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JH-XI-10-02

Catalog #: 7304 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7304/2
JH-XI-10-02 | CAS No. 2209085-22-1 | Active Degraders
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Description: CDK8 Degrader (PROTAC®)

Chemical Name: 15-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-N-[(3β,5α,17β)-17-(7-isoquinolinyl)androstan-3-yl]-N-methyl-4,7,10,13-tetraoxapentadecanamide

Purity: ≥98%

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Biological Activity

JH-XI-10-02 is a CDK8 Degrader comprising the cereblon binding ligand Pomalidomide (Cat. No. 6302) joined by a linker to a CDK8 inhibitor. JH-XI-10-02 (1 μM) induces significant proteasome-dependent degradation of CDK8 in Jurkat cells after 24 h, with no significant effect on CDK19 levels.

Technical Data

M.Wt:
920.16
Formula:
C53H69N5O9
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2209085-22-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute.

Product Datasheets

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