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JW 480

Catalog #: 4327 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4327/10
4327/50
JW 480 | CAS No. 1354359-53-7 | Hydrolase Inhibitors
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Description: Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)

Chemical Name: 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate

Purity: ≥98%

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Biological Activity

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

Technical Data

M.Wt:
333.42
Formula:
C22H23NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1354359-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute.

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