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BSJ-4-116

Catalog #: 7528 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7528/5
BSJ-4-116 | CAS No. 2519823-34-6 | Active Degraders
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Description: Selective CDK12 PROTAC® Degrader

Chemical Name: N-[7-[(3R)-3-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-1-piperidinyl]heptyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

Purity: ≥98%

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Biological Activity

BSJ-4-116 is a selective CDK12 PROTAC® Degrader. BSJ-4-116 selectively degrades CDK12 over a panel of other kinases and exhibits no degradation of CDK13 or cyclin K. The compound inhibits growth of T-ALL cells and sensitizes them to PARP inhibitor Olaparib (Cat. No. 7579).

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
837.39
Formula:
C40H49ClN8O8S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2519823-34-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Product Datasheets

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