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Potent and reversible SARM1 NAD hydrolase inhibitor
Potent CD38 inhibitor; active in vivo
Selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
Influenza virus neuraminidase inhibitor; antiviral prodrug
HIF-PH inhibitor; erythropoietic
O-GlcNAcase and β-hexosaminidase inhibitor
α/β-hydrolase domain 6 (ABHD6) inhibitor; antiepileptic
Selective PFKFB3 inhibitor
Potent O-GlcNAcase inhibitor
Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant
Potent and selective MTH1 inhibitor
Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
Potent and selective N-SMase2 inhibitor; brain penetrant
Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor
Potent influenza virus neuraminidase inhibitor
Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
Potent and selective O-GlcNAcase (OGA) inhibitor
Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
Potent and selective NUDT15 hydrolase inhibitor
Molecular glue; induces degradation of NQAT1
Potent and selective vanin 1 inhibitor