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Learn MoreSerotonergic Neuronal Markers
This interactive graphic lists some of the most commonly used serotonergic neuronal markers including Tryptophan Hydroxylase and the Serotonin Transporter (SERT or 5-HTTLPR). Clicking on a marker will take you to the R&D Systems selection of antibodies directed against that molecule. Clicking on a marker that is designated by (novusbio.com) will take you to the Novus Biologicals’ website and their antibody offerings for that protein. Additionally, use the buttons below to see markers associated with different neuronal subtypes.
Overview
Serotonin, also called 5-hydroxytryptamine (5-HT), is a monoamine signaling molecule that functions throughout the entire body. The majority of serotonin is produced in the digestive tract and is important for normal gut function and sensation. In the mammalian central nervous system, serotonin production is restricted to neurons located in the raphe nuclei of the midbrain. These neurons have an extensive axonal network that innervate numerous targets both rostrally and caudally, allowing serotonin to influence a multitude of diverse behaviors and physiological functions. Serotonergic neurons in the rostral raphe nuclei innervate multiple cortical and subcortical structures, while axons from serotonergic neurons in the caudal raphe nuclei terminate in the brainstem and spinal cord. Serotonin has been shown to regulate sleep, circadian rhythms, appetite, mood, learning, memory, and neuroendocrine function. Low serotonin levels have been associated with a number of psychiatric disorders including depression, anxiety, bipolar disorder, obsessive-compulsive disorder, and addiction.
