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Potent AMPK inhibitor; also BMP type I receptor inhibitor
Prototypical PI 3-kinase inhibitor; also inhibits other kinases
Potent and selective mTOR inhibitor
H+-ATPase (vacuolar) inhibitor
Potent inhibitor of SERCA ATPase
Anti-inflammatory glucocorticoid
mTOR inhibitor; immunosuppressant
Promotes assembly and inhibits disassembly of microtubules
Selective and high affinity cathepsin D inhibitor
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
Protein kinase C inhibitor
mTOR inhibitor; Immunosuppressant
Activator of LKB1/AMPK; antidiabetic agent
Highly selective P2X1 antagonist
Histone deacetylase inhibitor
Antibiotic; GlcNAc phosphotransferase inhibitor
Disrupts protein translocation to Golgi
p53 inhibitor. Also aryl hydrocarbon receptor agonist
Antimalarial; inhibits apoptosis and autophagy
DNA-methylating antitumor agent
Inhibitor of PI 3-kinase, mTOR and DNA-PK
H+-ATPase (vacuolar) inhibitor
STAT3 inhibitor; also inhibits mTORC1 signaling
Potent and selective mTOR inhibitor
Cathepsin inhibitor; interferes with autolysosomal digestion
Inositol monophosphatase inhibitor
HMG-CoA reductase inhibitor
Class III PI 3-kinase inhibitor; also inhibits autophagy
Positive regulator of autophagy
Autophagy inhibitor; also TLR9 inhibitor
Potent and selective p97 ATPase (VCP) allosteric inhibitor
Inhibitor of neuronal NaV channels; anticonvulsant
p97 ATPase (VCP) inhibitor
Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor
ATP-competitive inhibitor of p97 ATPase
mTOR inhibitor; antitumor
Potent and selective Foxo1 inhibitor; orally bioavailable
H+-ATPase activator; activates autophagy; inactivates mTORC1 signaling
Selective SIRT1 activator; induces autophagy and mitochondrial biogenesis
Inducer of autophagy via interaction of p62 and LC3