GNF 5

Catalog # Availability Size / Price Qty
4908/10
4908/50
GNF 5 | CAS No. 778277-15-9 | Abl Kinase Inhibitors
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Description: Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)

Chemical Name: N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide

Purity: ≥98%

Product Details
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Biological Activity

GNF 5 is a selective, non-ATP competitive allosteric inhibitor of Bcr-Abl (IC50 = 220 nM for wild-type Abl). Binds the myristate-binding site of Abl. Acts in combination with nilotinib to inhibit T315I Bcr-Abl in vitro and in vivo. Analog of GNF 2 (Cat. No. 4399). GNF 5 decreases mitochondrial function in lung cancer cells.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GNF 5 is reviewed on the chemical probes website.

Technical Data

M.Wt:
418.37
Formula:
C20H17F3N4O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
778277-15-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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