IL-26/AK155: Products

IL-26 was originally cloned from herpesvirus saimiri (HVS)-transformed T-cells and named AK155. In addition to HVS-transformed T cells, IL-26 is also expressed in other virally-transformed T cell lines, fresh peripheral mononuclear cells, activated NK cells and T cells. A mouse homolog of human IL-26 has not been identified. Mature IL-26 is a homodimer in solution. IL-26 binds with high-affinity to a heterodimeric complex consisting of the ligand-binding IL-20 R alpha and non-ligand-binding IL-10 R beta. Activation of the receptor complex results in rapid phosphorylation of STAT1 and STAT3.