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AMZ 30

Catalog #: 6923 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6923/50
6923/10
AMZ 30 | CAS No. 1313613-09-0 | Hydrolase Inhibitors
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Description: Potent, selective and irreversible protein phosphatase methylesterase-1 (PME-1) inhibitor

Chemical Name: (2E)-2-[(4-Fluorophenyl)sulfonyl]-3-[1-[(3-nitrophenyl)sulfonyl]-1H-pyrrol-2-yl]-2-propenenitrile

Purity: ≥98%

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Biological Activity

AMZ 30 is a potent, selective and irreversible inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 600 nM) with > 100-fold selectivity for PME-1 over other serine hydrolases in human cell lysates. AMZ 30 inactivates PME-1 and reduces the demethylated form of serine/threonine protein phosphatase 2A (PP2A) in HEK 293T cells. AMZ 30 perturbs leucine carboxyl methyltransferase-1 (LCMT1)-PME-1 methylation equilibrium leading to shortening of mitotic spindles and mitotic arrest in HeLa cells. It also shows antiproliferative properties in an in vitro model of endometrial carcinoma.

Technical Data

M.Wt:
461.45
Formula:
C19H12FN3O6S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1313613-09-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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