Home / Hydrolase Inhibitors / Thiamet G

Thiamet G

Catalog #: 4390
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4390/10
Thiamet G | CAS No. 1009816-48-1 | Hydrolase Inhibitors
1 Image
Description: Potent O-GlcNAcase inhibitor

Chemical Name: (3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-pyrano[3,2-d]thiazole-6,7-diol

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Thiamet G is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.

Technical Data

M.Wt:
248.3
Formula:
C9H16N2O4S
Solubility:
Soluble to 50 mM in DMSO
Storage:
Store at -20°C
CAS No:
1009816-48-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Thiamet G

The citations listed below are publications that use Tocris products. Selected citations for Thiamet G include:

4 Citations: Showing 1 - 4

  1. O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis.
    Authors: Taparra Et al.
    J Clin Invest  2018;128:4924
  2. Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice.
    Authors: Jonathan C Et al.
    Nat Neurosci  2015;18:1183-9
  3. Epigenetic switching by the metabolism-sensing factors in the generation of orexin neurons from mouse embryonic stem cells.
    Authors: Hayakawa Et al.
    J Biol Chem  2013;288:17099
  4. Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation.
    Authors: Maury Et al.
    Stem Cell Res  2013;11:926

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Thiamet G

There are currently no reviews for this product. Be the first to review Thiamet G and earn rewards!

Have you used Thiamet G?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.