Obtustatin
Purity: ≥95%
Biological Activity
Obtustatin is a highly potent integrin α1β1 inhibitor (IC50 = 0.8 nM for α1β1 binding to type IV collagen). Selective for α1β1 over α2β1, αIIbβ3, αvβ3, α4β1, α5β6, α9β1 and α4β7. Inhibits FGF2-stimulated angiogenesis in the chicken chorioallantoic model. Displays antitumor efficacy in a synergistic mouse model of Lewis lung carcinoma; blocks human melanoma growth in nude mice.Technical Data
(Modifications: Disulfide bridges: 1-10, 6-29, 7-34, 19-36)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3
WS Chen, Z Cao, S Sugaya, MJ Lopez, VG Sendra, N Laver, H Leffler, UJ Nilsson, J Fu, J Song, L Xia, P Hamrah, N Panjwani
Nat Commun, 2016;7(0):11302. -
Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa.
Moreno-Murciano et al.
Protein Sci., 2003;12:366 -
Obtustatin: a potent and selective inhibitor of α1β1 integrin in vitro and angiogenesis in vivo.
Marcinkiewicz et al.
Cancer Res., 2003;63:2020 -
Angiostatic activity of obtustatin as α1β1 integrin inhibitor in experimental melanoma growth.
Brown et al.
Int.J.Cancer, 2008;123:2195
Product Datasheets
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Citations for Obtustatin
The citations listed below are publications that use Tocris products. Selected citations for Obtustatin include:
5 Citations: Showing 1 - 5
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Collagen I Fibrous Substrates Modulate the Proliferation and Secretome of Estrogen Receptor-Positive Breast Tumor Cells in a Hormone-Restricted Microenvironment.
Authors: Elaine T Et al.
ACS Biomater Sci Eng 2021;7:2430-2443
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The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model.
Authors: Elsa Et al.
Invest New Drugs 2019;37:1044-1051
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Collagen Type 1 accelerates healing of ruptured fetal membranes.
Authors: Mogami
Sci Rep 2018;8(1):696
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Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche
Authors: Baghdadi
Nature 2018;557:714
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Modulation of interactions of neuroblastoma cell lines with extracellular matrix proteins affects their sensitivity to treatment with the anti-GD2 ganglioside antibody 14G2a.
Authors: Hanna Et al.
Int J Oncol 2017;50:1899-1914
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