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PDGF R beta: Products
PDGF R beta is a transmembrane receptor tyrosine kinase (RTK) that primarily binds to the PDGF-BB isoform of the growth factor. Ligand binding induces receptor homodimerization or heterodimerization with PDGF R alpha followed by autophosphorylation and signal transduction. PDGF receptor signaling is attenuated by SHP-2 phosphatase activity and by receptor endocytosis and lysosomal degradation. The expression of the alpha and beta receptors is independently regulated in various cell types. A soluble splice variant of PDGF R beta binds PDGF with high affinity and functions as a potent PDGF antagonist.
Products:
- Primary Antibodies
- Small Molecules
- Proteins & Enzymes
- ELISAs
- Proteome Profiler Antibody Arrays
- cDNA Clones
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"PDGF R beta" has 55 results in Products.
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Proteome Profiler Human Phospho-Kinase Array Kit
Contains 4 sets of 2 membranes - each spotted in duplicate with antibodies against 37 different kinases and 2 related total proteins
Proteome Profiler Human Phospho-RTK Array Kit
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Imatinib mesylate
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
