Nutlin 3a
Chemical Name: 4-[[(4S,5R)-4,5-Bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-piperazinone
Purity: ≥97%
Biological Activity
Nutlin 3a is an MDM2 antagonist (IC50 = 90 nM); inhibits the MDM2-p53 interaction. Active enantiomer of Nutlin-3 (Cat. No. 3984). Induces expression for P53 regulated genes. Suppresses tumor growth in vivo >98% in prostate cancer and osteosarcoma cancer models. Antiproliferative.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy.
Tovar et al.
Proc.Natl.Acad.Sci.USA., 2006;103:1888 -
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.
Vassilev et al.
Science, 2004;303:844 -
Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers
Z Ying, S Beronja
Cell Stem Cell, 2020;0(0):.
Product Datasheets
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Citations for Nutlin 3a
The citations listed below are publications that use Tocris products. Selected citations for Nutlin 3a include:
2 Citations: Showing 1 - 2
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p53 mitigates the effects of oncogenic HRAS in urothelial cells via the repression of MCOLN1.
Authors: Catherine Et al.
iScience 2021;24:102701
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Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers.
Authors: Slobodan Et al.
Cell Stem Cell 2020;26:403-419.e4
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