Dopaminergic Neuronal Markers
This interactive graphic lists some of the most commonly used dopaminergic neuronal markers including Tyrosine Hydroxylase. Clicking on a marker will take you to the R&D Systems selection of antibodies directed against that molecule. Clicking on a marker that is designated by (novusbio.com) will take you to the Novus Biologicals’ website and their antibody offerings for that protein. Additionally, use the buttons below to see markers associated with different neuronal subtypes.
Transporter Substrates
Transporter Substrates
Overview
Dopaminergic neurons produce the monoamine neurotransmitter dopamine and are involved in voluntary movement, memory, emotional and motivated behaviors, and neuroendocrine regulation. The mammalian brain contains nine different dopaminergic neuron cell groups that are dispersed throughout the midbrain, hypothalamus, and olfactory bulb. The axons of these neurons project to their target areas via dopaminergic pathways. There are four main dopamine pathways in the brain: the tuberoinfundibular pathway, the mesolimbic pathway, the mesocortical pathway, and the nigrostriatal pathway. Dysregulation of dopamine signaling has been associated with addiction, schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder. In addition, a reduction of dopamine function in the nigrostriatal pathway due to the loss of dopamine neurons in the substantia nigra is one main pathological feature of Parkinson’s disease.