Human IL-26/AK155 Antibody

Catalog #: AF1375
6 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF1375
AF1375-SP

All IL-26/AK155 Antibodies

Product Details

Citations (6)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IL-26/AK155 Antibody Summary

Species Reactivity

Human

Specificity

Detects human IL-26 in direct ELISAs and Western blots. In these formats, less than 5% cross‑reactivity with recombinant human IL-10 is observed.

Source

Polyclonal Goat IgG

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human IL‑26/AK155 Monomer (Catalog # 1375-IL)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IL-26/AK155

IL-26 was originally cloned from herpesvirus saimiri (HVS)-transformed T cells and named AK155 (1). It is a member of the IL-10 family of class II cytokines that signal via heterodimeric receptor complexes composed of two type I transmembrane receptor subunits (2). The human IL-26 gene has been mapped to chromosome 12q15. It encodes a 171 amino acid polypeptide with a 21 amino acid signal peptide. In addition to HVS-transformed T cells, IL-26 is also expressed in other virus transformed T cell lines, fresh peripheral mononuclear cells, activated NK cells and T cells. A mouse homologue of human IL-26 has not been identified. IL-26 binds with high-affinity to the heterodimeric complex consisting of the ligand-binding IL-20 R alpha and non ligand-binding IL-10 R beta (3). Activation of the receptor complex results in rapid phosphorylation of STAT1 and STAT3. Although the IL-26 receptor complex is highly specific for IL-26 and is not activated by other class II cytokines, the individual subunits of the IL-26 receptor complex are components in receptor complexes for other class II cytokines (1). IL-20 R alpha can form dimers with IL-20 R beta to function as signaling receptors for IL-19, IL-20, and IL-24. IL-10 R beta can complex with IL-10 R alpha, IL-22 R, and IL-28 R alpha to transduce signals for IL-10, IL-22, and the three novel IFNs (IL-28A, IL-28B and IL-29), respectively. The physiological functions of IL-26 remain to be determined. IL-26 was reported to be a homodimer in solution (1).

References

Knappe. A. et al. (2000) J. Virology 74:3881.
Renauld, J.-C. (2003) Nature Reviews Immunology 3:667.
Sheikh, F. et al. (2004) J. Immunol. 172(4):2006.
Unpublished data (2003) R&D Systems, Inc.

Long Name

Interleukin 26

Entrez Gene IDs

55801 (Human)

Alternate Names

AK155; AK155IL-26interleukin-26; IL26; IL-26; interleukin 26; Protein AK155

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citations for Human IL-26/AK155 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis
Authors: Fries, A;Saidoune, F;Kuonen, F;Dupanloup, I;Fournier, N;Guerra de Souza, AC;Haniffa, M;Ma, F;Gudjonsson, JE;Roesner, L;Li, Y;Werfel, T;Conrad, C;Gottardo, R;Modlin, RL;Di Domizio, J;Gilliet, M;
Nature communications
Species: Human
Sample Types: Whole Tissue
Applications: IHC
IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells
Authors: T Itoh, R Hatano, Y Horimoto, T Yamada, D Song, H Otsuka, Y Shirakawa, S Mastuoka, N Iwao, TM Aune, NH Dang, Y Kaneko, K Okumura, C Morimoto, K Ohnuma
Cell Death & Disease, 2021-05-21;12(6):520.
Species: Human
Sample Types: Whole Cells
Applications: ICC, PLA
Regulation of pulmonary graft-versus-host disease by IL-26+CD26+CD4 T lymphocytes.
Authors: Ohnuma K, Hatano R, Aune T, Otsuka H, Iwata S, Dang N, Yamada T, Morimoto C
J Immunol, 2015-03-18;194(8):3697-712.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization
IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation.
Authors: Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P
PLoS Biol, 2012-09-25;10(9):e1001395.
Species: Human
Sample Types: Serum
Applications: ELISA Development
The role of the novel Th17 cytokine IL-26 in intestinal inflammation.
Authors: Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, Diepolder HM, Auernhammer CJ, Brand S
Gut, 2008-05-15;58(9):1207-17.
Species: Human
Sample Types: Serum, Whole Tissue
Applications: ELISA Development, IHC-P
Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
Authors: Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, Dickensheets H, Dumoutier L, Renauld JC, Zdanov A, Donnelly RP, Kotenko SV
J. Immunol., 2004-02-15;172(4):2006-10.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot