ISO 1
Chemical Name: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester
Purity: ≥98%
Biological Activity
ISO 1 is a macrophage migration inhibitory factor (MIF) inhibitor (IC50 = 7 μM); inhibits MIF tautomerase activity in vitro and in vivo. Protective against mouse models of streptozotocin-induced diabetes mellitus; blocks anti-inflammatory response following LPS exposure and increases survival. Inhibits airway remodeling in a mouse model of chronic asthma. Cell permeable; orally bioavailable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The macrophage migration inhibitory factor pathway in human B cells is tightly controlled and dysregulated in multiple sclerosis
L Rijvers, MJ Melief, RM van der Vu, M Stéphant, J van Langel, AF Wierenga-W, JM Hogervorst, AJ Geurts-Moe, FCGJ Sweep, RQ Hintzen, MM van Luijn
Eur. J. Immunol., 2018;0(0):. -
The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.
Lubetsky et al.
J.Biol.Chem., 2002;277:24976 -
ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis.
Al-Abed et al.
J.Biol.Chem., 2005;280:36541 -
Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes.
Cvetkovic et al.
Endocrinology, 2005;146:2942 -
ISO-1, a macrophage migration inhibitory factor antagonist, inhibits airway remodeling in a murine model of chronic asthma.
Chen et al.
Mol.Med., 2010;16:400 -
Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer
I Cotzomi-Or, A Rosas-Cruz, D Ramírez-Ra, J Reyes-Leyv, M Rodriguez-, P Aguilar-Al, P Maycotte
Biology (Basel), 2020;9(1):.
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Citations for ISO 1
The citations listed below are publications that use Tocris products. Selected citations for ISO 1 include:
4 Citations: Showing 1 - 4
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Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis.
Authors: Heide L Et al.
JCI Insight 2022;7
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Autophagy Inhibition Induces the Secretion of Macrophage Migration Inhibitory Factor (MIF) with Autocrine and Paracrine Effects on the Promotion of Malignancy in Breast Cancer.
Authors: Julio Et al.
Biology (Basel) 2020;9
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Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression.
Authors: Justin D Et al.
Front Immunol 2020;11:1191
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The expression of microRNA-451 in human endometriotic lesions is inversely related to that of macrophage migration inhibitory factor (MIF) and regulates MIF expression and modulation of epithelial cell survival.
Authors: Graham Et al.
Hum Reprod 2015;30:642
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