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BRD PHOTAC-I-3

Catalog #: 7319 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7319/5
BRD PHOTAC-I-3 | CAS No. 2370997-94-5 | Active Degraders
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Description: Photoswitchable BET bromodomain Degrader (PHOTAC)

Chemical Name: 2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f]-[1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-(4-((E)-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)diazenyl)-2,6-dimethoxyphenoxy)acetamido)butyl)acetamide

Purity: ≥98%

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Biological Activity

BRD PHOTAC-I-3 is a photoswitchable BET bromodomain degrader (PHOTAC, PHOtochemically TArgeting Chimera). BRD PHOTAC-I-3 comprises a ligand for an E3 ligase, a photoswitch, and the BET bromodomain targeting ligand (+)-JQ1 (Cat. No. 4499). Exhibits cytotoxicity and degrades BRD4, BRD3 and to a lesser extent BRD2 in lymphoblast cells upon irradiation with 390 nm light, but not in the dark. BRD2 antibodies validated for Western Blot also available: Catalog # NBP1-30475 and NBP2-75422.

Technical Data

M.Wt:
935.45
Formula:
C46H47ClN10O8S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2370997-94-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from New York University

Background References

  1. PHOTACs enable optical control of protein degradation.
    Reynders et al.
    Sci.Adv., 2020;6:eaay5064

Product Datasheets

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