Fluoxetine hydrochloride

Biological Activity

Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. Binds to the human 5-HT transporter with a K_i of 0.9 nmol/l and is between 150- and 900-fold selective over 5-HT_1A, 5-HT_2A, H₁, α₁, α₂-adrenergic, and muscarinic receptors. Antidepressant. Induces differentiation of neuronal precursors, enhancing neuronal characteristics. Fluoxetine also inhibits assembly and activation of the NLRP3-ASC inflammasome and prevents degeneration of retinal pigmented epithelium (RPE) cells in an animal model of dry age-related macular degeneration (AMD).

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Increased cellular turnover in response to fluoxetine in neuronal precursors derived from human embryonic stem cells.
   Chang et al.
   Int.J.Dev.Biol., 2010;54:707
3. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites.
   Owens et al.
   J.Pharmacol.Exp.Ther., 1997;283:1305
4. Fluoxetine selectively alters 5-hydroxytryptamine_1A and γ-aminobutyric acid_B receptor-mediated hyperpolarization in area CA1, but not area CA3, hippocampal pyramidal cells.
   Beck et al.
   J.Pharmacol.Exp.Ther., 1997;281:115
5. Fluoxetine. A review of its pharmacodynamic properties, and therapeutic efficacy in depressive illness.
   Benfield et al.
   Drugs, 1986;32:481
6. Increased cellular turnover in response to fluox. in neuronal precursors derived from human embryonic stem cells.
   Chang et al.
   Int.J.Dev.Biol., 2010;54:707
7. Identification of fluoxetine as a direct NLRP3 inhibitor to treat atrophic macular degeneration.
   Ambati et al.
   Proc.Natl.Acad.Sci.USA, 2021;118

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