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Apcin

Catalog #: 5747
5 Citations Datasheet / COA / SDS
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5747/10
5747/50
Apcin | CAS No. 300815-04-7 | Ubiquitin Ligase (E3) Inhibitors
1 Image
Description: Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Chemical Name: 3-(2-Methyl-5-nitroimidazol-1-yl)-N-(2,2,2-trichloro-1-phenylaminoethyl)propionamide

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Apcin is a Cdc20 inhibitor; inhibits Cdc20-substrate interaction. Blocks substrate-mediated Cdc20 loading onto the anaphase-promoting complex (APC). Inhibits APC-dependent ubiquitylation. Prolongs mitotic duration in RPE1 cells in combination with proTAME (prodrug of TAME (Cat.No. 4506)) in vitro.

Technical Data

M.Wt:
438.65
Formula:
C13H14Cl3N7O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
300815-04-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
    Sackton KL, Dimova N, Zeng X et al.
    Nature.
  2. Targeting Cdc20 as a novel cancer therapeutic strategy.
    Wang et al.
    Pharmacol.Ther., 2015;151:141
  3. Hyperphosphorylation of CDH1 in glioblastoma cancer stem cells attenuates APC/CCDH1 activity and pharmacological inhibition of APC/CCDH1/CDC20 compromises viability
    K De, TM Grubb, AA Zalenski, KE Pfaff, D Pal, S Majumder, MK Summers, M Venere
    Mol. Cancer Res., 2019;0(0):.

Product Datasheets

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Citations for Apcin

The citations listed below are publications that use Tocris products. Selected citations for Apcin include:

5 Citations: Showing 1 - 5

  1. AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation.
    Authors: Venturina Et al.
    Life Sci Alliance  2023;6
  2. Kinetochore deterioration concommitant with centromere weakening during aging in mouse oocyte meiosis-I.
    Authors: Lin Et al.
    FASEB J  2023;37:e22922
  3. Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit.
    Authors: Shabaz Et al.
    Elife  2020;9
  4. Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk.
    Authors: Afonso Et al.
    Elife  2019;8
  5. Tetraploidy causes chromosomal instability in acentriolar mouse embryos.
    Authors: Greg Et al.
    Nat Commun  2019;10:4834

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