Active Degraders: Products
Degraders are a way to knock down target proteins within cells. They are made up of binding moieties for an E3 ubiquitin ligase and a target protein joined by a linker. These hybrid molecules induce selective, proteasome-dependent degradation of target proteins. Degraders be also used to investigate the downstream effects of protein knockdown or to interfere with specific signaling pathways.
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"Active Degraders" has 86 results in Products.
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FAM-DEALA-Hyp-YIPD
Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity
FAM-DEALAHypYIPMDDDFQLRSF
Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity
NAMPT PROTAC® A7
Potent and selective nicotinamide phosphoribosyl transferase (NAMPT) Degrader (PROTAC®)