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Dopaminergic Neuronal Markers

This interactive graphic lists some of the most commonly used dopaminergic neuronal markers including Tyrosine Hydroxylase. Clicking on a marker will take you to the R&D Systems selection of antibodies directed against that molecule. Clicking on a marker that is designated by (novusbio.com) will take you to the Novus Biologicals’ website and their antibody offerings for that protein. Additionally, use the buttons below to see markers associated with different neuronal subtypes.

Property title
Fluorescent Neurotransmitter
Transporter Substrates
Fluorescent Neurotransmitter
Transporter Substrates
Dopamine beta-Hydroxylase
Dopamine beta-Hydroxylase
FOLR1
FOLR1
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GIRK2
GIRK2
HNF-3 beta/FoxA2
HNF-3 beta/FoxA2
LMX1b
LMX1b
Nurr1/NGFI-B beta/NR4A2
Nurr1/NGFI-B beta/NR4A2
SLC6A2/NET
SLC6A2/NET
SLC6A3/DAT1
SLC6A3/DAT1
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Tyrosine Hydroxylase
Tyrosine Hydroxylase

Overview

Dopaminergic neurons produce the monoamine neurotransmitter dopamine and are involved in voluntary movement, memory, emotional and motivated behaviors, and neuroendocrine regulation. The mammalian brain contains nine different dopaminergic neuron cell groups that are dispersed throughout the midbrain, hypothalamus, and olfactory bulb. The axons of these neurons project to their target areas via dopaminergic pathways. There are four main dopamine pathways in the brain: the tuberoinfundibular pathway, the mesolimbic pathway, the mesocortical pathway, and the nigrostriatal pathway. Dysregulation of dopamine signaling has been associated with addiction, schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. In addition, a reduction of dopamine function in the nigrostriatal pathway due to the loss of dopamine neurons in the substantia nigra is one main pathological feature of Parkinson’s disease.

Data Examples

Tyrosine Hydroxylase in Human Brain. Tyrosine Hydroxylase was detected in immersion-fixed paraffin-embedded sections of human brain (medulla) using a Mouse Anti-Human/Mouse Tyrosine Hydroxylase Monoclonal Antibody (R&D Systems, Catalog # MAB7566). The tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (R&D Systems, Catalog # CTS002; brown) and counterstained with hematoxylin (blue). Specific staining was localized to neurons.
Visualization of Presynaptic Terminals of Dopaminergic Neurons. Cultured dopaminergic neurons were treated with FFN 200, a selective fluorescent VMAT2 substrate (Tocris, Catalog # 5911), to visualize synaptic vesicles and then stimulated with K+ to trigger exocytosis. Video is comprised of time lapse images acquired at 12 images/minute.