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DSRM-3716

Catalog #: 7414
1 Citation Datasheet / COA / SDS
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7414/50
DSRM-3716 | CAS No. 58142-99-7 | Hydrolase Inhibitors
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Description: Potent and reversible SARM1 NAD hydrolase inhibitor

Chemical Name: 5-Iodoisoquinoline

Purity: ≥98%

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Citations (1)
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Biological Activity

DSRM-3716 is a potent, reversible inhibitor of SARM1 NAD(+) hydrolase (IC50 = 75 nM), which displays selectivity for SARM1 over related enzymes NAMPT and NMNAT and a panel of receptors and transporters. In vitro, DSRM-3716 decreases cyclic adenosine diphosphate ribose (cADPR) levels in mouse dorsal root ganglia (DRG) neurons, and protects mouse DRG and iPSC-derived human motor neurons against axonal degeneration. In axons with rotenone (Cat. No. 3616)-induced mitochondrial injury, DSRM-3716 rescues axons displaying indicators of degeneration.

Technical Data

M.Wt:
255.06
Formula:
C9H6IN
Solubility:
Soluble to 100 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
58142-99-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for DSRM-3716

The citations listed below are publications that use Tocris products. Selected citations for DSRM-3716 include:

1 Citation: Showing 1 - 1

  1. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo.
    Authors: Melanie Et al.
    Cell Rep Methods  2022;2:100260

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