Compounds for NSC Differentiation: Products

γ-secretase inhibitor; induces neuronal differentiation; blocks Notch signaling

Adenylyl cyclase activator

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Selective ALK2 inhibitor

Potent Smoothened receptor agonist; activates the Hedgehog signaling pathway

γ-secretase inhibitor; induces neuronal differentiation

Endogenous retinoic acid receptor agonist

Forskolin synthesized to Ancillary Material Grade

PDE inhibitor (non-selective)

FGFR1 and -3 inhibitor

DAPT synthesized to Ancillary Material Grade

Activator of LKB1/AMPK; antidiabetic agent

Histone deacetylase inhibitor

Endogenous agonist of LPA1 and LPA2

5-HT reuptake inhibitor

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

LDN 193189 synthesized to cGMP guidelines

Synthetic retinoid; induces differentiation of stem cells

Induces neurogenesis in mature skeletal muscle cells

Selective inducer of neuronal differentiation in hippocampal neural progenitors

NAMPT activator; also proneurogenic and neuroprotective

Selective GPR55 agonist; also promotes NSC proliferation and differentiation

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Glutathione (GSH) precursor; maintains stem cell function in culture.

Sterile-filtered 10 mM solution of LDN 193189 pre-dissolved in water

Retinoic acid synthesized to Ancillary Material Grade