), Recombinant Human BMP-7 (354-BP), Recombinant Human EGF (236-EG), Recombinant Human FGF-10 (345-FG), Recombinant Human Noggin (6057-NG), Recombinant Human R-Spondin 1 (4645-RS), and Recombinant Human Wnt-3a (5036-WN), along with the other reagents listed in the liver organoid initiation medium recipe in the human liver organoid culture protocol. After 3 days, liver organoid expansion medium was added for 7-10 days, followed by liver organoid differentiation medium, which includes Recombinant Human HGF (Catalog # 294-HG), Recombinant Human BMP-7 (354-BP), Recombinant Human EGF (236-EG), and Recombinant Human FGF-19 (969-FG), along with the other reagents listed in the liver organoid differentiation medium recipe in the human liver organoid culture protocol. Differentiated human liver organoids were stained using a (A) Mouse Anti-Human Serum Albumin Monoclonal Antibody (MAB1455; red) and a (B) Goat Anti-Human HNF-3beta Antigen Affinity-purified Polyclonal Antibody (AF2400; red) and counterstained with DAPI (5748; blue).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: HGF

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE‑like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity (1‑5). Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive
disulfide‑linked HGF with a 60 kDa alpha  and 30 kDa beta  chain. Alternate splicing generates human HGF isoforms that lack the proteinase‑like domain and different numbers of the Kringle domains. Human HGF shares 91%‑94% aa sequence identity with bovine, canine, feline, mouse, and rat HGF. HGF binds heparan-sulfate proteoglycans and the widely expressed receptor tyrosine kinase, HGF R/c-MET (6, 7). HGF-dependent c-MET activation is implicated in the development of many human cancers (8). HGF regulates epithelial morphogenesis by inducing cell scattering and branching tubulogenesis (9, 10). HGF induces the up‑regulation of integrin alpha 2 beta 1 in epithelial cells by a selective increase in alpha 2 gene transcription (11). This integrin serves as a collagen I receptor, and its blockade disrupts epithelial cell branching tubulogenesis (11, 12). HGF can also alter epithelium morphology by the induction of nectin‑1 alpha  ectodomain shedding, an adhesion protein component of adherens junctions (13). In the thyroid, HGF induces the proliferation, motility, and loss of differentiation markers of thyrocytes and inhibits TSH‑stimulated iodine uptake (14). HGF promotes the motility of cardiac stem cells in damaged myocardium (15).

References
  1. Karihaloo, A. et al. (2005) Nephron Exp. Nephrol. 100:e40.
  2. Hammond, D.E. et al. (2004) Curr. Top. Microbiol. Immunol. 286:21.
  3. Rosario, M. and W. Birchmeier (2004) Dev. Cell 7:3.
  4. Lesk, A.M. and W.D. Fordham (1996) J. Mol. Biol. 258:501.
  5. Nakamura, T. et al. (1989) Nature 342:440.
  6. Mizuno, K., et al. (1994) J. Biol. Chem. 269:1131.
  7. Gheradi, E. et al. (2003) Proc. Natl. Acad. Sci. 100:12039.
  8. Corso, S. et al. (2005) Trends Mol. Med. 11:284.
  9. Maeshima, A. et al. (2000) Kid. Int. 58:1511.
  10. Montesano, R. et al. (1991) Cell 67:901.
  11. Chiu, S-J. et al. (2002) J. Biomed. Sci. 9:261.
  12. Saelman, E.U.M. et al. (1995) J. Cell Sci. 108:3531.
  13. Tanaka, Y. et al. (2002) Biochem. Biophys. Res. Commun. 299:472.
  14. Mineo, R. et al. (1994) Endocrinology 145:4355.
  15. Urbanek, K. et al. (2005) Circ. Res. 97:663.
Long Name
Hepatocyte Growth Factor
Entrez Gene IDs
3082 (Human); 15234 (Mouse); 24446 (Rat); 403441 (Canine); 102133907 (Cynomolgus Monkey); 493705 (Feline)
Alternate Names
deafness, autosomal recessive 39; DFNB39; EC 3.4.21; EC 3.4.21.7; fibroblast-derived tumor cytotoxic factor; F-TCF; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin-A; Hepatopoietin A; HGF; HGFB; HPTA; HPTAhepatocyte growth factor; lung fibroblast-derived mitogen; Scatter factor; SF; SFhepatopoeitin-A

Citations for Recombinant Human HGF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

111 Citations: Showing 1 - 10
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  1. IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models
    Authors: M Carbonaro, K Wang, H Huang, D Frleta, A Patel, A Pennington, M Desclaux, S Moller-Tan, J Grindley, J Altarejos, J Zhong, G Polites, W Poueymirou, S Jaspers, C Kyratsous, B Zambrowicz, A Murphy, JC Lin, LE Macdonald, C Daly, M Sleeman, G Thurston, Z Li
    Science Advances, 2023-04-14;9(15):eadf4490.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  2. Pomegranate Extract Affects Gut Biofilm Forming Bacteria and Promotes Intestinal Mucosal Healing Regulating the Crosstalk between Epithelial Cells and Intestinal Fibroblasts
    Authors: G Rizzo, SE Pineda Cha, E Vandenkoor, CL Cárdenas R, V Cento, V Garlatti, M Wozny, G Sammarco, A Di Claudio, L Meanti, S Elangovan, A Romano, G Roda, L Loy, A Dal Buono, R Gabbiadini, S Lovisa, R Rusconi, A Repici, A Armuzzi, S Vetrano
    Nutrients, 2023-04-05;15(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma
    Authors: S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo
    Cancer Medicine, 2023-01-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. ERK Signaling Pathway Is Constitutively Active in NT2D1 Non-Seminoma Cells and Its Inhibition Impairs Basal and HGF-Activated Cell Proliferation
    Authors: Gesualdi, L;Berardini, M;Scicchitano, B;Castaldo, C;Bizzarri, M;Filippini, A;Riccioli, A;Schiraldi, C;Ferranti, F;Liguoro, D;Mancini, R;Ricci, G;Catizone, A;
    Biomedicines
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin heterozygosity reveals metabolic dysregulation and cellular heterogeneity
    Authors: JE Kaserman, RB Werder, F Wang, T Matte, MI Higgins, M Dodge, J Lindstrom-, P Bawa, A Hinds, E Bullitt, IS Caballero, X Shi, RE Gerszten, N Brunetti-P, M Liesa, C Villacorta, AN Hollenberg, DN Kotton, AA Wilson
    Cell Reports, 2022-12-06;41(10):111775.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. MET-induced CD73 restrains STING-mediated immunogenicity of EGFR-mutant lung cancer
    Authors: R Yoshida, M Saigi, T Tani, BF Springer, H Shibata, S Kitajima, NR Mahadevan, M Campisi, W Kim, Y Kobayashi, TC Thai, K Haratani, Y Yamamoto, SK Sundararam, EH Knelson, A Vajdi, I Canadas, R Uppaluri, CP Paweletz, JJ Miret, PH Lizotte, PC Gokhale, PA Janne, DA Barbie
    Cancer Research, 2022-11-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Physical and functional interactome atlas of human receptor tyrosine kinases.
    Authors: Salokas K, Liu X, Ohman T, Chowdhury I, Gawriyski L, Keskitalo S, Varjosalo M
    EMBO Rep, 2022-04-05;23(6):e54041.
    Species: Human
    Sample Types: Transfected Whole Cells
    Applications: Bioassay
  8. High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development
    Authors: J Krumm, K Sekine, P Samaras, A Brazovskaj, M Breunig, R Yasui, A Kleger, H Taniguchi, M Wilhelm, B Treutlein, JG Camp, B Kuster
    Cell Reports, 2022-03-29;38(13):110604.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells
    Authors: P Banerjee, GY Xiao, X Tan, VJ Zheng, L Shi, MNB Rabassedas, HF Guo, X Liu, J Yu, L Diao, J Wang, WK Russell, J Roszik, CJ Creighton, JM Kurie
    Nature Communications, 2021-11-03;12(1):6354.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes
    Authors: E Zahmatkesh, MH Ghanian, I Zarkesh, Z Farzaneh, M Halvaei, Z Heydari, F Moeinvazir, A Othman, M Ruo beta, A Piryaei, R Gramignoli, S Yakhkeshi, A Nüssler, M Najimi, H Baharvand, M Vosough
    Cells, 2021-05-21;10(6):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  11. Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells
    Authors: X Chamling, A Kallman, W Fang, CA Berlinicke, JL Mertz, P Devkota, IEM Pantoja, MD Smith, Z Ji, C Chang, A Kaushik, L Chen, KA Whartenby, PA Calabresi, HQ Mao, H Ji, TH Wang, DJ Zack
    Nature Communications, 2021-01-28;12(1):652.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
    Authors: C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi
    Cell Stem Cell, 2021-01-04;28(2):331-342.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. The PI3K/AKT Pathway Is Activated by HGF in NT2D1 Non-Seminoma Cells and Has a Role in the Modulation of Their Malignant Behavior
    Authors: L Gesualdi, E Leonetti, A Cucina, BM Scicchitan, S Sorrentino, MG Tarsitano, A Isidori, M Bizzarri, A Filippini, A Riccioli, M Cammarota, V Gigantino, G Ricci, A Catizone
    Int J Mol Sci, 2020-11-17;21(22):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function
    Authors: AC Hedman, DE McNulty, Z Li, L Gorisse, RS Annan, DB Sacks
    J Biol Chem, 2020-10-21;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Adaptation and selection shape clonal evolution of tumors during residual disease and recurrence
    Authors: A Walens, J Lin, JS Damrauer, B McKinney, R Lupo, R Newcomb, DB Fox, NW Mabe, J Gresham, Z Sheng, AB Sibley, T De Buyssch, H Kelkar, PA Mieczkowsk, K Owzar, JV Alvarez
    Nat Commun, 2020-10-06;11(1):5017.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  16. Alcohol abrogates human norovirus infectivity in a pH-dependent manner
    Authors: S Sato, N Matsumoto, K Hisaie, S Uematsu
    Sci Rep, 2020-09-28;10(1):15878.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC
    Authors: C Volz, S Breid, C Selenz, A Zaplatina, K Golfmann, L Meder, F Dietlein, S Borchmann, S Chatterjee, M Siobal, J Schöttle, A Florin, M Koker, M Nill, L Ozreti?, N Uhlenbrock, S Smith, R Büttner, H Miao, B Wang, HC Reinhardt, D Rauh, M Hallek, A Acker-Palm, LC Heukamp, RT Ullrich
    Cell Rep, 2020-04-28;31(4):107568.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation
    Authors: M Grosch, S Ittermann, E Rusha, T Greisle, C Ori, DJ Truong, AC O'Neill, A Pertek, GG Westmeyer, M Drukker
    BMC Biol., 2020-04-22;18(1):42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer
    Authors: A Fumagalli, KC Oost, L Kester, J Morgner, L Bornes, L Bruens, L Spaargaren, M Azkanaz, T Schelfhors, E Beerling, MC Heinz, D Postrach, D Seinstra, AM Sieuwerts, JWM Martens, S van der El, M van Baalen, D Bhowmick, N Vrisekoop, SIJ Ellenbroek, SJE Suijkerbui, HJ Snippert, J van Rheene
    Cell Stem Cell, 2020-03-12;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  21. CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
    Authors: K Han, SE Pierce, A Li, K Spees, GR Anderson, JA Seoane, YH Lo, M Dubreuil, M Olivas, RA Kamber, M Wainberg, K Kostyrko, MR Kelly, M Yousefi, SW Simpkins, D Yao, K Lee, CJ Kuo, PK Jackson, A Sweet-Cord, A Kundaje, AJ Gentles, C Curtis, MM Winslow, MC Bassik
    Nature, 2020-03-11;580(7801):136-141.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells
    Authors: NJ Hogrebe, P Augsornwor, KG Maxwell, L Velazco-Cr, JR Millman
    Nat. Biotechnol., 2020-02-24;0(0):.
    Species: Human
    Sample Types: cell culture
    Applications: Cell Culture
  23. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
    Authors: Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
    Nat. Immunol., 2020-02-17;21(3):274-286.
    Species: Human
    Sample Types: Cells
    Applications: Cell Culture
  24. ER stress reliever enhances functionalities of in vitro cultured hepatocytes
    Authors: JS Kim, SI Hwang, JL Ryu, HS Hong, JM Lee, SM Lee, X Jin, C Han, JH Kim, J Han, MR Lee, DH Woo
    Stem Cell Res, 2020-02-12;43(0):101732.
    Species: Human
    Sample Types: cell culture
  25. Metformin reduces HGF-induced resistance to alectinib via the inhibition of Gab1
    Authors: H Chen, C Lin, T Peng, C Hu, C Lu, L Li, Y Wang, R Han, M Feng, F Sun, Y He
    Cell Death Dis, 2020-02-10;11(2):111.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. In vitro metabolic zonation through oxygen gradient on a chip
    Authors: F Tonon, GG Giobbe, A Zambon, C Luni, O Gagliano, A Floreani, G Grassi, N Elvassore
    Sci Rep, 2019-09-19;9(1):13557.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis
    Authors: YC Kim, J Lee, JN An, JH Kim, YW Choi, L Li, SH Kwon, MY Lee, B Lee, JG Jeong, SS Yu, CS Lim, YS Kim, S Kim, SH Yang, JP Lee
    Sci Rep, 2019-09-17;9(1):13495.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Proliferation
  29. Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation
    Authors: L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn
    Mol. Vis., 2019-06-30;25(0):329-344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation
    Authors: S Ashraf, S Bell, C O'Leary, P Canning, I Micu, JA Fernandez, M O'Hare, P Barabas, H McCauley, DP Brazil, AW Stitt, JG McGeown, TM Curtis
    JCI Insight, 2019-03-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. PGE2 -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors
    Authors: GA Khan, S Bhagat, MI Alam
    J. Leukoc. Biol., 2019-03-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer
    Authors: R Graves-Dea, G Bogatcheva, S Rehman, Y Lu, JN Higginboth, B Singh
    Oncotarget, 2019-02-12;10(13):1320-1333.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Paeoniflorin Inhibits Hepatocyte Growth Factor- (HGF-) Induced Migration and Invasion and Actin Rearrangement via Suppression of c-Met-Mediated RhoA/ROCK Signaling in Glioblastoma
    Authors: G Yu, Z Wang, S Zeng, S Liu, C Zhu, R Xu, RE Liu
    Biomed Res Int, 2019-02-11;2019(0):9053295.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors
    Authors: H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin
    Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
    Authors: L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin
    Nat Commun, 2019-01-21;10(1):364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. c-Src Recruitment is Involved in c-MET-Mediated Malignant Behaviour of NT2D1 Non-Seminoma Cells
    Authors: E Leonetti, L Gesualdi, KC Scheri, S Dinicola, L Fattore, MG Masiello, A Cucina, R Mancini, M Bizzarri, G Ricci, A Catizone
    Int J Mol Sci, 2019-01-14;20(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Failures in preclinical and clinical trials of c-Met inhibitors: evaluation of pathway activity as a promising selection criterion
    Authors: VS Hughes, DW Siemann
    Oncotarget, 2019-01-04;10(2):184-197.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells
    Authors: T Navas, TD Pfister, S Colantonio, A Aziz, L Dieckman, RG Saul, J Kaczmarczy, S Borgel, SY Alcoser, MG Hollingshe, YH Lee, DP Bottaro, T Hiltke, G Whiteley, N Takebe, RJ Kinders, RE Parchment, JE Tomaszewsk, JH Doroshow
    PLoS ONE, 2018-06-21;13(6):e0199361.
    Applications: ELISA (Standard)
  39. Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages
    Authors: J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao
    Cell Transplant, 2018-06-13;0(0):9636897187803.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Combined c-Met/Trk inhibition overcomes resistance to CDK4/6 inhibitors in Glioblastoma
    Authors: I Olmez, Y Zhang, L Manigat, M Benamar, B Brenneman, I Nakano, J Godlewski, A Bronisz, J Lee, T Abbas, R Abounader, B Purow
    Cancer Res., 2018-05-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
    Authors: J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li
    Cell, 2018-03-22;0(0):.
    Species: Squirrel
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Focal Adhesion Kinase a Potential Therapeutic Target for Pancreatic Cancer and Malignant Pleural Mesothelioma
    Authors: R Kanteti, T Mirzapoiaz, JJ Riehm, I Dhanasingh, B Mambetsari, J Wang, P Kulkarni, G Kaushik, P Seshachary, MP Ponnusamy, HL Kindler, MW Nasser, SK Batra, R Salgia
    Cancer Biol. Ther., 2018-02-22;0(0):0.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B
    Authors: R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi
    Cell Transplant, 2018-02-01;27(2):299-309.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Collagen-Binding Hepatocyte Growth Factor (HGF) alone or with a Gelatin- furfurylamine Hydrogel Enhances Functional Recovery in Mice after Spinal Cord Injury
    Authors: K Yamane, T Mazaki, Y Shiozaki, A Yoshida, K Shinohara, M Nakamura, Y Yoshida, D Zhou, T Kitajima, M Tanaka, Y Ito, T Ozaki, A Matsukawa
    Sci Rep, 2018-01-17;8(1):917.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  45. Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver
    Authors: WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair
    Cell Transplant, 2017-12-01;26(12):1868-1877.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro
    Authors: YJ Han, YH Kang, SB Shivakumar, D Bharti, YB Son, YH Choi, WU Park, JH Byun, GJ Rho, BW Park
    Int J Med Sci, 2017-11-02;14(13):1418-1429.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain
    Authors: H Park, D Kim, E Kim, JK Sa, HW Lee, S Yu, J Oh, SH Kim, Y Yoon, DH Nam
    Int J Mol Sci, 2017-09-13;18(9):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  48. A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
    Authors: Hugh S O'Neill
    J Tissue Eng Regen Med, 2017-06-19;0(0):.
    Species: N/A
    Sample Types: Complex Sample Type
    Applications: Bioassay
  49. The MET/AXL/FGFR inhibitor S49076 impairs Aurora B activity and improves the antitumor efficacy of radiotherapy
    Authors: C Clémenson, C Chargari, W Liu, M Mondini, C Ferté, MF Burbridge, V Cattan, A Jacquet-Be, E Deutsch
    Mol. Cancer Ther., 2017-06-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Multilineage communication regulates human liver bud development from pluripotency
    Authors: JG Camp, K Sekine, T Gerber, H Loeffler-W, H Binder, M Gac, S Kanton, J Kageyama, G Damm, D Seehofer, L Belicova, M Bickle, R Barsacchi, R Okuda, E Yoshizawa, M Kimura, H Ayabe, H Taniguchi, T Takebe, B Treutlein
    Nature, 2017-06-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. MRI tracking of autologous pancreatic progenitor-derived insulin-producing cells in monkeys
    Authors: C Zou, Y Lu, X Teng, S Wang, X Sun, F Huang, G Shu, X Huang, H Guo, Z Chen, J Zhang, YA Zhang
    Sci Rep, 2017-05-31;7(1):2505.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
    Authors: Benjamin Y Owusu, Shantasia Thomas, Phanindra Venukadas, Zhenfu Han, James W Janetka, Robert A Galemmo, Lidija Klampfer
    Oncotarget, 2017-05-29;0(0):1949-2553.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Establishment of a refined culture method for rat colon organoids
    Authors: H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura
    Biochem. Biophys. Res. Commun., 2017-05-27;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling
    Authors: S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi
    Mol. Ther., 2017-04-24;25(6):1420-1433.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
    Authors: F Sakurai, S Mitani, T Yamamoto, K Takayama, M Tachibana, K Watashi, T Wakita, S Iijima, Y Tanaka, H Mizuguchi
    Sci Rep, 2017-04-04;7(0):45698.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes
    Authors: ZS Nevin, DC Factor, RT Karl, P Douvaras, J Laukka, MS Windrem, SA Goldman, V Fossati, GM Hobson, PJ Tesar
    Am. J. Hum. Genet., 2017-03-30;100(4):617-634.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells
    Authors: Y Song, J Jang, TH Shin, SM Bae, JS Kim, KM Kim, SJ Myung, EK Choi, HR Seo
    J. Exp. Clin. Cancer Res, 2017-03-03;36(1):38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Lung Basal Stem Cells Rapidly Repair DNA Damage Using the Error-Prone Nonhomologous End-Joining Pathway
    Authors: CE Weeden, Y Chen, SB Ma, Y Hu, G Ramm, KD Sutherland, GK Smyth, ML Asselin-La
    PLoS Biol, 2017-01-26;15(1):e2000731.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells
    Authors: Jong Seok Lee
    Yonsei Med. J., 2017-01-01;58(1):9-18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells?
    Authors: SW Lee, JU Chong, SO Min, SY Bak, KS Kim
    Cell Transplant, 2016-11-24;26(5):855-866.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Effect of undifferentiated versus hepatogenic partially differentiated mesenchymal stem cells on hepatic and cognitive functions in liver cirrhosis
    Authors: DA Elberry, SN Amin, RS Esmail, LA Rashed, MM Gamal
    EXCLI J, 2016-11-07;15(0):652-670.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  62. ABBV-399, a c-Met Antibody Drug Conjugate that Targets Both MET Amplified and c-Met Overexpressing Tumors, Irrespective of MET Pathway Dependence
    Clin Cancer Res, 2016-08-29;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration
    Authors: Yasuhiro Ikeda
    Stem Cells Transl Med, 2016-03-17;5(5):694-702.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFkappaB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.
    Authors: Rudisch A, Dewhurst M, Horga L, Kramer N, Harrer N, Dong M, van der Kuip H, Wernitznig A, Bernthaler A, Dolznig H, Sommergruber W
    PLoS ONE, 2015-04-28;10(4):e0124283.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation.
    Authors: Czysz, Katherin, Minger, Stephen, Thomas, Nick
    PLoS ONE, 2015-02-06;10(2):e0117689.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. A comprehensive transcriptional portrait of human cancer cell lines.
    Authors: Klijn C, Durinck S, Stawiski E, Haverty P, Jiang Z, Liu H, Degenhardt J, Mayba O, Gnad F, Liu J, Pau G, Reeder J, Cao Y, Mukhyala K, Selvaraj S, Yu M, Zynda G, Brauer M, Wu T, Gentleman R, Manning G, Yauch R, Bourgon R, Stokoe D, Modrusan Z, Neve R, de Sauvage F, Settleman J, Seshagiri S, Zhang Z
    Nat Biotechnol, 2014-12-08;33(3):306-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors.
    Authors: Falcon B, Swearingen M, Gough W, Lee L, Foreman R, Uhlik M, Hanson J, Lee J, McClure D, Chintharlapalli S
    PLoS ONE, 2014-09-11;9(9):e106901.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Reciprocal activating crosstalk between c-Met and caveolin 1 promotes invasive phenotype in hepatocellular carcinoma.
    Authors: Korhan P, Erdal E, Kandemis E, Cokakli M, Nart D, Yilmaz F, Can A, Atabey N
    PLoS ONE, 2014-08-22;9(8):e105278.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Molecular evidence for OCT4-induced plasticity in adult human fibroblasts required for direct cell fate conversion to lineage specific progenitors.
    Authors: Mitchell R, Szabo E, Shapovalova Z, Aslostovar L, Makondo K, Bhatia M
    Stem Cells, 2014-08-01;32(8):2178-87.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
    Authors: Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G
    J Biol Chem, 2014-06-27;289(33):22835-49.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. High efficient differentiation of functional hepatocytes from porcine induced pluripotent stem cells.
    Authors: Ao, Ying, Mich-Basso, Jocelyn, Lin, Bo, Yang, Lei
    PLoS ONE, 2014-06-20;9(6):e100417.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Receptor tyrosine kinase c-Met controls the cytoskeleton from different endosomes via different pathways.
    Authors: Menard L, Parker P, Kermorgant S
    Nat Commun, 2014-05-19;5(0):3907.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Three-dimensional lung tumor microenvironment modulates therapeutic compound responsiveness in vitro--implication for drug development.
    Authors: Ekert, Jason E, Johnson, Kjell, Strake, Brandy, Pardinas, Jose, Jarantow, Stephen, Perkinson, Robert, Colter, David C
    PLoS ONE, 2014-03-17;9(3):e92248.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Role of PAX8 in the regulation of MET and RON receptor tyrosine kinases in non-small cell lung cancer.
    Authors: Kanteti R, El-Hashani E, Dhanasingh I, Tretiakova M, Husain A, Sharma S, Sharma J, Vokes E, Salgia R
    BMC Cancer, 2014-03-14;14(0):185.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Activated platelets interfere with recruitment of mesenchymal stem cells to apoptotic cardiac cells via high mobility group box 1/Toll-like receptor 4-mediated down-regulation of hepatocyte growth factor receptor MET.
    Authors: Vogel S, Chatterjee M, Metzger K, Borst O, Geisler T, Seizer P, Muller I, Mack A, Schumann S, Buhring H, Lang F, Sorg R, Langer H, Gawaz M
    J Biol Chem, 2014-02-24;289(16):11068-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Simultaneous inhibition of the HGF/MET and Erk1/2 pathways affect uveal melanoma cell growth and migration.
    Authors: Chattopadhyay, Chandran, Grimm, Elizabet, Woodman, Scott E
    PLoS ONE, 2014-02-13;9(2):e83957.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
    Nat Biotechnol, 2013-12-01;32(1):84-91.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Bioassay
  78. CCAAT/enhancer binding protein-mediated regulation of TGFbeta receptor 2 expression determines the hepatoblast fate decision.
    Authors: Takayama K, Kawabata K, Nagamoto Y, Inamura M, Ohashi K, Okuno H, Yamaguchi T, Tashiro K, Sakurai F, Hayakawa T, Okano T, Furue M, Mizuguchi H
    Development, 2013-11-27;141(1):91-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells.
    Authors: Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, Markmann J, Miyazaki S, Miyazaki J, Szot G, Bottino R, Kim S
    Elife, 2013-11-19;2(0):e00940.
  80. Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse.
    Authors: Ramani V, Sanderson R
    Matrix Biol, 2013-10-18;35(0):215-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Long-term self-renewal of human ES/iPS-derived hepatoblast-like cells on human laminin 111-coated dishes.
    Authors: Takayama K, Nagamoto Y, Mimura N, Tashiro K, Sakurai F, Tachibana M, Hayakawa T, Kawabata K, Mizuguchi H
    Stem Cell Reports, 2013-10-03;1(4):322-35.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Pericytes modulate endothelial sprouting.
    Authors: Chang, William, Andrejecsk, Jillian, Kluger, Martin S, Saltzman, W Mark, Pober, Jordan S
    Cardiovasc Res, 2013-09-16;100(3):492-500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Multipotent human mesenchymal stromal cells mediate expansion of myeloid-derived suppressor cells via hepatocyte growth factor/c-met and STAT3.
    Authors: Yen B, Yen M, Hsu P, Liu K, Wang C, Bai C, Sytwu H
    Stem Cell Reports, 2013-07-25;1(2):139-51.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion.
    Authors: Sugiyama N, Gucciardo E, Tatti O, Varjosalo M, Hyytiainen M, Gstaiger M, Lehti K
    J Cell Biol, 2013-04-29;201(3):467-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.
    Authors: Hasenauer S, Malinger D, Koschut D, Pace G, Matzke A, von Au A, Orian-Rousseau V
    PLoS ONE, 2013-04-23;8(4):e62357.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Essential role for endocytosis in the growth factor-stimulated activation of ERK1/2 in endothelial cells.
    Authors: Gourlaouen, Morgane, Welti, Jonathan, Vasudev, Naveen S, Reynolds, Andrew R
    J Biol Chem, 2013-01-22;288(11):7467-80.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma.
    Authors: Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, Ciciarello M, Scambia G, Palumbo A, Locatelli F, De Cristofaro R, Rutella S
    J Transl Med, 2012-12-11;10(0):247.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells.
    Authors: Thatava T, Kudva Y, Edukulla R, Squillace K, De Lamo J, Khan Y, Sakuma T, Ohmine S, Terzic A, Ikeda Y
    Mol Ther, 2012-11-27;21(1):228-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations.
    Authors: Furcht C, Munoz Rojas A, Nihalani D, Lazzara M
    Oncogene, 2012-07-09;32(18):2346-55, 2355.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
    Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
    Stem Cells, 2011-06-01;29(6):964-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Neuropilin-1 signaling through p130Cas tyrosine phosphorylation is essential for growth factor-dependent migration of glioma and endothelial cells.
    Authors: Evans IM, Yamaji M, Britton G, Pellet-Many C, Lockie C, Zachary IC, Frankel P
    Mol. Cell. Biol., 2011-01-18;31(6):1174-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity.
    Authors: Ramani VC, Yang Y, Ren Y
    J. Biol. Chem., 2010-12-03;286(8):6490-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.
    Authors: Casazza A, Finisguerra V, Capparuccia L
    J. Clin. Invest., 2010-07-26;120(8):2684-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.
    Authors: Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE
    Am. J. Physiol., Cell Physiol., 2009-12-09;298(3):C465-76.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Imbalance in the pro-hepatocyte growth factor activation system in bleomycin-induced lung fibrosis in mice.
    Authors: Phin S, Marchand-Adam S, Fabre A, Marchal-Somme J, Bantsimba-Malanda C, Kataoka H, Soler P, Crestani B
    Am. J. Respir. Cell Mol. Biol., 2009-05-15;42(3):286-93.
    Species: Mouse
    Sample Types: BALF
    Applications: Activation
  96. Alternative proteolytic processing of hepatocyte growth factor during wound repair.
    Authors: Buchstein N, Hoffmann D, Smola H, Lang S, Paulsson M, Niemann C, Krieg T, Eming SA
    Am. J. Pathol., 2009-04-23;174(6):2116-28.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Endogenous hepatocyte growth factor is a niche signal for subventricular zone neural stem cell amplification and self-renewal.
    Authors: Nicoleau C, Benzakour O, Agasse F, Thiriet N, Petit J, Prestoz L, Roger M, Jaber M, Coronas V
    Stem Cells, 2009-02-01;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  98. A role for calcium-calmodulin in regulating nitric oxide production during skeletal muscle satellite cell activation.
    Authors: Tatsumi R, Wuollet AL, Tabata K, Nishimura S, Tabata S, Mizunoya W, Ikeuchi Y, Allen RE
    Am. J. Physiol., Cell Physiol., 2009-01-21;296(4):C922-9.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Control
  99. Purification and characterization of mouse lacrimal gland epithelial cells and reconstruction of an acinarlike structure in three-dimensional culture.
    Authors: Ueda Y, Karasawa Y, Satoh Y, Nishikawa S, Imaki J, Ito M
    Invest. Ophthalmol. Vis. Sci., 2008-12-20;50(5):1978-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor.
    Authors: Schnickmann S, Camacho-Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, Szabowski A, Breuhahn K
    J. Invest. Dermatol., 2008-11-20;129(5):1140-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types.
    Authors: Reed SA, Johnson SE
    J. Cell. Physiol., 2008-05-01;215(2):329-36.
    Species: Equine
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.
    Authors: Watanabe K, Bianco C, Strizzi L, Hamada S, Mancino M, Bailly V, Mo W, Wen D, Miatkowski K, Gonzales M, Sanicola M, Seno M, Salomon DS
    J. Biol. Chem., 2007-08-24;282(43):31643-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor.
    Authors: Skibinski G, Elborn JS, Ennis M
    Am. J. Physiol. Lung Cell Mol. Physiol., 2007-03-23;293(1):L69-76.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. A fusion protein of hepatocyte growth factor for immobilization to collagen.
    Authors: Kitajima T, Terai H, Ito Y
    Biomaterials, 2007-01-19;28(11):1989-97.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
    Authors: Li F, Shetty AK, Sugahara K
    J. Biol. Chem., 2006-12-04;282(5):2956-66.
    Species: Fish - Prionace glauca (Blue Shark)
    Sample Types: Peptide
    Applications: Bioassay
  106. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006-10-01;191(1):65-81.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Multipotent adult progenitor cells from swine bone marrow.
    Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
    Stem Cells, 2006-08-24;24(11):2355-66.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles.
    Authors: Lai WK, Sun PJ, Zhang J, Jennings A, Lalor PF, Hubscher S, McKeating JA, Adams DH
    Am. J. Pathol., 2006-07-01;169(1):200-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics.
    Authors: Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP
    Invest. Ophthalmol. Vis. Sci., 2006-06-01;47(6):2701-8.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  110. Differentiation of human embryonic stem cells into hepatocytes in 2D and 3D culture systems in vitro.
    Authors: Baharvand H, Hashemi SM, Kazemi Ashtiani S, Farrokhi A
    Int. J. Dev. Biol., 2006-01-01;50(7):645-52.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I.
    Authors: Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM
    Cancer Res., 1998-09-01;58(17):4008-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. Does Recombinant Human HGF Protein (Catalog # 294-HG or 294-HG/CF) contain any tags?

    • Recombinant Human HGF Protein (Catalog # 294-HG or 294-HG/CF) does not contain any tags. Please refer to the Source section on the product-specific page for sequence information.

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Recombinant Human HGF Protein
By Anonymous on 07/25/2023
Application: Cell migration/motility
Recombinant Human HGF Protein
By Anonymous on 08/20/2021
Application: Immunoassay Standard
Recombinant Human HGF Protein
By Danny Tam on 12/21/2017
Application: In vitro bioactivity in cell culture
Recombinant Human HGF Protein
By Anonymous on 11/16/2017
Application: Immunoassay Standard

A sandwich ELISA was made with MAB694 as the capture and BAF294 as the detection using 294-HG as the immunoassay calibrator.

Immunoassay Standard Recombinant Human HGF Protein 294-HG
Recombinant Human HGF Protein
By Anonymous on 09/08/2017
Application: stimulate met activity in cancer cells
Other Recombinant Human HGF Protein 294-HG
Recombinant Human HGF Protein
By Anonymous on 01/13/2016
Application: CellProlif