VPS10P-domain Family

Vacuolar protein sorting 10 protein (VPS10P)-domain receptors are type 1 transmembrane proteins that bind a range of ligands including neurotrophins, neuropeptides, and other transmembrane proteins. In veterbrates there are five members of the family, Sortilin, sorting protein-related receptor with A-type repeats (SorLA), sortilin-related receptor CNS expressed 1 (SorCS1), SorCS2, and SorCS3. These multifunctional molecules have been shown to affect neuronal viability and function by regulating protein transport and signal transduction. Each receptor is expressed in distinct neuronal populations, suggesting discrete functions in different cell types.