Simvastatin

Biological Activity

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels
   K Zhang, W Song, D Li, X Jin
   Exp Ther Med, 2017;13(5):1719-1724.
2. STAT and bone formation.
   Garrett et al.
   Curr.Pharm.Des., 2001;7:715
3. Potential anticancer effects of STAT: fact or fiction?
   Kaushal et al.
   Endothelium, 2003;10:49
4. Pharmacological effects of HMG CoA reductase inhibitors other than lipoprotein modulation.
   White
   J.Clin.Pharmacol., 1999;39:111
5. Preclinical pharmacokinetics of STAT.
   Reinoso et al.
   Methods Find.Exp.Clin.Pharmacol., 2002;24:593

Product Datasheets