Human TrkC Antibody Summary
Cys32-Asp428
Accession # Q96CY4
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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TrkC in Rat Spinal Cord. TrkC was detected in perfusion fixed frozen sections of rat spinal cord using 15 µg/mL Mouse Anti-Human TrkC Monoclonal Antibody (Catalog # MAB373) overnight at 4 °C. Tissue was stained (red). View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TrkC
The neurotrophins, including NGF, BDNF, NT-3, and NT-4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases (1, 2). p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low-affinity to transduce cellular signaling pathways that synergize or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3 (1-2). All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC's showing 94% amino acid sequence identity (5). The proteins also exhibit cross-species activity. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system (6).
- Huang, E.J. and L.F. Reichardt. (2003) Annu. Rev. Biochem. 72:(epub ahead of print).
- Dechant, G. (2001) Cell Tissue Res. 305:229.
- Schneider, R. and M. Schweiger (1991) Oncogene 6:1807.
- Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
- Menn, B. et al. (1998) J. Comp. Neurol. 401:47.
- Shelton, D. et al. (1995) J. Neurosci. 15:477.
Product Datasheets
Citations for Human TrkC Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer
Authors: N Apóstolo, SN Smukowski, J Vanderlind, G Condomitti, V Rybakin, J Ten Bos, L Trobiani, S Portegies, KM Vennekens, NV Gounko, D Comoletti, KD Wierda, JN Savas, J de Wit
Nat Commun, 2020-10-14;11(1):5171.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations
Authors: M Oczko-Wojc, M Swierniak, J Krajewska, M Kowalska, M Kowal, T Stokowy, B Wojtas, D Rusinek, A Pawlaczek, A Czarniecka, S Szpak-Ulcz, T Gawlik, E Chmielik, T Tyszkiewic, B Nikiel, D Lange, M Jarzab, M Wiench, B Jarzab
Sci Rep, 2017-02-09;7(0):42074.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Recombinant adenovirus vector-mediated functional expression of neurotropin-3 receptor (TrkC) in neural stem cells.
Authors: Wang JM, Zeng YS, Liu RY, Huang WL, Xiong Y, Wang YH, Chen SJ, Teng YD
Exp. Neurol., 2006-09-27;203(1):123-7.
Species: Human
Sample Types: Cell Lysates, Whole Cells
Applications: ICC, Western Blot -
The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma.
Authors: Nassenstein C, Braun A, Erpenbeck VJ, Lommatzsch M, Schmidt S, Krug N, Luttmann W, Renz H, Virchow JC
J. Exp. Med., 2003-08-04;198(3):455-67.
Species: Human
Sample Types: Whole Cells
Applications: ICC
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