NS 9283

Catalog # Availability Size / Price Qty
5112/10
5112/50
NS 9283 | CAS No. 913830-15-6 | Nicotinic (a4b2) Receptor Modulators
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Description: Positive allosteric modulator of α4β2 nAChRs

Chemical Name: 3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.

Technical Data

M.Wt:
248.24
Formula:
C14H8N4O
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
913830-15-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for NS 9283

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