TC 2559 difumarate
Chemical Name: 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate
Purity: ≥98%
Biological Activity
TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC50 values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)2(β2)3 receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors.
Bencherif et al.
Eur.J.Pharmacol., 2000;409:45 -
The nicotinic α4β2 receptor selective agonist, TC-2559, increases DA neuronal activity in the ventral tegmental area of rat midbrain slices.
Chen et al.
Neuropharmacology, 2003;45:334 -
5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors.
Zwart et al.
Eur.J.Pharmacol., 2006;539:10
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Citations for TC 2559 difumarate
The citations listed below are publications that use Tocris products. Selected citations for TC 2559 difumarate include:
2 Citations: Showing 1 - 2
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Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
Authors: Kiguchi
J Neuroinflammation 2018;15(1):96
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Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals.
Authors: Sun Et al.
Mol Cancer Ther 2009;8:110
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