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CPS2

Catalog #: 7800 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7800/2
CPS2 | CAS No. 2756741-90-7 | Active Degraders
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Description: Potent and selective CDK2 Degrader (PROTAC®)

Chemical Name: 4-[[5-Amino-1-[(3-methyl-2-thienyl)carbonyl]-1H-1,2,4-triazol-3-yl]amino]-N-[2-[[1-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]ethyl]benzenesulfonamide

Purity: ≥98%

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Biological Activity

CPS2 is a potent and selective CDK2 Degrader (PROTAC®) (IC50 = 24 nM). It induces CDK2 degradation in several AML cell lines, including NB4, U937, OCI-AML2, OCI-AML3 and Kasumi-1 cells. It induces differentiation of AML cell lines, primary AML cells, and granulocytic differentiation of HSCs.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
890.95
Formula:
C38H42N12O10S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2756741-90-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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