AZD 1480
Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
Purity: ≥98%
Biological Activity
AZD 1480 is a potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway.
Ioannidis S et al.
J.Med.Chem., 2011;54:262 -
Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480.
Xin et al.
Cancer Res., 2011;71:6601
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Citations for AZD 1480
The citations listed below are publications that use Tocris products. Selected citations for AZD 1480 include:
2 Citations: Showing 1 - 2
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Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes.
Authors: John D Et al.
ASN Neuro 2021;13:17590914211033650
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Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells.
Authors: Maarten H Et al.
Biochem Biophys Rep 2020;24:100832
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