Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways & Lineage-specific Markers
Click on a cell type below to view a subset of molecules used as markers for the identification of that cell type.
Get Print CopyFactors
Factors
Factors
Factors
Stem Cells
Stem Cells
Differentiation Kit
Differentiation Kit
Progenitors
Progenitors
Stem Cells
Stem Cells
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Differentiation Kit
Differentiation Kit
Stem Cells
Stem Cells
Ligand
Ligand
Stem Cells
Stem Cells
Ligand
Ligand
11,13,15
11,13,15
Ligand
Ligand
Progenitors
Progenitors
Differentiation Kit
Differentiation Kit
Progenitors
Progenitors
Progenitors
Progenitors
Lung Cells
Lung Cells
Stem Cells
Stem Cells
Overview of Embryonic and Induced Pluripotent Stem Cells & Lineage-specific Markers
Embryonic stem (ES) cells and induced pluripotent stem (iPS) cells are self-renewing progenitors that have the capacity to differentiate into cells of the ectoderm, mesoderm, and endoderm. Naturally existing ES cells can be isolated from the inner cell mass of a blastocyst while iPS cells are generated from terminally differentiated somatic cells through induced expression of specific transcription factors, including Oct-3/4, KLF4, SOX2, and c-Myc. Regardless of the source, pluripotent stem cells hold enormous potential in basic and clinical studies through their ability to differentiate into a wide variety of cell types, including neurons, pancreatic beta cells, cardiomyocytes, and progenitor cells of the liver, lung and skin. The mechanisms controlling ES/iPS self-renewal and differentiation are influenced by a diverse set of growth factors, receptors, intracellular signaling molecules, and transcription factors. Cell fate determination often requires a tightly regulated temporal sequence of growth factor presentation and transcription factor expression. The factors depicted below are known to influence ES/iPS pluripotency, proliferation, and lineage commitment. ES/iPS cells and their differentiated progeny can be identified by the expression of a unique combination of cell surface markers and transcription factors. Unique identifiers for each cell can be viewed by clicking on that cell-type within the lineage pathway.
To learn more, please visit Induced Pluripotent Stem Cells at Bio-Techne.
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