Home / Nicotinic (a4b2) Receptor Modulators / Desformylflustrabromine hydrochloride

Desformylflustrabromine hydrochloride

Catalog #: 3328 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3328/10
3328/50
Desformylflustrabromine hydrochloride | CAS No. 951322-11-5 | Nicotinic (a4b2) Receptor Modulators
1 Image
Description: Positive allosteric modulator of α4β2 nAChRs; also muscle-type nAChR inhibitor

Chemical Name: 6-Bromo-2-(1,1-dimethyl-2-propenyl)-N-1H-indole-3-ethanamine hydrochloride

Purity: ≥98%

Product Details
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Desformylflustrabromine hydrochloride is a positive allosteric modulator of nicotinic α4β2 receptors; selectively increases the ionic current through α4β2 in the presence of ACh. Displays 14.7-fold selectivity for α4β2 over homomeric (α7) receptors. Moderately cytotoxic in HCT-116 cells. Also inhibits human muscle (αβεδ) and Torpedo (αβγδ) nAChRs (IC50 values are 1.0 and 0.1 μM, respectively) by binding in the ion channel.

Technical Data

M.Wt:
357.72
Formula:
C16H21BrN2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
951322-11-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Desformylflustrabromine (dFBr) and [3H]dFBr-labeled binding sites in a nicotinic acetylcholine receptor.
    Hamouda et al.
    Mol.Pharmacol., 2015;88:1
  2. Synthesis of desformylflustrabromine and its evaluation as an α4β2 and α7 nACh receptor modulator.
    Kim et al.
    Bioorg.Med.Chem.Lett., 2007;17:4855
  3. Potentiation of human α4β2 neuronal nicotinic receptors by a Flustra foliacea metabolite.
    Sala et al.
    Neurosci.Lett., 2005;373:44
  4. Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with α4β2 neuronal nicotinic acetylcholine receptor orthosteric ligands.
    Weltzin and Schulte
    J.Pharm.Exp.Ther., 2010;334:917

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs
Loading...

Reviews for Desformylflustrabromine hydrochloride

There are currently no reviews for this product. Be the first to review Desformylflustrabromine hydrochloride and earn rewards!

Have you used Desformylflustrabromine hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.