ML 184
Chemical Name: 3-[[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl]-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
Purity: ≥98%
Biological Activity
ML 184 is a selective GPR55 agonist (EC50 = 250 nM). Exhibits >100-fold selectivity for GPR55 over GPR35, CB1 and CB2. Increases proliferation of neural stem cells and promotes neuronal differentiation in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis.
Hill et al.
Br.J.Pharmacol., 2018;175:3407 -
Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou et al.
Biochemistry, 2011;50:5633
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