A23187, free acid
Chemical Name: 5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Purity: ≥98%
Biological Activity
A23187, free acid is a calcium ionophore that induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo. Can be used to induce autophagy in mammalian cells.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differential effects of endoplasmic reticulum stress-induced autophagy on cell survival.
Ding et al.
J.Biol.Chem., 2007;282:4702 -
Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not NADPH oxidase.
Kajitani et al.
Biosci.Biotechnol.Bichem., 2007;71:2701 -
Zn2+, derived from cell preparation, partly attenuates Ca2+-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.
Sakanashi et al.
Toxicol.In Vitro, 2009;23:338 -
Platelet particle formation by anti-GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexameth. blockade of platelet phospholipase A2, 12-lipoxygenase, and
Nardi et al.
Blood, 2007;110:1989
Product Datasheets
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Citations for A23187, free acid
The citations listed below are publications that use Tocris products. Selected citations for A23187, free acid include:
11 Citations: Showing 1 - 10
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The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Authors: Goldberg Et al.
Aging Cell 2018;17
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Bimodal fluorogenic sensing of matrix proteolytic signatures in lung cancer.
Authors: Megía-Fernández Et al.
Org Biomol Chem 2018;16:8056
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Potential therapeutic action of nitrite in sickle cell disease.
Authors: Wajih Et al.
Redox Biol 2017;12:1026
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Necrotic pyknosis is a morphologically and biochemically distinct event from apoptotic pyknosis.
Authors: Hou Et al.
J Cell Sci 2016;129:3084
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Piezo1 links mechanical forces to red blood cell volume.
Authors: Cahalan Et al.
Cardiovasc Res 2015;4
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Biomechanical forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis.
Authors: Díaz Et al.
J Exp Med 2015;212:665
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iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis.
Authors: Schöndorf Et al.
Nat Commun 2014;5:4028
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Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
BMC Cancer 2013;4:e969
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Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade.
Authors: Yung Et al.
Neuropharmacology 2013;13:327
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Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice.
Authors: Cheang Et al.
Cell Death Dis 2011;92:267
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Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A.
Authors: Arozarena Et al.
Cancer Cell 2011;19:45
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