PX 12

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
   
   Nat Immunol, 2016;0(0):.
2. BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
   Zhu J, Sun L, Lin S
   J. Exp. Clin. Cancer Res., 2012;31(0):31.
3. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
   You B, Shin H, Park W
   Int J Oncol, 2014;44(1):301-8.
4. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
   Shin H, You B, Park W
   Oncol Lett, 2013;6(6):1804-1810.
5. Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.
   Kirkpatrick et al.
   Biochem.Pharmacol., 1998;55:987
6. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation.
   Welsh et al.
   Mol.Cancer.Ther., 2003;2:235
7. The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
   Jordan et al.
   Clin.Cancer Res., 2005;11:529

Product Datasheets