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Antifibrotic agent; regulates cytokine levels in vivo
Binds cereblon; also TNF-α synthesis inhibitor
Macrophage migration inhibitory factor (MIF) inhibitor
gp130 inhibitor; blocks cytokine-triggered gp130 signaling
Suppressor of MDK expression; inhibits PI 3-K signaling
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase
Selective Syk kinase inhibitor
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate
Reported macrophage migration inhibitory factor (MIF) inhibitor
Cereblon binder; also TNF-α inhibitor and antiangiogenic
Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin
Immunomodulator; reduces production of pro-inflammatory cytokines
Immunomodulatory and antitumor compound
Active metabolite binds CPSF3; Pro-drug
Potent and selective IRAK4 inhibitor
gp130 agonist; brain penetrant and neuroprotectant
NLRP3 inflammasome inhibitor
TIR-TIR interaction inhibitor
Inhibitor of pro-inflammatory mediator release from mast cells
TRAF6-Ubc13 interaction inhibitor
Potent NLRP3 inflammasome inhibitor
Innate defence regulator peptide
