Sodium butyrate

Catalog # Availability Size / Price Qty
3850/50
Sodium butyrate | CAS No. 156-54-7 | Class I Histone Deacetylases Inhibitors
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Description: Histone deacetylase inhibitor

Chemical Name: Butanoic acid sodium salt

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Biological Activity

Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.

Technical Data

M.Wt:
110.09
Formula:
C4H7NaO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
156-54-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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