Nicotinic Acetylcholine R alpha 4/CHRNA4: Products
CHRNA4 is a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. CHRNA4 is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in CHRNA4 cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in CHRNA4 that provide protection against nicotine addiction have been described.
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"Nicotinic Acetylcholine R alpha 4/CHRNA4" has 14 results in Products.
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Desformylflustrabromine hydrochloride
Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor
CMPI hydrochloride
Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
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