RJR 2403 oxalate

Catalog #: 1053
6 Citations Datasheet / COA / SDS

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RJR 2403 oxalate | CAS No. 220662-95-3 | Nicotinic (a4b2) Receptor Agonists

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Description: Selective α4β2 nAChR agonist

Alternative Names: Metanicotine, TC-2403

Chemical Name: (E)-N-Methyl-4-(3-pyridinyl)-3-buten-1-amine oxalate

Purity: ≥99%

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Product Details

Citations (6)

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Biological Activity

RJR 2403 oxalate is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (K_i values are 26 and 36000 nM for α4β2 and α7 receptors respectively). Active in vivo.

Technical Data

M.Wt:

252.27

Formula:

C₁₀H₁₄N₂.C₂H₂O₄

Solubility:

Soluble to 100 mM in water

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

220662-95-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

RJR-2403: a nicotinic agonist with CNS selectivity I. In vitro characterization.
Bencherif et al.
J.Pharmacol.Exp.Ther., 1996;279:1413
Antinociceptive and pharmacological effects of metanicotine, a selective nicotinic agonist.
Damaj et al.
J.Pharmacol.Exp.Ther., 1999;291:390
RJR-2403: a nicotinic agonist with CNS selectivity II. In vivo characterization.
Lippiello et al.
J.Pharmacol.Exp.Ther., 1996;279:1422

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Citations for RJR 2403 oxalate

The citations listed below are publications that use Tocris products. Selected citations for RJR 2403 oxalate include:

6 Citations: Showing 1 - 6

Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.
Authors: Kiss Et al.
PLoS One 2014;9:e109538
Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
Authors: Zhong Et al.
Dev Neurobiol 2013;8:e82719
α4β2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion.
Authors: Scholze Et al.
Cardiovasc Res 2011;71:390
Chronic cerebral ischaemia forms new cholinergic mechanisms of learning and memory.
Authors: Zakharova Et al.
Int J Alzheimers Dis 2011;2010:954589
Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses.
Authors: Li Et al.
Neurosci Lett 2009;462:20
A novel nicotinic acetylcholine receptor subtype in basal forebrain cholinergic neurons with high sensitivity to amyloid peptides.
Authors: Liu Et al.
J Neurosci 2009;29:918

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