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MDM2 antagonist; inhibits MDM2-p53 interaction
(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
MDM2 antagonist; active enantiomer of Nutlin-3 (Cat. No. 3984)
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Potent and selective CSN5 (COP9 signalosome) inhibitor
Hdm2 inhibitor; activates p53-dependent transcription
Selective inhibitor of E3 ubiquitin ligase
Selective Skp2 inhibitor; suppresses E3 ligase activity
High-affinity inhibitor of VHL
Cereblon binder; also TNF-α inhibitor and antiangiogenic
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo
Molecular glue; pre-mRNA splicing modulator
Potent and selective cereblon Degrader (PROTAC®); cell-permeable
MDM2-p53 interaction inhibitor
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
Bmi-1 inhibitor; antitumor
High affinity MDM2 inhibitor
High affinity Smurf1 inhibitor; enhances BMP signaling
HECT E3 ubiquitin ligase inhibitor
Negative control for VH 298
(+)-JQ1 based PROTAC® with selectivity for BRD4
Homo-PROTAC® for self-degradation of pVHL30
Multikinase Degrader (PROTAC®)
Negative control for TL 12-186 (Cat. No. 6524)
Potent MDM2 inhibitor; inhibits MDM2-p53 interaction
Potent, selective and reversible DCN1-UBC12 interaction inhibitor
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
SPOP E3 ubiquitin ligase inhibitor
Negative control for CSN5i-3 (Cat. No. 7089)
MAGE-A11 inhibitor; disrupts MAGE-A11:PCF11 interaction
TRAF6-Ubc13 interaction inhibitor
Inhibitor of VHL; blocks interaction of VHL and HIF-α
Potent covalent inhibitor of Cereblon