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OGT 2115

Catalog #: 2710
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2710/1
2710/10
OGT 2115 | CAS No. 853929-59-6 | Antiangiogenic Compounds
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Description: Antiangiogenic. Heparanase inhibitor

Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid

Purity: ≥97%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

OGT 2115 is a heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).

Technical Data

M.Wt:
495.3
Formula:
C24H16BrFN2O4
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥97%
Storage:
Store at RT
CAS No:
853929-59-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dengue Virus NS1 Disrupts the Endothelial Glycocalyx, Leading to Hyperpermeability

    PLoS Pathog, 2016;12(7):e1005738.
  2. Heparanase: a target for drug discovery in cancer and inflammation.
    McKenzie
    Br.J.Pharmacol., 2007;151:1
  3. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor.
    Courtney et al.
    Bioorg.Med.Chem.Letts., 2005;15:2295

Product Datasheets

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Citations for OGT 2115

The citations listed below are publications that use Tocris products. Selected citations for OGT 2115 include:

4 Citations: Showing 1 - 4

  1. Heparanase attenuates axon degeneration following sciatic nerve transection.
    Authors: Whitehead
    Sci Rep  2018;8(1):5219
  2. Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.
    Authors: Agelidis Et al.
    Cell Rep  2017;20:439
  3. Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
    Authors: Changyaleket Et al.
    J Neuroinflammation  2017;14:137
  4. Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components.
    Authors: Glasner
    PLoS Pathogens  2017;13(11):e1006673

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