RJR 2403 oxalate
Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate
Purity: ≥99%
Biological Activity
RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
Bencherif et al.
J.Pharmacol.Exp.Ther., 1996;279:1413 -
Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.
Damaj et al.
J.Pharmacol.Exp.Ther., 1999;291:390 -
RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization.
Lippiello et al.
J.Pharmacol.Exp.Ther., 1996;279:1422
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Citations for RJR 2403 oxalate
The citations listed below are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:
6 Citations: Showing 1 - 6
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Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
Authors: Kiss Et al.
PLoS One 2014;9:e109538
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Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Dev Neurobiol 2013;8:e82719
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α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion.
Authors: Scholze Et al.
Cardiovasc Res 2011;71:390
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Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.
Authors: Zakharova Et al.
Int J Alzheimers Dis 2011;2010:954589
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Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
Authors: Li Et al.
Neurosci Lett 2009;462:20
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A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.
Authors: Liu Et al.
J Neurosci 2009;29:918
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