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Binds cereblon; also TNF-α synthesis inhibitor
Antiangiogenic. Heparanase inhibitor
Potent and selective α1β1 inhibitor
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Antiallergic; inhibits inflammatory mediator release from mast cells
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Src family kinase inhibitor. Also Hsp90 inhibitor
MCT inhibitor; decreases glycoloysis
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Potent VEGFR inhibitor; also inhibits other RTKs
Potent and selective JAK2 inhibitor; antiangiogenic