FAM-DEALA-Hyp-YIPD

Catalog #: 7287 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
7287/1

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Description: Fluorescent HIF-1α peptide; can be used to evaluate the effect of VHL binding on degradation activity

Purity: ≥95%

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Biological Activity

FAM-DEALA-Hyp-YIPD is a fluorescent HIF-1α peptide (K_d = 180-560 nM). Can be used to assess VHL binding in Fluorescence Polarization (FP) displacement assay, and evaluate the effect of VHL binding on degradation activity. Excitation maximum = 485 nm, emission maximum = 535 nm. Longer peptide version, FAM-DEALAHypYIPMDDDFQLRSF (Cat. No. 7452), also available.

Optical Data for FAM-DEALA-Hyp-YIPD

λ_abs	485 nm
λ_em	520 nm
Closest Laser line	488 nm
Application	Fluorescence polarization (FP) displacement assays

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Technical Data

M.Wt:

1477.48

Formula:

C₇₁H₈₄N₁₀O₂₅

Sequence:

DEALAXYIPD

(Modifications: Asp-1 = 5-FAM-Asp, X-6 = Hyp)

Solubility:

Soluble to 1 mg/ml in 0.01M PBS

Purity:

≥95%

Storage:

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

SPR-measured kinetics of PROTAC ternary complexes influence target degradation rate.
Roy et al.
ACS Chem.Biol., 2019;14:361
Identification and characterization of Von Hippel-Lindau-recruiting proteolysis targeting chimeras (PROTACs) of TANK-binding kinase 1.
Crew et al.
J.Med.Chem., 2018;61:583

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