Metformin hydrochloride

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2864/100
Metformin hydrochloride | CAS No. 1115-70-4 | AMPK Activators
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Description: Activator of LKB1/AMPK; antidiabetic agent

Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride

Product Details
Citations (17)
Supplemental Products
Reviews (1)

Biological Activity

Metformin hydrochloride is an antidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines via inhibition of mitochondrial complex I (MRC-1). Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy. Identified by chemoinformatics as targeting human host proteins that interact with SARS-CoV-2. Metformin hydrochloride prevents brain atrophy, and slows the pace of aging across diverse tissues in animal studies.

Technical Data

M.Wt:
165.62
Formula:
C4H11N5.HCl
Solubility:
Soluble to 100 mM in water and to 20 mM in DMSO with gentle warming
Storage:
Store at RT
CAS No:
1115-70-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Metformin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Metformin hydrochloride include:

17 Citations: Showing 1 - 10

  1. Metformin decelerates aging clock in male monkeys.
    Authors: Yang Et al.
    Cell  2024;187:1
  2. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress.
    Authors: Westergard Et al.
    EMBO Mol Med  2019;11
  3. Altered steady state and activity-dependent de novo protein expression in fragile X syndrome.
    Authors: Bowling Et al.
    Nat Commun  2019;10:1710
  4. AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic Activation.
    Authors: Marinangeli Et al.
    iScience  2018;9:1
  5. Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment.
    Authors: Xintaropoulou Et al.
    BMC Cancer  2018;18:636
  6. Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage.
    Authors: Massey
    Sci Rep  2017;7:40778
  7. Effects of MET and a Mammalian Target of Rapamycin (mTOR) ATP-Competitive Inhibitor on Targeted Metabolomics in Pancreatic Cancer Cell Line.
    Authors: Soliman Et al.
    Metabolomics (Los Angel)  2017;6
  8. Vitamin C alleviates aging defects in a stem cell model for Werner syndrome.
    Authors: Li Et al.
    Protein Cell  2016;7:478
  9. Development of telmis. in the therapy of spinal cord injury: pre-clinical study in rats.
    Authors: Lin Et al.
    Nat Commun  2015;9:4709
  10. Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells.
    Authors: Naka Et al.
    BMC Cancer  2015;6:8039

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Metformin hydrochloride in vitro
By Anonymous on 11/11/2024
Species: Mouse

Used on cell lines to test senolytic activity.


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